Advances in treating HER2-positive breast cancer: an interview with Sunil Verma.

abstract：BACKGROUND:Atrazine (2-chloro-4-ethytlamino-6-isopropylamine-1,3,5-triazine; ATR), is the most commonly applied broad-spectrum herbicide in the world. Unintentional overspray of ATR poses an immune function health hazard. The biomolecular mechanisms responsible for ATR-induced immunotoxicity, however, are little unders...

journal_title：BMC medicine

authors： Zhang X,Wang M,Gao S,Ren R,Zheng J,Zhang Y

更新日期：2011-10-27 00:00:00

abstract：BACKGROUND:The inverse equity hypothesis asserts that new health policies initially widen inequality, then attenuate inequalities over time. Since 2004, the UK's pay-for-performance scheme for chronic disease management (CDM) in primary care general practices (the Quality and Outcomes Framework) has permitted practices...

journal_title：BMC medicine

authors： Lowrie R,McConnachie A,Williamson AE,Kontopantelis E,Forrest M,Lannigan N,Mercer SW,Mair FS

更新日期：2017-04-11 00:00:00

abstract：BACKGROUND:Wide implementation of mammography screening has resulted in increased numbers of women diagnosed with breast carcinoma in situ. We aimed to determine the risk of invasive breast cancer in relatives of patients with breast carcinoma in situ in comparison to the risk in relatives of patients with invasive bre...

journal_title：BMC medicine

authors： Mukama T,Fallah M,Brenner H,Xu X,Sundquist K,Sundquist J,Kharazmi E

更新日期：2020-11-05 00:00:00

abstract：BACKGROUND:Virtual histology intravascular ultrasound (VH-IVUS) imaging is an innovative tool for the morphological evaluation of coronary atherosclerosis. Evidence for the effects of statin therapy on VH-IVUS parameters have been inconclusive. Consequently, we performed a systematic review and meta-analysis to investi...

journal_title：BMC medicine

authors： Banach M,Serban C,Sahebkar A,Mikhailidis DP,Ursoniu S,Ray KK,Rysz J,Toth PP,Muntner P,Mosteoru S,García-García HM,Hovingh GK,Kastelein JJ,Serruys PW,Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group.

更新日期：2015-09-18 00:00:00

abstract：BACKGROUND:Comorbidity between depressive and anxiety disorders is common. A hypothesis of the network perspective on psychopathology is that comorbidity arises due to the interplay of symptoms shared by both disorders, with overlapping symptoms acting as so-called bridges, funneling symptom activation between symptom ...

journal_title：BMC medicine

authors： Groen RN,Ryan O,Wigman JTW,Riese H,Penninx BWJH,Giltay EJ,Wichers M,Hartman CA

更新日期：2020-09-29 00:00:00

abstract：BACKGROUND:Ancestral environmental exposures to a variety of environmental factors and toxicants have been shown to promote the epigenetic transgenerational inheritance of adult onset disease. The present work examined the potential transgenerational actions of the insecticide dichlorodiphenyltrichloroethane (DDT) on o...

journal_title：BMC medicine

authors： Skinner MK,Manikkam M,Tracey R,Guerrero-Bosagna C,Haque M,Nilsson EE

更新日期：2013-10-23 00:00:00

abstract：:A decade ago celiac disease was considered extremely rare outside Europe and, therefore, was almost completely ignored by health care professionals. In only 10 years, key milestones have moved celiac disease from obscurity into the popular spotlight worldwide. Now we are observing another interesting phenomenon that i...

journal_title：BMC medicine

authors： Sapone A,Bai JC,Ciacci C,Dolinsek J,Green PH,Hadjivassiliou M,Kaukinen K,Rostami K,Sanders DS,Schumann M,Ullrich R,Villalta D,Volta U,Catassi C,Fasano A

更新日期：2012-02-07 00:00:00

abstract：BACKGROUND:The 2012 World Health Assembly set a target for Member States to reduce premature non-communicable disease (NCD) mortality by 25% over the period 2010 to 2025. This reflected concerns about increasing NCD mortality burdens among productive adults globally. This article first considers whether the WHO target ...

journal_title：BMC medicine

authors： Santosa A,Rocklöv J,Högberg U,Byass P

更新日期：2015-03-30 00:00:00

abstract：BACKGROUND:In July 2014, an outbreak of Ebola virus disease (EVD) started in Pujehun district, Sierra Leone. On January 10th, 2015, the district was the first to be declared Ebola-free by local authorities after 49 cases and a case fatality rate of 85.7%. The Pujehun outbreak represents a precious opportunity for impro...

journal_title：BMC medicine

authors： Ajelli M,Parlamento S,Bome D,Kebbi A,Atzori A,Frasson C,Putoto G,Carraro D,Merler S

更新日期：2015-11-26 00:00:00

abstract：BACKGROUND:Due to the overlapping clinical features of coronavirus disease 2019 (COVID-19) and influenza, parallels are often drawn between the two diseases. Patients with pre-existing cardiovascular diseases (CVD) are at a higher risk for severe manifestations of both illnesses. Considering the high transmission rate ...

journal_title：BMC medicine

authors： Khan MS,Shahid I,Anker SD,Solomon SD,Vardeny O,Michos ED,Fonarow GC,Butler J

更新日期：2020-12-18 00:00:00

abstract：BACKGROUND:Pancreatic cancer (PaC) remains extremely lethal worldwide even after resection. PaC resection rates are low, making prognostic studies in resected PaC difficult. This large international population-based study aimed at exploring factors associated with survival in patients with resected TNM stage I-II PaC r...

journal_title：BMC medicine

authors： Huang L,Balavarca Y,van der Geest L,Lemmens V,Van Eycken L,De Schutter H,Johannesen TB,Zadnik V,Primic-Žakelj M,Mägi M,Grützmann R,Besselink MG,Schrotz-King P,Brenner H,Jansen L

更新日期：2019-03-25 00:00:00

abstract：BACKGROUND:All rigorous primary cardiovascular disease (CVD) prevention guidelines recommend absolute CVD risk scores to identify high- and low-risk patients, but laboratory testing can be impractical in low- and middle-income countries. The purpose of this study was to compare the ranking performance of a simple, non-...

journal_title：BMC medicine

authors： Gaziano TA,Pandya A,Steyn K,Levitt N,Mollentze W,Joubert G,Walsh CM,Motala AA,Kruger A,Schutte AE,Naidoo DP,Prakaschandra DR,Laubscher R

更新日期：2013-07-24 00:00:00

abstract：BACKGROUND:Several accomplishments have been achieved in triple-negative breast cancer (TNBC) research over the last year. The phase III IMpassion130 trial comparing chemotherapy plus atezolizumab versus chemotherapy plus placebo brought breast cancer into the immunotherapy era. Nevertheless, despite encouraging result...

journal_title：BMC medicine

authors： Marra A,Viale G,Curigliano G

更新日期：2019-05-09 00:00:00

abstract：:The stratification of patients for treatment of prostate cancer is based on very general parameters like prostate-specific antigen, Gleason score, and TNM classification. We use these rough parameters for selection of active surveillance, active treatment, and even for the treatment selection in metastasized or castra...

journal_title：BMC medicine

authors： Sedelaar JP,Schalken JA

更新日期：2015-05-09 00:00:00

abstract：BACKGROUND:International medical graduates working in the UK are more likely to be censured in relation to fitness to practise compared to home graduates. Performance on the General Medical Council's (GMC's) Professional and Linguistic Assessments Board (PLAB) tests and English fluency have previously been shown to pre...

journal_title：BMC medicine

authors： Tiffin PA,Paton LW,Mwandigha LM,McLachlan JC,Illing J

更新日期：2017-03-20 00:00:00

abstract：BACKGROUND:Inappropriate treatment of non-malaria fevers with artemisinin-based combination therapies (ACTs) is a growing concern, particularly in light of emerging artemisinin resistance, but it is a behavior that has proven difficult to change. Pay for performance (P4P) programs have generated interest as a mechanism...

journal_title：BMC medicine

authors： Menya D,Platt A,Manji I,Sang E,Wafula R,Ren J,Cheruiyot O,Armstrong J,Neelon B,O'Meara WP

更新日期：2015-10-16 00:00:00

abstract：BACKGROUND:We investigated interactions between genetically and autoimmune-mediated coagulopathies by inducing experimental antiphospholipid syndrome (eAPS) in mice carrying the factor V Leiden (FVL) mutation. METHODS:eAPS was induced in heterozygous and homozygous FVL transgenic mice (C57BL/6 background) by immunizat...

journal_title：BMC medicine

authors： Katzav A,Grigoriadis NC,Ebert T,Touloumi O,Blank M,Pick CG,Shoenfeld Y,Chapman J

更新日期：2013-04-04 00:00:00

abstract：BACKGROUND:Recent reviews on placebo effects in clinical trials suggest that objective changes following placebo treatments may not exist or, at least, have been considerably overestimated. However, the possibility that yet unidentified subsets of parameters are responsive to placebo treatments has not been taken into ...

journal_title：BMC medicine

authors： Meissner K,Distel H,Mitzdorf U

更新日期：2007-03-19 00:00:00

abstract：BACKGROUND:Israeli citizens have been exposed to intense and ongoing terrorism since September 2000. We previously studied the mental health impact of terrorism on the Israeli population (Bleich et al., 2002), however the long-term impact of ongoing terrorism has not yet been examined. The present study evaluated the p...

journal_title：BMC medicine

authors： Bleich A,Gelkopf M,Melamed Y,Solomon Z

更新日期：2006-08-27 00:00:00

abstract：BACKGROUND:Monogenic diabetes (MgD) accounts for 1-2% of all diabetes cases. In adults, MgD is difficult to distinguish from common diabetes causes. We assessed the diagnosis rate and genetic spectrum of MgD using next-generation sequencing in patients with late adolescence/adult-onset diabetes referred for a clinical ...

journal_title：BMC medicine

authors： Donath X,Saint-Martin C,Dubois-Laforgue D,Rajasingham R,Mifsud F,Ciangura C,Timsit J,Bellanné-Chantelot C,Monogenic Diabetes Study Group of the Société Francophone du Diabète.

更新日期：2019-07-11 00:00:00

abstract：BACKGROUND:Coronavirus disease 2019 (COVID-19) has infected more than 4 million people within 4 months. There is an urgent need to properly identify high-risk cases that are more likely to deteriorate even if they present mild diseases on admission. METHODS:A multicenter nested case-control study was conducted in four...

journal_title：BMC medicine

authors： Shi J,Li Y,Zhou X,Zhang Q,Ye X,Wu Z,Jiang X,Yu H,Shao L,Ai JW,Zhang H,Xu B,Sun F,Zhang W

更新日期：2020-06-03 00:00:00

abstract：:There is evidence that the life expectancy (LE) of individuals infected with the human immunodeficiency virus (HIV) has increased since the introduction of combination antiretroviral therapy (cART). However, mortality rates in recent years in HIV-positive individuals appear to have remained higher than would be expect...

journal_title：BMC medicine

authors： Sabin CA

更新日期：2013-11-27 00:00:00

abstract：BACKGROUND:Ineffective risk stratification can delay diagnosis of serious disease in patients with hematuria. We applied a systems biology approach to analyze clinical, demographic and biomarker measurements (n = 29) collected from 157 hematuric patients: 80 urothelial cancer (UC) and 77 controls with confounding patho...

journal_title：BMC medicine

authors： Emmert-Streib F,Abogunrin F,de Matos Simoes R,Duggan B,Ruddock MW,Reid CN,Roddy O,White L,O'Kane HF,O'Rourke D,Anderson NH,Nambirajan T,Williamson KE

更新日期：2013-01-17 00:00:00

abstract：:The internet has opened up vast possibilities for research. An increasing number of studies are being conducted using the internet as both a source of data and a venue for research. Use of the internet in research has created many challenges, not just for those conducting and reviewing the studies, but also for editor...

journal_title：BMC medicine

authors： Harriman S,Patel J

更新日期：2014-07-15 00:00:00

abstract：BACKGROUND:Australia was one of the first countries to introduce a publicly funded national human papillomavirus (HPV) vaccination program that commenced in April 2007, using the quadrivalent HPV vaccine targeting 12- to 13-year-old girls on an ongoing basis. Two-year catch-up programs were offered to 14- to 17- year-o...

journal_title：BMC medicine

authors： Gertig DM,Brotherton JM,Budd AC,Drennan K,Chappell G,Saville AM

更新日期：2013-10-22 00:00:00

abstract：:The damage to health caused by intimate partner violence demands effective responses from healthcare providers and healthcare systems worldwide. To date, most evidence for the few existing, effective interventions in use comes from high-income countries. Gupta et al. provide rare evidence of a nurse-delivered intimate...

journal_title：BMC medicine

authors： Taft A,Colombini M

更新日期：2017-07-12 00:00:00

abstract：BACKGROUND:Caregivers may promote the uptake of science into patient care and the practice of evidence-informed medicine. The purpose of this study was to determine whether caregiver-mediated (non-clinical caregiver-delivered) interventions are effective in improving patient, caregiver, provider, or health system outco...

journal_title：BMC medicine

authors： Fiest KM,McIntosh CJ,Demiantschuk D,Leigh JP,Stelfox HT

更新日期：2018-07-12 00:00:00

abstract：BACKGROUND:Bangladesh, India and Nepal are working towards the elimination of visceral leishmaniasis (VL) by 2015. In 2005 the World Health Organization/Training in Tropical Diseases launched an implementation research programme to support integrated vector management for the elimination of VL from Bangladesh, India an...

journal_title：BMC medicine

authors： Joshi AB,Das ML,Akhter S,Chowdhury R,Mondal D,Kumar V,Das P,Kroeger A,Boelaert M,Petzold M

更新日期：2009-10-05 00:00:00

abstract：BACKGROUND:Vaccination has reduced the global incidence of measles to the lowest rates in history. However, local interruption of measles virus transmission requires sustained high levels of population immunity that can be challenging to achieve and maintain. The herd immunity threshold for measles is typically stipula...

journal_title：BMC medicine

authors： Funk S,Knapp JK,Lebo E,Reef SE,Dabbagh AJ,Kretsinger K,Jit M,Edmunds WJ,Strebel PM

更新日期：2019-09-25 00:00:00

abstract：BACKGROUND:Intimate partner violence is common among women having abortions, with between 6% and 22% reporting recent violence from an intimate partner. Concern about violence is a reason some pregnant women decide to terminate their pregnancies. Whether risk of violence decreases after having an abortion, remains unkn...

journal_title：BMC medicine

authors： Roberts SC,Biggs MA,Chibber KS,Gould H,Rocca CH,Foster DG

更新日期：2014-09-29 00:00:00