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Enterovirus D68 Antivirals: Past, Present, and Future.

Abstract：

:Enterovirus D68 (EV-D68) is an RNA virus that causes respiratory illnesses mainly in children. In severe cases, it can lead to neurological complications such as acute flaccid myelitis (AFM). EV-D68 belongs to the enterovirus genera of the Picornaviridae family, which also includes many other significant human pathogens such as poliovirus, enterovirus A71, and rhinovirus. There are currently no vaccines or antivirals against EV-D68. In this review, we present the current understanding of the link between EV-D68 and AFM, the mechanism of viral replication, and recent progress in developing EV-D68 antivirals by targeting various viral proteins and host factors that are essential for viral replication. The future directions of EV-D68 antiviral drug discovery and the criteria for drugs to reach clinical trials are also discussed.

journal_name

ACS Infect Dis

journal_title

ACS infectious diseases

authors

Hu Y,Musharrafieh R,Zheng M,Wang J

doi

10.1021/acsinfecdis.0c00120

subject

Has Abstract

pub_date

2020-07-10 00:00:00

pages

1572-1586

issue

7

issn

2373-8227

journal_volume

6

pub_type

杂志文章

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