Antagonizing Vancomycin Resistance in Enterococcus by Surface Localized Antimicrobial Display-Derived Peptides.

abstract：:Three O. volvulus immunogenic peptide sequences recently discovered by peptide microarray were adapted to a lateral flow assay (LFA). The LFA employs gold nanoshells as novel high-contrast reporter nanoparticles and detects a serological response against the 3 peptides, found in OvOC9384, OvOC198, and OvOC5528, respec...

journal_title：ACS infectious diseases

authors： Gonzalez-Moa MJ,Van Dorst B,Lagatie O,Verheyen A,Stuyver L,Biamonte MA

更新日期：2018-06-08 00:00:00

abstract：:Intravenous artesunate is effective against cerebral malaria (CM), but high mortality and neurological sequelae in survivors are inevitable. We investigated the effect of combined artesunate and tetramethylpyrazine using mouse models of experimental cerebral malaria (ECM). Artesunate + tetramethylpyrazine reduced micr...

journal_title：ACS infectious diseases

authors： Jiang X,Chen L,Zheng Z,Chen Y,Weng X,Guo Y,Li K,Yang T,Qu S,Liu H,Li Y,Zhu X

更新日期：2020-09-11 00:00:00

abstract：:Recent epidemiological studies have revealed that Porphyromonas gingivalis, a major pathogen in periodontal disease, is associated with the development of oral squamous cell carcinoma (OSCC). However, the underlying mechanisms induced by P. gingivalis have not been well-defined. We aimed to determine the role of P. gi...

journal_title：ACS infectious diseases

authors： Chang C,Wang H,Liu J,Pan C,Zhang D,Li X,Pan Y

更新日期：2019-08-09 00:00:00

abstract：:4-Oxo-4-phenyl-but-2-enoates inhibit MenB, the 1,4-dihydroxyl-2-naphthoyl-CoA synthase in the bacterial menaquinone (MK) biosynthesis pathway, through the formation of an adduct with coenzyme A (CoA). Here, we show that the corresponding methyl butenoates have MIC values as low as 0.35-0.75 µg/mL against drug sensitiv...

journal_title：ACS infectious diseases

authors： Matarlo JS,Lu Y,Daryaee F,Daryaee T,Ruzsicska B,Walker SG,Tonge PJ

更新日期：2016-05-13 00:00:00

abstract：:The general secretion (Sec) pathway is a conserved essential pathway in bacteria and is the primary route of protein export across the cytoplasmic membrane. During protein export, the signal peptidase LepB catalyzes the cleavage of the signal peptide and subsequent release of mature proteins into the extracellular spa...

journal_title：ACS infectious diseases

authors： Bonnett SA,Ollinger J,Chandrasekera S,Florio S,O'Malley T,Files M,Jee JA,Ahn J,Casey A,Ovechkina Y,Roberts D,Korkegian A,Parish T

更新日期：2016-12-09 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection remains a major cause of morbidity and mortality worldwide. HBV surface antigen loss is considered a functional cure and is an ideal goal for antiviral therapy. However, current treatment regimens, including nucleos(t)ide analogues or interferons monotherapy and combination th...

journal_title：ACS infectious diseases

authors： Zhu W,Liu H,Zhang X

更新日期：2019-05-10 00:00:00

abstract：:Metallo-β-lactamases (MBLs) are a growing threat to the continued efficacy of β-lactam antibiotics. Recently, aspergillomarasmine A (AMA) was identified as an MBL inhibitor, but the mode of inhibition was not fully characterized. Equilibrium dialysis and metal analysis studies revealed that 2 equiv of AMA effectively ...

journal_title：ACS infectious diseases

authors： Bergstrom A,Katko A,Adkins Z,Hill J,Cheng Z,Burnett M,Yang H,Aitha M,Mehaffey MR,Brodbelt JS,Tehrani KHME,Martin NI,Bonomo RA,Page RC,Tierney DL,Fast W,Wright GD,Crowder MW

更新日期：2018-02-09 00:00:00

abstract：:Candida albicans is an opportunistic pathogenic yeast and is responsible for candidiasis. It readily colonizes host tissues and implant devices, and forms biofilms, which play an important role in pathogenesis and drug resistance. In this study, the antibiofilm, antihyphal, and antivirulence activities of nepodin, iso...

journal_title：ACS infectious diseases

authors： Lee JH,Kim YG,Khadke SK,Yamano A,Watanabe A,Lee J

更新日期：2019-07-12 00:00:00

abstract：:Ebola virus (EBOV), a member of the family Filoviridae, is a nonsegmented negative-sense RNA virus that causes severe, often lethal, disease in humans. EBOV RNA synthesis is carried out by a complex that includes several viral proteins. The function of this machinery is essential for viral gene expression and viral re...

journal_title：ACS infectious diseases

authors： Edwards MR,Pietzsch C,Vausselin T,Shaw ML,Bukreyev A,Basler CF

更新日期：2015-08-14 00:00:00

abstract：:Marburg virus causes sporadic outbreaks of severe hemorrhagic fever with high case fatality rates. Approved, effective, and safe therapeutic or prophylactic countermeasures are lacking. To address this, we used phage display to engineer a synthetic antibody, sFab H3, which binds the Marburg virus VP35 protein (mVP35)....

journal_title：ACS infectious diseases

authors： Amatya P,Wagner N,Chen G,Luthra P,Shi L,Borek D,Pavlenco A,Rohrs H,Basler CF,Sidhu SS,Gross ML,Leung DW

更新日期：2019-08-09 00:00:00

abstract：:The spread of plasmid borne resistance enzymes in clinical Staphylococcus aureus isolates is rendering trimethoprim and iclaprim, both inhibitors of dihydrofolate reductase (DHFR), ineffective. Continued exploitation of these targets will require compounds that can broadly inhibit these resistance-conferring isoforms....

journal_title：ACS infectious diseases

authors： Reeve SM,Si D,Krucinska J,Yan Y,Viswanathan K,Wang S,Holt GT,Frenkel MS,Ojewole AA,Estrada A,Agabiti SS,Alverson JB,Gibson ND,Priestley ND,Wiemer AJ,Donald BR,Wright DL

更新日期：2019-11-08 00:00:00

abstract：:Although iron is essential for bacteria, the nutrient presents problems of toxicity and solubility. Bacteria circumvent these problems with the aid of iron storage proteins where Fe3+ is deposited and, when necessary, mobilized as Fe2+ for metabolic requirements. In Pseudomonas aeruginosa, Fe3+ is compartmentalized in...

journal_title：ACS infectious diseases

authors： Soldano A,Yao H,Chandler JR,Rivera M

更新日期：2020-03-13 00:00:00

abstract：:Quaternary ammonium compounds (QACs) have historically served as a first line of defense against pathogenic bacteria. Recent reports have shown that QAC resistance is increasing at an alarming rate, especially among methicillin-resistant Staphylococcus aureus (MRSA), and preliminary work has suggested that the number ...

journal_title：ACS infectious diseases

authors： Jennings MC,Buttaro BA,Minbiole KP,Wuest WM

更新日期：2015-07-10 00:00:00

abstract：:Evolving antimicrobial resistance has motivated the search for novel targets and alternative therapies. Caseinolytic protease (ClpP) has emerged as an enticing new target since its function is conserved and essential for bacterial fitness, and because its inhibition or dysregulation leads to bacterial cell death. ClpP...

journal_title：ACS infectious diseases

authors： Binepal G,Mabanglo MF,Goodreid JD,Leung E,Barghash MM,Wong KS,Lin F,Cossette M,Bansagi J,Song B,Balasco Serrão VH,Pai EF,Batey RA,Gray-Owen SD,Houry WA

更新日期：2020-12-11 00:00:00

abstract：:Pandemics such as influenza, smallpox, and plague have caused the loss of hundreds of millions of lives and have occurred for many centuries. Fortunately, they have been largely eliminated by the use of vaccinations and drugs. More recently, Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (M...

journal_title：ACS infectious diseases

authors： Oldfield E,Malwal SR

更新日期：2020-07-10 00:00:00

abstract：:Protein S-palmitoylation is an important post-translational modification (PTM) in blood stages of the malaria parasite, Plasmodium falciparum. S-palmitoylation refers to reversible covalent modification of cysteine residues of proteins by saturated fatty acids. In vivo, palmitoylation is regulated by concerted activit...

journal_title：ACS infectious diseases

authors： Siddiqui MA,Singh S,Malhotra P,Chitnis CE

更新日期：2020-03-13 00:00:00

abstract：:The worldwide emergence of New Delhi metallo-β-lactamase-1 (NDM-1) as a carbapenemase able to hydrolyze nearly all available β-lactam antibiotics has characterized the past decade, endangering efficacious antibacterial treatments. No inhibitors for NDM-1 are available in therapy, nor are promising compounds in the pip...

journal_title：ACS infectious diseases

authors： Linciano P,Cendron L,Gianquinto E,Spyrakis F,Tondi D

更新日期：2019-01-11 00:00:00

abstract：:Flaviviruses causes significant human disease. Recent outbreaks of the Zika virus highlight the need to develop effective therapies for this class of viruses. Previously we identified niclosamide as a broad-spectrum inhibitor for flaviviruses by targeting the interface between viral protease NS3 and its cofactor NS2B....

journal_title：ACS infectious diseases

authors： Li Z,Xu J,Lang Y,Fan X,Kuo L,D'Brant L,Hu S,Samrat SK,Trudeau N,Tharappel AM,Rugenstein N,Koetzner CA,Zhang J,Chen H,Kramer LD,Butler D,Zhang QY,Zhou J,Li H

更新日期：2020-10-09 00:00:00

abstract：:Computer-aided screening of antimicrobial peptides (AMPs) is a promising approach for discovering novel therapies against multidrug-resistant bacterial infections. Here, we functionally and structurally characterized an Escherichia coli-derived AMP (EcDBS1R5) previously designed through pattern identification [α-helic...

journal_title：ACS infectious diseases

authors： Cardoso MH,Cândido ES,Chan LY,Der Torossian Torres M,Oshiro KGN,Rezende SB,Porto WF,Lu TK,de la Fuente-Nunez C,Craik DJ,Franco OL

更新日期：2018-12-14 00:00:00

abstract：:The emergence and worldwide prevalence of New Delhi metallo-β-lactamase 1 (NDM-1) expressing Gram-negative bacteria with resistance against most β-lactam antibiotics pose a serious threat to human health. However, no NDM-1 inhibitors are clinically approved at present. Herein, based on the lead compound captopril, a s...

journal_title：ACS infectious diseases

authors： Meng Z,Tang ML,Yu L,Liang Y,Han J,Zhang C,Hu F,Yu JM,Sun X

更新日期：2019-06-14 00:00:00

abstract：:Glycopeptide antibiotics (GPAs) are a key weapon in the fight against drug resistant bacteria, with vancomycin still a mainstream therapy against serious Gram-positive infections more than 50 years after it was first introduced. New, more potent semisynthetic derivatives that have entered the clinic, such as dalbavanc...

journal_title：ACS infectious diseases

authors： Blaskovich MAT,Hansford KA,Butler MS,Jia Z,Mark AE,Cooper MA

更新日期：2018-05-11 00:00:00

abstract：:RNA-dependent RNA polymerases (RdRPs) from nonsegmented negative strand (NNS) RNA viruses perform both mRNA transcription and genome replication, and these activities are regulated by their interactions with RNA and other accessory proteins within the ribonucleoprotein (RNP) complex. Detailed biochemical characterizat...

journal_title：ACS infectious diseases

authors： Balakrishnan A,Price E,Luu C,Shaul J,Wartchow C,Cantwell J,Vo T,DiDonato M,Spraggon G,Hekmat-Nejad M

更新日期：2020-10-09 00:00:00

abstract：:Balhimycin, a vancomycin-type glycopeptide, is a lipid II targeting antibiotic produced by Amycolatopsis balhimycina. A. balhimycina has developed a self-resistance mechanism based on the synergistic action of different enzymes resulting in modified peptidoglycan. The canonical resistance mechanism against glycopeptid...

journal_title：ACS infectious diseases

authors： Frasch HJ,Kalan L,Kilian R,Martin T,Wright GD,Stegmann E

更新日期：2015-06-12 00:00:00

abstract：:Enterohemorrhagic Escherichia coli (EHEC) is the causative agent of severe diarrheal disease in humans. Cattle are the natural reservoir of EHEC, and approximately 75% of EHEC infections in humans stem from bovine products. Many common bacterial pathogens, including EHEC, rely on chemical communication systems, such a...

journal_title：ACS infectious diseases

authors： Styles MJ,Early SA,Tucholski T,West KHJ,Ge Y,Blackwell HE

更新日期：2020-12-11 00:00:00

abstract：:Vaccines and antivirals to combat dengue, Zika, and other flavivirus pathogens present a major, unmet medical need. Vaccine development has been severely challenged by the antigenic diversity of these viruses and the propensity of non-neutralizing, cross-reactive antibodies to facilitate cellular infection and increas...

journal_title：ACS infectious diseases

authors： Li PC,Jang J,Hsia CY,Groomes PV,Lian W,de Wispelaere M,Pitts JD,Wang J,Kwiatkowski N,Gray NS,Yang PL

更新日期：2019-03-08 00:00:00

abstract：:The Burkholderia cepacia complex is a group of Gram-negative bacteria that are opportunistic pathogens in immunocompromised individuals, such as those with cystic fibrosis (CF) or chronic granulomatous disease (CGD). Burkholderia are intrinsically resistant to many antibiotics and the lack of antibiotic development ne...

journal_title：ACS infectious diseases

authors： Daly SM,Sturge CR,Marshall-Batty KR,Felder-Scott CF,Jain R,Geller BL,Greenberg DE

更新日期：2018-05-11 00:00:00

abstract：:We describe cross-reactive human antibodies recognizing influenza B viruses spanning nearly 80 years of antigenic drift. Structures show that they engage the receptor-binding site (RBS) of the viral hemagglutinin with strong similarities to their influenza A counterparts, despite structural differences between the RBS...

journal_title：ACS infectious diseases

authors： Bajic G,Harrison SC

更新日期：2021-01-08 00:00:00

abstract：:Daptomycin is a calcium-dependent lipopeptide antibiotic that is used clinically against various Gram-positive pathogens. It acts on bacterial cell membranes, whose susceptibility varies with the content of phosphatidylglycerol (PG). Some studies have reported that daptomycin permeabilizes and depolarizes bacterial ce...

journal_title：ACS infectious diseases

authors： Taylor R,Beriashvili D,Taylor S,Palmer M

更新日期：2017-11-10 00:00:00

abstract：:Conventional antibiotics are not effective in treating infections caused by drug-resistant or persistent nongrowing bacteria, creating a dire need for the development of new antibiotics. We report that the small molecule nTZDpa, previously characterized as a nonthiazolidinedione peroxisome proliferator-activated recep...

journal_title：ACS infectious diseases

authors： Kim W,Steele AD,Zhu W,Csatary EE,Fricke N,Dekarske MM,Jayamani E,Pan W,Kwon B,Sinitsa IF,Rosen JL,Conery AL,Fuchs BB,Vlahovska PM,Ausubel FM,Gao H,Wuest WM,Mylonakis E

更新日期：2018-11-09 00:00:00

abstract：:Gram-negative bacteria are intrinsically resistant to many antibiotics. Species that have acquired multidrug resistance and cause infections that are effectively untreatable present a serious threat to public health. The problem is broadly recognized and tackled at both the fundamental and applied levels. This paper s...

journal_title：ACS infectious diseases

authors： Zgurskaya HI,Löpez CA,Gnanakaran S

更新日期：2015-01-01 00:00:00