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Cerebral Organoid Models for Neurotropic Viruses.

Abstract：

:Across zoonotic pathogens, RNA viruses are responsible for disproportionate levels of human disease, suffering, and death. Neurotropic RNA viruses (e.g., rabies, Japanese and Eastern Equine Encephalitis, Ebola, West Nile, Powassan) infect the brain and spinal cord, causing meningitis, encephalitis, microcephaly, and Guillain-Barré syndrome. Mechanistic data explaining the molecular mechanisms of these diseases are lacking, and the enclosure of the central nervous system and the associated meninges in bone complicates access for diagnosis, clinical treatment, and research. Here, we discuss new tissue models, imaging methods, and molecular techniques that are changing research aimed at understanding the pathogenesis of neurotropic RNA viruses.

journal_name

ACS Infect Dis

journal_title

ACS infectious diseases

authors

Antonucci J,Gehrke L

doi

10.1021/acsinfecdis.9b00339

subject

Has Abstract

pub_date

2019-12-13 00:00:00

pages

1976-1979

issue

12

issn

2373-8227

journal_volume

5

pub_type

杂志文章

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