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Systematic Analysis of Structure Similarity between Zika Virus and Other Flaviviruses.

Abstract：

:Zika virus (ZIKV) infection has caused global concern because of its association with fetal microcephaly and serious neurological complications in adults since 2016. Currently, no specific anti-ZIKV therapy is available to control ZIKV infection. During the last couple of years, the intensive investigation of ZIKV structure has provided significant information for structure-based vaccine and drug design. In this review, we summarized the research progress on the structures of ZIKV and its component proteins. We analyzed the structure identity and the differences between ZIKV and other flaviviruses. This information is crucial to guiding structure-based anti-ZIKV inhibitors and vaccine discovery.

journal_name

ACS Infect Dis

journal_title

ACS infectious diseases

authors

Hu Y,Sun L

doi

10.1021/acsinfecdis.9b00047

subject

Has Abstract

pub_date

2019-07-12 00:00:00

pages

1070-1080

issue

7

issn

2373-8227

journal_volume

5

pub_type

杂志文章,评审

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