Abstract：
:We describe cross-reactive human antibodies recognizing influenza B viruses spanning nearly 80 years of antigenic drift. Structures show that they engage the receptor-binding site (RBS) of the viral hemagglutinin with strong similarities to their influenza A counterparts, despite structural differences between the RBS of influenza A and B. Our data show that these antibodies readily cross-react with both influenza B Victoria and Yamagata lineages. We also note that all antibodies are encoded by IGHV3-9/IGK1-33. Future research will provide insight into the prevalence of these antibodies in the human population.
journal_name
ACS Infect Disjournal_title
ACS infectious diseasesauthors
Bajic G,Harrison SCdoi
10.1021/acsinfecdis.0c00726subject
Has Abstractpub_date
2021-01-08 00:00:00pages
1-5issue
1issn
2373-8227journal_volume
7pub_type
杂志文章abstract：:Recent studies on 3,6-diphenylated imidazopyridazines have demonstrated impressive in vitro activity and in vivo efficacy in mouse models of malaria infection. Herein, we report the synthesis and antiplasmodium evaluation of a new series of amidated analogues and demonstrate that these compounds potently inhibit Plasm...
journal_title：ACS infectious diseases
pub_type： 杂志文章
doi：10.1021/acsinfecdis.0c00481
更新日期：2021-01-08 00:00:00
abstract：:Many viruses, including the hepatitis C virus (HCV), are dependent on the host RNA silencing pathway for replication. In this study, we screened small molecule probes, previously reported to disrupt loading of the RNA-induced silencing complex (RISC), including 6-hydroxydopamine (6-OHDA), suramin (SUR), and aurintrica...
journal_title：ACS infectious diseases
pub_type： 杂志文章
doi：10.1021/acsinfecdis.6b00098
更新日期：2016-11-11 00:00:00
abstract：:In order to identify the most attractive starting points for drugs that can be used to prevent malaria, a diverse chemical space comprising tens of thousands to millions of small molecules may need to be examined. Achieving this throughput necessitates the development of efficient ultra-high-throughput screening metho...
journal_title：ACS infectious diseases
pub_type： 杂志文章
doi：10.1021/acsinfecdis.5b00143
更新日期：2016-04-08 00:00:00
abstract：:The spread of plasmid borne resistance enzymes in clinical Staphylococcus aureus isolates is rendering trimethoprim and iclaprim, both inhibitors of dihydrofolate reductase (DHFR), ineffective. Continued exploitation of these targets will require compounds that can broadly inhibit these resistance-conferring isoforms....
journal_title：ACS infectious diseases
pub_type： 杂志文章
doi：10.1021/acsinfecdis.9b00222
更新日期：2019-11-08 00:00:00
abstract：:Ebola virus (EBOV), a member of the family Filoviridae, is a nonsegmented negative-sense RNA virus that causes severe, often lethal, disease in humans. EBOV RNA synthesis is carried out by a complex that includes several viral proteins. The function of this machinery is essential for viral gene expression and viral re...
journal_title：ACS infectious diseases
pub_type： 杂志文章
doi：10.1021/acsinfecdis.5b00053
更新日期：2015-08-14 00:00:00
abstract：:Novel combination therapies are desperately needed for combating lung infections caused by bacterial "superbugs". This study aimed to investigate the synergistic antibacterial activity of polymyxin B in combination with the cystic fibrosis (CF) drugs KALYDECO (ivacaftor) and ORKAMBI (ivacaftor + lumacaftor) against Gr...
journal_title：ACS infectious diseases
pub_type： 杂志文章
doi：10.1021/acsinfecdis.6b00035
更新日期：2016-07-08 00:00:00
abstract：:Glycosylated proteins (i.e., mucins, IgG) are important mediators of innate antiviral immunity in the vagina; however, our current knowledge of the role that glycan themselves play in genital immunity is relatively low. Herein, we evaluate the relationship between innate antiviral immunity and glycomic composition in ...
journal_title：ACS infectious diseases
pub_type： 杂志文章,随机对照试验
doi：10.1021/acsinfecdis.8b00157
更新日期：2018-11-09 00:00:00
abstract：:Antibiotic resistance can come at a high cost, both in terms of fitness for the pathogen and poorer outcomes for patients. The fitness landscape encountered by bacterial pathogens varies greatly throughout patient populations in terms of host immunity as well as the duration and spectrum of antibiotics encountered. Se...
journal_title：ACS infectious diseases
pub_type： 杂志文章
doi：10.1021/acsinfecdis.8b00158
更新日期：2018-09-14 00:00:00
abstract：:In this study, we describe a simple and rapid antibacterial susceptibility testing (AST) method for Staphylococcus aureus called S. aureus specific fluorescence resonance energy transfer (FRET) probe-based AST (SF-AST), which is based on an S. aureus specific FRET probe (SF probe) that detects micrococcal nuclease (MN...
journal_title：ACS infectious diseases
pub_type： 杂志文章
doi：10.1021/acsinfecdis.9b00260
更新日期：2020-02-14 00:00:00
abstract：:Neurotoxicity is an unwanted side effect for patients when receiving parenteral colistin therapy. The development of effective neuroprotective agents that can be coadministered during colistin therapy remains a priority area in antimicrobial chemotherapy. The present study aimed to investigate the protective effect of...
journal_title：ACS infectious diseases
pub_type： 杂志文章
doi：10.1021/acsinfecdis.0c00107
更新日期：2020-06-12 00:00:00
abstract：:Although many new anti-infectives have been discovered and developed solely using phenotypic cellular screening and assay optimization, most researchers recognize that structure-guided drug design is more practical and less costly. In addition, a greater chemical space can be interrogated with structure-guided drug de...
journal_title：ACS infectious diseases
pub_type： 杂志文章,评审
doi：10.1021/acsinfecdis.7b00276
更新日期：2018-03-09 00:00:00
abstract：:A method for the fast isolation, propagation, and characterization of very low count bacteriophages active against pathogenic bacterial strains is described in this study. Bacteriophages with a count of 102 phage particles were dynamically adhered from the maximum 10 mL blood plasma sample onto the nanostructured part...
journal_title：ACS infectious diseases
pub_type： 杂志文章
doi：10.1021/acsinfecdis.0c00358
更新日期：2020-10-09 00:00:00
abstract：:A series of derivatives of the 4,5-disubstituted class of 2-deoxystreptamine aminoglycoside antibiotics neomycin, paromomycin, and ribostamycin was prepared and assayed for (i) their ability to inhibit protein synthesis by bacterial ribosomes and by engineered bacterial ribosomes carrying eukaryotic decoding A sites, ...
journal_title：ACS infectious diseases
pub_type： 杂志文章
doi：10.1021/acsinfecdis.9b00128
更新日期：2019-10-11 00:00:00
abstract：:4-Oxo-4-phenyl-but-2-enoates inhibit MenB, the 1,4-dihydroxyl-2-naphthoyl-CoA synthase in the bacterial menaquinone (MK) biosynthesis pathway, through the formation of an adduct with coenzyme A (CoA). Here, we show that the corresponding methyl butenoates have MIC values as low as 0.35-0.75 µg/mL against drug sensitiv...
journal_title：ACS infectious diseases
pub_type： 杂志文章
doi：10.1021/acsinfecdis.6b00023
更新日期：2016-05-13 00:00:00
abstract：:In the field of Parkinson's disease (PD) research, leucine-rich repeat kinase 2 (LRRK2) remains one of the most enigmatic kinases. LRRK2 pathogenic mutations result in increased kinase activity, making LRRK2 an attractive therapeutic target for PD. For over 10 years, the identification of a bona fide substrate and a p...
journal_title：ACS infectious diseases
pub_type： 杂志文章
doi：10.1021/acsinfecdis.9b00051
更新日期：2019-06-14 00:00:00
abstract：:In response to the urgent need for new antibiotic development strategies, antimicrobial peptides and their synthetic mimetics are being investigated as promising alternatives to traditional antibiotics. To facilitate their development into clinically viable candidates, we need to understand what molecular features and...
journal_title：ACS infectious diseases
pub_type： 杂志文章
doi：10.1021/acsinfecdis.8b00079
更新日期：2018-08-10 00:00:00
abstract：:Vaccines and antivirals to combat dengue, Zika, and other flavivirus pathogens present a major, unmet medical need. Vaccine development has been severely challenged by the antigenic diversity of these viruses and the propensity of non-neutralizing, cross-reactive antibodies to facilitate cellular infection and increas...
journal_title：ACS infectious diseases
pub_type： 杂志文章
doi：10.1021/acsinfecdis.8b00322
更新日期：2019-03-08 00:00:00
abstract：:To explore the possibility of constrained peptides to target Plasmodium-infected cells, we designed a J domain mimetic derived from Plasmodium falciparum calcium-dependent protein kinase 1 ( PfCDPK1) as a strategy to disrupt J domain binding and inhibit PfCDPK1 activity. The J domain disruptor (JDD) peptide was confor...
journal_title：ACS infectious diseases
pub_type： 杂志文章
doi：10.1021/acsinfecdis.8b00347
更新日期：2019-04-12 00:00:00
abstract：:Balhimycin, a vancomycin-type glycopeptide, is a lipid II targeting antibiotic produced by Amycolatopsis balhimycina. A. balhimycina has developed a self-resistance mechanism based on the synergistic action of different enzymes resulting in modified peptidoglycan. The canonical resistance mechanism against glycopeptid...
journal_title：ACS infectious diseases
pub_type： 杂志文章
doi：10.1021/acsinfecdis.5b00011
更新日期：2015-06-12 00:00:00
abstract：:The recent outbreak of coronavirus disease 2019 (COVID-19) highlights an urgent need for therapeutics. Through a series of drug repurposing screening campaigns, niclosamide, an FDA-approved anthelminthic drug, was found to be effective against various viral infections with nanomolar to micromolar potency such as SARS-...
journal_title：ACS infectious diseases
pub_type： 杂志文章,评审
doi：10.1021/acsinfecdis.0c00052
更新日期：2020-05-08 00:00:00
abstract：:Negamycin is a hydrophilic antimicrobial translation inhibitor that crosses the lipophilic inner membrane of Escherichia coli via at least two transport routes to reach its intracellular target. In a minimal salts medium, negamycin's peptidic nature allows illicit entry via a high-affinity route by hijacking the Dpp d...
journal_title：ACS infectious diseases
pub_type： 杂志文章
doi：10.1021/acsinfecdis.5b00027
更新日期：2015-05-08 00:00:00
abstract：:Innate and developed resistance mechanisms of bacteria to antibiotics are obstacles in the design of novel drugs. However, antibacterial prodrugs and conjugates have shown promise in circumventing resistance and tolerance mechanisms via directed delivery of antibiotics to the site of infection or to specific species o...
journal_title：ACS infectious diseases
pub_type： 杂志文章,评审
doi：10.1021/acsinfecdis.9b00019
更新日期：2019-06-14 00:00:00
abstract：:Evolving antimicrobial resistance has motivated the search for novel targets and alternative therapies. Caseinolytic protease (ClpP) has emerged as an enticing new target since its function is conserved and essential for bacterial fitness, and because its inhibition or dysregulation leads to bacterial cell death. ClpP...
journal_title：ACS infectious diseases
pub_type： 杂志文章
doi：10.1021/acsinfecdis.0c00599
更新日期：2020-12-11 00:00:00
abstract：:Enterohemorrhagic Escherichia coli (EHEC) is the causative agent of severe diarrheal disease in humans. Cattle are the natural reservoir of EHEC, and approximately 75% of EHEC infections in humans stem from bovine products. Many common bacterial pathogens, including EHEC, rely on chemical communication systems, such a...
journal_title：ACS infectious diseases
pub_type： 杂志文章
doi：10.1021/acsinfecdis.0c00654
更新日期：2020-12-11 00:00:00
abstract：:The genomes of diverse mycobacterial species encode multiple proteins with the canonical l,d-transpeptidase (Ldt) sequence motif. The reason for this apparent redundancy is not well understood, but evidence suggests paralogous Ldts may serve niche roles in maintaining and/or remodeling mycobacterial peptidoglycan. We ...
journal_title：ACS infectious diseases
pub_type： 信件
doi：10.1021/acsinfecdis.9b00234
更新日期：2019-12-13 00:00:00
abstract：:Superoxide anion radical is generated as a natural byproduct of aerobic metabolism but is also produced as part of the oxidative burst of the innate immune response design to kill pathogens. In living systems, superoxide is largely managed through superoxide dismutases (SODs), families of metalloenzymes that use Fe, M...
journal_title：ACS infectious diseases
pub_type： 杂志文章,评审
doi：10.1021/acsinfecdis.8b00026
更新日期：2018-06-08 00:00:00
abstract：:The fusion between the viral and the target cell membrane is a crucial step in the life cycle of enveloped viruses. The blocking of this process is a well-known therapeutic approach that led to the development of the fusion inhibitor peptide enfuvirtide, clinically used against human immunodeficiency virus (HIV) type ...
journal_title：ACS infectious diseases
pub_type： 杂志文章
doi：10.1021/acsinfecdis.8b00321
更新日期：2019-04-12 00:00:00
abstract：:Emerging β-lactamase-mediated resistance is threatening the clinical utility of the single most prominent class of antibacterial agents used in medicine, the β-lactams. The diazabicyclooctane avibactam is able to inhibit a wider range of serine β-lactamases than has been previously observed with β-lactamase inhibitors...
journal_title：ACS infectious diseases
pub_type： 杂志文章
doi：10.1021/acsinfecdis.5b00007
更新日期：2015-04-10 00:00:00
abstract：:The convergence of competitive fitness experiments and phenotypic screening would seem to be an auspicious beginning for validation of an antibacterial target. IMPDH was already identified an essential protein in Mycobacterium tuberculosis when not one, but two, groups discovered inhibitors with promising antitubercul...
journal_title：ACS infectious diseases
pub_type： 杂志文章
doi：10.1021/acsinfecdis.6b00185
更新日期：2017-01-13 00:00:00
abstract：:Quaternary ammonium compounds (QACs) have historically served as a first line of defense against pathogenic bacteria. Recent reports have shown that QAC resistance is increasing at an alarming rate, especially among methicillin-resistant Staphylococcus aureus (MRSA), and preliminary work has suggested that the number ...
journal_title：ACS infectious diseases
pub_type： 杂志文章
doi：10.1021/acsinfecdis.5b00032
更新日期：2015-07-10 00:00:00
