Biogenic and Biomimetic Carriers as Versatile Transporters To Treat Infections.

abstract：:Decreasing the therapeutic pipeline for vancomycin-resistant Enterococci (VRE) calls for novel strategies to enhance our antibacterial arsenal. Herein, we investigated the potential applications of surface localized antimicrobial display (SLAY)-derived cationic peptides in the fight against VanA operon mediated vancom...

journal_title：ACS infectious diseases

authors： Liu Y,Jia Y,Yang K,Li R,Xiao X,Wang Z

更新日期：2020-05-08 00:00:00

abstract：:The general secretion (Sec) pathway is a conserved essential pathway in bacteria and is the primary route of protein export across the cytoplasmic membrane. During protein export, the signal peptidase LepB catalyzes the cleavage of the signal peptide and subsequent release of mature proteins into the extracellular spa...

journal_title：ACS infectious diseases

authors： Bonnett SA,Ollinger J,Chandrasekera S,Florio S,O'Malley T,Files M,Jee JA,Ahn J,Casey A,Ovechkina Y,Roberts D,Korkegian A,Parish T

更新日期：2016-12-09 00:00:00

abstract：:The maintenance of deoxyribonucleotide triphosphate (dNTP) homeostasis through synthesis and degradation is critical for accurate genomic and mitochondrial DNA replication fidelity. Trypanosoma brucei makes use of both the salvage and de novo pathways for the provision of pyrimidine dNTPs. In this respect, the sterile...

journal_title：ACS infectious diseases

authors： Yagüe-Capilla M,Castillo-Acosta VM,Bosch-Navarrete C,Ruiz-Pérez LM,González-Pacanowska D

更新日期：2021-01-08 00:00:00

abstract：:Superoxide anion radical is generated as a natural byproduct of aerobic metabolism but is also produced as part of the oxidative burst of the innate immune response design to kill pathogens. In living systems, superoxide is largely managed through superoxide dismutases (SODs), families of metalloenzymes that use Fe, M...

journal_title：ACS infectious diseases

authors： Schatzman SS,Culotta VC

更新日期：2018-06-08 00:00:00

abstract：:Daptomycin is a calcium-dependent lipopeptide antibiotic that is used clinically against various Gram-positive pathogens. It acts on bacterial cell membranes, whose susceptibility varies with the content of phosphatidylglycerol (PG). Some studies have reported that daptomycin permeabilizes and depolarizes bacterial ce...

journal_title：ACS infectious diseases

authors： Taylor R,Beriashvili D,Taylor S,Palmer M

更新日期：2017-11-10 00:00:00

abstract：:Human African trypanosomiasis (HAT) is a fatal infectious disease caused by the eukaryotic pathogen Trypanosoma brucei (Tb). Available treatments are difficult to administer and have significant safety issues. S-Adenosylmethionine decarboxylase (AdoMetDC) is an essential enzyme in the parasite polyamine biosynthetic p...

journal_title：ACS infectious diseases

authors： Volkov OA,Cosner CC,Brockway AJ,Kramer M,Booker M,Zhong S,Ketcherside A,Wei S,Longgood J,McCoy M,Richardson TE,Wring SA,Peel M,Klinger JD,Posner BA,De Brabander JK,Phillips MA

更新日期：2017-07-14 00:00:00

abstract：:Glycopeptide antibiotics (GPAs) are a key weapon in the fight against drug resistant bacteria, with vancomycin still a mainstream therapy against serious Gram-positive infections more than 50 years after it was first introduced. New, more potent semisynthetic derivatives that have entered the clinic, such as dalbavanc...

journal_title：ACS infectious diseases

authors： Blaskovich MAT,Hansford KA,Butler MS,Jia Z,Mark AE,Cooper MA

更新日期：2018-05-11 00:00:00

abstract：:Vaccines and antivirals to combat dengue, Zika, and other flavivirus pathogens present a major, unmet medical need. Vaccine development has been severely challenged by the antigenic diversity of these viruses and the propensity of non-neutralizing, cross-reactive antibodies to facilitate cellular infection and increas...

journal_title：ACS infectious diseases

authors： Li PC,Jang J,Hsia CY,Groomes PV,Lian W,de Wispelaere M,Pitts JD,Wang J,Kwiatkowski N,Gray NS,Yang PL

更新日期：2019-03-08 00:00:00

abstract：:Streptococcus agalactiae (Group B Streptococcus, GBS) is a Gram-positive bacterial pathogen that causes invasive infections in both children and adults. During pregnancy, GBS is a significant cause of infection of the fetal membranes (chorioamnionitis), which can lead to intra-amniotic infection, preterm birth, stillb...

journal_title：ACS infectious diseases

authors： Ackerman DL,Doster RS,Weitkamp JH,Aronoff DM,Gaddy JA,Townsend SD

更新日期：2017-08-11 00:00:00

abstract：:The worldwide emergence of New Delhi metallo-β-lactamase-1 (NDM-1) as a carbapenemase able to hydrolyze nearly all available β-lactam antibiotics has characterized the past decade, endangering efficacious antibacterial treatments. No inhibitors for NDM-1 are available in therapy, nor are promising compounds in the pip...

journal_title：ACS infectious diseases

authors： Linciano P,Cendron L,Gianquinto E,Spyrakis F,Tondi D

更新日期：2019-01-11 00:00:00

abstract：:Innate and developed resistance mechanisms of bacteria to antibiotics are obstacles in the design of novel drugs. However, antibacterial prodrugs and conjugates have shown promise in circumventing resistance and tolerance mechanisms via directed delivery of antibiotics to the site of infection or to specific species o...

journal_title：ACS infectious diseases

authors： Cheng AV,Wuest WM

更新日期：2019-06-14 00:00:00

abstract：:The fusion between the viral and the target cell membrane is a crucial step in the life cycle of enveloped viruses. The blocking of this process is a well-known therapeutic approach that led to the development of the fusion inhibitor peptide enfuvirtide, clinically used against human immunodeficiency virus (HIV) type ...

journal_title：ACS infectious diseases

authors： Gomes B,Sanna G,Madeddu S,Hollmann A,Santos NC

更新日期：2019-04-12 00:00:00

abstract：:Bacterial quorum sensing (QS) is being contemplated as a promising target for developing innovative diagnostic and therapeutic strategies. Here we report for the first time the development of antibodies against 2-heptyl-4-quinolone (HHQ), a signaling molecule from the pqs QS system of Pseudomonas aeruginosa, involved ...

journal_title：ACS infectious diseases

authors： Montagut EJ,Vilaplana L,Martin-Gomez MT,Marco MP

更新日期：2020-12-11 00:00:00

abstract：:The enzyme N-myristoyltransferase (NMT) catalyzes the essential fatty acylation of substrate proteins with myristic acid in eukaryotes and is a validated drug target in the parasite Trypanosoma brucei, the causative agent of African trypanosomiasis (sleeping sickness). N-Myristoylation typically mediates membrane loca...

journal_title：ACS infectious diseases

authors： Wright MH,Paape D,Price HP,Smith DF,Tate EW

更新日期：2016-06-10 00:00:00

abstract：:Malaria remains a major global health problem. In 2015 alone, more than 200 million cases of malaria were reported, and more than 400,000 deaths occurred. Since 2010, emerging resistance to current front-line ACTs (artemisinin combination therapies) has been detected in endemic countries. Therefore, there is an urgenc...

journal_title：ACS infectious diseases

authors： Chaparro MJ,Calderón F,Castañeda P,Fernández-Alvaro E,Gabarró R,Gamo FJ,Gómez-Lorenzo MG,Martín J,Fernández E

更新日期：2018-04-13 00:00:00

abstract：:RNA-dependent RNA polymerases (RdRPs) from nonsegmented negative strand (NNS) RNA viruses perform both mRNA transcription and genome replication, and these activities are regulated by their interactions with RNA and other accessory proteins within the ribonucleoprotein (RNP) complex. Detailed biochemical characterizat...

journal_title：ACS infectious diseases

authors： Balakrishnan A,Price E,Luu C,Shaul J,Wartchow C,Cantwell J,Vo T,DiDonato M,Spraggon G,Hekmat-Nejad M

更新日期：2020-10-09 00:00:00

abstract：:The envelope glycoprotein (Env) enables HIV-1 cell entry through fusion of host-cell and viral membranes induced by the transmembrane subunit gp41. Antibodies targeting the C-terminal sequence of the membrane-proximal external region (C-MPER) block the fusogenic activity of gp41 and achieve neutralization of divergent...

journal_title：ACS infectious diseases

authors： Torralba J,de la Arada I,Carravilla P,Insausti S,Rujas E,Largo E,Eggeling C,Arrondo JLR,Apellániz B,Nieva JL

更新日期：2020-08-14 00:00:00

abstract：:The α-Gal antigen [Galα(1,3)Galβ(1,4)GlcNAcα] is an immunodominant epitope displayed by infective trypomastigote forms of Trypanosoma cruzi, the causative agent of Chagas disease. A virus-like particle displaying a high density of α-Gal was found to be a superior reagent for the ELISA-based serological diagnosis of Ch...

journal_title：ACS infectious diseases

authors： Brito CR,McKay CS,Azevedo MA,Santos LC,Venuto AP,Nunes DF,D'Ávila DA,Rodrigues da Cunha GM,Almeida IC,Gazzinelli RT,Galvão LM,Chiari E,Sanhueza CA,Finn MG,Marques AF

更新日期：2016-12-09 00:00:00

abstract：:In response to the urgent need for new antibiotic development strategies, antimicrobial peptides and their synthetic mimetics are being investigated as promising alternatives to traditional antibiotics. To facilitate their development into clinically viable candidates, we need to understand what molecular features and...

journal_title：ACS infectious diseases

authors： Artim CM,Phan NN,Alabi CA

更新日期：2018-08-10 00:00:00

abstract：:Photodynamic inactivation (PDI) protocols using photoactive metallated porphyrin-doped conjugated polymer nanoparticles (CPNs) and blue light were developed to eliminate multidrug-resistant pathogens. CPNs-PDI protocols using varying particle concentrations and irradiation doses were tested against nine pathogenic bac...

journal_title：ACS infectious diseases

authors： Martínez SR,Ibarra LE,Ponzio RA,Forcone MV,Wendel AB,Chesta CA,Spesia MB,Palacios RE

更新日期：2020-08-14 00:00:00

abstract：:Violacein is a tryptophan-derived purple pigment produced by environmental bacteria, which displays multiple biological activities, including strong inhibition of Gram-positive pathogens. Here, we applied a combination of experimental approaches to identify the mechanism by which violacein kills Gram-positive bacteria...

journal_title：ACS infectious diseases

authors： Cauz ACG,Carretero GPB,Saraiva GKV,Park P,Mortara L,Cuccovia IM,Brocchi M,Gueiros-Filho FJ

更新日期：2019-04-12 00:00:00

abstract：:Flaviviruses causes significant human disease. Recent outbreaks of the Zika virus highlight the need to develop effective therapies for this class of viruses. Previously we identified niclosamide as a broad-spectrum inhibitor for flaviviruses by targeting the interface between viral protease NS3 and its cofactor NS2B....

journal_title：ACS infectious diseases

authors： Li Z,Xu J,Lang Y,Fan X,Kuo L,D'Brant L,Hu S,Samrat SK,Trudeau N,Tharappel AM,Rugenstein N,Koetzner CA,Zhang J,Chen H,Kramer LD,Butler D,Zhang QY,Zhou J,Li H

更新日期：2020-10-09 00:00:00

abstract：:The spread of plasmid borne resistance enzymes in clinical Staphylococcus aureus isolates is rendering trimethoprim and iclaprim, both inhibitors of dihydrofolate reductase (DHFR), ineffective. Continued exploitation of these targets will require compounds that can broadly inhibit these resistance-conferring isoforms....

journal_title：ACS infectious diseases

authors： Reeve SM,Si D,Krucinska J,Yan Y,Viswanathan K,Wang S,Holt GT,Frenkel MS,Ojewole AA,Estrada A,Agabiti SS,Alverson JB,Gibson ND,Priestley ND,Wiemer AJ,Donald BR,Wright DL

更新日期：2019-11-08 00:00:00

abstract：:Zika virus (ZIKV) infection has caused global concern because of its association with fetal microcephaly and serious neurological complications in adults since 2016. Currently, no specific anti-ZIKV therapy is available to control ZIKV infection. During the last couple of years, the intensive investigation of ZIKV str...

journal_title：ACS infectious diseases

authors： Hu Y,Sun L

更新日期：2019-07-12 00:00:00

abstract：:Enterovirus 71 (EV71) is a major etiological agent of hand, foot, and mouth disease, for which there is no antiviral therapy. We have developed densely sulfated disaccharide heparan sulfate (HS) analogues that are potent small molecule inhibitors of EV71 infection, binding to the viral capsid and acting as decoy recep...

journal_title：ACS infectious diseases

authors： Earley DF,Bailly B,Maggioni A,Kundur AR,Thomson RJ,Chang CW,von Itzstein M

更新日期：2019-10-11 00:00:00

abstract：:Coronaviruses first garnered widespread attention in 2002 when the severe acute respiratory syndrome coronavirus (SARS-CoV) emerged from bats in China and rapidly spread in human populations. Since then, Middle East respiratory syndrome coronavirus (MERS-CoV) emerged and still actively infects humans. The recent SARS-...

journal_title：ACS infectious diseases

authors： Firpo MR,Mastrodomenico V,Hawkins GM,Prot M,Levillayer L,Gallagher T,Simon-Loriere E,Mounce BC

更新日期：2020-10-06 00:00:00

abstract：:Boronic acid transition state inhibitors (BATSIs) are known reversible covalent inhibitors of serine β-lactamases. The selectivity and high potency of specific BATSIs bearing an amide side chain mimicking the β-lactam's amide side chain are an established and recognized synthetic strategy. Herein, we describe a new cl...

journal_title：ACS infectious diseases

authors： Caselli E,Fini F,Introvigne ML,Stucchi M,Taracila MA,Fish ER,Smolen KA,Rather PN,Powers RA,Wallar BJ,Bonomo RA,Prati F

更新日期：2020-07-10 00:00:00

abstract：:Protein S-palmitoylation is an important post-translational modification (PTM) in blood stages of the malaria parasite, Plasmodium falciparum. S-palmitoylation refers to reversible covalent modification of cysteine residues of proteins by saturated fatty acids. In vivo, palmitoylation is regulated by concerted activit...

journal_title：ACS infectious diseases

authors： Siddiqui MA,Singh S,Malhotra P,Chitnis CE

更新日期：2020-03-13 00:00:00

abstract：:Understanding molecular properties of outer membrane channels of Gram-negative bacteria is of fundamental significance as they are the entry point of polar antibiotics into bacteria. Outer membrane proteomics revealed OccK8 (OprE) to be among the five most expressed substrate specific channels of the clinically import...

journal_title：ACS infectious diseases

authors： Samanta S,Bodrenko I,Acosta-Gutiérrez S,D'Agostino T,Pathania M,Ghai I,Schleberger C,Bumann D,Wagner R,Winterhalter M,van den Berg B,Ceccarelli M

更新日期：2018-10-12 00:00:00

abstract：:Poor patient adherence to antiretroviral medication represents a major obstacle for managing disease and reducing rates of new HIV infections. The measurement of patient drug levels is the most objective method of determining adherence. Tenofovir and tenofovir diphosphate are metabolites of some of the most common HIV...

journal_title：ACS infectious diseases

authors： Sevenler D,Bardon A,Fernandez Suarez M,Marshall L,Toner M,Drain PK,Sandlin RD

更新日期：2020-07-10 00:00:00