Efficient Blocking of Enterovirus 71 Infection by Heparan Sulfate Analogues Acting as Decoy Receptors.

abstract：:Daptomycin is a lipopeptide antibiotic approved for use against Gram-positive organisms, including highly resistant species. A number of studies have suggested that daptomycin kills bacteria by membrane permeabilization and depolarization. Recently a model membrane system consisting of 1,2-dimyristoyl-sn-glycero-3-pho...

journal_title：ACS infectious diseases

authors： Zhang J,Scoten K,Straus SK

更新日期：2016-10-14 00:00:00

abstract：:The general secretion (Sec) pathway is a conserved essential pathway in bacteria and is the primary route of protein export across the cytoplasmic membrane. During protein export, the signal peptidase LepB catalyzes the cleavage of the signal peptide and subsequent release of mature proteins into the extracellular spa...

journal_title：ACS infectious diseases

authors： Bonnett SA,Ollinger J,Chandrasekera S,Florio S,O'Malley T,Files M,Jee JA,Ahn J,Casey A,Ovechkina Y,Roberts D,Korkegian A,Parish T

更新日期：2016-12-09 00:00:00

abstract：:Novel combination therapies are desperately needed for combating lung infections caused by bacterial "superbugs". This study aimed to investigate the synergistic antibacterial activity of polymyxin B in combination with the cystic fibrosis (CF) drugs KALYDECO (ivacaftor) and ORKAMBI (ivacaftor + lumacaftor) against Gr...

journal_title：ACS infectious diseases

authors： Schneider EK,Azad MA,Han ML,Tony Zhou Q,Wang J,Huang JX,Cooper MA,Doi Y,Baker MA,Bergen PJ,Muller MT,Li J,Velkov T

更新日期：2016-07-08 00:00:00

abstract：:Many viruses, including the hepatitis C virus (HCV), are dependent on the host RNA silencing pathway for replication. In this study, we screened small molecule probes, previously reported to disrupt loading of the RNA-induced silencing complex (RISC), including 6-hydroxydopamine (6-OHDA), suramin (SUR), and aurintrica...

journal_title：ACS infectious diseases

authors： Lafreniere MA,Powdrill MH,Singaravelu R,Pezacki JP

更新日期：2016-11-11 00:00:00

abstract：:Natural product antibiotics have played an essential role in the treatment of bacterial infection in addition to serving as useful tools to explore the intricate biology of bacteria. Our current arsenal of antibiotics operate through the inhibition of well-defined bacterial targets critical for replication and growth....

journal_title：ACS infectious diseases

authors： Liu K,Huigens RW 3rd

更新日期：2020-04-10 00:00:00

abstract：:Neurotoxicity is an unwanted side effect for patients when receiving parenteral colistin therapy. The development of effective neuroprotective agents that can be coadministered during colistin therapy remains a priority area in antimicrobial chemotherapy. The present study aimed to investigate the protective effect of...

journal_title：ACS infectious diseases

authors： Dai C,Xiong J,Wang Y,Shen J,Velkov T,Xiao X

更新日期：2020-06-12 00:00:00

abstract：:The α-Gal antigen [Galα(1,3)Galβ(1,4)GlcNAcα] is an immunodominant epitope displayed by infective trypomastigote forms of Trypanosoma cruzi, the causative agent of Chagas disease. A virus-like particle displaying a high density of α-Gal was found to be a superior reagent for the ELISA-based serological diagnosis of Ch...

journal_title：ACS infectious diseases

authors： Brito CR,McKay CS,Azevedo MA,Santos LC,Venuto AP,Nunes DF,D'Ávila DA,Rodrigues da Cunha GM,Almeida IC,Gazzinelli RT,Galvão LM,Chiari E,Sanhueza CA,Finn MG,Marques AF

更新日期：2016-12-09 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection remains a major cause of morbidity and mortality worldwide. HBV surface antigen loss is considered a functional cure and is an ideal goal for antiviral therapy. However, current treatment regimens, including nucleos(t)ide analogues or interferons monotherapy and combination th...

journal_title：ACS infectious diseases

authors： Zhu W,Liu H,Zhang X

更新日期：2019-05-10 00:00:00

abstract：:In order to identify the most attractive starting points for drugs that can be used to prevent malaria, a diverse chemical space comprising tens of thousands to millions of small molecules may need to be examined. Achieving this throughput necessitates the development of efficient ultra-high-throughput screening metho...

journal_title：ACS infectious diseases

authors： Swann J,Corey V,Scherer CA,Kato N,Comer E,Maetani M,Antonova-Koch Y,Reimer C,Gagaring K,Ibanez M,Plouffe D,Zeeman AM,Kocken CH,McNamara CW,Schreiber SL,Campo B,Winzeler EA,Meister S

更新日期：2016-04-08 00:00:00

abstract：:Intravenous artesunate is effective against cerebral malaria (CM), but high mortality and neurological sequelae in survivors are inevitable. We investigated the effect of combined artesunate and tetramethylpyrazine using mouse models of experimental cerebral malaria (ECM). Artesunate + tetramethylpyrazine reduced micr...

journal_title：ACS infectious diseases

authors： Jiang X,Chen L,Zheng Z,Chen Y,Weng X,Guo Y,Li K,Yang T,Qu S,Liu H,Li Y,Zhu X

更新日期：2020-09-11 00:00:00

abstract：:Photodynamic inactivation (PDI) protocols using photoactive metallated porphyrin-doped conjugated polymer nanoparticles (CPNs) and blue light were developed to eliminate multidrug-resistant pathogens. CPNs-PDI protocols using varying particle concentrations and irradiation doses were tested against nine pathogenic bac...

journal_title：ACS infectious diseases

authors： Martínez SR,Ibarra LE,Ponzio RA,Forcone MV,Wendel AB,Chesta CA,Spesia MB,Palacios RE

更新日期：2020-08-14 00:00:00

abstract：:The Burkholderia cepacia complex is a group of Gram-negative bacteria that are opportunistic pathogens in immunocompromised individuals, such as those with cystic fibrosis (CF) or chronic granulomatous disease (CGD). Burkholderia are intrinsically resistant to many antibiotics and the lack of antibiotic development ne...

journal_title：ACS infectious diseases

authors： Daly SM,Sturge CR,Marshall-Batty KR,Felder-Scott CF,Jain R,Geller BL,Greenberg DE

更新日期：2018-05-11 00:00:00

abstract：:Biogenic and biomimetic therapeutics are a relatively new class of systems that are of physiological origin and/or take advantage of natural pathways or aim at mimicking these to improve selective interaction with target tissue. The number of biogenic and bioengineered avenues for drug therapy and diagnostics has mult...

journal_title：ACS infectious diseases

authors： Goes A,Fuhrmann G

更新日期：2018-06-08 00:00:00

abstract：:Protein S-palmitoylation is an important post-translational modification (PTM) in blood stages of the malaria parasite, Plasmodium falciparum. S-palmitoylation refers to reversible covalent modification of cysteine residues of proteins by saturated fatty acids. In vivo, palmitoylation is regulated by concerted activit...

journal_title：ACS infectious diseases

authors： Siddiqui MA,Singh S,Malhotra P,Chitnis CE

更新日期：2020-03-13 00:00:00

abstract：:Hypervirulent Klebsiella pneumoniae (hvKp) is an underrecognized pathotype of K. pneumoniae since the majority of cases have occurred in East Asia. However, hvKp is a public health threat due to its ability to infect healthy individuals, ongoing dissemination, and acquisition of resistance determinants. hvKp-directed ...

journal_title：ACS infectious diseases

authors： Russo TA,Gulick AM

更新日期：2019-07-12 00:00:00

abstract：:Subunit vaccines composed of protein antigens covalently attached to Toll-like receptor (TLR) agonists elicit superior immune responses compared to mixtures of antigens and TLR agonists. Among different conjugation approaches, enzyme-mediated ligation is one of the few that provides an opportunity for the generation o...

journal_title：ACS infectious diseases

authors： Xu Z,Rivera-Hernandez T,Moyle PM

更新日期：2020-07-10 00:00:00

abstract：:The ability to respire and generate adenosine triphosphate (ATP) is essential for the physiology, persistence, and pathogenicity of Mycobacterium tuberculosis, which causes tuberculosis. By employing a lead repurposing strategy, the malarial cytochrome bc1 inhibitor SCR0911 was tested against mycobacteria. Docking stu...

journal_title：ACS infectious diseases

authors： Chong SMS,Manimekalai MSS,Sarathy JP,Williams ZC,Harold LK,Cook GM,Dick T,Pethe K,Bates RW,Grüber G

更新日期：2020-04-10 00:00:00

abstract：:The emergence and worldwide prevalence of New Delhi metallo-β-lactamase 1 (NDM-1) expressing Gram-negative bacteria with resistance against most β-lactam antibiotics pose a serious threat to human health. However, no NDM-1 inhibitors are clinically approved at present. Herein, based on the lead compound captopril, a s...

journal_title：ACS infectious diseases

authors： Meng Z,Tang ML,Yu L,Liang Y,Han J,Zhang C,Hu F,Yu JM,Sun X

更新日期：2019-06-14 00:00:00

abstract：:Quaternary ammonium compounds (QACs) have historically served as a first line of defense against pathogenic bacteria. Recent reports have shown that QAC resistance is increasing at an alarming rate, especially among methicillin-resistant Staphylococcus aureus (MRSA), and preliminary work has suggested that the number ...

journal_title：ACS infectious diseases

authors： Jennings MC,Buttaro BA,Minbiole KP,Wuest WM

更新日期：2015-07-10 00:00:00

abstract：:Computer-aided screening of antimicrobial peptides (AMPs) is a promising approach for discovering novel therapies against multidrug-resistant bacterial infections. Here, we functionally and structurally characterized an Escherichia coli-derived AMP (EcDBS1R5) previously designed through pattern identification [α-helic...

journal_title：ACS infectious diseases

authors： Cardoso MH,Cândido ES,Chan LY,Der Torossian Torres M,Oshiro KGN,Rezende SB,Porto WF,Lu TK,de la Fuente-Nunez C,Craik DJ,Franco OL

更新日期：2018-12-14 00:00:00

abstract：:The convergence of competitive fitness experiments and phenotypic screening would seem to be an auspicious beginning for validation of an antibacterial target. IMPDH was already identified an essential protein in Mycobacterium tuberculosis when not one, but two, groups discovered inhibitors with promising antitubercul...

journal_title：ACS infectious diseases

authors： Hedstrom L

更新日期：2017-01-13 00:00:00

abstract：:Bacterial coinfection in COVID-19 patients has the potential to complicate treatments and accelerate the development of antibiotic resistance in the clinic due to the widespread use of broad-spectrum antibiotics, including in Indonesia. The surge of COVID-19 patients may worsen antibiotic overuse; therefore, informati...

journal_title：ACS infectious diseases

authors： Prasetyoputri A

更新日期：2021-01-27 00:00:00

abstract：:Amonabactins are a group of four related catecholate siderophores produced by several species of the genus Aeromonas, including A. hydrophila and the fish pathogen A. salmonicida subsp. salmonicida. Although the gene cluster encoding amonabactin biosynthesis also contains a gene that could encode the ferri-siderophore...

journal_title：ACS infectious diseases

authors： Rey-Varela D,Cisneros-Sureda J,Balado M,Rodríguez J,Lemos ML,Jiménez C

更新日期：2019-11-08 00:00:00

abstract：:Glycopeptide antibiotics (GPAs) are a key weapon in the fight against drug resistant bacteria, with vancomycin still a mainstream therapy against serious Gram-positive infections more than 50 years after it was first introduced. New, more potent semisynthetic derivatives that have entered the clinic, such as dalbavanc...

journal_title：ACS infectious diseases

authors： Blaskovich MAT,Hansford KA,Butler MS,Jia Z,Mark AE,Cooper MA

更新日期：2018-05-11 00:00:00

abstract：:The increasing problem of multidrug resistance (MDR) in bacteria calls for discovery of new molecules and diagnostic methodologies that are effective against a wide range of microbial pathogens. We have studied the role of alexidine dihydrochloride (alex) as a bioaffinity ligand against lipopolysaccharide (LPS), a pat...

journal_title：ACS infectious diseases

authors： Jagtap P,Mishra R,Khanna S,Kumari P,Mittal B,Kashyap HK,Gupta S

更新日期：2018-11-09 00:00:00

abstract：:Malaria continues to be a significant cause of death and morbidity worldwide, and there is a need for new antimalarial drugs with novel targets. We have focused as a potential target for drug development on N-myristoyl transferase (NMT), an enzyme that acylates a wide range of substrate proteins. The NMT substrates in...

journal_title：ACS infectious diseases

authors： Schlott AC,Holder AA,Tate EW

更新日期：2018-04-13 00:00:00

abstract：:Poor patient adherence to antiretroviral medication represents a major obstacle for managing disease and reducing rates of new HIV infections. The measurement of patient drug levels is the most objective method of determining adherence. Tenofovir and tenofovir diphosphate are metabolites of some of the most common HIV...

journal_title：ACS infectious diseases

authors： Sevenler D,Bardon A,Fernandez Suarez M,Marshall L,Toner M,Drain PK,Sandlin RD

更新日期：2020-07-10 00:00:00

abstract：:Decreasing the therapeutic pipeline for vancomycin-resistant Enterococci (VRE) calls for novel strategies to enhance our antibacterial arsenal. Herein, we investigated the potential applications of surface localized antimicrobial display (SLAY)-derived cationic peptides in the fight against VanA operon mediated vancom...

journal_title：ACS infectious diseases

authors： Liu Y,Jia Y,Yang K,Li R,Xiao X,Wang Z

更新日期：2020-05-08 00:00:00

abstract：:The worldwide emergence of New Delhi metallo-β-lactamase-1 (NDM-1) as a carbapenemase able to hydrolyze nearly all available β-lactam antibiotics has characterized the past decade, endangering efficacious antibacterial treatments. No inhibitors for NDM-1 are available in therapy, nor are promising compounds in the pip...

journal_title：ACS infectious diseases

authors： Linciano P,Cendron L,Gianquinto E,Spyrakis F,Tondi D

更新日期：2019-01-11 00:00:00

abstract：:Streptococcus agalactiae (Group B Streptococcus, GBS) is a Gram-positive bacterial pathogen that causes invasive infections in both children and adults. During pregnancy, GBS is a significant cause of infection of the fetal membranes (chorioamnionitis), which can lead to intra-amniotic infection, preterm birth, stillb...

journal_title：ACS infectious diseases

authors： Ackerman DL,Doster RS,Weitkamp JH,Aronoff DM,Gaddy JA,Townsend SD

更新日期：2017-08-11 00:00:00