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Aerobactin Synthesis Proteins as Antivirulence Targets in Hypervirulent Klebsiella pneumoniae.

Abstract：

:Hypervirulent Klebsiella pneumoniae (hvKp) is an underrecognized pathotype of K. pneumoniae since the majority of cases have occurred in East Asia. However, hvKp is a public health threat due to its ability to infect healthy individuals, ongoing dissemination, and acquisition of resistance determinants. hvKp-directed antivirulence therapy is appealing since it has the potential to minimize resistance selection. The discovery that aerobactin is a critical hvKp-specific virulence factor has made its biosynthetic enzymes attractive targets for the development of small molecule inhibitors. However, identification of additional high value targets is needed to enable a robust countermeasure program for this evolving superbug.

journal_name

ACS Infect Dis

journal_title

ACS infectious diseases

authors

Russo TA,Gulick AM

doi

10.1021/acsinfecdis.9b00117

subject

Has Abstract

pub_date

2019-07-12 00:00:00

pages

1052-1054

issue

7

issn

2373-8227

journal_volume

5

pub_type

杂志文章

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