Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential.

abstract：:At present, there is no licensed antiviral drug against dengue virus (DENV) infection. Mouse models of DENV infection have been widely used for preclinical evaluation of antivirals. However, only in a few instances so far have the data obtained from preclinical mouse model testing been associated with data from clinic...

journal_title：ACS infectious diseases

authors： Watanabe S,Low JG,Vasudevan SG

更新日期：2018-07-13 00:00:00

abstract：:Bacterial quorum sensing (QS) is being contemplated as a promising target for developing innovative diagnostic and therapeutic strategies. Here we report for the first time the development of antibodies against 2-heptyl-4-quinolone (HHQ), a signaling molecule from the pqs QS system of Pseudomonas aeruginosa, involved ...

journal_title：ACS infectious diseases

authors： Montagut EJ,Vilaplana L,Martin-Gomez MT,Marco MP

更新日期：2020-12-11 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection remains a major cause of morbidity and mortality worldwide. HBV surface antigen loss is considered a functional cure and is an ideal goal for antiviral therapy. However, current treatment regimens, including nucleos(t)ide analogues or interferons monotherapy and combination th...

journal_title：ACS infectious diseases

authors： Zhu W,Liu H,Zhang X

更新日期：2019-05-10 00:00:00

abstract：:Superoxide anion radical is generated as a natural byproduct of aerobic metabolism but is also produced as part of the oxidative burst of the innate immune response design to kill pathogens. In living systems, superoxide is largely managed through superoxide dismutases (SODs), families of metalloenzymes that use Fe, M...

journal_title：ACS infectious diseases

authors： Schatzman SS,Culotta VC

更新日期：2018-06-08 00:00:00

abstract：:Gram-negative bacteria are intrinsically resistant to many antibiotics. Species that have acquired multidrug resistance and cause infections that are effectively untreatable present a serious threat to public health. The problem is broadly recognized and tackled at both the fundamental and applied levels. This paper s...

journal_title：ACS infectious diseases

authors： Zgurskaya HI,Löpez CA,Gnanakaran S

更新日期：2015-01-01 00:00:00

abstract：:The fusion between the viral and the target cell membrane is a crucial step in the life cycle of enveloped viruses. The blocking of this process is a well-known therapeutic approach that led to the development of the fusion inhibitor peptide enfuvirtide, clinically used against human immunodeficiency virus (HIV) type ...

journal_title：ACS infectious diseases

authors： Gomes B,Sanna G,Madeddu S,Hollmann A,Santos NC

更新日期：2019-04-12 00:00:00

abstract：:Enterohemorrhagic Escherichia coli (EHEC) is the causative agent of severe diarrheal disease in humans. Cattle are the natural reservoir of EHEC, and approximately 75% of EHEC infections in humans stem from bovine products. Many common bacterial pathogens, including EHEC, rely on chemical communication systems, such a...

journal_title：ACS infectious diseases

authors： Styles MJ,Early SA,Tucholski T,West KHJ,Ge Y,Blackwell HE

更新日期：2020-12-11 00:00:00

abstract：:Glycosylated proteins (i.e., mucins, IgG) are important mediators of innate antiviral immunity in the vagina; however, our current knowledge of the role that glycan themselves play in genital immunity is relatively low. Herein, we evaluate the relationship between innate antiviral immunity and glycomic composition in ...

journal_title：ACS infectious diseases

authors： Koppolu S,Wang L,Mathur A,Nigam JA,Dezzutti CS,Isaacs C,Meyn L,Bunge KE,Moncla BJ,Hillier SL,Rohan LC,Mahal LK

更新日期：2018-11-09 00:00:00

abstract：:The increasing problem of multidrug resistance (MDR) in bacteria calls for discovery of new molecules and diagnostic methodologies that are effective against a wide range of microbial pathogens. We have studied the role of alexidine dihydrochloride (alex) as a bioaffinity ligand against lipopolysaccharide (LPS), a pat...

journal_title：ACS infectious diseases

authors： Jagtap P,Mishra R,Khanna S,Kumari P,Mittal B,Kashyap HK,Gupta S

更新日期：2018-11-09 00:00:00

abstract：:Violacein is a tryptophan-derived purple pigment produced by environmental bacteria, which displays multiple biological activities, including strong inhibition of Gram-positive pathogens. Here, we applied a combination of experimental approaches to identify the mechanism by which violacein kills Gram-positive bacteria...

journal_title：ACS infectious diseases

authors： Cauz ACG,Carretero GPB,Saraiva GKV,Park P,Mortara L,Cuccovia IM,Brocchi M,Gueiros-Filho FJ

更新日期：2019-04-12 00:00:00

abstract：:Amonabactins are a group of four related catecholate siderophores produced by several species of the genus Aeromonas, including A. hydrophila and the fish pathogen A. salmonicida subsp. salmonicida. Although the gene cluster encoding amonabactin biosynthesis also contains a gene that could encode the ferri-siderophore...

journal_title：ACS infectious diseases

authors： Rey-Varela D,Cisneros-Sureda J,Balado M,Rodríguez J,Lemos ML,Jiménez C

更新日期：2019-11-08 00:00:00

abstract：:4-Oxo-4-phenyl-but-2-enoates inhibit MenB, the 1,4-dihydroxyl-2-naphthoyl-CoA synthase in the bacterial menaquinone (MK) biosynthesis pathway, through the formation of an adduct with coenzyme A (CoA). Here, we show that the corresponding methyl butenoates have MIC values as low as 0.35-0.75 µg/mL against drug sensitiv...

journal_title：ACS infectious diseases

authors： Matarlo JS,Lu Y,Daryaee F,Daryaee T,Ruzsicska B,Walker SG,Tonge PJ

更新日期：2016-05-13 00:00:00

abstract：:Enterovirus D68 (EV-D68) is an RNA virus that causes respiratory illnesses mainly in children. In severe cases, it can lead to neurological complications such as acute flaccid myelitis (AFM). EV-D68 belongs to the enterovirus genera of the Picornaviridae family, which also includes many other significant human pathoge...

journal_title：ACS infectious diseases

authors： Hu Y,Musharrafieh R,Zheng M,Wang J

更新日期：2020-07-10 00:00:00

abstract：:The root cause of the antibiotic resistance crisis is the ability of bacteria to evolve resistance to a multitude of antibiotics and other environmental toxins. The regulation of adaptation is difficult to pinpoint due to extensive phenotypic heterogeneity arising during evolution. Here, we investigate the mechanisms ...

journal_title：ACS infectious diseases

authors： Erickson KE,Otoupal PB,Chatterjee A

更新日期：2015-11-13 00:00:00

abstract：:Candida albicans is an opportunistic pathogenic yeast and is responsible for candidiasis. It readily colonizes host tissues and implant devices, and forms biofilms, which play an important role in pathogenesis and drug resistance. In this study, the antibiofilm, antihyphal, and antivirulence activities of nepodin, iso...

journal_title：ACS infectious diseases

authors： Lee JH,Kim YG,Khadke SK,Yamano A,Watanabe A,Lee J

更新日期：2019-07-12 00:00:00

abstract：:The genomes of diverse mycobacterial species encode multiple proteins with the canonical l,d-transpeptidase (Ldt) sequence motif. The reason for this apparent redundancy is not well understood, but evidence suggests paralogous Ldts may serve niche roles in maintaining and/or remodeling mycobacterial peptidoglycan. We ...

journal_title：ACS infectious diseases

authors： Zandi TA,Marshburn RL,Stateler PK,Brammer Basta LA

更新日期：2019-12-13 00:00:00

abstract：:In response to the urgent need for new antibiotic development strategies, antimicrobial peptides and their synthetic mimetics are being investigated as promising alternatives to traditional antibiotics. To facilitate their development into clinically viable candidates, we need to understand what molecular features and...

journal_title：ACS infectious diseases

authors： Artim CM,Phan NN,Alabi CA

更新日期：2018-08-10 00:00:00

abstract：:Individuals who exhibit long-term HIV suppression and CD4 T-cell preservation without antiretroviral therapy are of great interest for HIV research. There is currently no robust method for rapid identification of these "HIV controller" subjects; however, HLA-B*57 (human leukocyte antigen (major histocompatibility comp...

journal_title：ACS infectious diseases

authors： Wu B,Ouyang Z,Lyon CJ,Zhang W,Clift T,Bone CR,Li B,Zhao Z,Kimata JT,Yu XG,Hu Y

更新日期：2017-12-08 00:00:00

abstract：:Conventional antibiotics are not effective in treating infections caused by drug-resistant or persistent nongrowing bacteria, creating a dire need for the development of new antibiotics. We report that the small molecule nTZDpa, previously characterized as a nonthiazolidinedione peroxisome proliferator-activated recep...

journal_title：ACS infectious diseases

authors： Kim W,Steele AD,Zhu W,Csatary EE,Fricke N,Dekarske MM,Jayamani E,Pan W,Kwon B,Sinitsa IF,Rosen JL,Conery AL,Fuchs BB,Vlahovska PM,Ausubel FM,Gao H,Wuest WM,Mylonakis E

更新日期：2018-11-09 00:00:00

abstract：:Malaria remains a major global health problem. In 2015 alone, more than 200 million cases of malaria were reported, and more than 400,000 deaths occurred. Since 2010, emerging resistance to current front-line ACTs (artemisinin combination therapies) has been detected in endemic countries. Therefore, there is an urgenc...

journal_title：ACS infectious diseases

authors： Chaparro MJ,Calderón F,Castañeda P,Fernández-Alvaro E,Gabarró R,Gamo FJ,Gómez-Lorenzo MG,Martín J,Fernández E

更新日期：2018-04-13 00:00:00

abstract：:The emergence and worldwide prevalence of New Delhi metallo-β-lactamase 1 (NDM-1) expressing Gram-negative bacteria with resistance against most β-lactam antibiotics pose a serious threat to human health. However, no NDM-1 inhibitors are clinically approved at present. Herein, based on the lead compound captopril, a s...

journal_title：ACS infectious diseases

authors： Meng Z,Tang ML,Yu L,Liang Y,Han J,Zhang C,Hu F,Yu JM,Sun X

更新日期：2019-06-14 00:00:00

abstract：:Streptococcus mutans ( S. mutans) is a Gram-positive human pathogen that is one of the major contributors to dental caries, a condition with an economic cost of over $100 billion per year in the United States. S. mutans secretes a 21-amino-acid peptide termed the competence stimulating peptide (21-CSP) to assess its p...

journal_title：ACS infectious diseases

authors： Bikash CR,Hamry SR,Tal-Gan Y

更新日期：2018-09-14 00:00:00

abstract：:The α-Gal antigen [Galα(1,3)Galβ(1,4)GlcNAcα] is an immunodominant epitope displayed by infective trypomastigote forms of Trypanosoma cruzi, the causative agent of Chagas disease. A virus-like particle displaying a high density of α-Gal was found to be a superior reagent for the ELISA-based serological diagnosis of Ch...

journal_title：ACS infectious diseases

authors： Brito CR,McKay CS,Azevedo MA,Santos LC,Venuto AP,Nunes DF,D'Ávila DA,Rodrigues da Cunha GM,Almeida IC,Gazzinelli RT,Galvão LM,Chiari E,Sanhueza CA,Finn MG,Marques AF

更新日期：2016-12-09 00:00:00

abstract：:Stimulator of interferon genes (STING) is an integral ER-membrane protein that can be activated by 2'3'-cGAMP synthesized by cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) upon binding of double-stranded DNA. It activates interferon (IFN) and inflammatory cytokine responses to defend against in...

journal_title：ACS infectious diseases

authors： Zhang X,Liu B,Tang L,Su Q,Hwang N,Sehgal M,Cheng J,Ma J,Zhang X,Tan Y,Zhou Y,Duan Z,DeFilippis VR,Viswanathan U,Kulp J,Du Y,Guo JT,Chang J

更新日期：2019-07-12 00:00:00

abstract：:The general secretion (Sec) pathway is a conserved essential pathway in bacteria and is the primary route of protein export across the cytoplasmic membrane. During protein export, the signal peptidase LepB catalyzes the cleavage of the signal peptide and subsequent release of mature proteins into the extracellular spa...

journal_title：ACS infectious diseases

authors： Bonnett SA,Ollinger J,Chandrasekera S,Florio S,O'Malley T,Files M,Jee JA,Ahn J,Casey A,Ovechkina Y,Roberts D,Korkegian A,Parish T

更新日期：2016-12-09 00:00:00

abstract：:Metallo-β-lactamases (MBLs) are a growing threat to the continued efficacy of β-lactam antibiotics. Recently, aspergillomarasmine A (AMA) was identified as an MBL inhibitor, but the mode of inhibition was not fully characterized. Equilibrium dialysis and metal analysis studies revealed that 2 equiv of AMA effectively ...

journal_title：ACS infectious diseases

authors： Bergstrom A,Katko A,Adkins Z,Hill J,Cheng Z,Burnett M,Yang H,Aitha M,Mehaffey MR,Brodbelt JS,Tehrani KHME,Martin NI,Bonomo RA,Page RC,Tierney DL,Fast W,Wright GD,Crowder MW

更新日期：2018-02-09 00:00:00

abstract：:Malaria continues to be a significant cause of death and morbidity worldwide, and there is a need for new antimalarial drugs with novel targets. We have focused as a potential target for drug development on N-myristoyl transferase (NMT), an enzyme that acylates a wide range of substrate proteins. The NMT substrates in...

journal_title：ACS infectious diseases

authors： Schlott AC,Holder AA,Tate EW

更新日期：2018-04-13 00:00:00

abstract：:Bacterial coinfection in COVID-19 patients has the potential to complicate treatments and accelerate the development of antibiotic resistance in the clinic due to the widespread use of broad-spectrum antibiotics, including in Indonesia. The surge of COVID-19 patients may worsen antibiotic overuse; therefore, informati...

journal_title：ACS infectious diseases

authors： Prasetyoputri A

更新日期：2021-01-27 00:00:00

abstract：:Antibiotic resistance can come at a high cost, both in terms of fitness for the pathogen and poorer outcomes for patients. The fitness landscape encountered by bacterial pathogens varies greatly throughout patient populations in terms of host immunity as well as the duration and spectrum of antibiotics encountered. Se...

journal_title：ACS infectious diseases

authors： Margolis E,Rosch JW

更新日期：2018-09-14 00:00:00

abstract：:Protein S-palmitoylation is an important post-translational modification (PTM) in blood stages of the malaria parasite, Plasmodium falciparum. S-palmitoylation refers to reversible covalent modification of cysteine residues of proteins by saturated fatty acids. In vivo, palmitoylation is regulated by concerted activit...

journal_title：ACS infectious diseases

authors： Siddiqui MA,Singh S,Malhotra P,Chitnis CE

更新日期：2020-03-13 00:00:00