Abstract：
Background:Panax ginseng is regarded as one of the best compounds for promoting health, and it has been used traditionally as a medicinal herb. Recently, Korean Red Ginseng (RG) has been shown to protect skin from aging and wrinkling; it can also relieve atopic dermatitis and allergy symptoms. This study aimed to evaluate RG's effects on the regeneration of the full-thickness skin wounds in rat. Methods:Full-thickness skin wounds were generated in rats, and then RG was administered either orally or topically. The wound-healing effects of RG were investigated by assessing wound size, mRNA expression patterns of genes related to wound healing, histological staining, and measurements of lipid, moisture, and elasticity in skin tissues. Results:The wound size was smaller, and tissue regeneration rate was faster in the RG-treated group than that in the control group on days 15 and 20 after initiating treatment. On postoperative day 20, skin lipid and moisture content had increased significantly in the RG-treated group. Significant increases in the gene expression levels of transforming growth factor-β1 and vascular endothelial growth factor were found in the RG group during the early stages of wound healing. Matrix metalloproteinase-1 and matrix metalloproteinase-9 showed significant increases in gene expression levels on day 20. Conclusion:The results suggested that RG may promote healing of full-thickness skin wounds in rats. They also provided basic insights into the effects of RG on skin regeneration, supporting its use as a dressing material for wound treatment and its development as a functional food.
journal_name
J Ginseng Resjournal_title
Journal of ginseng researchauthors
Park KS,Park DHdoi
10.1016/j.jgr.2017.12.006subject
Has Abstractpub_date
2019-04-01 00:00:00pages
226-235issue
2eissn
1226-8453issn
2093-4947pii
S1226-8453(17)30034-9journal_volume
43pub_type
杂志文章abstract：Background:The biological and pharmacological effects of BST204, a fermented ginseng extract, have been reported in various disease conditions. However, its molecular action in metabolic disease remains poorly understood. In this study, we identified the antiadipogenic activity of BST204 resulting from its inhibition o...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2018.08.002
更新日期：2020-01-01 00:00:00
abstract：:The transformation of ginsenoside Rb1 into a specific minor ginsenoside using Aspergillus niger KCCM 11239, as well as the identification of the transformed products and the pathway via thin layer chromatography and high performance liquid chromatography were evaluated to develop a new biologically active material. Th...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2013.11.008
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Blind and excessive application of fertilizers was found during the cultivation of Panax notoginseng in fields, as well as increase in root rot disease incidence. METHODS:Both "3414" application and orthogonal test designs were performed at Shilin county, Yunnan province, China, for NPK (nitrogen, phosphoru...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2015.04.003
更新日期：2016-01-01 00:00:00
abstract：Background:Ginsenosides, which are bioactive components in ginseng, can be converted to smaller compounds for improvement of their pharmacological activities. The conversion methods include heating; acid, alkali, and enzymatic treatment; and microbial conversion. The aim of this study was to determine the bioconversion...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2017.07.004
更新日期：2019-01-01 00:00:00
abstract：:Chronic liver disease, one of the most common diseases, typically arises from nonalcoholic fatty liver disease, alcoholic liver disease, chronic viral hepatitis, or hepatocellular carcinoma. Therefore, there is a pressing need for improved treatment strategies. Korean Red Ginseng has been known to have positive effect...
journal_title：Journal of ginseng research
pub_type： 杂志文章,评审
doi：10.1016/j.jgr.2016.11.004
更新日期：2017-10-01 00:00:00
abstract：:In this study, photosynthetic parameters such as the net photosynthesis rate, stomatal conductance, intercellular CO2 concentration, and transpiration rate were examined in selected ginseng varieties and/or lines that are resistant (Yunpoong, HTIR 1, HTIR 2, and HTIR 3) and susceptible (Chunpoong) to high temperature ...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.5142/jgr.2012.36.4.461
更新日期：2012-10-01 00:00:00
abstract：BACKGROUND:The current typical drying methods for red ginseng are sun drying and hot-air drying. The purpose of this study was to investigate drying characteristics of red ginseng by using far-infrared drying. METHODS:The far-infrared drying tests on red ginseng were conducted at two drying stages: (1) high temperatur...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2015.04.001
更新日期：2015-10-01 00:00:00
abstract：:Ginsenoside (ginseng saponin), the principal component of ginseng, is responsible for the pharmacological and biological activities of ginseng. We isolated lactic acid bacteria from Kimchi using esculin agar, to produce β-glucosidase. We focused on the bio-transformation of ginsenoside. Phylogenetic analysis was perfo...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.5142/jgr.2012.36.3.291
更新日期：2012-07-01 00:00:00
abstract：BACKGROUND:Compound K (CK) is a bioactive derivative of ginsenoside Rb1 in Panax ginseng (Korean ginseng). Its biological and pharmacological activities have been studied in various disease conditions, although its immunomodulatory role in innate immunity mediated by monocytes/macrophages has been poorly understood. In...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2016.06.004
更新日期：2017-07-01 00:00:00
abstract：Background:Black ginseng (BG) has greatly enhanced pharmacological activities relative to white or red ginseng. However, the effect and molecular mechanism of BG on muscle growth has not yet been examined. In this study, we investigated whether BG could regulate myoblast differentiation and myotube hypertrophy. Method...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2017.08.009
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Steaming of ginseng is known to change its chemical composition and biological activity. This study was carried out to investigate the effect of different steaming time-scales on chemical constituents and antiproliferative activity of Vietnamese ginseng (VG). METHODS:VG was steamed at 105°C for 2-20 h. Its ...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2015.01.006
更新日期：2015-07-01 00:00:00
abstract：BACKGROUND:We evaluated the drug interaction profile of Red Ginseng (RG) with respect to the activities of major cytochrome P450 (CYP) enzymes and the drug transporter P-glycoprotein (P-gp) in healthy Korean volunteers. METHODS:This article describes an open-label, crossover study. CYP probe cocktail drugs, caffeine, ...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2015.11.005
更新日期：2016-10-01 00:00:00
abstract：:Ginseng is one of the most widely used herbal medicines and is reported to have a wide range of therapeutic and pharmacological applications. Ginseng may also be potentially valuable in treating cardiovascular diseases. Research concerning cardiovascular disease is focusing on purified individual ginsenoside constitue...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.5142/jgr.2012.36.1.16
更新日期：2012-01-01 00:00:00
abstract：Background:Panax ginseng is a well-known immune modulator, and there is concern that its immune-enhancing effects may negatively affect patients with rheumatoid arthritis (RA) by worsening symptoms or increasing the risk of adverse effects from other drugs. In this randomized, crossover clinical trial, we evaluated the...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2017.01.006
更新日期：2018-04-01 00:00:00
abstract：BACKGROUND:Ginsenoside Rb1 (G-Rb1), the major active constituent of ginseng, improves insulin sensitivity and exerts antidiabetic effects. We tested whether the insulin-sensitizing and antidiabetic effects of G-Rb1 results from a reduction in ectopic fat accumulation, mediated by inhibition of lipolysis in adipocytes. ...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2014.11.004
更新日期：2015-07-01 00:00:00
abstract：Background:Cytochrome P450 enzymes catalyze a wide range of reactions in plant metabolism. Besides their physiological functions on primary and secondary metabolites, P450s are also involved in herbicide detoxification via hydroxylation or dealkylation. Ginseng as a perennial plant offers more sustainable solutions to ...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2019.04.005
更新日期：2019-10-01 00:00:00
abstract：:This study compared the contents of ginsenosides depending on steaming conditions of red ginsengs to provide basic information for developing functional foods using red ginsengs. The red ginseng steamed eight times at 98℃ ranked atop the amounts of prosapogenins ever detected in red ginsengs (ginsenoside Rg2, Rg3, Rg5...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.5142/jgr.2012.36.1.102
更新日期：2012-01-01 00:00:00
abstract：Background:Ginsenoside Rh2 (GRh2) is a characterized component in red ginseng widely used in Korea and China. GRh2 exhibits a wide range of pharmacological activities, such as anti-inflammatory, antioxidant, and anticancer properties. However, its effects on Toxoplasma gondii (T. gondii) infection have not been clarifi...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2019.06.002
更新日期：2020-09-01 00:00:00
abstract：Background:Panax ginseng Meyer has been used as a nourishing edible herb in East Asia for thousands of years. 25-OH-PPT was first discovered as a natural rare triterpenoid saponin in ginseng stems and leaves by our group. Research found that it showed strong inhibitory effects on α-glucosidase and protein tyrosine phos...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2019.11.002
更新日期：2021-01-01 00:00:00
abstract：:Identification of the origins of Panax ginseng has been issued in Korea scientifically and economically. We describe a metabolomics approach used for discrimination and prediction of ginseng roots from different origins in Korea. The fresh ginseng roots from six ginseng cooperative associations (Gangwon, Gaeseong, Pun...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.5142/jgr.2013.37.341
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND:Although the aerial parts of hydroponic Panax ginseng are reported to contain higher contents of total ginsenosides than those of roots, the isolation and identification of active metabolites from the aerial parts of hydroponic P. ginseng have not been carried out so far. METHODS:The aerial parts of hydropo...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2014.10.005
更新日期：2015-04-01 00:00:00
abstract：Background:Ginseng is a commonly used herbal medicine in treating various medical conditions. Chronic gut inflammation is a recognized factor for the development of colorectal cancer (CRC). In this project, Asian ginseng berry polysaccharide preparations were used to assess their effects on CRC and related immune regul...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2018.12.010
更新日期：2020-03-01 00:00:00
abstract：BACKGROUND:Panax ginseng is a traditional herb used for medicinal purposes in eastern Asia. P. ginseng contains various ginsenosides with pharmacological effects. In this study, floralginsenoside A (FGA), ginsenoside Rd (GRD), and ginsenoside Re (GRE) were purified from P. ginseng berry. METHODS:Chemical structures of...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2017.03.005
更新日期：2017-10-01 00:00:00
abstract：Background:The circadian rhythm is the internal clock that controls sleep-wake cycles, metabolism, cognition, and several processes in the body, and its disruption has been associated with aging. The differentiated embryo chondrocyte (Dec) gene is related to circadian rhythm. To our knowledge, there are no reports of t...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2020.09.003
更新日期：2021-01-01 00:00:00
abstract：Background:The root and rhizome are historically and officially utilized medicinal parts of Panax notoginseng (PN) (Burk.) F. H. Chen, which in raw and steamed forms are used differently in practice. Methods:To investigate the differences in chemical composition and bioactivities of PN root and rhizome between raw and...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2017.11.004
更新日期：2019-07-01 00:00:00
abstract：Background:Korean ginseng (Panax ginseng) plays an anti-inflammatory role in a variety of inflammatory diseases such as gastritis, hepatitis, and colitis. However, inflammation-regulatory activity of the calyx of the P. ginseng berry has not been thoroughly evaluated. To understand whether the calyx portion of the P. g...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2017.06.003
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:Radiotherapy is one of the most important modalities in cancer treatment; however, normal tissue damage is a serious concern. Drug development for the protection or reduction of normal tissue damage is therefore a clinical issue. Herein, we evaluated the protective properties of Panax ginseng Meyer and its c...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2016.02.006
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND:Roles of immune reaction and toll-like receptor-4 (TLR-4) have widely been established in the pathogenesis of alcoholic liver disease (ALD). METHODS:We evaluated the biologic efficacy of Korean Red Ginseng (KRG), urushiol, and probiotics (Lactobacillus rhamnosus R0011 and Lactobacillus acidophilus R0052) in...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2014.04.002
更新日期：2014-07-01 00:00:00
abstract：:Jilin Province is one of the principal production bases of traditional Chinese medicine (TCM) in China with its typical preponderance in TCM resources, research and development power, and industrialization capacity. The province has 2,790 species of TCM materials in total. Over 20% of the TCM materials in common use a...
journal_title：Journal of ginseng research
pub_type： 杂志文章,评审
doi：10.1016/j.jgr.2014.05.007
更新日期：2014-10-15 00:00:00
abstract：BACKGROUND:Identifying suitable site for growing mountain-cultivated ginseng is a concern for ginseng producers. This study was conducted to evaluate the soil properties of cultivation sites for mountain-cultivated ginseng in Hamyang-gun, which is one of the most well-known areas for mountain-cultivated ginseng in Kore...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2014.06.004
更新日期：2015-01-01 00:00:00
