Neuroimaging and clinical outcomes of oral anticoagulant-associated intracerebral hemorrhage.


OBJECTIVE:Whether intracerebral hemorrhage (ICH) associated with non-vitamin K antagonist oral anticoagulants (NOAC-ICH) has a better outcome compared to ICH associated with vitamin K antagonists (VKA-ICH) is uncertain. METHODS:We performed a systematic review and individual patient data meta-analysis of cohort studies comparing clinical and radiological outcomes between NOAC-ICH and VKA-ICH patients. The primary outcome measure was 30-day all-cause mortality. All outcomes were assessed in multivariate regression analyses adjusted for age, sex, ICH location, and intraventricular hemorrhage extension. RESULTS:We included 7 eligible studies comprising 219 NOAC-ICH and 831 VKA-ICH patients (mean age = 77 years, 52.5% females). The 30-day mortality was similar between NOAC-ICH and VKA-ICH (24.3% vs 26.5%; hazard ratio = 0.94, 95% confidence interval [CI] = 0.67-1.31). However, in multivariate analyses adjusting for potential confounders, NOAC-ICH was associated with lower admission National Institutes of Health Stroke Scale (NIHSS) score (linear regression coefficient = -2.83, 95% CI = -5.28 to -0.38), lower likelihood of severe stroke (NIHSS > 10 points) on admission (odds ratio [OR] = 0.50, 95% CI = 0.30-0.84), and smaller baseline hematoma volume (linear regression coefficient = -0.24, 95% CI = -0.47 to -0.16). The two groups did not differ in the likelihood of baseline hematoma volume < 30cm3 (OR = 1.14, 95% CI = 0.81-1.62), hematoma expansion (OR = 0.97, 95% CI = 0.63-1.48), in-hospital mortality (OR = 0.73, 95% CI = 0.49-1.11), functional status at discharge (common OR = 0.78, 95% CI = 0.57-1.07), or functional status at 3 months (common OR = 1.03, 95% CI = 0.75-1.43). INTERPRETATION:Although functional outcome at discharge, 1 month, or 3 months was comparable after NOAC-ICH and VKA-ICH, patients with NOAC-ICH had smaller baseline hematoma volumes and less severe acute stroke syndromes. Ann Neurol 2018;84:702-712.


Ann Neurol


Annals of neurology


Tsivgoulis G,Wilson D,Katsanos AH,Sargento-Freitas J,Marques-Matos C,Azevedo E,Adachi T,von der Brelie C,Aizawa Y,Abe H,Tomita H,Okumura K,Hagii J,Seiffge DJ,Lioutas VA,Traenka C,Varelas P,Basir G,Krogias C,Purrucke




Has Abstract


2018-11-01 00:00:00












  • FK506-induced neurotoxicity in liver transplantation.

    abstract::We report FK506-induced neurotoxicity in 14 of 44 consecutive patients following orthoptic liver transplantation. In 10 of these 14 patients, postural hand tremors were found in the first weeks following surgery, transient apraxia of speech in 3, and generalized tonic-clonic seizures were noted in 2 patients. Other ma...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Wijdicks EF,Wiesner RH,Dahlke LJ,Krom RA

    更新日期:1994-04-01 00:00:00

  • Localization and effects of neuropeptide Y, vasoactive intestinal polypeptide, substance P, and calcitonin gene-related peptide in human temporal arteries.

    abstract::Nerve fibers containing neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP), substance P (SP), and calcitonin gene-related peptide (CGRP) were seen in the adventitia or at the adventitia-media border of the human temporal artery. Pharmacological experiments on isolated temporal artery segments revealed that ...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Jansen I,Uddman R,Hocherman M,Ekman R,Jensen K,Olesen J,Stiernholm P,Edvinsson L

    更新日期:1986-10-01 00:00:00

  • Dependence of the Achilles tendon reflex on the excitability of spinal reflex pathways.

    abstract::Muscle afferent activity from the triceps surae was recorded during experimentally induced alterations in amplitude of the Achilles tendon jerk. No changes in the neural afferent response to tendon percussion or in the background level of neural activity occurred when the reflex response was altered by discomfort, dis...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Burke D,McKeon B,Skuse NF

    更新日期:1981-12-01 00:00:00

  • Retinal nerve fiber layer axonal loss and visual dysfunction in optic neuritis.

    abstract::Axonal loss is thought to be a likely cause of persistent disability after a multiple sclerosis relapse; therefore, noninvasive in vivo markers specific for axonal loss are needed. We used optic neuritis as a model of multiple sclerosis relapse to quantify axonal loss of the retinal nerve fiber layer (RNFL) and second...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Trip SA,Schlottmann PG,Jones SJ,Altmann DR,Garway-Heath DF,Thompson AJ,Plant GT,Miller DH

    更新日期:2005-09-01 00:00:00

  • Fluctuations of CD4+ T-cell subsets in remitting-relapsing multiple sclerosis.

    abstract::Patients with multiple sclerosis (MS) frequently have selective depletion of the CD45R+CD4+ T-cell subset during active phases of disease. To study the relationship between changes in this subset and the onset of objective clinical exacerbations of disease, a longitudinal study was undertaken. Two CD4+ T-cell subsets ...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Rose LM,Ginsberg AH,Rothstein TL,Ledbetter JA,Clark EA

    更新日期:1988-08-01 00:00:00

  • Cerebrospinal fluid levels of MMP-2, 7, and 9 are elevated in association with human immunodeficiency virus dementia.

    abstract::Pathological evidence suggests that alterations of the blood-brain barrier (BBB) may occur in association with human immunodeficiency virus (HIV) dementia (HIVD). Increased BBB permeability could contribute to the development of dementia by facilitating the entry of activated and infected monocytes, as well as potenti...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Conant K,McArthur JC,Griffin DE,Sjulson L,Wahl LM,Irani DN

    更新日期:1999-09-01 00:00:00

  • Central nervous system maturation in the stressed premature.

    abstract::The developmental sequence of sleep cycles has been found to be a useful index of central nervous system maturation in premature infants. To determine the effects of severe reversible stress on the maturation of sleep cycles, 6- to 8-hour sleep studies were done on 10 premature infants with severe hyaline membrane dis...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Holmes GL,Logan WJ,Kirkpatrick BV,Meyer EC

    更新日期:1979-12-01 00:00:00

  • Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet.

    abstract:OBJECTIVE:The full anticonvulsant effect of the ketogenic diet (KD) can require weeks to develop in rats, suggesting that altered gene expression is involved. The KD typically is used in pediatric epilepsies, but is effective also in adolescents and adults. Our goal was to use microarray and complementary technologies ...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Bough KJ,Wetherington J,Hassel B,Pare JF,Gawryluk JW,Greene JG,Shaw R,Smith Y,Geiger JD,Dingledine RJ

    更新日期:2006-08-01 00:00:00

  • Genomic analysis reveals frequent TRAF7 mutations in intraneural perineuriomas.

    abstract::Intraneural perineuriomas are benign peripheral nerve sheath tumors that cause progressive debilitating focal extremity weakness. The etiology of perineuriomas is largely unknown. We utilized whole exome sequencing, copy number algorithm evaluation, and high-resolution whole genome microarray to investigate for a gene...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Klein CJ,Wu Y,Jentoft ME,Mer G,Spinner RJ,Dyck PJ,Dyck PJ,Mauermann ML

    更新日期:2017-02-01 00:00:00

  • Motor nerve biopsy: clinical usefulness and histopathological criteria.

    abstract::Early differential diagnosis of motor neuropathies (MN) and lower motor neuron diseases (LMND) is important, as prognosis and therapeutic approaches are different. We evaluated the diagnostic contribution of the biopsy of the motor branch of the obturator nerve and gracilis muscle in 21 consecutive patients in which, ...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Riva N,Iannaccone S,Corbo M,Casellato C,Sferrazza B,Lazzerini A,Scarlato M,Cerri F,Previtali SC,Nobile-Orazio E,Comi G,Quattrini A

    更新日期:2011-01-01 00:00:00

  • Hemorrhagic complications in vein of Galen malformations.

    abstract::The authors report on a series of spontaneous intracranial hemorrhages associated with vein of Galen aneurysmal malformations (VGAMs). Thirty-four children with VGAMs have been treated at this institution since 1986. Eight children (24%) harbored the mural-type malformation, and 26 (76%) had the choroidal-type lesion....

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Meyers PM,Halbach VV,Phatouros CP,Dowd CF,Malek AM,Lempert TE,Lefler JE,Higashida RT

    更新日期:2000-06-01 00:00:00

  • Free amino acid levels in amyotrophic lateral sclerosis.

    abstract::To evaluate reports of abnormal levels of free amino acids (AA) in patients with amyotrophic lateral sclerosis (ALS), we studied serum, cerebrospinal fluid, and urine AA in 12 patients with ALS and 12 controls matched for age, sex, and severity of disability. ALS patients had statistically significant elevations in se...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Patten BM,Harati Y,Acosta L,Jung SS,Felmus MT

    更新日期:1978-04-01 00:00:00

  • Risk in complex genetics: "all models are wrong but some are useful".

    abstract::Although genome-wide association studies (GWAS) have proven remarkably effective at identifying reliably associated genetic variants, the biology underlying these discoveries is rarely immediately apparent and in most cases seems bound to require extensive fine mapping and functional analysis before it is revealed. In...

    journal_title:Annals of neurology

    pub_type: 杂志文章,评审


    authors: Sawcer S,Wason J

    更新日期:2012-10-01 00:00:00

  • Phenobarbital modifies seizure-related brain injury in the developing brain.

    abstract::To investigate the potential role of drug therapy in preventing or exacerbating seizure-related brain injury in the prepubescent brain, we administered kainic acid to rats at postnatal day 35. Therapy with daily phenobarbital was started directly before or 1 day after kainic acid was administered, and was continued th...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Mikati MA,Holmes GL,Chronopoulos A,Hyde P,Thurber S,Gatt A,Liu Z,Werner S,Stafstrom CE

    更新日期:1994-09-01 00:00:00

  • Hypoperfusion of Wernicke's area predicts severity of semantic deficit in acute stroke.

    abstract::Based on earlier findings that the presence of word comprehension impairment (a deficit in the meaning of words, or lexical semantics) in acute stroke was strongly associated with the presence of hypoperfusion or infarct in Wernicke's area, we tested the hypothesis that the severity of word comprehension impairment wa...

    journal_title:Annals of neurology

    pub_type: 临床试验,杂志文章


    authors: Hillis AE,Wityk RJ,Tuffiash E,Beauchamp NJ,Jacobs MA,Barker PB,Selnes OA

    更新日期:2001-11-01 00:00:00

  • Introduction of automated systems to evaluate touch-pressure, vibration, and thermal cutaneous sensation in man.

    abstract::Systems for automatic assessment of cutaneous touch-pressure, vibratory, and thermal sensation have been developed. These systems use stimuli which are quantified and reproducible, a two-alternative forced-choice technique, and programmed steps to test, score, and report. If normal responses from series of healthy per...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Dyck PJ,Zimmerman IR,O'Brien PC,Ness A,Caskey PE,Karnes J,Bushek W

    更新日期:1978-12-01 00:00:00

  • Descending paralysis resulting from occult wound botulism.

    abstract::A 30-year-old male drug abuser developed ophthalmoplegia, bulbar paralysis, and limb weakness responsive to edrophonium. However, potentiation of a low-amplitude evoked muscle action potential was produced with repetitive nerve stimulation at 10 Hz, and the clinical and electrophysiological data suggested the diagnosi...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Rapoport S,Watkins PB

    更新日期:1984-09-01 00:00:00

  • Selective vulnerability in Huntington's disease: preferential loss of cannabinoid receptors in lateral globus pallidus.

    abstract::Selective neuronal vulnerability is a key feature of the neuropathology of Huntington's disease. We used [3H]CP-55,940, a synthetic cannabinoid, to label cannabinoid receptors in tissue sections from individuals dying with Huntington's disease and from normal control subjects. The density of cannabinoid receptors in s...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Richfield EK,Herkenham M

    更新日期:1994-10-01 00:00:00

  • Cerebrospinal fluid vasopressin and increased intracranial pressure.

    abstract::Cerebrospinal fluid and plasma vasopressin were measured in patients with cerebral disorders associated with varying levels of elevated intracranial pressure. The mean cerebrospinal fluid vasopressin concentration was significantly increased in patients with pseudotumor cerebri (2.0 +/- 0.2 [SEM] pg/ml), intracranial ...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Sørensen PS,Gjerris F,Hammer M

    更新日期:1984-05-01 00:00:00

  • Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China.

    abstract:OBJECTIVE:Narcolepsy is caused by the loss of hypocretin/orexin neurons in the hypothalamus, which is likely the result of an autoimmune process. Recently, concern has been raised over reports of narcolepsy in northern Europe following H1N1 vaccination. METHODS:The study is a retrospective analysis of narcolepsy onset...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Han F,Lin L,Warby SC,Faraco J,Li J,Dong SX,An P,Zhao L,Wang LH,Li QY,Yan H,Gao ZC,Yuan Y,Strohl KP,Mignot E

    更新日期:2011-09-01 00:00:00

  • Abnormal pattern electroretinograms in patients with senile dementia of the Alzheimer type.

    abstract::Patients with senile dementia of the Alzheimer type frequently have difficulty performing visual tasks. These difficulties may be due, at least partially, to degenerative changes in both the primary visual pathway and the visual association areas. To determine whether retinal ganglion cell dysfunction contributes to v...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Trick GL,Barris MC,Bickler-Bluth M

    更新日期:1989-08-01 00:00:00

  • Dopaminergic dsyfunction in Tourette syndrome.

    abstract::A prospective clinical and biochemical study on the effects of treatment with haloperidol has been performed in seven patients with Tourette syndrome. Pretreatment cerebrospinal fluid levels of homovanillic acid (CSF HVA) were significantly reduce in all patients, whereas 5-hydroxyindoleacetic acid was reduced in only...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Singer HS,Butler IJ,Tune LE,Seifert WE Jr,Coyle JT

    更新日期:1982-10-01 00:00:00

  • Environmental enrichment slows disease progression in R6/2 Huntington's disease mice.

    abstract::Huntington's disease is a genetic disorder that causes motor dysfunction, personality changes, dementia, and premature death. There is currently no effective therapy. Several transgenic models of Huntington's disease are available, the most widely used of which is the R6/2 mouse, because of its rapid disease progressi...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Hockly E,Cordery PM,Woodman B,Mahal A,van Dellen A,Blakemore C,Lewis CM,Hannan AJ,Bates GP

    更新日期:2002-02-01 00:00:00

  • Motor fluctuations in Parkinson's disease: central pathophysiological mechanisms, Part I.

    abstract::The duration of the antiparkinsonian action of levodopa was studied in 48 patients with various response patterns to the oral administration of the dopamine precursor. Deterioration in motor scores after abrupt cessation of a steady-state intravenous levodopa infusion occurred at two successive rates: an initial rapid...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Fabbrini G,Mouradian MM,Juncos JL,Schlegel J,Mohr E,Chase TN

    更新日期:1988-09-01 00:00:00

  • Complex segregation analysis of Parkinson's disease: The Mayo Clinic Family Study.

    abstract:OBJECTIVE:To conduct complex segregation analyses of Parkinson's disease (PD). METHODS:Data on the familial aggregation of PD remain conflicting. We conducted a historical cohort study of 1,234 relatives of 162 patients with PD representative of people of Olmsted County, MN, and of 3,009 relatives of 411 patients with...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: McDonnell SK,Schaid DJ,Elbaz A,Strain KJ,Bower JH,Ahlskog JE,Maraganore DM,Rocca WA

    更新日期:2006-05-01 00:00:00

  • A new mitochondrial DNA mutation associated with progressive dementia and chorea: a clinical, pathological, and molecular genetic study.

    abstract::A novel mitochondrial DNA transfer RNA mutation at position 5549 was identified in a patient with dementia, chorea, cerebellar ataxia, deafness, and peripheral neuropathy in the absence of clinical myopathy. Muscle biopsy specimens showed ragged red and cytochrome oxidase-negative fibers, and reduced complex I activit...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Nelson I,Hanna MG,Alsanjari N,Scaravilli F,Morgan-Hughes JA,Harding AE

    更新日期:1995-03-01 00:00:00

  • Persistent vegetative state with high cerebral blood flow following profound hypoglycemia.

    abstract::A persistent vegetative state (severe dementia) developed in a 30-year-old man following hypoglycemic coma. Despite the poor clinical outcome, sensory evoked response recovered between 6 and 34 months after the insult. The cerebral blood flow level at rest after 34 months was slightly above the normal range. This find...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Agardh CD,Rosén I,Ryding E

    更新日期:1983-10-01 00:00:00

  • Putamen volume reduction on magnetic resonance imaging exceeds caudate changes in mild Huntington's disease.

    abstract::The characteristic pathological features of Huntington's disease (HD) are neostriatal atrophy and neuronal loss. Although neuroradiological studies often show caudate atrophy in patients with moderate HD, frequently no caudate atrophy is found early in the illness. There have been no quantitative reports to date on in...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Harris GJ,Pearlson GD,Peyser CE,Aylward EH,Roberts J,Barta PE,Chase GA,Folstein SE

    更新日期:1992-01-01 00:00:00

  • Lack of association of very low density lipoprotein receptor gene polymorphism with Caucasian Alzheimer's disease.

    abstract::To determine whether the association of the very low density lipoprotein receptor (VLDL-R) gene with Alzheimer's disease (AD), which has recently been identified in Japanese AD patients, is commonly observed in AD patients of other ethnic backgrounds, we have investigated the allele frequency of the polymorphic CGG re...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Okuizumi K,Onodera O,Seki K,Tanaka H,Namba Y,Ikeda K,Saunders AM,Pericak-Vance MA,Roses AD,Tsuji S

    更新日期:1996-08-01 00:00:00

  • Myelin basic protein in Alzheimer disease neuronal fractions and mammalian neurofilament preparations.

    abstract::We previously reported a marked increase of a 20,000 molecular weight (MW) protein, P20, in some neuronal fractions and whole cortical homogenates isolated from affected cortex in Alzheimer disease; P20 comigrated electrophoretically with an unidentified, major 20,000 MW protein present in human neurofilament (NF) fra...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Selkoe DJ,Brown BA,Salazar FJ,Marotta CA

    更新日期:1981-11-01 00:00:00