Abstract:
:For centuries our image of the skeleton has been one of an inert structure playing a supporting role for muscles and a protective role for inner organs like the brain. Cell biology and physiology modified this view in the 20st century by defining the constant interplay between bone-forming and bone resorbing cells that take place during bone growth and remodeling, therefore demonstrating that bone is as alive as any other tissues in the body. During the past 40 years human and, most important, mouse genetics, have allowed not only the refinement of this notion by identifying the many genes and regulatory networks responsible for the crosstalk existing between bone cells, but have redefined the role of bone by showing that its influence goes way beyond its own physiology. Among its newly identified functions is the regulation of energy metabolism by 2 bone-derived hormones, osteocalcin and lipocalin-2. Their biology and respective roles in this process are the topic of this review.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Ducy Pdoi
10.1210/endocr/bqaa149subject
Has Abstractpub_date
2020-10-01 00:00:00issue
10eissn
0013-7227issn
1945-7170pii
5895464journal_volume
161pub_type
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