Decreased Activity of the Ghrhr and Gh Promoters Causes Dominantly Inherited GH Deficiency in Humanized GH1 Mouse Models.

abstract：:The technologies for pancreatic β-cell-specific gene overexpression or knockout are fundamental for investigations of functional genes in vivo. Here we generated the Ins1-Cre-Dsred and Ins1-rtTA mouse models, which expressed the Cre recombinase or reverse tetracycline regulatable transactivator (rtTA) without hGH mini...

journal_title：Endocrinology

authors： Cheng Y,Su Y,Shan A,Jiang X,Ma Q,Wang W,Ning G,Cao Y

更新日期：2015-07-01 00:00:00

abstract：:Immunosympathectomy produced by treatment of newborn rats with antibodies to nerve growth factor (NGF) delays ovarian development and disrupts estrous cyclicity. While these alterations have been ascribed to loss of sympathetic neurons innervating the ovary, the treatment also causes partial loss of ovarian sensory in...

journal_title：Endocrinology

authors： Lara HE,McDonald JK,Ahmed CE,Ojeda SR

更新日期：1990-11-01 00:00:00

abstract：:Previous studies demonstrated the involvement of transforming growth factor-alpha (TGF alpha), a member of the epidermal growth factor (EGF) family, in the developmental regulation of hypothalamic LHRH release. Although both TGF alpha and EGF stimulate LHRH release, they do not appear to act directly on LHRH neurons, ...

journal_title：Endocrinology

authors： Ma YJ,Berg-von der Emde K,Rage F,Wetsel WC,Ojeda SR

更新日期：1997-01-01 00:00:00

abstract：:Periconceptional undernutrition (PCUN) results in an earlier prepartum activation of the pituitary-adrenal axis in twin compared with singleton fetuses. We have tested the hypotheses that the functional development of the fetal sheep adrenal is delayed in twins compared with singletons in early gestation and that PCUN...

journal_title：Endocrinology

authors： MacLaughlin SM,Walker SK,Kleemann DO,Sibbons JP,Tosh DN,Gentili S,Coulter CL,McMillen IC

更新日期：2007-04-01 00:00:00

abstract：:In order to elucidate the putative role of inhibin in regulation of spermatogenesis, expression of inhibin subunits was examined at defined stages of the cycle of the rat seminiferous epithelium. Twenty 2-mm segments of seminiferous tubules at stages XIII-I, II-VI, VII-VIII, and IX-XII were dissected using the transil...

journal_title：Endocrinology

authors： Bhasin S,Krummen LA,Swerdloff RS,Morelos BS,Kim WH,diZerega GS,Ling N,Esch F,Shimasaki S,Toppari J

更新日期：1989-02-01 00:00:00

abstract：:To determine the presence of a PRL-binding protein (PRL-BP) in rat serum, female rats were ovariectomized and administered sc estradiol benzoate capsules. Serum was incubated with [125I]rat PRL (rPRL) for 1 h at 37 C with or without different doses of rPRL, ovine PRL (oPRL), or rGH. Separation of the [125I]rPRL-PRL-BP...

journal_title：Endocrinology

authors： Cohen H,Guillaumot P,Sabbagh I

更新日期：1993-06-01 00:00:00

abstract：:The guinea pig adrenal cortex is grossly composed of two regions: an outer, yellow zone and an inner, brown zone. These zones, which represent 33% and 66% of the total adrenocortical volume, respectively, can be separated by blunt dissection. It has been previously reported that specific pregnenolone and pregnenolone ...

journal_title：Endocrinology

authors： Strott CA,Goff AK,Lyons CD

更新日期：1981-12-01 00:00:00

abstract：:We developed a coculture system comprising primary rat adipocytes and L6 rat skeletal muscle cells to allow investigation of the effects of physiologically relevant mixtures of adipokines. We observed that coculture, or adipocyte-conditioned media, increased glucose uptake in muscle cells. An adipokine that could pote...

journal_title：Endocrinology

authors： Vu V,Kim W,Fang X,Liu YT,Xu A,Sweeney G

更新日期：2007-09-01 00:00:00

abstract：:The hippocampus is essentially involved in learning and memory processes. Its functions are affected by various neuromodulators, including 17beta-estradiol, testosterone, and retinoid. Brain-synthesized steroid hormones act as autocrine and paracrine modulators. The regulatory mechanism underlying brain steroidogenesi...

journal_title：Endocrinology

authors： Munetsuna E,Hojo Y,Hattori M,Ishii H,Kawato S,Ishida A,Kominami SA,Yamazaki T

更新日期：2009-09-01 00:00:00

abstract：:A new perfusion system of isolated rat femora was established, and the effect of PTH or calcitonin (CT) on cAMP release from the adult bone was examined. Stimulation of cAMP release from the isolated perfused bone peaked rapidly between 5 and 10 min after human PTH (hPTH)-(1-34) or eel CT injection, respectively, and ...

journal_title：Endocrinology

authors： Sugimoto T,Fukase M,Tsutsumi M,Imai Y,Hishikawa R,Yoshimoto Y,Fujita T

更新日期：1985-11-01 00:00:00

abstract：:The activity of many endocrine cells is regulated by gamma-aminobutyric acid (GABA). The effects of GABA are mediated by GABAA and/or GABAB receptors. While GABAB receptors in the central nervous system have now been extensively characterized, little is known of the function and pharmacology of GABAB receptors on endo...

journal_title：Endocrinology

authors： De Koning HP,Jenks BG,Roubos EW

更新日期：1993-02-01 00:00:00

abstract：:Monolayer cultures of mouse adrenal tumor cell line Y-1 have been used to investigate the effects of glucocorticoid on cell replication, [3H]thymidine incorporation into the trichloroacetic acid-precipitated cell fraction, steroidogenesis, and the ACTH receptors of adrenocortical cells. Corticosterone at a concentrati...

journal_title：Endocrinology

authors： Saito E,Mukai M,Muraki T,Ichikawa Y,Homma M

更新日期：1979-02-01 00:00:00

abstract：:Spinal cord hemisection between T2 and T3 inhibits compensatory adrenal growth when the contralateral but not the ipsilateral adrenal is removed (p less than 0.01). Pretreatment of left adrenals with 1 or 2% lidocaine, but not with saline, before removal inhibits compensatory right adrenal growth that is normally obse...

journal_title：Endocrinology

authors： Engeland WC,Dallman MF

更新日期：1976-12-01 00:00:00

abstract：:The 11 beta-hydroxysteroid dehydrogenase type 2 (11 beta HSD-2) enzyme is thought to confer aldosterone specificity upon mineralocorticoid target tissues by protecting the mineralocorticoid receptor from binding by the more abundant glucocorticoids, corticosterone and cortisol. We have developed a Chinese hamster ovar...

journal_title：Endocrinology

authors： Morita H,Zhou M,Foecking MF,Gomez-Sanchez EP,Cozza EN,Gomez-Sanchez CE

更新日期：1996-06-01 00:00:00

abstract：:A number of cytokines have been found to be potent regulators of bone resorption and to share the properties originally attributed to osteoclast-activating factor. One such activity, differentiation-inducing factor (DIF, D-factor) from mouse spleen cells, shares a number of biological and biochemical properties with t...

journal_title：Endocrinology

authors： Reid LR,Lowe C,Cornish J,Skinner SJ,Hilton DJ,Willson TA,Gearing DP,Martin TJ

更新日期：1990-03-01 00:00:00

abstract：:PTH and PTH-related peptide (PTHrP) have been shown to bind to and activate the same PTH/PTHrP receptor. Recent studies have demonstrated, however, the presence of additional receptors specific for each ligand. We used the PTHrP and PTH/PTHrP receptor gene knock-out models to investigate whether this receptor mediates...

journal_title：Endocrinology

authors： Lanske B,Divieti P,Kovacs CS,Pirro A,Landis WJ,Krane SM,Bringhurst FR,Kronenberg HM

更新日期：1998-12-01 00:00:00

abstract：:The atrial natriuretic peptide (ANP) gene is expressed in several extraatrial tissues in which ANP may be involved in the regulation of autocrine or paracrine functions. In the ovary, the synthesis of ANP, its binding sites, and a physiological role were found. The ANP system in the oviduct, however, is yet to be defi...

journal_title：Endocrinology

authors： Kim SH,Cho KW,Kim SZ,Koh GY

更新日期：1997-06-01 00:00:00

abstract：:Although kisspeptin is the primary stimulator of gonadotropin-releasing hormone secretion and therefore the hypothalamic-pituitary-gonadal axis, recent findings suggest kisspeptin can also regulate additional neuroendocrine processes including release of growth hormone (GH). Here we show that central delivery of kissp...

journal_title：Endocrinology

authors： Foradori CD,Whitlock BK,Daniel JA,Zimmerman AD,Jones MA,Read CC,Steele BP,Smith JT,Clarke IJ,Elsasser TH,Keisler DH,Sartin JL

更新日期：2017-10-01 00:00:00

abstract：:Complete hypothalamic deafferentation, either limited to the median eminence, arcuate nucleus, and basal parts of ventromedial nuclei, or comprising ventromedial nuclei and dorsomedial hypothalamus as well reduced considerably the rise of immunoassayable serum TSH in adult male rats rendered hypothyroid by administrat...

journal_title：Endocrinology

authors： Hefco E,Krulich L,Aschenbrenner JE

更新日期：1975-11-01 00:00:00

abstract：:The mechanism of the hypophosphatemic effect of thyrocalcitonin (TCT) is uncertain and may involve removal of inorganic phosphate (P1) from the plasma by heretofore unidentified organs. Rats, 192 g. thyroparathyroidectomized 16-24 h earlier, received 100 MRC mU TCT or vehicle (V) SC and 100 muCi 32PO4 iv. One h later ...

journal_title：Endocrinology

authors： Meyer RA Jr,Meyer MH

更新日期：1975-04-01 00:00:00

abstract：:The p44/p42 MAPKs (ERK1/2) cascade regulates beta-cell nuclear events, which modulates cell differentiation and gene transcription, whereas its implication in processes occurring in the cytoplasm, such as activation of the exocytotic machinery, is still unclear. Using the MIN6 beta-cell line and isolated rat islets of...

journal_title：Endocrinology

authors： Longuet C,Broca C,Costes S,Hani EH,Bataille D,Dalle S

更新日期：2005-02-01 00:00:00

abstract：:Thyroid hormone is essential for normal proliferation and differentiation of chondrocytes. Thus, untreated congenital hypothyroidism is marked by severe short stature. The monocarboxylate transporter 8 (MCT8) is a highly specific transporter for thyroid hormone. The hallmarks of Allan-Herndon-Dudley syndrome, caused b...

journal_title：Endocrinology

authors： Abe S,Namba N,Abe M,Fujiwara M,Aikawa T,Kogo M,Ozono K

更新日期：2012-08-01 00:00:00

abstract：:A transient increase in serum progesterone concentrations (to 1 ng/ml for 1-2 days) is observed in the majority of ewes before the first estrous cycle of the breeding season. To determine whether such a brief antecedent rise in progesterone ensures initiation of a full-length cycle by the next LH surge, synthetic GnRH...

journal_title：Endocrinology

authors： Legan SJ,I'Anson H,Fitzgerald BP,Akaydin MS Jr

更新日期：1985-10-01 00:00:00

abstract：:An isolated perfused rabbit ovary preparation was used to determine the effects of cyanoketone, a potent inhibitor of 3 beta-hydroxysteroid dehydrogenase, on ovulation, ovum maturation and fertilizability, and steroid production. In the first experiment, cyanoketone (10(-4) M) was added to the perfusate of one ovary. ...

journal_title：Endocrinology

authors： Yoshimura Y,Hosoi Y,Bongiovanni AM,Santulli R,Atlas SJ,Wallach EE

更新日期：1987-06-01 00:00:00

abstract：:PTH-related protein (PTHrP) and its receptor are expressed in vascular smooth muscle cells and are believed to participate in the local regulation of vascular tone. To explore the function of locally produced PTHrP in vascular smooth muscle in vivo, we developed transgenic mice that overexpress PTHrP in smooth muscle ...

journal_title：Endocrinology

authors： Maeda S,Sutliff RL,Qian J,Lorenz JN,Wang J,Tang H,Nakayama T,Weber C,Witte D,Strauch AR,Paul RJ,Fagin JA,Clemens TL

更新日期：1999-04-01 00:00:00

abstract：:Insulin receptor substrate-1 (IRS-1), the primary substrate for the insulin receptor tyrosine kinase in most cells and tissues, is a key component of the insulin signaling network. Numerous studies have documented the trafficking of IRS-1 from the cell membrane to intracellular, extranuclear compartments. During the c...

journal_title：Endocrinology

authors： Boylan JM,Gruppuso PA

更新日期：2002-11-01 00:00:00

abstract：:The effects of nerve activation and of the catecholamines epinephrine and norepinephrine on adrenal corticosteroid release were investigated in intact isolated perfused pig adrenals with preserved nerve supply. To study the contact zones of medullary and cortical tissues, porcine adrenals were examined on the histolog...

journal_title：Endocrinology

authors： Bornstein SR,Ehrhart-Bornstein M,Scherbaum WA,Pfeiffer EF,Holst JJ

更新日期：1990-08-01 00:00:00

abstract：:Arterial pressure (AP), heart rate (HR), and cardiovascular diseases, including ischemic heart attack and cerebrovascular accident, show diurnal variation. Evidence that circadian-related genes contribute to cardiovascular control has been accumulated. In this study, we measured the AP and HR of Clock mutant mice on t...

journal_title：Endocrinology

authors： Sei H,Oishi K,Chikahisa S,Kitaoka K,Takeda E,Ishida N

更新日期：2008-07-01 00:00:00

abstract：:The possible role of atrial natriuretic factor (ANF) in the regulation of adrenal sensitivity to angiotensin II (AII) was investigated in vivo and in vitro by analyzing the characteristics of the inhibitory effect of ANF on aldosterone production stimulated by AII and other stimuli. In isolated adrenal glomerulosa cel...

journal_title：Endocrinology

authors： Aguilera G

更新日期：1987-01-01 00:00:00

abstract：:The effect of fibroblast growth factor (FGF) on LH-stimulated testosterone production was investigated using primary cultures of rat testicular cells. Testicular cells obtained from neonatal rats (8-9 days of age) were maintained in culture for 3 days and then challenged with LH with or without basic FGF. After 3 addi...

journal_title：Endocrinology

authors： Fauser BC,Baird A,Hsueh AJ

更新日期：1988-12-01 00:00:00