Neural mediation of compensatory adrenal growth.

abstract：:PRL has been reported to exist as a number of mol wt and charge variants. We have attempted to determine the relationships among the charge and lower mol wt variants by two-dimensional gel analysis of pituitary and pituitary cell extracts. Silver-stained gels of the extracts showed three major charge isoforms of 24,00...

journal_title：Endocrinology

authors： Oetting WS,Walker AM

更新日期：1985-10-01 00:00:00

abstract：:Cortisol in concentrations similar to the unbound levels of the hormone in human plasma can reverse the inhibition of vascular reactivity produced by prolactin. In the rat mesenteric vascular bed, cortisol alone in similar concentrations had no significant effect on the pressor responses to norepinephrine: the action ...

journal_title：Endocrinology

authors： Horrobin DF,Mtabaji JP,Manku MS

更新日期：1976-08-01 00:00:00

abstract：:Nicotine is a potent stimulus for the secretion of ACTH, and norepinephrinergic neurons originating in the brainstem are involved. Prior reports using in vivo microdialysis in alert rats have shown that nicotine, administered i.p. or into the fourth ventricle, stimulated the release of norepinephrine (NE) into the hyp...

journal_title：Endocrinology

authors： Fu Y,Matta SG,Valentine JD,Sharp BM

更新日期：1997-05-01 00:00:00

abstract：:Thyroid hormones play a major role in body homeostasis, regulating energy expenditure and cardiovascular function. Given that obese people or athletes might consider rapid weight loss as beneficial, voluntary intoxication with T4 preparations is a growing cause for thyrotoxicosis. However, the long-lasting effects of ...

journal_title：Endocrinology

authors： Hoefig CS,Harder L,Oelkrug R,Meusel M,Vennström B,Brabant G,Mittag J

更新日期：2016-07-01 00:00:00

abstract：:Obesity is often associated with an impairment of the hypothalamic-pituitary-gonadal axis. The leptin-deficient ob/ob mouse model is characterized by a morbid obesity with a sterility in males and females that is corrected by continuous leptin treatment. Since ob/ob mice are maintained on the C57BL/6J inbred genetic b...

journal_title：Endocrinology

authors： Ewart-Toland A,Mounzih K,Qiu J,Chehab FF

更新日期：1999-02-01 00:00:00

abstract：:More than 150 hypothalamic fractions were reassayed for luteinizing hormone-releasing hormone (LHRH) and follicle stimulating hormone-releasing hormone (FSHRH) activities in search for LHRH and FSHRH which differ from the decapeptide (pyro)Glu-His-Trp-Ser-Try-Gly-Leu-Arg-Pro-Gly-NH2 (I). Among the porcine fractions te...

journal_title：Endocrinology

authors： Schally AV,Arimura A,Redding TW,Debeljuk L,Carter W,Dupont A,Vilchez-Martinez JA

更新日期：1976-02-01 00:00:00

abstract：:Morphological plasticity in response to estradiol is a hallmark of astrocytes in the arcuate nucleus. The functional consequences of these morphological changes have remained relatively unexplored. Here we report that in the arcuate nucleus estradiol significantly increased the protein levels of the two enzymes in the...

journal_title：Endocrinology

authors： Blutstein T,Baab PJ,Zielke HR,Mong JA

更新日期：2009-07-01 00:00:00

abstract：:To explore the role of transforming growth factor-beta (TGF beta) isoforms and other growth-related genes during prostate morphogenesis in the mouse, we examined mRNA levels in fetal day 17 urogenital sinus, mesenchyme (UGM), and epithelium (UGE) as well as in the ventral, dorsal, and anterior lobes of the adult prost...

journal_title：Endocrinology

authors： Timme TL,Truong LD,Merz VW,Krebs T,Kadmon D,Flanders KC,Park SH,Thompson TC

更新日期：1994-03-01 00:00:00

abstract：:Fat intake has long been associated with the development of obesity. The studies described herein show that fat adversely affects adipocyte adrenergic receptor (AR) expression and function. As beta 3AR agonists have been shown to acutely reduce adipose tissue mass and improve thermogenesis in genetically obese rodents...

journal_title：Endocrinology

authors： Collins S,Daniel KW,Petro AE,Surwit RS

更新日期：1997-01-01 00:00:00

abstract：:We investigated whether genetic selection for growth influences pituitary GH secretion in two strains of rats, LL (large) and SS (small). Animals were bled every 15 min for 6 h via an indwelling atrial Silastic catheter, and GH levels were determined by RIA. LL and SS males displayed a low frequency, high amplitude ep...

journal_title：Endocrinology

authors： O'Sullivan D,Millard WJ,Badger TM,Martin JB,Martin RJ

更新日期：1986-11-01 00:00:00

abstract：:The castration-induced regression and testosterone stimulated regrowth of the vasculature in the rat ventral prostate lobe were studied using stereological techniques. Seven days after castration, the endothelial cell proliferation rate (bromodeoxyuridine labeling index); the total weights of blood vessel walls, blood...

journal_title：Endocrinology

authors： Franck-Lissbrant I,Häggström S,Damber JE,Bergh A

更新日期：1998-02-01 00:00:00

abstract：:The scaffolding protein, protein targeting to glycogen (PTG), orchestrates the signaling of several metabolic enzymes involved in glycogen synthesis. However, little is known concerning the regulation of PTG itself. In this study, we have cloned and characterized the mouse promoter of PTG. We identified multiple FoxA2...

journal_title：Endocrinology

authors： Cheng A,Zhang M,Crosson SM,Bao ZQ,Saltiel AR

更新日期：2006-07-01 00:00:00

abstract：:One of the hypotheses attempting to explain the etiology of the human disease X-linked hypophosphatemia (XLH) posits renal hypersensitivity to parathyroid hormone (PTH). These studies were designed to test this hypothesis in vivo, using the hemizygous hypophosphatemic (Hyp/Y) mouse as an animal model for XLH. Vehicle ...

journal_title：Endocrinology

authors： Kiebzak GM,Meyer RA Jr

更新日期：1982-03-01 00:00:00

abstract：:The purpose of the present study was to further examine the hypothesis that activation of G protein-coupled receptor 54 (GPR54) signaling at the end of the juvenile phase of primate development is responsible for initiation of gonadarche and the onset of puberty. Accordingly, we determined whether repetitive iv admini...

journal_title：Endocrinology

authors： Plant TM,Ramaswamy S,Dipietro MJ

更新日期：2006-02-01 00:00:00

abstract：:Transforming growth factor-beta (TGF beta) is a multifunctional growth factor in bone that is secreted as a latent complex and must be activated in order to influence cellular activity. We have investigated the influence of dexamethasone (Dex; a potent glucocorticoid) on the secretion and activation of latent TGF beta...

journal_title：Endocrinology

authors： Oursler MJ,Riggs BL,Spelsberg TC

更新日期：1993-11-01 00:00:00

abstract：:A heterologous RIA for rat GH-releasing factor (rGRF) was established using synthetic rGRF-(1-43)OH for both standard reference and radioiodination with the antiserum produced against human GRF-(1-44) NH2. The regional distribution of rGRF-like immunoreactivity (LI) in rat hypothalamus was examined according to the Pa...

journal_title：Endocrinology

authors： Kita T,Chihara K,Abe H,Minamitani N,Kaji H,Kodama H,Kashio Y,Okimura Y,Fujita T,Ling N

更新日期：1985-01-01 00:00:00

abstract：:The presence of multiple monomeric forms has been described for estrogen receptor (ER) in different target tissues. Using [3H]tamoxifen aziridine ([3H]TA) to covalently label ER and sodium dodecyl sulfate-polyacrylamide gel electrophoresis to analyze labeled products, ER forms were investigated in pituitary cytosol an...

journal_title：Endocrinology

authors： Geffroy-Roisne S,Duval J,Thieulant ML

更新日期：1992-09-01 00:00:00

abstract：:The largest subtype of breast cancer is characterized by the expression and activity of the estrogen receptor alpha (ERalpha/ER). Although several effective therapies have significantly improved survival, the adaptability of cancer cells means that patients frequently stop responding or develop resistance to endocrine...

journal_title：Endocrinology

authors： Farcas AM,Nagarajan S,Cosulich S,Carroll JS

更新日期：2021-02-01 00:00:00

abstract：:P19 EPI-7, a differentiated murine embryonal carcinoma cell line with an epithelioid morphology, does not require external growth factors for proliferation under clonal and subconfluent conditions. At saturation density, however, cells become quiescent in the G1/G0 phase of the cell cycle from which they can be restim...

journal_title：Endocrinology

authors： van Zoelen EJ,Koornneef I,Holthuis JC,Ward-van Oostwaard TM,Feijen A,de Poorter TL,Mummery CL,van Buul-Offers SC

更新日期：1989-04-01 00:00:00

abstract：:The seasonal changes in response to the negative feedback action of estradiol on LH secretion were studied in two groups of ovariectomized Japanese monkeys (Macaca fuscata fuscata; n = 6). Blood samples were collected two to three times a week, and changes in serum concentrations of LH, estradiol, and progesterone wer...

journal_title：Endocrinology

authors： Nozaki M,Watanabe G,Taya K

更新日期：1991-03-01 00:00:00

abstract：:Aside from studies of a possible synergism between T3 and glucocorticoids in regulating GH mRNA, there have been few previous studies of the modulation by hormones and other factors of glucocorticoid hormone regulation of pituitary cell GH gene expression. We have employed a serum-free medium containing no exogenously...

journal_title：Endocrinology

authors： Gick GG,Bancroft C

更新日期：1987-05-01 00:00:00

abstract：:Testicular cytosol from Sprague-Dawley rats was shown to possess an estradiol binding component which exhibited the properties of a receptor. Specific binding of estradiol by the receptor was shown, at 4C in vitro, to reach equilibrium by 6 h. That level of binding was maintained at a plateau for 18 h. Estradiol bindi...

journal_title：Endocrinology

authors： Abney TO

更新日期：1976-08-01 00:00:00

abstract：:Local androgen synthesis in prostate cancer (PC) may contribute to the development of castration-resistant PC (CRPC), but pathways controlling intratumoral steroidogenic enzyme expression in PC are unknown. We investigated the effects of activin, a factor involved in the regulation of PC growth and steroidogenic enzym...

journal_title：Endocrinology

authors： Hofland J,van Weerden WM,Steenbergen J,Dits NF,Jenster G,de Jong FH

更新日期：2012-12-01 00:00:00

abstract：:Vascularly perfused duodenal loops from normal vitamin D-replete chicks were used to obtain insight with regards to the possible mechanism(s) by which 1,25-dihydroxy-vitamin D3 [1,25(OH)2D3] rapidly stimulates intestinal Ca2+ transport (transcaltachia). The phorbol ester, 12-o-tetradecanoyl phorbol-13 acetate (TPA) (1...

journal_title：Endocrinology

authors： de Boland AR,Norman A

更新日期：1990-07-01 00:00:00

abstract：:Berberine, a hypoglycemic agent, has recently been shown to activate AMP-activated protein kinase (AMPK) contributing to its beneficial metabolic effects in peripheral tissues. However, whether berberine exerts a regulatory effect on beta-cells via AMPK or other signaling pathways and counteracts glucolipotoxicity rem...

journal_title：Endocrinology

authors： Zhou L,Wang X,Shao L,Yang Y,Shang W,Yuan G,Jiang B,Li F,Tang J,Jing H,Chen M

更新日期：2008-09-01 00:00:00

abstract：:As4.1 cells are derived from a renin-expressing kidney tumor induced by tissue-specific oncogene-mediated tumorigenesis in transgenic mice. These cells express high levels of renin messenger RNA (mRNA) and synthesize prorenin and renin; they were therefore used as a model to further investigate the molecular biology o...

journal_title：Endocrinology

authors： Thompson HA,Burson JM,Lang JA,Gross KW,Sigmund CD

更新日期：1995-07-01 00:00:00

abstract：:Blepharophimosis ptosis epicanthus inversus syndrome (BPES) is a human disorder caused by mutations in the forkhead transcription factor gene FOXL2 and is characterized by facial dysmorphology combined in some cases with ovarian failure. To better understand the role of FOXL2 in the etiology of ovarian failure in BPES...

journal_title：Endocrinology

authors： Loffler KA,Zarkower D,Koopman P

更新日期：2003-07-01 00:00:00

abstract：:The hypothesis that hydrogen peroxide generation occurs in the corpora lutea of superovulated rats during luteolysis was tested using a peroxide-dependent inhibitor of catalase, 3-amino-1,2,4-triazole (AT). Luteal regression was induced during midpseudopregnancy by injection of 500 micrograms prostaglandin F2 alpha (P...

journal_title：Endocrinology

authors： Riley JC,Behrman HR

更新日期：1991-04-01 00:00:00

abstract：:The evolution of the IGF binding protein (IGFBP) gene family has been difficult to resolve. Both chromosomal and serial duplications have been suggested as mechanisms for the expansion of this gene family. We have identified and annotated IGFBP sequences from a wide selection of vertebrate species as well as Branchios...

journal_title：Endocrinology

authors： Daza DO,Sundström G,Bergqvist CA,Duan C,Larhammar D

更新日期：2011-06-01 00:00:00

abstract：:The concentration of biologically active LH in rhesus monkey (Macaca mulatta) serum was measured by a highly sensitive bioassay based upon testosterone production by dispersed rat interstitial cells. The sensitivity of the in vitro bioassay was equal to or higher than that of radioimmunoassay, with detection limits of...

journal_title：Endocrinology

authors： Dufau ML,Hodgen GD,Goodman AL,Catt KJ

更新日期：1977-06-01 00:00:00