Are ovarian steroids required for ovum maturation and fertilization? Effects of cyanoketone on the in vitro perfused rabbit ovary.

abstract：:Pulmonary alveolar type 2 cells act as a reservoir of stem cells which can be induced to proliferate during periods of lung growth and repair after lung injury. Despite the importance of this process, the mechanisms that regulate type 2 cell proliferation have not been well characterized. We show in this study that in...

journal_title：Endocrinology

authors： Mouhieddine OB,Cazals V,Maitre B,Le Bouc Y,Chadelat K,Clement A

更新日期：1994-07-01 00:00:00

abstract：:Levels of vasopressin, oxytocin, and neurophysin were measured by RIA in the hypothalamus, pituitary, and plasma of infant rats (2-30 days old). At all ages, ip injection of a hypertonic solution of 5 g/100 ml NaCl produced a marked increase in levels of vasopressin and neurophpysin in plasma, up to 21 microU/ml and 5...

journal_title：Endocrinology

authors： Singinq C,Robinson AG,Seif SM

更新日期：1980-09-01 00:00:00

abstract：:The direct effects of cortisol and cortisone on insulin and glucagon secretion by the isolated perfused rat pancreas were examined. Cortisone, but not cortisol, in a final concentration of 10(-4) M acutely and strongly inhibited both phases of glucose- and arginine-induced insulin secretion. In repeated pulse administ...

journal_title：Endocrinology

authors： Barseghian G,Levine R,Epps P

更新日期：1982-11-01 00:00:00

abstract：:Calcium (Ca2+) ionophore A23187 increased the intracellular cAMP content and PRL release in normal rat anterior pituitary cells. Cotreatment with dopamine reduced both control and A23187-stimulated cAMP accumulation and PRL release. The dopamine antagonist spiperone restored the response of cAMP to ionophoric stimulat...

journal_title：Endocrinology

authors： Schettini G,Cronin MJ,MacLeod RM

更新日期：1983-05-01 00:00:00

abstract：:The insulin-like growth factors (IGF)-I and -II are bound to specific carrier proteins in the circulation. For investigation of their physiological role, the acid-stable subunit of the major binding protein (SmBP) was isolated from human plasma Cohn fraction IV. Its effect on the mitogenic activity of IGF-I was studie...

journal_title：Endocrinology

authors： Blum WF,Jenne EW,Reppin F,Kietzmann K,Ranke MB,Bierich JR

更新日期：1989-08-01 00:00:00

abstract：:Mouse uterine estrogen receptor (ER) was purified about 11,000-fold from normal mouse uteri by affinity chromatography. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the purified ER demonstrated a major component of 65,000 mol wt with minor fragments of the 54,000- and 37,000-dalton species, as judged b...

journal_title：Endocrinology

authors： Horigome T,Golding TS,Quarmby VE,Lubahn DB,McCarty K Sr,Korach KS

更新日期：1987-12-01 00:00:00

abstract：:Studies show that a subset of transgender men desire children; however, there is a paucity of literature on the effect of gender-affirming testosterone therapy on reproductive function. In this manuscript, we will review the process of gender-affirming hormone therapy for transgender men and what is known about ovaria...

journal_title：Endocrinology

authors： Moravek MB,Kinnear HM,George J,Batchelor J,Shikanov A,Padmanabhan V,Randolph JF

更新日期：2020-03-01 00:00:00

abstract：:Thyroid hormones are of considerable importance for vertebrate reproductive function and during development. To further assess the role of these compounds in this capacity, we examined the expression pattern of the type 2 iodothyronine deiodinase (D2), which converts T(4) to the more active hormone T(3), in the rat ut...

journal_title：Endocrinology

authors： Galton VA,Martinez E,Hernandez A,St Germain EA,Bates JM,St Germain DL

更新日期：2001-05-01 00:00:00

abstract：:Centrally administered histamine (HA) stimulates the secretion of adenohypophysial POMC-derived peptides, which subsequently cause release of corticosterone. The effect of HA on POMC-derived peptide release is indirect, and it is possible that hypothalamic neurons containing corticotropin-releasing hormone (CRH), argi...

journal_title：Endocrinology

authors： Kjaer A,Larsen PJ,Knigge U,Warberg J

更新日期：1994-09-01 00:00:00

abstract：:The localization of calcitonin gene-related peptide (CGRP)-like immunoreactivity in the adrenal gland of the frog, Rana ridibunda, was examined by the indirect immunofluorescence technique. Using an antiserum directed against rat alpha-CGRP, the presence of a network of positive fibers was observed in the adrenal pare...

journal_title：Endocrinology

authors： Esneu M,Delarue C,Remy-Jouet I,Manzardo E,Fasolo A,Fournier A,Saint-Pierre S,Conlon JM,Vaudry H

更新日期：1994-07-01 00:00:00

abstract：:The physicochemical and immunological properties of androgen receptors from kidney and brain of testicular-feminized (Tfm) mutant mice and wild-type mice were compared. Analysis by gel filtration and sucrose density gradients revealed that the mol wt of the mutant receptor was 66K (38A; 3.8S) which was significantly s...

journal_title：Endocrinology

authors： Young CY,Johnson MP,Prescott JL,Tindall DJ

更新日期：1989-02-01 00:00:00

abstract：:Dopaminergic (DA) neurons located in the preoptico-hypothalamic region of the brain exert a major neuroendocrine control on reproduction, growth, and homeostasis by regulating the secretion of anterior pituitary (or adenohypophysis) hormones. Here, using a retrograde tract tracing experiment, we identified the neurons...

journal_title：Endocrinology

authors： Fontaine R,Affaticati P,Bureau C,Colin I,Demarque M,Dufour S,Vernier P,Yamamoto K,Pasqualini C

更新日期：2015-08-01 00:00:00

abstract：:GH is believed to play a role in promoting insulin resistance in patients with diabetes and with GH excess. The means by which GH produces insulin resistance may be through direct suppression of glucose metabolism in target cells (insulin-independent) or by interfering with the ability of insulin to stimulate glucose ...

journal_title：Endocrinology

authors： Foster CM,Hale PM,Jing HW,Schwartz J

更新日期：1988-08-01 00:00:00

abstract：:Prolonged exposure to elevated FFA levels has been shown to induce peripheral insulin resistance and to alter the beta-cell secretory response to glucose. To investigate the effects of FFAs on preproinsulin gene expression, we measured insulin release, cell content, and messenger RNA (mRNA) levels in rat islets after ...

journal_title：Endocrinology

authors： Ritz-Laser B,Meda P,Constant I,Klages N,Charollais A,Morales A,Magnan C,Ktorza A,Philippe J

更新日期：1999-09-01 00:00:00

abstract：:GnRH neurons are regulated by hypothalamic kisspeptin neurons. Recently, galanin was identified in a subpopulation of kisspeptin neurons. Although the literature thoroughly describes kisspeptin activation of GnRH neurons, little is known about the effects of galanin on GnRH neurons. This study investigated whether gal...

journal_title：Endocrinology

authors： Constantin S,Wray S

更新日期：2016-08-01 00:00:00

abstract：:The issue of how progesterone affects mammary gland growth is controversial, and the mechanism governing the effects of the hormone remains mostly unknown. We have previously shown that G protein-coupled receptor 30 (GPR30) is a progestin target gene whose expression correlates with progestin-induced growth inhibition...

journal_title：Endocrinology

authors： Ahola TM,Manninen T,Alkio N,Ylikomi T

更新日期：2002-09-01 00:00:00

abstract：:Japanese quail, a species with a precocial pattern of development, were used as a model for studying the ontogeny of thyroid responses to TSH. Thiourea was administered to embryos early in incubation, and the effects were assessed by measuring thyroid 32P uptake, serum thyroid hormones, thyroid weights, and body weigh...

journal_title：Endocrinology

authors： McNabb FM,Stanton FW,Weirich RT,Hughes TE

更新日期：1984-04-01 00:00:00

abstract：:GH feeds back at the level of the central nervous system to alter the release of somatostatin and GRF, resulting in altered GH release. The purpose of this study was to see whether the concentration of GH, impinging directly on the somatotrophs of the adenohypophysis, would alter the responsiveness of the somatotrophs...

journal_title：Endocrinology

authors： Kraicer J,Lussier B,Moor BC,Cowan JS

更新日期：1988-04-01 00:00:00

abstract：:ACTH produced a 75% increase in pregnenolone biosynthesis from endogenous precursors in isolated cells prepared from the rat Snell adrenocortical carcinoma 494. On the addition of 24- and 25-hydroxycholesterol to the tumor cells, the rate of pregnenolone synthesis increased 10-fold but was insensitive to the presence ...

journal_title：Endocrinology

authors： Mason JI,Robidoux WF

更新日期：1979-11-01 00:00:00

abstract：:It was shown previously that epidermal growth factor (EGF) plays a role in the testosterone-dependent fetal Wolffian duct differentiation. In this communication, the role of EGF was further investigated by determining whether EGF receptor plays a role in mediating the effect of EGF during Wolffian duct (male duct) dif...

journal_title：Endocrinology

authors： Gupta C,Jaumotte J

更新日期：1993-10-01 00:00:00

abstract：:Inside-out plasma membrane vesicles from a glucose-responsive rat insulinoma showed an ATP- and Mg2(+)-dependent uptake of Ca2+. The Km (concentration giving half-maximal activity) for Ca2+ was 60 nM. In the presence of 0.4 microM free Ca2+, the Km for ATP was 15 microM, and the Km for Mg2+ was 4 microM. Glucose (30 m...

journal_title：Endocrinology

authors： Hoenig M,Culberson LH,Ferguson DC

更新日期：1991-03-01 00:00:00

abstract：:Exposure of quiescent bovine parathyroid cells to serum or a serum substitute caused an elevation in [3H] thymidine incorporation, followed by an increase in cell number. This was preceded by a rapid transient rise in c-myc and c-fos proto-oncogene mRNA levels. Alterations in the medium calcium concentration had no ef...

journal_title：Endocrinology

authors： Kremer R,Bolivar I,Goltzman D,Hendy GN

更新日期：1989-08-01 00:00:00

abstract：:To study the localization of PRL in mammary epithelial cells (MEC) and to characterize PRL forms in serum, milk, and mammary tissue, two groups of lactating rats, a control group and a bromocriptine-treated group, were compared. In serum and milk from control rats, two forms of PRL (25 and 23 kDa) were detected by imm...

journal_title：Endocrinology

authors： Lkhider M,Delpal S,Bousquet MO

更新日期：1996-11-01 00:00:00

abstract：:In this study on highly enriched populations of cultured rat corticotropes, Ca2+ channel inhibitors were used to identify subtypes of the high threshold Ca2+ channel current under voltage clamp conditions. From a holding potential (-50 mV) that eliminated the low threshold T-type current, 52 +/- 4% of the total curren...

journal_title：Endocrinology

authors： Kuryshev YA,Childs GV,Ritchie AK

更新日期：1995-09-01 00:00:00

abstract：:Neuromedin-N (NN) and neurotensin (NT) were shown recently to be encoded in the same precursor molecule. Colocalization and corelease of ileal NT and NN have not yet been demonstrated and were investigated in the rat using antisera that separately recognized intact NT and NN in ileal extracts. Immunofluorescence label...

journal_title：Endocrinology

authors： Cuber JC,Herrmann C,Kitabgi P,Bosshard A,Bernard C,De Nadai F,Chayvialle JA

更新日期：1990-03-01 00:00:00

abstract：:LH treatment of isolated medium (3- to 7-mm) follicles from porcine ovaries stimulated pregnenolone synthesis by mitochondria isolated from these tissues. This LH stimulation of pregnenolone synthesis was observed regardless of whether exogenous cholesterol was added to the mitochondrial assay system, suggesting that ...

journal_title：Endocrinology

authors： Neymark MA,Bieszczad RR,Dimino MJ

更新日期：1984-02-01 00:00:00

abstract：:The present study was undertaken to identify the mechanisms underlying the effect of insulin-like growth factor (IGF-I) on LH receptor in rat granulosa cells. Treatment with FSH, as expected, produced a substantial increase in LH receptor messenger RNA (mRNA) level, and concurrent treatment with increasing concentrati...

journal_title：Endocrinology

authors： Hirakawa T,Minegishi T,Abe K,Kishi H,Ibuki Y,Miyamoto K

更新日期：1999-11-01 00:00:00

abstract：:There is considerable evidence that CRH can suppress food intake. As hypothalamic CRH, a main site of CRH expression, is also negatively regulated by glucocorticoids, it is unclear whether anorexia and weight loss in adrenal insufficiency are attributable to elevated CRH or to decreased glucocorticoid levels. To disti...

journal_title：Endocrinology

authors： Jacobson L

更新日期：1999-01-01 00:00:00

abstract：:131I therapy is a widely accepted treatment for differentiated thyroid cancers which can accumulate iodide. We evaluated the efficiency of 131I therapy against tumors which are transfected with the Na+/I- symporter (NIS) gene. We transfected the rat NIS cDNA expression vector into malignantly transformed rat thyroid c...

journal_title：Endocrinology

authors： Shimura H,Haraguchi K,Miyazaki A,Endo T,Onaya T

更新日期：1997-10-01 00:00:00

abstract：:Mineralocorticoid receptor (MR), highly expressed in the hippocampus, binds corticosteroid hormones and coordinately participates, with the glucocorticoid receptor, to the control of stress responses, memorization, and behavior. To investigate the impact of MR in neuronal survival, we generated murine embryonic stem (...

journal_title：Endocrinology

authors： Munier M,Law F,Meduri G,Le Menuet D,Lombès M

更新日期：2012-03-01 00:00:00