Leukemia inhibitory factor: a novel bone-active cytokine.

abstract：:Neurotensin (NT) is a peptide expressed in the brain and in the gastrointestinal tract. Brain NT inhibits food intake, but the effects of peripheral NT are less investigated. In this study, peripheral NT decreased food intake in both mice and rats, which was abolished by a NT antagonist. Using c-Fos immunohistochemist...

journal_title：Endocrinology

authors： Ratner C,Skov LJ,Raida Z,Bächler T,Bellmann-Sickert K,Le Foll C,Sivertsen B,Dalbøge LS,Hartmann B,Beck-Sickinger AG,Madsen AN,Jelsing J,Holst JJ,Lutz TA,Andrews ZB,Holst B

更新日期：2016-09-01 00:00:00

abstract：:An assay was developed to detect tritium-labeled ovine FSH beta-subunit [( 3H]oFSH beta) secreted from primary ovine pituitary cultures. This procedure used affinity-enriched antibodies raised against reduced and carbamylmethylated oFSH beta (RCM-oFSH beta) in a two-cycle immunoextraction procedure. A discrete species...

journal_title：Endocrinology

authors： Whitfield GK,Miller WL

更新日期：1984-07-01 00:00:00

abstract：:The differential regulation of neurotensin (NT), calcitonin (CT), and CT gene-related peptide (CGRP) production was studied in the clonal, rat C cell-derived, 44-2C cell line. Two experimental paradigms were used: cells were incubated with maximally effective concentrations of calcium (4.0 mM); alternatively, cells we...

journal_title：Endocrinology

authors： Zeytin FN,Rusk S,Leff SE

更新日期：1987-07-01 00:00:00

abstract：:p-Tyramine, an endogenous amine with sympathomimetic action, is found in the mammalian hypothalamus. When injected ip, p-tyramine reduced serum PRL without altering LH and TSH serum titers in adult orchidectomized rats and rats subjected to ether or immobilization stress. The hyperprolactinemia achieved by this last p...

journal_title：Endocrinology

authors： Becú-Villalobos D,Lacau de Mengido IM,Libertun C

更新日期：1985-05-01 00:00:00

abstract：:This study provides the first demonstration that human hepatocarcinoma-derived cell line HepG2 contains GnRH receptors and responds to various molecular forms of GnRH in terms of inhibition of proliferation in a time- and dose-related manner. In addition, GnRH peptides also significantly inhibited the uptake of [3H]th...

journal_title：Endocrinology

authors： Pati D,Habibi HR

更新日期：1995-01-01 00:00:00

abstract：:Free radical production and lipid peroxidation are potentially important mediators in testicular physiology and toxicology. The cytochrome P450 enzymes of the steroidogenic pathway are known to produce free radicals. The present study was conducted to elucidate in vivo the gonadotropin regulation of free radical-media...

journal_title：Endocrinology

authors： Peltola V,Huhtaniemi I,Metsa-Ketela T,Ahotupa M

更新日期：1996-01-01 00:00:00

abstract：:The effect of 3 alpha-hydroxy-4-pregnen-20-one (3HP), a Sertoli cell steroid, on the secretion of gonadotropins from rat anterior pituitary cells in culture was examined and subsequently compared with the action of other gonadal steroids and steroids structurally related to 3HP. Pituitary cells from randomly cycling, ...

journal_title：Endocrinology

authors： Wood PH,Wiebe JP

更新日期：1989-07-01 00:00:00

abstract：:Pulmonary surfactant is a developmentally and hormonally regulated lipoprotein synthesized exclusively in alveolar type II cells. Surfactant protein-A (SP-A) gene transcription in human fetal lung in culture is stimulated by glucocorticoids and cAMP; cAMP also enhances the rate of type II cell differentiation. The CCA...

journal_title：Endocrinology

authors： Breed DR,Margraf LR,Alcorn JL,Mendelson CR

更新日期：1997-12-01 00:00:00

abstract：:Most studies of lipoprotein requirements for steroid secretion by the adrenal have examined the mixed cell population of the whole gland; none have examined lipoprotein requirements of guinea pig adrenocortical cells. In this study the effect of exogenous lipoprotein on the ability of cells from each of the different ...

journal_title：Endocrinology

authors： Black VH

更新日期：1987-02-01 00:00:00

abstract：:The effect of beta-endorphin upon plasma arg8-vasopressin release was studied in vivo in rabbits and in vitro in rat neural lobes. Following intravenous administration of 200 mug/kg synthetic beta-endorphin plasma AVP rose significantly by five minutes after injection and remained elevated for twenty-five minutes comp...

journal_title：Endocrinology

authors： Weitzman RE,Fisher DA,Minick S,Ling N,Guillemin R

更新日期：1977-11-01 00:00:00

abstract：:Complementary DNA-encoding proteins with high homology to steroidogenic acute regulatory proteins (StAR) of mammals were cloned from rainbow trout head kidney and a mixture of several brook trout tissues. A cDNA encoding an MLN64 homolog was also cloned from brook trout. The C-terminal domains of rainbow trout StAR an...

journal_title：Endocrinology

authors： Kusakabe M,Todo T,McQuillan HJ,Goetz FW,Young G

更新日期：2002-06-01 00:00:00

abstract：:There are many precedents for the production from a single precursor of multiple peptides, with independent receptors and different bioactivities. Gastrin-releasing peptide (GRP) is initially synthesized as amino acids 1-27 of a 125-residue precursor, proGRP, and is subsequently cleaved and amidated to form GRP18-27. ...

journal_title：Endocrinology

authors： Patel O,Dumesny C,Shulkes A,Baldwin GS

更新日期：2007-03-01 00:00:00

abstract：:With the rapid changes in lifestyle in modern society, including the high nutritional intake and reduced physical activity, the incidence of metabolic diseases has been increasing year by year. Obstructive sleep apnea syndrome (OSAS) is a sleep disorder, usually characterized by sudden pauses of breathing during sleep...

journal_title：Endocrinology

authors： Li M,Li X,Lu Y

更新日期：2018-07-01 00:00:00

abstract：:Like insulin-like growth factor binding protein-3 (IGFBP-3), IGFBP-5 forms a ternary complex with insulin-like growth factor (IGF)-I or IGF-II, and the acid-labile subunit (ALS). The study of IGFBP-5/IGFBP-6 chimeric proteins with amino-terminal and middle domain swaps, has revealed the existence of a site in the midd...

journal_title：Endocrinology

authors： Twigg SM,Kiefer MC,Zapf J,Baxter RC

更新日期：2000-01-01 00:00:00

abstract：:Glutamate (Glu) is the most prevalent excitatory neurotransmitter in the brain and has been implicated in the regulation of GnRH secretion in several mammalian species, including the monkey. To investigate the neuroanatomical basis for Glu-GnRH interactions, we performed an immunocytochemical study at both the light a...

journal_title：Endocrinology

authors： Goldsmith PC,Thind KK,Perera AD,Plant TM

更新日期：1994-02-01 00:00:00

abstract：:We have investigated the ability of fetal rat skin to heal an excisional wound in vitro. Skin from the backs of E17-E19 rats was wounded using a 1-mm diameter cutting needle and suspended in culture on a 6-pin cradle for 72 h. Neither contraction nor epithelial closure was observed within wounds created in skin from E...

journal_title：Endocrinology

authors： Belford DA

更新日期：1997-09-01 00:00:00

abstract：:The occurrence of the thyroid hormone-binding plasma protein transthyretin in the bloodstream was investigated for four American marsupial species. Serum samples were analyzed by incubation with radioactive T4, followed by electrophoresis, then autoradiography, and Western blotting. Transthyretin was found in serum fr...

journal_title：Endocrinology

authors： Richardson SJ,Wettenhall RE,Schreiber G

更新日期：1996-08-01 00:00:00

abstract：:Elevated activin A levels in inhibin-deficient mice promote the development of gonadal tumors and induce cachexia by reducing muscle, liver, stomach, and fat mass. Because activin A is an important regulator of tissue growth, inhibiting the actions of this TGFβ family ligand may halt or reverse pathology in diseased t...

journal_title：Endocrinology

authors： Makanji Y,Walton KL,Chan KL,Gregorevic P,Robertson DM,Harrison CA

更新日期：2011-10-01 00:00:00

abstract：:The atrial natriuretic peptide (ANP) gene is expressed in several extraatrial tissues in which ANP may be involved in the regulation of autocrine or paracrine functions. In the ovary, the synthesis of ANP, its binding sites, and a physiological role were found. The ANP system in the oviduct, however, is yet to be defi...

journal_title：Endocrinology

authors： Kim SH,Cho KW,Kim SZ,Koh GY

更新日期：1997-06-01 00:00:00

abstract：:Hepatic synthesis of alpha 2u-globulin and its mRNA in the male rat is dependent on androgen, glucocorticoid, T4, insulin, and GH. Some of these hormones may act directly on the liver, while others may influence alpha 2u-globulin synthesis through indirect physiological changes. In the present study the specific role ...

journal_title：Endocrinology

authors： Murty CV,Rao KV,Roy AK

更新日期：1987-11-01 00:00:00

abstract：:Decidual tissue of the rat produces a hormone with physiological and biochemical characteristics similar to those of PRL. Because PRL affects both follicular and luteal production of testosterone and estradiol, it was of interest to determine whether decidual luteotropin affects basal and/or LH-stimulated ovarian secr...

journal_title：Endocrinology

authors： Gibori G,Kalison B,Warshaw ML,Basuray R,Glaser LA

更新日期：1985-05-01 00:00:00

abstract：:Protein kinase-C (PKC) has been suggested as a possible mediator of the antigonadotropic action of prostaglandin F2 alpha (PGF2 alpha) in luteal cells. To examine this possibility, we evaluated the effects of phorbol ester [12-O-tetradecanoylphorbol-13-acetate (TPA)] in relation to those of PGF2 alpha on cAMP accumula...

journal_title：Endocrinology

authors： Musicki B,Aten RF,Behrman HR

更新日期：1990-03-01 00:00:00

abstract：:The ovulatory LH surge results in follicular inflammation with an increase in cytokines and PGs. Reactive oxygen species (ROS) are also produced during inflammatory processes. To study ROS generation during the ovulatory cascade, preovulatory follicles were dissected from immature female rats primed with PMSG. Follicl...

journal_title：Endocrinology

authors： Kodaman PH,Behrman HR

更新日期：2001-02-01 00:00:00

abstract：:GnRH autoregulates GnRH neurons through an ultrashort feedback loop. One potential mechanism is the regulation of K(+) channel activity through the GnRH receptor. Whereas GnRH inhibits the activity of the M-current in peripheral neurons, there is no direct evidence that the M-current is involved in the autoregulatory ...

journal_title：Endocrinology

authors： Xu C,Roepke TA,Zhang C,Rønnekleiv OK,Kelly MJ

更新日期：2008-05-01 00:00:00

abstract：:Adipose tissue secretes a variety of bioactive signaling molecules, termed adipokines, which regulate numerous biological functions including appetite, energy balance, glucose homeostasis, and inflammation. Chemerin is a novel adipokine that regulates adipocyte differentiation and metabolism by binding to and activati...

journal_title：Endocrinology

authors： Ernst MC,Haidl ID,Zúñiga LA,Dranse HJ,Rourke JL,Zabel BA,Butcher EC,Sinal CJ

更新日期：2012-02-01 00:00:00

abstract：:To address the neural mediation of the eating-inhibitory effect of circulating glucagon-like peptide-1 (GLP-1), we investigated the effects of 1) intra-fourth ventricular infusion of the GLP-1 receptor antagonist exendin-9 or 2) area postrema lesion on the eating-inhibitory effect of intrameal hepatic portal vein (HPV...

journal_title：Endocrinology

authors： Punjabi M,Arnold M,Rüttimann E,Graber M,Geary N,Pacheco-López G,Langhans W

更新日期：2014-05-01 00:00:00

abstract：:Hypothalamic-pituitary-thyroid (HPT) axis activity is important for energy homeostasis, and is modified by stress. Maternal separation (MS) alters the stress response and predisposes to metabolic disturbances in the adult. We therefore studied the effect of MS on adult HPT axis activity. Wistar male and female pups we...

journal_title：Endocrinology

authors： Jaimes-Hoy L,Gutiérrez-Mariscal M,Vargas Y,Pérez-Maldonado A,Romero F,Sánchez-Jaramillo E,Charli JL,Joseph-Bravo P

更新日期：2016-08-01 00:00:00

abstract：:PTH and PTH-related peptide (PTHrP) have been shown to bind to and activate the same PTH/PTHrP receptor. Recent studies have demonstrated, however, the presence of additional receptors specific for each ligand. We used the PTHrP and PTH/PTHrP receptor gene knock-out models to investigate whether this receptor mediates...

journal_title：Endocrinology

authors： Lanske B,Divieti P,Kovacs CS,Pirro A,Landis WJ,Krane SM,Bringhurst FR,Kronenberg HM

更新日期：1998-12-01 00:00:00

abstract：:The utility of the established ACTH secreting mouse pituitary tumor cell line AtT20 for investigating early glucocorticoid inhibition was examined. Three different strains of the cell line D1, D16v, and D16:16, respectively, were analyzed. In initial studies CRF and phorbol esters were used as secretagogues to examine...

journal_title：Endocrinology

authors： Woods MD,Shipston MJ,Mullens EL,Antoni FA

更新日期：1992-12-01 00:00:00

abstract：:Neuropeptide Y (NPY) readily stimulates the release of hypothalamic LHRH and pituitary LH release in intact and gonadal steroid-primed gonadectomized rats. We have now tested the hypothesis that the release and synthesis of hypothalamic NPY may be regulated by gonadal steroids. To measure the effects of gonadal hormon...

journal_title：Endocrinology

authors： Sahu A,Phelps CP,White JD,Crowley WR,Kalra SP,Kalra PS

更新日期：1992-06-01 00:00:00