Obstructive Sleep Apnea Syndrome and Metabolic Diseases.

abstract：:The contribution of the insulin receptor beta-subunit acidic domain, amino acids 1262-1291, to receptor function was analyzed. A mutant insulin receptor complementary DNA lacking this domain was created. Rat-1 fibroblasts were stably transfected with plasmids containing the mutant insulin receptor complementary DNA an...

journal_title：Endocrinology

authors： Rolband GC,Williams JF,Webster NJ,Olefsky JM

更新日期：1993-09-01 00:00:00

abstract：:The heart has epicardial adipose tissue that produces adipokines and mesenchymal stem cells. Systemic adipose tissue is involved in the pathophysiology of obesity-related heart diseases. However, the method for analyzing the direct interaction between adipose tissue and cardiomyocytes has not been established. Here we...

journal_title：Endocrinology

authors： Anan M,Uchihashi K,Aoki S,Matsunobu A,Ootani A,Node K,Toda S

更新日期：2011-04-01 00:00:00

abstract：:The androgen receptor (AR) in Sertoli cells mediates the actions of testosterone on spermatogenesis. However, the transcription factors responsible for AR gene regulation in Sertoli cells remain unknown. In this study, we determined that nuclear factor-kappaB (NF-kappaB) regulates transcription of AR in primary cultur...

journal_title：Endocrinology

authors： Zhang L,Charron M,Wright WW,Chatterjee B,Song CS,Roy AK,Brown TR

更新日期：2004-02-01 00:00:00

abstract：:T3 and rT3 production rates in the fetus account for roughly only a third of the total T4 production rate; thus, the fate of the majority of T4 produced in the fetus is unknown (the "T4 disposal gap"). We developed sensitive and specific T4 sulfate (T4S) and T3 sulfate (T3S) RIAs to investigate the roles of these comp...

journal_title：Endocrinology

authors： Wu S,Polk D,Wong S,Reviczky A,Vu R,Fisher DA

更新日期：1992-10-01 00:00:00

abstract：:Studies on hormone-receptor interactions generally assume that the formation of a hormone-receptor complex is a reversible process. This assumption has been examined directly in three experiments using liver membrane receptor preparations from pregnant rats and ovine PRL (oPRL). In Exp 1, Receptors were preincubated w...

journal_title：Endocrinology

authors： van der Gugten AA,Waters MJ,Murthy GS,Friesen HG

更新日期：1980-01-01 00:00:00

abstract：:Progesterone modulates estrogen-stimulated responses in the uterus. Calbindin-D 9k (CaBP9k), a 17 beta-estradiol-responsive gene expressed in the uterus, was used as a marker to examine the interactions between endogenous progesterone and estradiol in the rat. The variations in uterine CaBP9k messenger RNAs (mRNAs) du...

journal_title：Endocrinology

authors： L'Horset F,Blin C,Brehier A,Thomasset M,Perret C

更新日期：1993-02-01 00:00:00

abstract：:Oxytocin (OT) is a hypothalamic nonapeptide that is synthesized as part of a larger precursor protein that also contains an approximately 10-kDa protein called neurophysin at its C-terminus. This precursor protein is trafficked through the regulated secretory pathway into secretory granules and then axonally transport...

journal_title：Endocrinology

authors： Zhang BJ,Kusano K,Zerfas P,Iacangelo A,Young WS 3rd,Gainer H

更新日期：2002-03-01 00:00:00

abstract：:The action of sex steroids on the growth and differentiation of target tissues requires the presence of specific intracellular receptors. We compared the distribution of cells containing estrogen receptor (ER) and/or progesterone receptor (PR) in rabbit uterus by immunohistochemistry using monoclonal antibodies direct...

journal_title：Endocrinology

authors： Zaino RJ,Clarke CL,Feil PD,Satyaswaroop PG

更新日期：1989-11-01 00:00:00

abstract：:UMR106-06 cells predominantly express the C1a isoform of the rat calcitonin (CT) receptor (CTR). We have compared the homologous regulation of the C1a CTR endogenously expressed in UMR106-06 cells with the cloned C1a CTR in transfected HEK 293 cells, in which expression is driven by a heterologous promoter. It was fou...

journal_title：Endocrinology

authors： Findlay DM,Houssami S,Christopoulos G,Sexton PM

更新日期：1996-11-01 00:00:00

abstract：:Kisspeptin-neurokinin B-dynorphin (KNDy) cells of the hypothalamus are a key component in the neuroendocrine regulation of GnRH secretion. Evidence in sheep and other species suggests that dynorphin released by KNDy cells inhibits pulsatile GnRH secretion by acting upon κ-opioid receptors (KOR). However, the precise a...

journal_title：Endocrinology

authors： Weems PW,Witty CF,Amstalden M,Coolen LM,Goodman RL,Lehman MN

更新日期：2016-06-01 00:00:00

abstract：:Angiotensin II is a potent octapeptide vasoconstrictor and regulator of cardiovascular and electrolyte homeostasis. Angiotensinogen, the protein precursor of angiotensin II, is synthesized by the liver and many other organs of the adult rat. To determine whether angiotensin may be present in early fetal development we...

journal_title：Endocrinology

authors： Lee HU,Campbell DJ,Habener JF

更新日期：1987-10-01 00:00:00

abstract：:Ghrelin is a growth hormone-releasing peptide recently discovered in the stomach of rat and human as an endogenous ligand for growth hormone-secretagogue receptor. In the present study, a full-length cDNA for mouse ghrelin has been cloned from the stomach using the oligo-capping and rapid amplification methods, and th...

journal_title：Endocrinology

authors： Tanaka M,Hayashida Y,Iguchi T,Nakao N,Nakai N,Nakashima K

更新日期：2001-08-01 00:00:00

abstract：:Female Wistar-Furth rats were implanted sc with GH3 rat pituitary tumor cells. Tumors were palpable by 4 weeks, and animals were killed periodically from 5-9 weeks. Tumor-bearing rats (n = 10) were heavier than their respective controls, reaching a weight of 372 +/- 3 by 9 weeks vs. 195 +/- 5 g in controls (mean +/- S...

journal_title：Endocrinology

authors： Yamashita S,Slanina S,Kado H,Melmed S

更新日期：1986-03-01 00:00:00

abstract：:We have previously demonstrated in vitro that 1alpha,25-dihydroxyvitamin D3 (calcitriol) treatment increases p27 expression and decreases cell proliferation in cultured thyroid carcinoma cell lines. We hypothesized that in vivo treatment with calcitriol would have a beneficial effect on thyroid carcinoma growth and pr...

journal_title：Endocrinology

authors： Dackiw AP,Ezzat S,Huang P,Liu W,Asa SL

更新日期：2004-12-01 00:00:00

abstract：:A myometrial explant culture system was developed to investigate the effect of progesterone and the antiprogestagen RU486 on prostacyclin (PGI2) and thromboxane A2 (TXA2) synthesis by the rat myometrium. After culture, eicosanoid synthesis was stimulated with arachidonic acid (AA) and the calcium ionophore A23187 (A23...

journal_title：Endocrinology

authors： Jeremy JY,Dandona P

更新日期：1986-08-01 00:00:00

abstract：:The proliferation and differentiation of testicular progenitor stem cells into highly specialized germ cells (spermatozoa) are largely controlled by the hormonally (FSH and testosterone) regulated adjacent supporting Sertoli cells. However, the factors involved in this control remain largely unknown. In the present st...

journal_title：Endocrinology

authors： Hellani A,Ji J,Mauduit C,Deschildre C,Tabone E,Benahmed M

更新日期：2000-08-01 00:00:00

abstract：:The effects of diabetes on basal calcium metabolism and the response to endocrine stimulation were studied in hepatocytes from acute and long term diabetic rats. Hepatocyte calcium sequestration and turnover were increased in both acute and chronic diabetes. Cytosolic free calcium (Cai2+) was significantly increased i...

journal_title：Endocrinology

authors： Studer RK,Ganas L

更新日期：1989-11-01 00:00:00

abstract：:The intermediary role of the putative inhibitory regulatory membrane protein "Ni" in the "antigonadal" activity of the neurohypophysial hormones was investigated in vitro with the use of a primary culture of rat testicular cells. To this end, use was made of the pertussis toxin (PT) probe, an exotoxin of Bordetella pe...

journal_title：Endocrinology

authors： Adashi EY,Resnick CE,Cronin MJ,Hewlett EL

更新日期：1984-08-01 00:00:00

abstract：:Oxytocin (OT) is released by the posterior pituitary during male orgasm and is supposed to participate in the ejaculatory process. We now report evidence demonstrating the presence of an OT receptor gene (real-time RT-PCR and Northern blot) and protein (immunohistochemistry, Western blot, and binding studies) expressi...

journal_title：Endocrinology

authors： Vignozzi L,Filippi S,Luconi M,Morelli A,Mancina R,Marini M,Vannelli GB,Granchi S,Orlando C,Gelmini S,Ledda F,Forti G,Maggi M

更新日期：2004-04-01 00:00:00

abstract：:These studies have examined the ontogeny of specific GH- and PRL-binding proteins in rabbit liver cytosol across the fetal, early neonatal, and adult periods. The precise hormonal specificity of binding of the somatotropic/lactogenic ligand, [125I]human GH, was determined by displacement with monoclonal antibodies aga...

journal_title：Endocrinology

authors： Ymer SI,Stevenson JL,Herington AC

更新日期：1989-07-01 00:00:00

abstract：:Neuropeptide Y (NPY) is highly expressed in the hypothalamus, where it regulates feeding and energy homeostasis. Interestingly, NPY and its receptors are also expressed in peripheral tissues with roles in metabolism, including pancreatic islets. In islets, NPY is known to suppress insulin secretion acutely. In additio...

journal_title：Endocrinology

authors： Machida Y,Bruinsma C,Hallinger DR,Roper SM,Garcia E,Trevino MB,Nadler J,Ahima R,Imai Y

更新日期：2014-12-01 00:00:00

abstract：:We have investigated the physiological regulation and functional significance of brain-derived neurotrophic factor (BDNF) in the endocrine melanotrope cells of the pituitary pars intermedia of the amphibian Xenopus laevis, which can adapt its skin color to the light intensity of its environment. In black-adapted anima...

journal_title：Endocrinology

authors： Kramer BM,Cruijsen PM,Ouwens DT,Coolen MW,Martens GJ,Roubos EW,Jenks BG

更新日期：2002-04-01 00:00:00

abstract：:The regulation of cholecystokinin octapeptide (CCK-8) secretion was studied using a fetal cerebral cortical cell culture system. After 2-3 weeks in culture, the cells were utilized for short-term release experiments. CCK-8 was measured by RIA and its identity was confirmed by HPLC. Depolarization of the cells with K+ ...

journal_title：Endocrinology

authors： Abucham J,Reichlin S

更新日期：1991-12-01 00:00:00

abstract：:Maintenance of male golden hamsters on short photoperiod leads to testicular regression due to pineal gland-mediated inhibition of the hypothalamo-hypophyseal reproductive system. This study clarifies the dynamics of the action of GnRH at the pituitary level after short photoperiod-induced gonadal regression. In Exp 1...

journal_title：Endocrinology

authors： Pieper DR

更新日期：1984-11-01 00:00:00

abstract：:We employed a short term system of dispersed adult mouse hypothalamic cells, as previously described in the rat, to examine the roles of calcium and calmodulin in SRIF release. Incubation studies were performed 24 h after hypothalamic cell dispersion. SRIF release, as determined by RIA was stimulated in a dose-depende...

journal_title：Endocrinology

authors： Richardson S,Twente S

更新日期：1985-07-01 00:00:00

abstract：:Experiments were performed in vitro to examine the possible role of calcium and calmodulin in GRF-induced somatostatin (SRIF) release from the median eminence. Adult male rats were used as tissue donors. The median eminences were first prestimulated in 0.4 ml Krebs Ringer bicarbonate glucose buffer (pH 7.4) containing...

journal_title：Endocrinology

authors： Aguila MC,McCann SM

更新日期：1988-07-01 00:00:00

abstract：:Perifused anterior hemipituitaries from one male and 4 female monkeys released GH and PRL in a pulsatile pattern, with mean +/- SE interpulse intervals of 8.2 +/- 0.4 and 8.5 +/- 0.3 min, as determined by a cycle detection computer algorithm. Mean hormone concentrations in the perifusate fractions collected at 2-min i...

journal_title：Endocrinology

authors： Stewart JK,Clifton DK,Koerker DJ,Rogol AD,Jaffe T,Goodner CJ

更新日期：1985-01-01 00:00:00

abstract：:PTH increases calcium reabsorption exclusively in the distal nephron. Two mechanisms of Ca++ transport through the basolateral membrane (BLM) have been described: the ATP-dependent and the sodium gradient-dependent transport. In the present study, we investigated the effect of PTH and (Bu)2cAMP on these two mechanisms...

journal_title：Endocrinology

authors： Bouhtiauy I,Lajeunesse D,Brunette MG

更新日期：1991-01-01 00:00:00

abstract：:Studies in rodents demonstrate that the mitogen, IGF-I, stimulates intestinal peptide YY (PYY) expression. To investigate whether the stimulatory influence of IGF-I is exerted at the level of gene transcription, rat PYY 5'-upstream sequences (-2800/+37 bp, -770/+37 bp, -127/+37 bp) fused to the firefly luciferase (luc...

journal_title：Endocrinology

authors： Wang G,Leiter AB,Englander EW,Greeley GH Jr

更新日期：2004-02-01 00:00:00

abstract：:The effects of epidermal growth factor (EGF) on glycogen metabolism and the binding of [125I]iodo-EGF to receptors in fetal rat hepatocytes have been examined. The actions of EGF have been compared with those of insulin-like growth factor I (IGF-I) and insulin. EGF (0.1-45 nM) stimulated dose-dependent increases in [1...

journal_title：Endocrinology

authors： Freemark M

更新日期：1986-08-01 00:00:00