Abstract:
:p-Tyramine, an endogenous amine with sympathomimetic action, is found in the mammalian hypothalamus. When injected ip, p-tyramine reduced serum PRL without altering LH and TSH serum titers in adult orchidectomized rats and rats subjected to ether or immobilization stress. The hyperprolactinemia achieved by this last procedure was inhibited by both tyramine and dopamine; tyramine produced the same effect as dopamine at a dose 5 times greater. When PRL levels were increased by pretreatment with alpha-methyl-p-tyrosine or haloperidol, once again both tyramine and dopamine lowered PRL titers. The hypoprolactinemic effect of p-tyramine was also observed in median eminence-lesioned animals, suggesting a pituitary site of action. These results show that low amounts of tyramine, a naturally occurring amine, can inhibit in vivo increases in PRL levels achieved physiologically or pharmacologically.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Becú-Villalobos D,Lacau de Mengido IM,Libertun Cdoi
10.1210/endo-116-5-2044subject
Has Abstractpub_date
1985-05-01 00:00:00pages
2044-8issue
5eissn
0013-7227issn
1945-7170journal_volume
116pub_type
杂志文章相关文献
ENDOCRINOLOGY文献大全abstract::We studied the direct effects of glucocorticoids on plasminogen activator (PA) production by rat granulosa cells. PA production was assayed by culturing rat granulosa cells on [125I]fibrin plates and determining the extent of fibrinolysis after addition of the specific substrate plasminogen. In granulosa cells from pr...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-124-4-1595
更新日期:1989-04-01 00:00:00
abstract::The present work aimed to determine the role played by protein kinase-C (PKC) in the alpha 1-adrenoceptor-induced activation of hepatic metabolism. The following observations indicate that activation of PKC is a condition necessary for alpha 1-adrenoceptor activation of hepatic functions, but not sufficient to mimic t...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.133.5.8404660
更新日期:1993-11-01 00:00:00
abstract::A serum-free, hormone- and factor-supplemented, defined medium was developed which maintains functional activity of primary cultures of adult islet cells and continuous islet cell lines. Medium supplements examined included proteose peptone (PP), transferrin (TrFe), insulin-like growth factor-I (IGF-I), an insulinotro...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-126-4-1895
更新日期:1990-04-01 00:00:00
abstract::In rat ovary, androgen receptor (AR) is predominantly expressed in granulosa cells and is developmentally regulated. However, the exact mechanism that is responsible for the regulation of AR in granulosa cells has not been elucidated. The aim of this study was to examine 1) the levels of AR messenger RNA (mRNA) expres...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.137.10.8828500
更新日期:1996-10-01 00:00:00
abstract::IL-18 was identified due to its ability to induce interferon-gamma (IFNgamma) production by T cells. It is a pleiotropic factor that shares structural features with IL-1 and functional activities with IL-12. IL-18 has a role in T cell development, where it has been demonstrated to act cooperatively with IL-12 to regul...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2002-220936
更新日期:2003-04-01 00:00:00
abstract::Exposure to environmental toxicants during fetal development alters gene expression and promotes disease later in life. Di-(2-ethylhexyl) phthalate (DEHP) is a plasticizer widely used for the manufacturing of consumer products. Exposure to DEHP has been associated with obesity, asthma, and low T levels. In utero expos...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2014-1436
更新日期:2015-01-01 00:00:00
abstract::Early postnatal hyperalimentation has long-term implications for obesity and developing renal disease. Suppressor of cytokine signaling (SOCS) 3 inhibits phosphorylation of signal transducer and activator of transcription (STAT) 3 and ERK1/2 and thereby plays a pivotal role in mediating leptin resistance. In addition,...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2011-1670
更新日期:2012-03-01 00:00:00
abstract::The in vitro effect of dopamine, haloperidol and pimozide on 32Pi incorporation into phosphatidylinositol, phosphatidylcholine and phosphatidylethanolamine by anterior pituitary glands was studied. Dopamine decreased the incorporation of 32Pi into phosphatidylinositol in a dose-related manner without affecting phospha...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-111-1-347
更新日期:1982-07-01 00:00:00
abstract::Gene expression of fibroblast growth factor-9 (FGF9) is decreased in granulosa cells (GC) of cystic follicles compared with normal dominant follicles in cattle. The objectives of this study were to investigate the effects of FGF9 on GC steroidogenesis, gene expression, and cell proliferation and to determine the hormo...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1003
更新日期:2012-09-01 00:00:00
abstract::11beta-hydroxysteroid dehydrogenases (11betaHSDs) catalyze interconversion of 11-hydroxy-glucocorticoids with inactive 11-keto metabolites. In blood vessel walls, loss of 11betaHSD1 is thought to reduce local glucocorticoid concentrations, reducing the progression of atheroma and enhancing angiogenesis. Conversely, on...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2006-0996
更新日期:2007-01-01 00:00:00
abstract::The effects of interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF alpha) on basal and TRH-induced TSH release, and the effects of IL-1 beta on the uptake of [125I]T3 and [125I]T4 and on nuclear binding of [125I]T3 were examined. Furthermore, the release of other anterior pituitary hormones in the pres...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.137.5.8612490
更新日期:1996-05-01 00:00:00
abstract::To elucidate the roles of the hypothalamic peptides, GH-releasing hormone (GRH) and somatostatin (SRIH), potentially responsible for altered GH dynamics in diabetes, we studied the time courses of their changes in level associated with altered GH secretion in streptozotocin (STZ)-induced diabetic mice. Diabetic mice w...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.136.10.7664670
更新日期:1995-10-01 00:00:00
abstract::The preoptic area (POA) of the male dove is a known target area for separable behavioral actions of testosterone and 17 beta-estradiol (E2) and contains an active aromatase system. We have examined the regulatory influence of gonadal hormones on aromatase using an in vitro microassay that measures conversion of [1 alp...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-118-6-2180
更新日期:1986-06-01 00:00:00
abstract::Immunohistochemical localization of androgen in the testes of both rat and squirrel monkey has been performed using an antiserum specific to testosterone and certain related androgens. The bound antibodies were visualized by coupling with antigammaglobulin labeled either with fluorescein isothiocyanate or with a horse...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-96-1-63
更新日期:1975-01-01 00:00:00
abstract::The maternal plasma concentrations of GH and PRL increase dramatically upon the initiation of lactation in the rat. In light of the fact that these two hormones have evolved from one common precursor, we sought to determine if the neuroendocrine mechanisms regulating their concomitant increase during lactation are com...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-124-1-464
更新日期:1989-01-01 00:00:00
abstract::Osteocalcin, a synthetic osteoblast-specific protein, has recently emerged as an important regulator of energy metabolism, but the underlying mechanisms are not fully understood. In the present study, mice fed a high-fat diet and receiving osteocalcin showed reduced body weight gain, less fat pad gain, and improved in...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-2144
更新日期:2013-03-01 00:00:00
abstract::The melanocortin-3 receptor (MC3R) and MC4R are known to play critical roles in energy homeostasis. However, the physiological functions of the MC3R remain poorly understood. Earlier reports indicated that the ventral tegmental area (VTA) is one of the highest sites of MC3R expression, and we sought to determine the f...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-2049
更新日期:2014-05-01 00:00:00
abstract::In GH4C1 cells, membrane depolarization induces a rapid and sustained increase in the cytosolic free calcium concentration ([Ca2+]i). In the present study we have investigated the role of [Ca2+]i in the regulation of basal intracellular pH (pHi). Depolarizing GH4C1 cells in buffer containing 0.4 mM extracellular Ca2+ ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.130.2.1733720
更新日期:1992-02-01 00:00:00
abstract::Commercially available preparations of natural porcine glucose-dependent insulinotropic polypeptide (GIP) were subjected to reverse phase HPLC. The material was found to give rise to 4 peaks which were characterized by HPLC-retention time and N-terminal sequence analysis. They represented: intact porcine GIP(1-42), 58...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-120-2-835
更新日期:1987-02-01 00:00:00
abstract::The secretion of LH, PRL, and cortisol was investigated in 4 sexually mature female rhesus macaques with cardiac catheters protected by tethers. Based on endocrine parameters, all 4 of the animals ovulated within 2 months from the time they were tethered, and regular menstrual cycles of 24-34 days were observed. The c...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-115-1-261
更新日期:1984-07-01 00:00:00
abstract::Kisspeptins, products of the KiSS-1 gene with ability to bind G protein-coupled receptor 54 (GPR54), have been recently identified as major gatekeepers of reproductive function with ability to potently activate the GnRH/LH axis. Yet, despite the diversity of functional states of the female gonadotropic axis, pharmacol...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2005-1463
更新日期:2006-06-01 00:00:00
abstract::Desensitization and internalization of G protein-coupled receptors can be mediated by phosphorylation within the C-terminal tail, facilitating beta-arrestin binding and targeting the receptor for internalization. Type II GnRH receptors (GnRH-Rs) show such regulation, but type I GnRH-Rs lack C-tails and are not rapidly...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2004-0092
更新日期:2004-08-01 00:00:00
abstract::Flavonoids are functional constituents of many fruits and vegetables. Some flavonoids have antidiabetic properties because they improve altered glucose and oxidative metabolisms of diabetic states. Procyanidins are flavonoids with an oligomeric structure, and it has been shown that they can improve the pathological ox...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2004-0764
更新日期:2004-11-01 00:00:00
abstract::Carbohydrate metabolism in pregnancy reflects the balance between counterregulatory hormones, which induce insulin resistance, and lactogenic hormones, which stimulate beta-cell proliferation and insulin production. Here we explored the interactions of prolactin (PRL) and glucocorticoids in the regulation of beta-cell...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2008-0051
更新日期:2008-11-01 00:00:00
abstract::PTH-related protein (PTHrP) and its receptor are expressed in vascular smooth muscle cells and are believed to participate in the local regulation of vascular tone. To explore the function of locally produced PTHrP in vascular smooth muscle in vivo, we developed transgenic mice that overexpress PTHrP in smooth muscle ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.140.4.6646
更新日期:1999-04-01 00:00:00
abstract::We investigated the effect of glucocorticoid on the generation of osteoclasts. In mouse bone marrow culture systems, dexamethasone, a synthetic glucocorticoid analog, enhanced osteoclast-like cell formation induced by 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] in a dose-dependent manner. Conversely, dexamethasone inhibit...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.134.3.8119150
更新日期:1994-03-01 00:00:00
abstract::Most of the constitutive hepatic P450 isoforms expressed in the rat exhibit dramatic gender differences. Whereas only male hepatocytes contain CYP2A2, 2C11, and 3A2, only female hepatocytes express CYP2C12 and 3- to 4-fold greater levels of CYP2C7. This sexually dimorphic expression of hepatic P450 isoforms is regulat...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.140.3.6545
更新日期:1999-03-01 00:00:00
abstract::Homologous anterior pituitaries grafted under the kidney capsule in hypophysectomized rats were studied 30 days after transplantation. Some cells maintained the ultrastructural features peculiar to the various cell types of normotopic glands, while the others were characterized by few, small, dense granules, spherical...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-104-1-226
更新日期:1979-01-01 00:00:00
abstract::Analyses of FSH secretion suggest pulsatile, nonpulsatile, or compositely pulsatile and nonpulsatile release modes. This may reflect the reduced signal-to-noise ratio inherent in FSH pulse estimation procedures and/or immunological-biological assay inconsistencies. To address these issues, we sampled cavernous sinus a...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.143.1.8644
更新日期:2002-01-01 00:00:00
abstract::The existence of a vasoactive molecule released in response to hCG is believed to be the main feature in the development of ovarian hyperstimulation syndrome (OHSS) in women, and vascular endothelial growth factor (VEGF) is the main candidate as the human chorionic gonadotropin (hCG) mediator. This study was conducted...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2002-220204
更新日期:2002-11-01 00:00:00