Inhibition of human hepatocarcinoma cell proliferation by mammalian and fish gonadotropin-releasing hormones.

abstract：:Exposure to testosterone (T) during d 30-90 of fetal life results in low-birth-weight offspring, hypergonadotropism, multifollicular ovaries, and early cessation of cyclicity. The multifollicular phenotype may result from failure of follicles to regress and consequent follicular persistence or, alternatively, increase...

journal_title：Endocrinology

authors： Steckler T,Wang J,Bartol FF,Roy SK,Padmanabhan V

更新日期：2005-07-01 00:00:00

abstract：:Recent evidence indicates a localized origin in the olfactory placode for the mammalian forebrain neurons that express GnRH. To identify the cellular and molecular signals that induce the GnRH phenotype, we cloned and characterized a cDNA encoding the GnRH prohormone, the precursor for both GnRH-I and GnRH-associated ...

journal_title：Endocrinology

authors： Hayes WP,Wray S,Battey JF

更新日期：1994-04-01 00:00:00

abstract：:It is established that androgens and unidentified Sertoli cell (SC)-derived factors can influence the development of adult Leydig cells (LC) in rodents, but the mechanisms are unclear. We evaluated adult LC development and function in SC-selective androgen receptor (AR) knockout (SCARKO) and complete AR knockout (ARKO...

journal_title：Endocrinology

authors： De Gendt K,Atanassova N,Tan KA,de França LR,Parreira GG,McKinnell C,Sharpe RM,Saunders PT,Mason JI,Hartung S,Ivell R,Denolet E,Verhoeven G

更新日期：2005-09-01 00:00:00

abstract：:Transfer of corticosterone from serum to milk was studied in lactating rats after ether and pentobarbital anesthesia. Two minutes after the onset of anesthesia stress, total serum and milk corticosterone concentrations were not significantly different. By 30 min, corticosterone concentrations in serum increased to a p...

journal_title：Endocrinology

authors： Yeh KY

更新日期：1984-10-01 00:00:00

abstract：:A surge of GnRH release signals the LH surge that triggers ovulation. The GnRH surge is dependent on a switch in estradiol feedback from negative to positive and, in rodents, a daily neural signal, likely from the suprachiasmatic nuclei. Vasoactive intestinal polypeptide (VIP) may be involved in suprachiasmatic nuclei...

journal_title：Endocrinology

authors： Christian CA,Moenter SM

更新日期：2008-06-01 00:00:00

abstract：:Immunoaffinity adsorption techniques, utilizing specific antisera for hCG and its subunits bound to Sepharose 4B, have been employed to separate hCG alpha beta dimer and free subunits of hCG. As previously reported by this and a number of other laboratories, trophoblast cells (in vivo and in vitro) produce free alpha ...

journal_title：Endocrinology

authors： Cole LA,Hartle RJ,Laferla JJ,Ruddon RW

更新日期：1983-09-01 00:00:00

abstract：:PTH-related protein (PTHrP) has been shown to be a major factor responsible for hypercalcemia of malignancy. PTHrP acts via the PTH/PTHrP receptor, and therefore, PTH antagonists might be expected to reverse the hypercalcemia in malignancy. In the present studies, the PTH antagonists [Tyr34]bovine (b) PTH-(7-34)NH2, [...

journal_title：Endocrinology

authors： Kukreja SC,D'Anza JJ,Wimbiscus SA,Fisher JE,McKee RL,Caulfield MP,Rosenblatt M

更新日期：1994-05-01 00:00:00

abstract：:Cellular distribution of progestin receptor immunoreactivity (PR-IR) in paraffin-embedded rabbit oviduct tissue was determined using a monoclonal antibody and the indirect immunoperoxidase method. Ampullar and isthmic tissue from ovariectomized animals primed with 17 beta-estradiol or vehicle alone was examined. As ex...

journal_title：Endocrinology

authors： Hyde BA,Blaustein JD,Black DL

更新日期：1989-09-01 00:00:00

abstract：:To understand the physiological role of ghrelin, it is crucial to study both the actions of ghrelin and the regulation of ghrelin secretion. Although ghrelin actions have been extensively revealed, the direct factors regulating ghrelin secretion by ghrelin-producing cells (X/A-like cells), however, is not fully unders...

journal_title：Endocrinology

authors： Iwakura H,Ariyasu H,Hosoda H,Yamada G,Hosoda K,Nakao K,Kangawa K,Akamizu T

更新日期：2011-07-01 00:00:00

abstract：:The PTH activates both adenylate cyclase and a mechanism that increases membrane-associated protein kinase-C (PKC) activity. To define the hormone's PKC activation domain we have used a panel of PTH fragments and ROS 17/2 rat osteosarcoma cells as the target cells. PTH equally and maximally increased PKC activity in R...

journal_title：Endocrinology

authors： Jouishomme H,Whitfield JF,Chakravarthy B,Durkin JP,Gagnon L,Isaacs RJ,MacLean S,Neugebauer W,Willick G,Rixon RH

更新日期：1992-01-01 00:00:00

abstract：:The GnRH neurosecretory system undergoes marked structural and functional changes throughout life. The initial goal of this study was to examine the neuroanatomical relationship between GnRH neurons and a glycoprotein implicated in neuroplasticity, the polysialylated form of neural cell adhesion molecule (PSA-NCAM). U...

journal_title：Endocrinology

authors： Viguié C,Jansen HT,Glass JD,Watanabe M,Billings HJ,Coolen L,Lehman MN,Karsch FJ

更新日期：2001-03-01 00:00:00

abstract：:Signals derived from other pituitary cells can have a dramatic effect on PRL gene expression and secretion by mammotropes. However, the intracellular mechanisms by which these effects are manifested on the target cell remain unexplored. Inasmuch as calcium is a key modulator of both gene expression and hormone export ...

journal_title：Endocrinology

authors： Abraham EJ,Villalobos C,Frawley LS

更新日期：1998-06-01 00:00:00

abstract：:Pure porcine cholecystokinin-33 [the triacontatriapeptide form of cholecystokinin (CCK-33)], gastric inhibitory polypeptide (GIP), and secretin were infused in rats in doses of 1, 10 and 1000 pmol/kg . min. The peptides were administered alone or in combination with glucose (40 mg/kg . min) or arginine (50 mg/kg . min...

journal_title：Endocrinology

authors： Szecówka J,Lins PE,Efendić S

更新日期：1982-04-01 00:00:00

abstract：:The issue of how progesterone affects mammary gland growth is controversial, and the mechanism governing the effects of the hormone remains mostly unknown. We have previously shown that G protein-coupled receptor 30 (GPR30) is a progestin target gene whose expression correlates with progestin-induced growth inhibition...

journal_title：Endocrinology

authors： Ahola TM,Manninen T,Alkio N,Ylikomi T

更新日期：2002-09-01 00:00:00

abstract：:Food deprivation in laboratory rats induces profound changes in the neuroendocrine system. We have investigated the hypothalamic and pituitary responses of the hypothalamo-pituitary thyroid axis to 48-h food deprivation in Sprague-Dawley rats. Peripheral T3 and hypophysial portal TRH were measured by RIA, and TSH beta...

journal_title：Endocrinology

authors： Blake NG,Eckland DJ,Foster OJ,Lightman SL

更新日期：1991-11-01 00:00:00

abstract：:We used the library subtraction technique to identify genes specifically expressed in the rat uterus during early pregnancy. One such gene was that for stathmin, a factor that is associated with tubulin binding and the destabilization of microtubules. Stathmin was expressed at higher levels in implantation sites than ...

journal_title：Endocrinology

authors： Tamura K,Hara T,Yoshie M,Irie S,Sobel A,Kogo H

更新日期：2003-04-01 00:00:00

abstract：:The trace element vanadium (V) exerts insulin-like effects in vitro. The present study examined its effects on glucose homeostasis in rats made diabetic by streptozotocin. Na3VO4 (0.2 or 0.5 mg/ml) was administered ad libitum in drinking water. Fed plasma glucose levels (approximately 26 mmol/liter) fell by 30% and 56...

journal_title：Endocrinology

authors： Brichard SM,Okitolonda W,Henquin JC

更新日期：1988-10-01 00:00:00

abstract：:Gonadotropin (GTH)-inhibitory hormone (GnIH) is a novel hypothalamic neuropeptide that inhibits GTH secretion in mammals and birds by acting on gonadotropes and GnRH neurons within the hypothalamic-pituitary-gonadal axis. GnIH and its orthologs that have an LPXRFamide (X = L or Q) motif at the C terminus (LPXRFamide p...

journal_title：Endocrinology

authors： Osugi T,Daukss D,Gazda K,Ubuka T,Kosugi T,Nozaki M,Sower SA,Tsutsui K

更新日期：2012-05-01 00:00:00

abstract：:We developed a coculture system comprising primary rat adipocytes and L6 rat skeletal muscle cells to allow investigation of the effects of physiologically relevant mixtures of adipokines. We observed that coculture, or adipocyte-conditioned media, increased glucose uptake in muscle cells. An adipokine that could pote...

journal_title：Endocrinology

authors： Vu V,Kim W,Fang X,Liu YT,Xu A,Sweeney G

更新日期：2007-09-01 00:00:00

abstract：:Prostaglandin E2 (PGE2) is specifically and reversibly bound by particulate fractions from adrenals from fetal calves and lambs. These binding sites appear to be located primarily in the adrenal medulla and have properties very similar to those which we have detected in adult human, bovine, and ovine adrenal medulla. ...

journal_title：Endocrinology

authors： Karaplis AC,Powell WS

更新日期：1981-12-01 00:00:00

abstract：:Recent evidence suggests that inflammation may be a common underlying cause of many obesity-associated conditions. To test whether obesity changes the response to inflammation, we investigated its effects on the acute phase of the inflammatory response to an endogenous pathogen, lipopolysaccharide (LPS). Diet-induced ...

journal_title：Endocrinology

authors： Pohl J,Woodside B,Luheshi GN

更新日期：2009-11-01 00:00:00

abstract：:The effects of retinoic acids (RAs) on development of seminal vesicles (SVs) of neonatal mice were investigated in vitro. SVs from 0-day-old male mice were cultured for 2-6 days in serum-free, chemically defined medium containing transferrin and BSA supplemented with 5alpha-dihydrotestosterone (DHT; 10(-8) M) and insu...

journal_title：Endocrinology

authors： Tanji N,Yokoyama M,Takeuchi M,Terada N,Dahiya R,Cunha GR

更新日期：1996-07-01 00:00:00

abstract：:Aldosterone selectivity in mineralocorticoid target tissues has been suggested to be due to 11 beta-hydroxysteroid dehydrogenase (11-OHSD), which, by inactivating the endogenous glucocorticoids cortisol and corticosterone (CS), would allow aldosterone to bind to the mineralocorticoid receptor that has equal affinity f...

journal_title：Endocrinology

authors： Náray-Fejes-Tóth A,Watlington CO,Fejes-Tóth G

更新日期：1991-07-01 00:00:00

abstract：:A complementary DNA, uterine-ovarian-specific gene 44 (UO-44), has been isolated from tamoxifen-induced rat uterine complementary DNA library using differential display techniques. UO-44 transcripts are found to be abundant in the uterus and ovary. UO-44 gene expression in the uterus is strictly regulated by estrogens...

journal_title：Endocrinology

authors： Huynh H,Ng CY,Lim KB,Ong CK,Ong CS,Tran E,Tuyen Nguyen TT,Chan TW

更新日期：2001-07-01 00:00:00

abstract：:Immunoreactive beta-endorphin (ir-beta EP) and immunoreactive N-acetyl-endorphin (ir-NacEP) have been demonstrated in the rat thyroid by specific RIA and characterized by reverse phase HPLC. In addition, pituitary and thyroid ir-beta EP and ir-NacEP levels have been determined after manipulation of the pituitary-thyro...

journal_title：Endocrinology

authors： Cheng MC,Smith AI,Funder JW

更新日期：1986-08-01 00:00:00

abstract：:Thyroid hormones play a major role in body homeostasis, regulating energy expenditure and cardiovascular function. Given that obese people or athletes might consider rapid weight loss as beneficial, voluntary intoxication with T4 preparations is a growing cause for thyrotoxicosis. However, the long-lasting effects of ...

journal_title：Endocrinology

authors： Hoefig CS,Harder L,Oelkrug R,Meusel M,Vennström B,Brabant G,Mittag J

更新日期：2016-07-01 00:00:00

abstract：:The Rice H500 rat Leydig cell tumor is a well characterized model of humoral hypercalcemia of malignancy (HHM). Circulating concentrations of PTH-related protein (PTHRP) have not been reported in this or any other animal model of HHM. Taking advantage of the marked N-terminal amino acid homology between rodent and hum...

journal_title：Endocrinology

authors： Gaich G,Burtis WJ

更新日期：1990-09-01 00:00:00

abstract：:A novel NADPH-dependent cytosolic 3,5,3'-triiodo-L-thyronine (T3)-binding protein (CTBP) was purified by sequential fractionation of rat liver cytosol on Q-Sepharose, phenyl-Sepharose, red-Sepharose, and polyacrylamide gel electrophoresis under nondenaturing conditions. The CTBP had a sedimentation coefficient of 5.1S...

journal_title：Endocrinology

authors： Kobayashi M,Hashizume K,Suzuki S,Ichikawa K,Takeda T

更新日期：1991-10-01 00:00:00

abstract：:We sequenced the complementary DNA (cDNA) encoding guinea pig LHRH from an expression library derived from the preoptic area-anterior hypothalamus. Data from in situ hybridization and RNase protection assays verified that the cloned cDNA was complementary to guinea pig LHRH messenger RNA. The architecture of the deduc...

journal_title：Endocrinology

authors： Jimenez-Liñan M,Rubin BS,King JC

更新日期：1997-10-01 00:00:00

abstract：:Interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) are proinflammatory cytokines that affect the secretion of several neuroendocrine hormones. In addition, glial cells synthesize and release IL-6, suggesting a paracrine role for this cytokine in the brain. We have examined the regulation of IL-6 release from glial ...

journal_title：Endocrinology

authors： Zumwalt JW,Thunstrom BJ,Spangelo BL

更新日期：1999-02-01 00:00:00