Inactivation by plasma may be responsible for lack of efficacy of parathyroid hormone antagonists in hypercalcemia of malignancy.

abstract：:The rat anterior pituitary expresses beta(2)-adrenoceptors (ARs) on somatotrophs, lactotrophs, and corticotrophs. The present study investigates whether beta(1)-ARs exist in the anterior pituitary, in which cell type(s) they are found, and whether they are regulated by glucocorticoids. As determined by quantitative RT...

journal_title：Endocrinology

authors： Janssens K,Krylyshkina O,Hersmus N,Vankelecom H,Denef C

更新日期：2008-05-01 00:00:00

abstract：:Activin is structurally related to polypeptide growth factors such as transforming-growth factor-beta, which may have paracrine and/or autocrine functions in the ovaries. We have investigated the action of activin on granulosa cell steroidogenesis in vitro in relation to preovulatory follicular development in vivo. Es...

journal_title：Endocrinology

authors： Miró F,Smyth CD,Hillier SG

更新日期：1991-12-01 00:00:00

abstract：:Melanocortins (MC) trigger a vagus nerve-mediated cholinergic-antiinflammatory pathway projecting to the testis. We tested whether pharmacological activation of brain MC receptors might protect the testis from the damage induced by ischemia-reperfusion. Adult male rats were subjected to 1-h testicular ischemia, follow...

journal_title：Endocrinology

authors： Minutoli L,Bitto A,Squadrito F,Irrera N,Rinaldi M,Nicotina PA,Arena S,Magno C,Marini H,Spaccapelo L,Ottani A,Giuliani D,Romeo C,Guarini S,Antonuccio P,Altavilla D

更新日期：2011-10-01 00:00:00

abstract：:Kisspeptins, products of the KiSS-1 gene with ability to bind G protein-coupled receptor 54 (GPR54), have been recently identified as major gatekeepers of reproductive function with ability to potently activate the GnRH/LH axis. Yet, despite the diversity of functional states of the female gonadotropic axis, pharmacol...

journal_title：Endocrinology

authors： Roa J,Vigo E,Castellano JM,Navarro VM,Fernández-Fernández R,Casanueva FF,Dieguez C,Aguilar E,Pinilla L,Tena-Sempere M

更新日期：2006-06-01 00:00:00

abstract：:A heat-stable protein which inhibits cAMP dependent protein kinase was prepared from the bovine thyroid 100,000 X g supernatant. This protein inhibited the cAMP-dependent protein kinase both from bovine thyroid cytosol and bovine thyroid plasma membranes. The inhibitory effect was noncompetitive with histone as substr...

journal_title：Endocrinology

authors： Hashizume K,DeGroot LJ

更新日期：1979-07-01 00:00:00

abstract：:In higher primates, FSH secretion appears to be regulated by a control system consistent with that described by the classical inhibin hypothesis. The purpose of the present experiment was to examine the time course of inhibin's action to suppress FSH secretion in the intact adult male rhesus monkey. To this end, five ...

journal_title：Endocrinology

authors： Ramaswamy S,Pohl CR,McNeilly AS,Winters SJ,Plant TM

更新日期：1998-08-01 00:00:00

abstract：:Androgen regulation of ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC) activities and accumulation of the mRNAs encoding these two enzymes in rodent kidney and accessory sex organs were studied. The ODC mRNA concentration and enzyme activity were increased by androgens in kidney, prosta...

journal_title：Endocrinology

authors： Crozat A,Palvimo JJ,Julkunen M,Jänne OA

更新日期：1992-03-01 00:00:00

abstract：:The long-acting synthetic enkephalin FK 33-824 (FK) potently inhibits LH secretion in gonadectomized prepubertal male and female rats. The effect is reversible by coinjection of naloxone. We have observed an age-related decrease in the ability of FK to reduce LH secretion in the 48 h post-gonadectomized rat. Thus, the...

journal_title：Endocrinology

authors： Wilkinson M,Bhanot R

更新日期：1982-03-01 00:00:00

abstract：:Mice with the recessively inherited obese-hyperglycemic syndrome (ob/ob) and their nonobese litter mates were studied over a 26-week period. The body weights and serum glucose levels of ob/ob mice began to rise markedly at 5-6 weeks of age and remained elevated throughout the period of study. Obese mice were significa...

journal_title：Endocrinology

authors： Larson BA,Sinha YN,Vanderlaan WP

更新日期：1976-01-01 00:00:00

abstract：:Otsuka Long-Evans Tokushima fatty (OLETF) rats lacking cholecystokinin-A receptors are hyperphagic, obese, and diabetic. Although exercise attenuates OLETF rats' obesity, the mechanisms underlying the effects of exercise are unclear. In this study, we determined the effects of running wheel activity on patterns of bod...

journal_title：Endocrinology

authors： Bi S,Scott KA,Hyun J,Ladenheim EE,Moran TH

更新日期：2005-04-01 00:00:00

abstract：:Neuropeptide Y (NPY) readily stimulates the release of hypothalamic LHRH and pituitary LH release in intact and gonadal steroid-primed gonadectomized rats. We have now tested the hypothesis that the release and synthesis of hypothalamic NPY may be regulated by gonadal steroids. To measure the effects of gonadal hormon...

journal_title：Endocrinology

authors： Sahu A,Phelps CP,White JD,Crowley WR,Kalra SP,Kalra PS

更新日期：1992-06-01 00:00:00

abstract：:The effect of synthetic ovine CRF on ACTH secretion of dispersed, domestic fowl pituitary cells was investigated. Cells preincubated for 2 h, 16 h, or after 48-h culture were incubated briefly with CRF (up to 4 h). ACTH was bioassayed using isolated rat adrenocortical cells; ACTH-(1-24) served as the standard for expr...

journal_title：Endocrinology

authors： Carsia RV,Weber H,Perez FM Jr

更新日期：1986-01-01 00:00:00

abstract：:Purinergic G protein-coupled receptors (P2YR) and ion-conducting receptor-channels (P2XR) are present in the pituitary. However, their identification, expression within pituitary cell subpopulations, and the ability to elevate intracellular Ca2+ concentration ([Ca2+]i) in response to ATP stimulation were incompletely ...

journal_title：Endocrinology

authors： Koshimizu TA,Tomić M,Wong AO,Zivadinovic D,Stojilkovic SS

更新日期：2000-11-01 00:00:00

abstract：:The present experiments investigated the time course of maternal modulation of GH secretion and examined the possible role of milk in the regulation of GH secretion in neonatal rats. Serum GH concentrations in neonatal rats were high at birth and declined over time postpartum. Separation of rat pups from their mothers...

journal_title：Endocrinology

authors： Kacsoh B,Terry LC,Meyers JS,Crowley WR,Grosvenor CE

更新日期：1989-09-01 00:00:00

abstract：:Pancreatic membrane receptors for cholecystokinin (CCK) in obese and nonobese Zucker rats were compared with the use of a biologically active [125I]iodo-CCK-8 radioprobe. Membrane homogenates from obese rats bound half the amount of radioligand in 2 h as did membranes from lean rats (specifically bound, 7.0% vs. 14.0%...

journal_title：Endocrinology

authors： Praissman M,Izzo RS

更新日期：1986-08-01 00:00:00

abstract：:In the present work we describe homologous desensitization of gonadotropin release from pituitary cells in response to short-term exposure to GnRH. Like the release process itself, desensitization requires receptor occupancy by an agonist. In contrast, however, inhibition of LH release by chelation of extracellular ca...

journal_title：Endocrinology

authors： Smith WA,Conn PM

更新日期：1983-01-01 00:00:00

abstract：:1,25-Dihydroxyvitamin D3 [1,25-(OH)2D3] and 24,25-(OH)2D3 differentially affect the specific activity of alkaline phosphatase (ALPase) and phospholipase-A2 (PLA2) of plasma membranes and extracellular matrix vesicles produced by costochondral reserve zone and growth zone cartilage chondrocytes in culture. In the prese...

journal_title：Endocrinology

authors： Schwartz Z,Schlader DL,Swain LD,Boyan BD

更新日期：1988-12-01 00:00:00

abstract：:Vascular smooth muscle cells (SMC) are major constituents of the medial layer of blood vessels and are involved in the development of atherosclerotic plaque. SMC secrete copious IL-6 under basal conditions that can be increased by cytokines such as tumor necrosis factor-alpha and interleukin-1beta (IL-1beta). The goal...

journal_title：Endocrinology

authors： Maret A,Clamens S,Delrieu I,Elhage R,Arnal JF,Bayard F

更新日期：1999-06-01 00:00:00

abstract：:Estrogen inhibits postmenopausal bone loss and decreases fracture risk. Unfortunately, estrogen replacement therapy has many undesirable side effects, the majority of which are due to stimulation of reproductive tissues. Tissue specific estrogen agonists provide a promising new alternative to natural estrogens for hor...

journal_title：Endocrinology

authors： Jimenez MA,Magee DE,Bryant HU,Turner RT

更新日期：1997-05-01 00:00:00

abstract：:Arachidonic acid metabolites have been implicated in the regulation of ACTH secretion. To define further which eicosanoid(s) is primarily involved, we examined the effects of both inhibitors of the three arachidonate metabolic pathways (cyclooxygenase, lipoxygenase, and epoxygenase) and specific eicosanoid products on...

journal_title：Endocrinology

authors： Won JG,Orth DN

更新日期：1994-10-01 00:00:00

abstract：:Inside-out plasma membrane vesicles from a glucose-responsive rat insulinoma showed an ATP- and Mg2(+)-dependent uptake of Ca2+. The Km (concentration giving half-maximal activity) for Ca2+ was 60 nM. In the presence of 0.4 microM free Ca2+, the Km for ATP was 15 microM, and the Km for Mg2+ was 4 microM. Glucose (30 m...

journal_title：Endocrinology

authors： Hoenig M,Culberson LH,Ferguson DC

更新日期：1991-03-01 00:00:00

abstract：:Increased toxicant exposure and resultant environmentally induced diseases are a tradeoff of industrial productivity. Dioxin [2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD)], a ubiquitous byproduct, is associated with a spectrum of diseases including endometriosis, a common, chronic disease in women. TCDD activates cytoch...

journal_title：Endocrinology

authors： Khan Z,Zheng Y,Jones TL,Delaney AA,Correa LF,Shenoy CC,Khazaie K,Daftary GS

更新日期：2018-01-01 00:00:00

abstract：:Tamoxifen, a partial competitive antagonist to the estrogen receptor, is a potent inhibitor of the proliferation of experimental mammary carcinoma in the rat and is widely used clinically in the treatment of breast cancer. Blockade of estrogen receptors present on neoplastic cells represents the classic mechanism of a...

journal_title：Endocrinology

authors： Tannenbaum GS,Gurd W,Lapointe M,Pollak M

更新日期：1992-06-01 00:00:00

abstract：:Up to now, no relevant tumor antigen has been identified in medullary thyroid carcinoma (MTC). The aim of the present study was to prove the concept of an immunization with an amino acid-modified calcitonin (CT) for the treatment of MTC in a transgenic mouse model. Amino acid-modified (human) CT has been chosen for va...

journal_title：Endocrinology

authors： Wuttke M,Papewalis C,Meyer Y,Kessler C,Jacobs B,Willenberg HS,Schinner S,Kouatchoua C,Baehring T,Scherbaum WA,Schott M

更新日期：2008-11-01 00:00:00

abstract：:The initial steps involved in mediating the transduction of PTH signal via its G protein-coupled receptors are well understood and occur through the activation of cAMP and phospholipase C pathways. However, the cellular and molecular mechanisms for subsequent receptor desensitization are less well understood. Recently...

journal_title：Endocrinology

authors： Miles RR,Sluka JP,Santerre RF,Hale LV,Bloem L,Boguslawski G,Thirunavukkarasu K,Hock JM,Onyia JE

更新日期：2000-01-01 00:00:00

abstract：:The adipokine leptin regulates energy homeostasis through ubiquitously expressed leptin receptors. Leptin has a number of major signaling targets in the brain, including cells of the anterior pituitary (AP). We have previously reported that mice lacking leptin receptors in AP somatotropes display growth hormone (GH) d...

journal_title：Endocrinology

authors： Allensworth-James M,Banik J,Odle A,Hardy L,Lagasse A,Moreira ARS,Bird J,Thomas CL,Avaritt N,Kharas MG,Lengner CJ,Byrum SD,MacNicol MC,Childs GV,MacNicol AM

更新日期：2021-03-01 00:00:00

abstract：:We have recently identified, characterized, and cloned a luteal microsomal 32-kDa phosphoprotein that we named PRAP (for PRL-receptor associated protein), and we have demonstrated that PRAP binds to the intracellular domain of the short but not the long form of the PRL receptor. In this study, we used PRAP cDNA to exa...

journal_title：Endocrinology

authors： Duan WR,Parmer TG,Albarracin CT,Zhong L,Gibori G

更新日期：1997-08-01 00:00:00

abstract：:Like insulin-like growth factor binding protein-3 (IGFBP-3), IGFBP-5 forms a ternary complex with insulin-like growth factor (IGF)-I or IGF-II, and the acid-labile subunit (ALS). The study of IGFBP-5/IGFBP-6 chimeric proteins with amino-terminal and middle domain swaps, has revealed the existence of a site in the midd...

journal_title：Endocrinology

authors： Twigg SM,Kiefer MC,Zapf J,Baxter RC

更新日期：2000-01-01 00:00:00

abstract：:The influence of periparturient secretion of PRL on cytological differentiation of mammary epithelial cells was studied in 17 multiparous, monotocous Holstein cows. Mammary tissue was obtained 10 days prepartum and 10 days postpartum from untreated cows and from cows treated with CB154 (2-Br-alpha-ergokryptin) or CB15...

journal_title：Endocrinology

authors： Akers RM,Bauman DE,Goodman GT,Capuco AV,Tucker HA

更新日期：1981-07-01 00:00:00

abstract：:[131I]Thyroglobulin [( 131I]Tg), prepared by either enzymatic iodination of human goiter Tg in vitro or isolation from the thyroids of rats previously injected with 131I, was digested with a solubilized enzyme mixture prepared from purified hog thyroid lysosomes. The digestion was performed at 37 C for 24 h under nitr...

journal_title：Endocrinology

authors： Tokuyama T,Yoshinari M,Rawitch AB,Taurog A

更新日期：1987-08-01 00:00:00