Abstract:
:In the present work we describe homologous desensitization of gonadotropin release from pituitary cells in response to short-term exposure to GnRH. Like the release process itself, desensitization requires receptor occupancy by an agonist. In contrast, however, inhibition of LH release by chelation of extracellular calcium or blockade of the calcium ion channel does not inhibit desensitization. Further, stimulation of gonadotropin release by ionophore A23187 (which mobilizes calcium without GnRH receptor occupancy) does not lead to desensitization. These findings indicate that the decrease in pituitary sensitivity to GnRH due to an initial exposure to the peptide can be uncoupled from LH release. The data provide the first evidence of a calcium-independent biological effect of the releasing hormone in cultured pituitary cells.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Smith WA,Conn PMdoi
10.1210/endo-112-1-408subject
Has Abstractpub_date
1983-01-01 00:00:00pages
408-10issue
1eissn
0013-7227issn
1945-7170journal_volume
112pub_type
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