Angiotensin II increases lipogenesis in 3T3-L1 and human adipose cells.

Abstract:

:Angiotensin II (Ang II) is one of numerous hormones recently shown to be synthesized and secreted by adipose cells. Although the function of Ang II in adipose tissue is unknown, several studies indirectly suggest that it may be involved in control of adiposity. Little is known, however, about direct actions of Ang II in adipose cells. To further investigate this issue, we first characterized the type of Ang II receptors in 3T3-L1 adipocytes. We then tested the hypothesis that Ang II exerted direct actions on adipocyte metabolism using both 3T3-L1 and human adipocyte models. We report here that Ang II significantly increased triglyceride content and the activities of two key lipogenic enzymes (fatty acid synthase, FAS and glycerol-3-phosphate dehydrogenase, GPDH) in 3T3-L1 adipocytes, and that these effects were mediated through the type-2 Ang II receptor. We also report that Ang II exerted similar effects in human adipose cells maintained in primary culture. Finally, we demonstrate that Ang II increased the transcription rate of the FAS and ob genes in 3T3-L1 and human adipose cells. These results indicate that Ang II may be involved in control of adiposity through regulation of lipid synthesis and storage in adipocytes.

journal_name

Endocrinology

journal_title

Endocrinology

authors

Jones BH,Standridge MK,Moustaid N

doi

10.1210/endo.138.4.5038

subject

Has Abstract

pub_date

1997-04-01 00:00:00

pages

1512-9

issue

4

eissn

0013-7227

issn

1945-7170

journal_volume

138

pub_type

杂志文章
  • Estrogen sulfotransferase: discrete and androgen-dependent expression in the male reproductive tract and demonstration of an in vivo function in the mouse epididymis.

    abstract::Estrogen sulfotransferase (EST) catalyzes the sulfoconjugation and inactivation of the steroid hormone estrogen. It is known previously that EST is expressed abundantly in Leydig cells of the testis. We recently have shown that male mice with targeted EST gene disruption developed age related Leydig cell and seminifer...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo.143.8.8943

    authors: Tong MH,Song WC

    更新日期:2002-08-01 00:00:00

  • Roles of Endogenous IL-10 and IL-10-Competent and CD5+ B Cells in Autoimmune Thyroiditis in NOD.H-2h4 Mice.

    abstract::Interleukin (IL)-10 is a highly important anti-inflammatory cytokine in the immune system. CD1dhi and CD5+ B cells are both traditionally defined IL-10-secreting B cells. In recent years, a B cell group with combined markers of CD1dhi and CD5+ has been widely studied as it has been reported to suppress autoimmunity in...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endocr/bqaa033

    authors: Qin J,Zhao N,Wang S,Liu S,Liu Y,Cui X,Wang S,Xiang Y,Fan C,Li Y,Shan Z,Teng W

    更新日期:2020-04-01 00:00:00

  • Activation of the Na+/H+ exchanger by cellular pH and extracellular Na+ in rat adipocytes; inhibition by isoproterenol.

    abstract::The activity of the Na+/H+ exchanger was studied by measuring the effects of intracellular pH (pHi) and extracellular Na+ [(Na+)o] on pHi recovery and 22Na uptake in rat adipocytes. The resting pHi was acidified from 7.30 +/- 0.02 to 6.99 +/- 0.01 with nigericin in the absence of (Na+)o. pHi recovery induced by 30 mM ...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo.136.7.7789340

    authors: Arsenis G

    更新日期:1995-07-01 00:00:00

  • Regulation of insulin-like growth factor I biosynthesis in porcine granulosa cells.

    abstract::In the present studies we examined the regulation of insulin-like growth factor I (IGF-I) expression in porcine granulosa cells in vitro. Using Northern analysis and ribonuclease protection assays with exon-specific probes, we identified the IGF-I messenger RNA (mRNA) transcripts present in these cells under basal and...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo.137.11.8895330

    authors: Samaras SE,Canning SF,Barber JA,Simmen FA,Hammond JM

    更新日期:1996-11-01 00:00:00

  • Strain-specific response to beta 3-adrenergic receptor agonist treatment of diet-induced obesity in mice.

    abstract::Fat intake has long been associated with the development of obesity. The studies described herein show that fat adversely affects adipocyte adrenergic receptor (AR) expression and function. As beta 3AR agonists have been shown to acutely reduce adipose tissue mass and improve thermogenesis in genetically obese rodents...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo.138.1.4829

    authors: Collins S,Daniel KW,Petro AE,Surwit RS

    更新日期:1997-01-01 00:00:00

  • Measurement of circulating parathyroid hormone-related protein in rats with humoral hypercalcemia of malignancy using a two-site immunoradiometric assay.

    abstract::The Rice H500 rat Leydig cell tumor is a well characterized model of humoral hypercalcemia of malignancy (HHM). Circulating concentrations of PTH-related protein (PTHRP) have not been reported in this or any other animal model of HHM. Taking advantage of the marked N-terminal amino acid homology between rodent and hum...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-127-3-1444

    authors: Gaich G,Burtis WJ

    更新日期:1990-09-01 00:00:00

  • Prostate-Specific Deletion of Cdh1 Induces Murine Prostatic Inflammation and Bladder Overactivity.

    abstract::Benign prostatic hyperplasia (BPH) is an age-related debilitating prostatic disease that is frequently associated with prostatic inflammation and bothersome lower urinary tract symptoms (LUTS). Animal models have shown that formalin- and bacterial-induced prostatic inflammation can induce bladder dysfunction; however,...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endocr/bqaa212

    authors: Pascal LE,Mizoguchi S,Chen W,Rigatti LH,Igarashi T,Dhir R,Tyagi P,Wu Z,Yang Z,de Groat WC,DeFranco DB,Yoshimura N,Wang Z

    更新日期:2021-01-01 00:00:00

  • Ectopic pituitary transplants stimulate synthesis and release of follicle-stimulating hormone in golden hamsters.

    abstract::It was previously reported that PRL can stimulate FSH release in immature female rats and PRL-deficient male dwarf mice. We have examined the effects of PRL-producing ectopic pituitary grafts on plasma FSH and LH levels in adult male golden hamsters during exposure to both long (14 h of light, 10 h of darkness) and sh...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-108-1-133

    authors: Bartke A,Siler-Khodr TM,Hogan MP,Roychoudhury P

    更新日期:1981-01-01 00:00:00

  • Administration of pharmacological amounts of 25(s),26-dihydroxyvitamin D3 reduces serum 1,25-dihydroxyvitamin D3 levels in rats.

    abstract::Pharmacological amounts of 25(s),26-dihydroxyvitamin D3 were administered to normal, vitamin D-replete rats in order to assess its pharmacological activity. Treatment with 25(s),26-dihydroxyvitamin D3 (20 micrograms/day for 1 week) caused a marked and significant fall in the circulating concentration of 1,25-dihydroxy...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-121-5-1671

    authors: Zerwekh JE,Harvey JA,Pak CY

    更新日期:1987-11-01 00:00:00

  • Secretory protein 7B2 is associated with pancreatic hormones within normal islets and some experimentally induced tumors.

    abstract::7B2 is a novel neuroendocrine polypeptide which belongs to an entirely new superfamily of proteins. In extension of previous reports on 7B2, these studies concern its expression in endocrine pancreatic tissue. They have been performed using specific antibodies prepared against two distinct synthetic fragments of 7B2 c...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-123-2-874

    authors: Benjannet S,Marcinkiewicz M,Falgueyret JP,Johnson DE,Seidah NG,Chrétien M

    更新日期:1988-08-01 00:00:00

  • Superfusion of normal and neoplastic mouse mammary tissue with estrogens.

    abstract::Slices of normal mammary tissue from pregnant and lactating mice and slices of neoplastic (MXT) mouse mammary tissue were superfused with estradiol (E2) and estrone (E1) each labeled with a different isotope. Isotope concentrations in tissue and perfusate at the steady state were used to calculate fractions and rates ...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-113-1-399

    authors: De Ryck LM,Raus JC

    更新日期:1983-07-01 00:00:00

  • Developmental regulation of unique adenosine 3',5'-monophosphate-specific phosphodiesterase variants during rat spermatogenesis.

    abstract::Previous studies from our laboratory have shown that messenger RNAs (mRNAs) coding for a cAMP-specific phosphodiesterase (PDE4A) are present in mature rat and mouse germ cells. However, no information is available about the properties of the expressed proteins. To determine their structure and regulation, the PDE4A is...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo.137.6.8641200

    authors: Naro F,Zhang R,Conti M

    更新日期:1996-06-01 00:00:00

  • Assessment of endothelin-A receptor expression in subcutaneous and orthotopic thyroid carcinoma xenografts in vivo employing optical imaging methods.

    abstract::Endothelin (ET) receptor dysregulation has been described in a number of pathophysiological processes, including cardiovascular disorders, renal failure, and cancer. The aim of this study was to evaluate the expression of the ET-A receptor (ET(A)R) in murine models of thyroid carcinoma using optical imaging methods. A...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/en.2011-2017

    authors: Büther K,Compeer MG,De Mey JG,Schober O,Schäfers M,Bremer C,Riemann B,Höltke C

    更新日期:2012-06-01 00:00:00

  • Isolation and characterization of myostatin complementary deoxyribonucleic acid clones from two commercially important fish: Oreochromis mossambicus and Morone chrysops.

    abstract::In mammals, skeletal muscle mass is negatively regulated by a muscle-derived growth/differentiating factor named myostatin (MSTN) that belongs to the transforming growth factor-beta superfamily. Although putative MSTN homologs have been identified from several vertebrates, nonmammalian orthologs remained poorly define...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo.142.4.8097

    authors: Rodgers BD,Weber GM,Sullivan CV,Levine MA

    更新日期:2001-04-01 00:00:00

  • Minireview: A hypothalamic role in energy balance with special emphasis on leptin.

    abstract::The hypothalamus is a major site for integration of central and peripheral signals that regulate energy homeostasis. Within the hypothalamus, neurons residing in the ARC (arcuate nucleus)-PVN (paraventricular)-PF/LH (perifornical/lateral hypothalamus) axis communicate among each other and are subjected to the influenc...

    journal_title:Endocrinology

    pub_type: 杂志文章,评审

    doi:10.1210/en.2004-0032

    authors: Sahu A

    更新日期:2004-06-01 00:00:00

  • Mouse placental lactogen-I: RIA and gestational profile in maternal serum.

    abstract::A RIA for mouse placental lactogen-I (mPL-I) was developed using recombinant mPL-I as the standard, radioligand, and antigen for antiserum production. Displacement curves for dilutions of serum and placental extracts from pregnant mice were parallel to the recombinant mPL-I standard curve. Serum from male and nonpregn...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-125-5-2253

    authors: Ogren L,Southard JN,Colosi P,Linzer DI,Talamantes F

    更新日期:1989-11-01 00:00:00

  • Testicular function in experimental uremia.

    abstract::A model for the study of testicular function in experimental uremia induced by subtotal nephrectomy in mature male rats is described. Glomerular filtration rate was reduced by 87%, resulting in stable uremia for up to 13 weeks with characteristic biochemical changes and reduction in weight of testes, prostate, seminal...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-117-5-1974

    authors: Handelsman DJ,Spaliviero JA,Turtle JR

    更新日期:1985-11-01 00:00:00

  • Estrogen-induced memory enhancements are blocked by acute bisphenol A in adult female rats: role of dendritic spines.

    abstract::Acute effects of bisphenol (BPA), an environmental chemical, on estradiol (17α or β-E2)-dependent recognition memory and dendritic spines in the medial prefrontal cortex and hippocampus were investigated in adult female rats. Ovariectomized rats received BPA 30 min before or immediately after a sample trial (viewing o...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/en.2012-1121

    authors: Inagaki T,Frankfurt M,Luine V

    更新日期:2012-07-01 00:00:00

  • Maternal diabetes impairs gastrulation and insulin and IGF-I receptor expression in rabbit blastocysts.

    abstract::Women with type 1 diabetes are subfertile. Diabetes negatively affects pregnancy by causing early miscarriage and poor prenatal outcomes. In this study we examine consequences of maternal type 1 diabetes on early embryo development, metabolic gene expression, and the pattern of insulin receptor (IR) and IGF-I receptor...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/en.2010-0187

    authors: Ramin N,Thieme R,Fischer S,Schindler M,Schmidt T,Fischer B,Navarrete Santos A

    更新日期:2010-09-01 00:00:00

  • Catecholestrogens and release of anterior pituitary gland hormones. II. Prolactin.

    abstract::We investigated the effects of the peripheral administration of 17 beta-estradiol (E2), estrone (E1), and the catecholestrogens, 2-hydroxyestradiol (2-OHE2) and 2-hydroxyestrone, (2-OHE1), on anterior pituitary gland PRL release in the prepuberal rat. Steroids in oil were injected sc into 25-day-old female and 35- to ...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-110-2-325

    authors: Rodriguez-Sierra JF,Blake CA

    更新日期:1982-02-01 00:00:00

  • Circadian and Ultradian Variations in Corticosterone Level Influence Functioning of the Male Mouse Basolateral Amygdala.

    abstract::The hypothalamic-pituitary-adrenal axis involves timed signaling between the hypothalamus, pituitary, and adrenal glands and back to the brain, causing an inherently oscillating system. Corticosteroids such as corticosterone (CORT) are secreted in a circadian rhythm, characterized by low and high levels at the start o...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/en.2018-00767

    authors: den Boon FS,de Vries T,Baelde M,Joëls M,Karst H

    更新日期:2019-04-01 00:00:00

  • Identification of binding proteins for nuclear localization signals of the glucocorticoid and thyroid hormone receptors.

    abstract::Nuclear entry of proteins the size of the glucocorticoid and thyroid hormone receptors appears to be mediated by an interaction of nuclear localization signals (NLSs) within the proteins and specific NLS-binding proteins. NLSs have been identified in the hinge region of both receptors. We have identified the cellular ...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo.132.3.8440170

    authors: LaCasse EC,Lochnan HA,Walker P,Lefebvre YA

    更新日期:1993-03-01 00:00:00

  • Endogenous aldosterone contributes to acute angiotensin II-stimulated plasminogen activator inhibitor-1 and preproendothelin-1 expression in heart but not aorta.

    abstract::To test the hypothesis that angiotensin (Ang) II induces profibrotic gene expression through endogenous aldosterone, we measured the effect of 4 h infusion (600 ng/kg x min) of Ang II on tissue mRNA expression of plasminogen activator inhibitor 1 (PAI-1), preproendothelin-1 (ppET-1), TGF-beta, and osteopontin in wild-...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/en.2008-1296

    authors: Luther JM,Wang Z,Ma J,Makhanova N,Kim HS,Brown NJ

    更新日期:2009-05-01 00:00:00

  • Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) rats.

    abstract::Leptin signaling in the hypothalamic arcuate nucleus (ARC) is hypothesized to play an important role in energy homeostasis. To investigate whether leptin signaling limited to this brain area is sufficient to reduce food intake and body weight, we used adenoviral gene therapy to express the signaling isoform of the lep...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/en.2002-0115

    authors: Morton GJ,Niswender KD,Rhodes CJ,Myers MG Jr,Blevins JE,Baskin DG,Schwartz MW

    更新日期:2003-05-01 00:00:00

  • Alcohol and fatty acid stimulation of neurotensin release from rat small intestine.

    abstract::We have previously reported that neurotensin (NT) is released from the small intestine and elevated in the hepatic-portal circulation in response to the perfusion of the small intestine with a micellar solution of oleic acid. In order to determine the minimum acyl chain length and whether the presence of a carboxylic ...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-116-3-1133

    authors: Ferris CF,Armstrong MJ,George JK,Stevens CA,Carraway RE,Leeman SE

    更新日期:1985-03-01 00:00:00

  • The goitrogen 6-n-propyl-2-thiouracil (PTU) given during testis development increases Sertoli and germ cell numbers per cyst in fish: the tilapia (Oreochromis niloticus) model.

    abstract::The main objectives of the present study were to investigate the effects of 6-n-propyl-2-thiouracil (PTU) on Sertoli cell proliferation, germ cell number, and testis size in Nile tilapias (Oreochromis niloticus). In this regard, young fish (approximately 1 g BW and approximately 3.5 cm total in length) were treated fo...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo.143.3.8666

    authors: Matta SL,Vilela DA,Godinho HP,França LR

    更新日期:2002-03-01 00:00:00

  • Extrahypothalamic neurophysin-containing perikarya, fiber pathways and fiber clusters in the rat brain.

    abstract::Immunoreactive neurophysin (Np) is demonstrated by the immunoperoxidase technique not only within neurones of the classical hypothalamo-neurohypophyseal system, but also in extrahypothalamic perikarya and fibers. Np-positive perikarya are found in the triangular nucleus of the septum. Np fibers join the stria terminal...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-102-1-334

    authors: Sofroniew MV,Weindl A

    更新日期:1978-01-01 00:00:00

  • The Thyroid Hormone Inactivating Enzyme Type 3 Deiodinase is Present in Bactericidal Granules and the Cytoplasm of Human Neutrophils.

    abstract::Neutrophils are important effector cells of the innate immune system. Thyroid hormone (TH) is thought to play an important role in their function. Intracellular TH levels are regulated by the deiodinating enzymes. The TH-inactivating type 3 deiodinase (D3) is expressed in infiltrating murine neutrophils, and D3 knocko...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/en.2016-1103

    authors: van der Spek AH,Bloise FF,Tigchelaar W,Dentice M,Salvatore D,van der Wel NN,Fliers E,Boelen A

    更新日期:2016-08-01 00:00:00

  • Modulation of arginine-induced insulin and glucagon secretion by the hepatic vagus nerve in the rat: effects of celiac vagotomy and administration of atropine.

    abstract::We hypothesized the existence of vagal arginine sensors in the liver which modulate arginine-induced pancreatic hormone secretion. The present study was carried out to examine the efferent pathways and receptor mechanisms from arginine sensors using selective vagotomies and autonomic drugs on the secretion of insulin ...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-127-4-2017

    authors: Tanaka K,Inoue S,Nagase H,Takamura Y

    更新日期:1990-10-01 00:00:00

  • Studies on rat pituitary homografts. I. In vitro biosynthesis and release of growth hormone and prolactin.

    abstract::Homologous anterior pituitaries grafted under the kidney capsule in hypophysectomized rats were studied 30 days after transplantation. Some cells maintained the ultrastructural features peculiar to the various cell types of normotopic glands, while the others were characterized by few, small, dense granules, spherical...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-104-1-226

    authors: Zanini A,Giannattasio G,De Camilli P,Panerai AE,Müller EE,Meldolesi J

    更新日期:1979-01-01 00:00:00