Proadrenomedullin N-terminal 20 peptide increases kinesin's velocity both in vitro and in vivo.

abstract：:17α-Ethinyl estradiol (EE), a synthetic analog of natural estrogen 17β-estradiol (E2), is extensively used in hormonal contraceptives and estrogen replacement therapy, and it has also been found in sewage effluents. Given that E2 is a well-known immunomodulator, surprisingly there has been only limited information on ...

journal_title：Endocrinology

authors： Dai R,Edwards MR,Heid B,Ahmed SA

更新日期：2019-01-01 00:00:00

abstract：:An increased activity of the hypothalamo-pituitary-adrenal axis resulting in exaggerated glucocorticoid secretion has been repeatedly described in patients with diabetes mellitus and in animal models of this disease. However, it has been pointed out that experimental diabetes is accompanied by a decreased glucocortico...

journal_title：Endocrinology

authors： Repetto EM,Sanchez R,Cipelli J,Astort F,Calejman CM,Piroli GG,Arias P,Cymeryng CB

更新日期：2010-01-01 00:00:00

abstract：:The effect of progesterone on the secretion of LH was studied in intact and castrated immature female sheep between 12 and 42 weeks of age. (First spontaneous ovulation occurs between 30 and 50 weeks of age.) Progesterone was administered by means of Silastic capsules inserted SC to achieve circulating progesterone co...

journal_title：Endocrinology

authors： Foster DL,Karsch FJ

更新日期：1976-07-01 00:00:00

abstract：:Actions of protein products resulting from alternative splicing of the Igf1 gene have received increasing attention in recent years. However, the significance and functional relevance of these observations remain poorly defined. To address functions of IGF-I splice variants, we examined the impact of loss of IGF-IEa a...

journal_title：Endocrinology

authors： Matheny RW Jr,Nindl BC

更新日期：2011-05-01 00:00:00

abstract：:A side population (SP) has been identified in a number of tissues, where it typically represents a small population enriched in stem/progenitor cells. In this study we show that the adult mouse anterior pituitary (AP) also contains a characteristic SP displaying verapamil-sensitive Hoechst dye efflux capacity. A major...

journal_title：Endocrinology

authors： Chen J,Hersmus N,Van Duppen V,Caesens P,Denef C,Vankelecom H

更新日期：2005-09-01 00:00:00

abstract：:The effect of bovine corneal extracellular matrix (ECM) on gonadotropin-primed rat granulosa cells in vitro was studied by examining the following parameters: 1) rate of cell attachment to culture dishes; 2) modulation of cell morphology; 3) specific binding of [125I]human(h)CG to LH/hCG receptors; 4) cAMP response to...

journal_title：Endocrinology

authors： Furman A,Rotmensch S,Kohen F,Mashiach S,Amsterdam A

更新日期：1986-05-01 00:00:00

abstract：:The concentrations and contents of vasoactive intestinal peptide (VIP) and cholecystokinin (CCK) in the brain and of these peptides along with secretin and glucagon-like immunoreactivity (GLI) in the gut were compared in a group of 16 5-day fasted adult Sprague-Dawley rats with the corresponding peptides in a group of...

journal_title：Endocrinology

authors： Zheng B,Eng J,Yalow RS

更新日期：1987-02-01 00:00:00

abstract：:Binding of atrial and brain natriuretic peptides to guanylyl cyclase-A/natriuretic peptide receptor-A produces second messenger cGMP, which plays an important role in maintaining renal and cardiovascular homeostasis. Mice carrying a targeted disruption of the Npr1 gene coding for guanylyl cyclase-A/natriuretic peptide...

journal_title：Endocrinology

authors： Das S,Au E,Krazit ST,Pandey KN

更新日期：2010-12-01 00:00:00

abstract：:We recently reported that aluminum administration to beagles stimulates uncoupled bone formation in the marrow cavity which increases trabecular bone volume and generates new osseous networks within the axial skeleton. To investigate whether this osteogenic process results from direct stimulation of bone cell replicat...

journal_title：Endocrinology

authors： Quarles LD,Wenstrup RJ,Castillo SA,Drezner MK

更新日期：1991-06-01 00:00:00

abstract：:Oxytocin (OT) receptors (OTRs) mediate reproductive functions, including the initiation of labor and milk ejection. OTR messenger RNA levels are highly regulated, reaching the greatest concentration in the uterus at the end of gestation, and in the mammary gland during lactation. Factors directly effecting changes in ...

journal_title：Endocrinology

authors： Hoare S,Copland JA,Wood TG,Jeng YJ,Izban MG,Soloff MS

更新日期：1999-05-01 00:00:00

abstract：:Limited proteolysis in vivo of insulin-like growth factor-binding protein-3 (IGFBP-3) by as yet unidentified serine proteases plays a key role in controlling the bioavailability of IGFBP-3-associated insulin-like growth factors (IGFs). Both the IGF system and the system of plasminogen activators (PAs) and their inhibi...

journal_title：Endocrinology

authors： Lalou C,Silve C,Rosato R,Segovia B,Binoux M

更新日期：1994-12-01 00:00:00

abstract：:The mechanism of the hypophosphatemic effect of thyrocalcitonin (TCT) is uncertain and may involve removal of inorganic phosphate (P1) from the plasma by heretofore unidentified organs. Rats, 192 g. thyroparathyroidectomized 16-24 h earlier, received 100 MRC mU TCT or vehicle (V) SC and 100 muCi 32PO4 iv. One h later ...

journal_title：Endocrinology

authors： Meyer RA Jr,Meyer MH

更新日期：1975-04-01 00:00:00

abstract：:Rat uterine and anterior pituitary microsomes each contain a population of specific estrogen-binding sites. Saturation binding of estradiol is demonstrable, with an affinity similar to that of the cytosol estrogen receptor (Ka = 1-2 X 10(10) M-1). Dissociation rate kinetic determinations, however, revealed that estrog...

journal_title：Endocrinology

authors： Watson GH,Muldoon TG

更新日期：1985-10-01 00:00:00

abstract：:Isolated renal cortical slices were used to study the conversion of 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] and 24,25-dihydroxyvitamin D3 [24,25](OH2)D3] by the rat kidney. Production of 1,25-(OH)2D3 and 24,25-(OH)2D3 was linear with time (30-90 min) and tissue weight (40-250 mg). Production of...

journal_title：Endocrinology

authors： Armbrecht HJ,Zenser TV,Davis BB

更新日期：1981-07-01 00:00:00

abstract：:Hypothalamic enzymatic activities capable of degrading LHRH may play a physiological role in the neuroendocrine control of LHRH. There is increasing evidence, however, that these enzymes are not peptide specific. The present study in the ewe analyzed the possibility that the specificity of LHRH-degrading activity (LHR...

journal_title：Endocrinology

authors： Advis JP,Kuljis RO,Dey G

更新日期：1985-06-01 00:00:00

abstract：:The dynamics of dopamine (DA) action on PRL release was studied in superfused rat anterior pituitary cell aggregates, cultured for for 5 days either in conventional or in serum-free defined medium. In aggregates cultured in conventional medium 0.1-1 nM DA applied for 20 min provoked a rapid and concentration-dependent...

journal_title：Endocrinology

authors： Denef C,Baes M,Schramme C

更新日期：1984-04-01 00:00:00

abstract：:In male rats maintained on a 12 h light-dark schedule (6 AM-6 PM), there is a nyctohemeral cycle of plasma prolactin which consists of a nadir at 11:30 AM and an apogee at approximately 11:30 PM. In rats exposed to constant darkness, this rhythm persists for 7 days. Seven days of constant light, however, reverses this...

journal_title：Endocrinology

authors： Kizer JS,Zivin JA,Jacobowitz DM,Kopin IJ

更新日期：1975-05-01 00:00:00

abstract：:The peptides angiotensin II (ANGII) and atrial natriuretic factor (ANF) regulate blood pressure and salt and water balance by producing antagonistic physiological effects in a variety of tissues. We used in vitro autoradiography with [125I] ANGII and [125I]ANF to compare receptor regulation for both peptides in variou...

journal_title：Endocrinology

authors： Wilson SK,Lynch DR,Ladenson PW

更新日期：1989-06-01 00:00:00

abstract：:Recently, California condors (Gymnogyps californianus) have been reintroduced to coastal regions of California where they feed on marine mammal carcasses. There is evidence that coastal-dwelling condors experience reproductive issues, such as eggshell thinning, likely resulting from exposure to endocrine-disrupting ch...

journal_title：Endocrinology

authors： Felton RG,Steiner CC,Durrant BS,Keisler DH,Milnes MR,Tubbs CW

更新日期：2015-12-01 00:00:00

abstract：:Angiogenic factors, including vascular endothelial growth factor (VEGF), are expressed during follicular development. Our objective was to investigate the role of VEGF in the early follicular phase to test whether early cyclic follicle development and selection are angiogenesis-dependent processes. After documentation...

journal_title：Endocrinology

authors： Zimmermann RC,Xiao E,Bohlen P,Ferin M

更新日期：2002-07-01 00:00:00

abstract：:A monoclonal antibody directed against bovine TSH was obtained by hybridoma technology. This antibody was specific for TSH and did not react with bovine LH and FSH. Affinity chromatography of crude TSH was performed on anti-TSH Sepharose. Bovine TSH was purified in a single step to near homogeneity by this technique, ...

journal_title：Endocrinology

authors： Lock AJ,van Denderen J,Aarden LA

更新日期：1988-01-01 00:00:00

abstract：:After incubation with 0.5 mM isobutylmethylxanthine, 1 microM dexamethasone, and 1 microM insulin for 72 h, 3T3-L1 cells acquire the phenotypic characteristics of mature adipocytes, including a hormone-sensitive particulate cAMP phosphodiesterase activity. In addition, adipocytes contain soluble cAMP and calmodulin-se...

journal_title：Endocrinology

authors： Elks ML,Manganiello VC,Vaughan M

更新日期：1984-10-01 00:00:00

abstract：:Purinergic G protein-coupled receptors (P2YR) and ion-conducting receptor-channels (P2XR) are present in the pituitary. However, their identification, expression within pituitary cell subpopulations, and the ability to elevate intracellular Ca2+ concentration ([Ca2+]i) in response to ATP stimulation were incompletely ...

journal_title：Endocrinology

authors： Koshimizu TA,Tomić M,Wong AO,Zivadinovic D,Stojilkovic SS

更新日期：2000-11-01 00:00:00

abstract：:Studying the mechanisms for the complex pathogenesis of polycystic ovary syndrome (PCOS) requires animal models with endocrine, reproductive, and metabolic features of the syndrome. Hyperandrogenism seems to be a central factor in PCOS, leading to anovulation and insulin resistance. In female rats, continuous administ...

journal_title：Endocrinology

authors： Maliqueo M,Sun M,Johansson J,Benrick A,Labrie F,Svensson H,Lönn M,Duleba AJ,Stener-Victorin E

更新日期：2013-01-01 00:00:00

abstract：:To determine if oxytocin (OT) is present in cynomolgus monkey corpus luteum, OT was measured by a specific and sensitive RIA in 13 corpora lutea, ovarian venous plasma on the ipsilateral side and peripheral venous plasma at different stages of the luteal phase. Serial dilution of acetic acid extract of the corpus lute...

journal_title：Endocrinology

authors： Khan-Dawood FS,Marut EL,Dawood MY

更新日期：1984-08-01 00:00:00

abstract：:Bromocriptine, a dopamine agonist, inhibited secretion of PRL and did not affect GH release from rat anterior pituitary cells in culture. The reversal of this inhibition of PRL release by butaclamol, a dopamine antagonist, was stereospecific; 10 nM d-butaclamol completely reversed the inhibition caused by 10 nM bromoc...

journal_title：Endocrinology

authors： West B,Dannies PS

更新日期：1979-04-01 00:00:00

abstract：:The maximum amounts of angiotensins II and III that were confined to the kidney during intrarenal arterial administration in conscious dogs were determined to be 2 and 12 pmol/kg X min, respectively. These doses were infused chronically intrarenally to uninephrectomized dogs. A significant reduction in urinary volume ...

journal_title：Endocrinology

authors： Dickstein GM,Woodson JF,Lamb NE,Rose CE Jr,Peach MJ,Carey RM

更新日期：1985-11-01 00:00:00

abstract：:Primary aldosteronism (PA) is a common form of endocrine hypertension that is characterized by the excessive production of aldosterone relative to suppressed plasma renin levels. PA is usually caused by either a unilateral aldosterone-producing adenoma or bilateral adrenal hyperplasia. Somatic mutations have been iden...

journal_title：Endocrinology

authors： Aragao-Santiago L,Gomez-Sanchez CE,Mulatero P,Spyroglou A,Reincke M,Williams TA

更新日期：2017-12-01 00:00:00

abstract：:Although many studies have investigated the complex interrelationships between thyroid hormone levels and insulin-glucose secretion and action, there is at present a lack of information concerning the effects of various thyroid hormone levels on insulin receptors. In the present study, rat liver membranes were prepare...

journal_title：Endocrinology

authors： DeRuyter H,Burman KD,Wartofsky L,Taylor SI

更新日期：1982-06-01 00:00:00

abstract：:Activators of protein kinase C, such as phorbol myristate acetate (PMA) and the synthetic diacylglycerol dioctanoylglycerol (diC8), either stimulate or inhibit PTH release depending on the extracellular Ca2+ concentration. By increasing PTH release at high extracellular Ca2+, these agents, in effect, block high Ca2(+)...

journal_title：Endocrinology

authors： Shoback DM,Chen TH

更新日期：1990-07-01 00:00:00