Targeted disruption of guanylyl cyclase-A/natriuretic peptide receptor-A gene provokes renal fibrosis and remodeling in null mutant mice: role of proinflammatory cytokines.

abstract：:Gastrin is natriuretic, but its renal molecular targets and signal transduction pathways are not fully known. In this study, we confirmed the existence of CCKBR (a gastrin receptor) in male human renal proximal tubule cells and discovered that gastrin induced S6 phosphorylation, a downstream component of the phosphati...

journal_title：Endocrinology

authors： Liu T,Jose PA

更新日期：2013-02-01 00:00:00

abstract：:Liver X receptors (LXRs) are nuclear receptors with established roles in cholesterol, lipid, and carbohydrate metabolism, although their function in adipocytes is not well characterized. Increased adipose tissue mass in obesity is associated with increased adipocyte lipolysis. Fatty acids (FA) generated by lipolysis c...

journal_title：Endocrinology

authors： Stenson BM,Rydén M,Steffensen KR,Wåhlén K,Pettersson AT,Jocken JW,Arner P,Laurencikiene J

更新日期：2009-09-01 00:00:00

abstract：:Prostacylin (PGI(2)), one of the major prostaglandins, is derived from arachidonic acid by the action of the cyclooxygenase (COX) system coupled to PGI(2) synthase (PGIS). The presence of the COX-2/PGIS at the nuclear and endoplasmic reticular membrane suggests differential signaling pathways of PGI(2) actions involvi...

journal_title：Endocrinology

authors： Lim H,Dey SK

更新日期：2002-09-01 00:00:00

abstract：:The existence of renin in a number of extrarenal tissues has been well documented, but the physiological role of extrarenal renin remains unknown. To study the physiological role of adrenal renin, we developed a serum-free culture system for adrenal capsular/zona glomrulosa explants. Explants showed good viability in ...

journal_title：Endocrinology

authors： Shier DN,Kusano E,Stoner GD,Franco-Saenz R,Mulrow PJ

更新日期：1989-07-01 00:00:00

abstract：:The hepatic extractions of gastric inhibitory polypeptide (GIP) and insulin were determined using in vitro and in vivo methods to assess the role of the liver in GIP metabolism and the possible effect of GIP on the hepatic extraction of insulin. During in vitro studies using the isolated perfused rat liver, infusion o...

journal_title：Endocrinology

authors： Hanks JB,Andersen DK,Wise JE,Putnam WS,Meyers WC,Jones RS

更新日期：1984-09-01 00:00:00

abstract：:The electrical responses of rat islet cells maintained in culture with varying levels of glucose were determined. After culture with 2.8 or 4.2 mM glucose, the beta-cells did not respond electrically to 27.8 mM glucose. However, after culture in 5.6 mM glucose, the cells responded to 27.8 mM glucose in short term expe...

journal_title：Endocrinology

authors： Pace CS,Conant S,Lacy PE

更新日期：1978-05-01 00:00:00

abstract：:To better understand the role of peptide growth factors in sex steroid hormone-mediated growth of the female reproductive tract, the effect of estrogen on the expression of transforming growth factor-alpha (TGF alpha) in mouse uterus was investigated. Our results show that estrogen induces the expression of TGF alpha ...

journal_title：Endocrinology

authors： Nelson KG,Takahashi T,Lee DC,Luetteke NC,Bossert NL,Ross K,Eitzman BE,McLachlan JA

更新日期：1992-10-01 00:00:00

abstract：:The neuropeptide kisspeptin (Kiss1) is integral to the advent of puberty and the generation of cyclical LH surges. Although many complex actions of Kiss1 are known, the mechanisms governing the processing/regulation of this peptide have not been unveiled. The metallo enzyme, endopeptidase 24.15 (thimet oligopeptidase)...

journal_title：Endocrinology

authors： Woitowich NC,Philibert KD,Leitermann RJ,Wungjiranirun M,Urban JH,Glucksman MJ

更新日期：2016-02-01 00:00:00

abstract：:Kisspeptins are new actors in the neuroendocrine regulation of reproduction. In vertebrates, the number of kiss genes varies from none to three. Zebrafish have two kiss genes, kiss1 and kiss2, and two kiss receptors (GPR54), kiss1r and kiss2r. To provide detailed information on the organization of the kiss systems in ...

journal_title：Endocrinology

authors： Servili A,Le Page Y,Leprince J,Caraty A,Escobar S,Parhar IS,Seong JY,Vaudry H,Kah O

更新日期：2011-04-01 00:00:00

abstract：:Previous studies established a positive relationship between oocyte competence and follistatin mRNA abundance. Herein, we used the bovine model to test the hypothesis that follistatin plays a functional role in regulation of early embryogenesis. Treatment of early embryos with follistatin during in vitro culture (befo...

journal_title：Endocrinology

authors： Lee KB,Bettegowda A,Wee G,Ireland JJ,Smith GW

更新日期：2009-05-01 00:00:00

abstract：:Transforming growth factor-beta (TGF beta) is a multifunctional growth factor in bone that is secreted as a latent complex and must be activated in order to influence cellular activity. We have investigated the influence of dexamethasone (Dex; a potent glucocorticoid) on the secretion and activation of latent TGF beta...

journal_title：Endocrinology

authors： Oursler MJ,Riggs BL,Spelsberg TC

更新日期：1993-11-01 00:00:00

abstract：:Developmental effects of genistein (Gen) on the mammary gland were investigated using outbred female CD-1 mice treated neonatally on d 1-5 by sc injections at doses of 0.5, 5, or 50 mg/kg.d. Examination of mammary gland whole mounts (no. 4) before puberty (4 wk) revealed no morphological differences in development aft...

journal_title：Endocrinology

authors： Padilla-Banks E,Jefferson WN,Newbold RR

更新日期：2006-10-01 00:00:00

abstract：:The pineal hormone melatonin regulates reproductive function in seasonally breeding mammals. Recent studies using 125I-labeled 2-iodomelatonin (I-MEL) reveal that the distribution of putative melatonin receptors is species-specific; only the hypophysial pars tuberalis (PT) is a consistent site of I-MEL binding in all ...

journal_title：Endocrinology

authors： Weaver DR,Reppert SM

更新日期：1990-11-01 00:00:00

abstract：:Contrary to widespread belief, the implantation of an embryo for the initiation of pregnancy is like a battle, in that the embryo uses a variety of coercive tactics to force its acceptance by the endometrium. We propose that embryo implantation involves a three-step process: (1) identification of a receptive endometri...

journal_title：Endocrinology

authors： Ashary N,Tiwari A,Modi D

更新日期：2018-02-01 00:00:00

abstract：:We have investigated the possibility that IGF-1 may play a role in the regulation of antler development. Plasma IGF-1 concentrations were measured throughout the first period of development of the pedicle and first antler of red deer (Cervus elaphus) to determine whether a relationship existed between growth of antler...

journal_title：Endocrinology

authors： Suttie JM,Gluckman PD,Butler JH,Fennessy PF,Corson ID,Laas FJ

更新日期：1985-02-01 00:00:00

abstract：:This study tested the hypothesis that in the female sheep, a short day (SD) breeder, puberty can occur normally in the absence of ambient short days. More specifically, the photoperiod cue timing the transition into adulthood is exposure to and then termination of a long day melatonin rhythm. Control lambs born in the...

journal_title：Endocrinology

authors： Foster DL,Ebling FJ,Claypool LE,Woodfill CJ

更新日期：1988-09-01 00:00:00

abstract：:Mice lacking steroid 5 alpha-reductase 1 and 2 were produced by gene targeting and breeding. Male mice without 5 alpha-reductase 2 or without both enzymes had fully formed internal and external genitalia and were fertile, but had smaller prostates and seminal vesicles than controls. T accumulated to high levels in the...

journal_title：Endocrinology

authors： Mahendroo MS,Cala KM,Hess DL,Russell DW

更新日期：2001-11-01 00:00:00

abstract：:The conceptus and endometrium secrete large amounts of prostaglandin E₂ (PGE₂) into the porcine uterine lumen during the periimplantation period. We hypothesized that PGE₂ acts on conceptus/trophoblast cells through auto- and paracrine mechanisms. Real-time RT-PCR analysis revealed that PGE₂ receptor (PTGER)2 mRNA was...

journal_title：Endocrinology

authors： Waclawik A,Kaczynski P,Jabbour HN

更新日期：2013-10-01 00:00:00

abstract：:To assess a potential underlying rhythm in the sensitivity of the pregnant primate myometrium to oxytocin we infused five pregnant rhesus monkeys (gestational age, 121-142 days) with oxytocin at three different periods of the 24-h day, in the order night, afternoon, and morning, via the maternal inferior vena cava. Ox...

journal_title：Endocrinology

authors： Honnebier MB,Myers T,Figueroa JP,Nathanielsz PW

更新日期：1989-09-01 00:00:00

abstract：:Swine granulosa cells cultured under serum-free conditions in vitro exhibit significant responsivity to the stimulatory actions of estradiol (E2) and FSH or LH. Under these conditions, granulosa cells harvested from either immature or mature Graafian follicles synthesized significantly increased quantities of progeste...

journal_title：Endocrinology

authors： Veldhuis JD,Gwynne JT,Strauss JF 3rd,Demers LM

更新日期：1984-06-01 00:00:00

abstract：:Although estrogens and estrogen receptors (ERs) are known to function in the male brain and reproductive tract, few studies have evaluated their involvement in the male hematopoietic and immune systems. This study was undertaken to determine the role of ERalpha in hematopoietic progenitor and B lymphocyte maturation. ...

journal_title：Endocrinology

authors： Thurmond TS,Murante FG,Staples JE,Silverstone AE,Korach KS,Gasiewicz TA

更新日期：2000-07-01 00:00:00

abstract：:Primary cultures of enzymatically dispersed rat anterior pituitary cells were used to examine the effect of pure 31 kilodalton bovine inhibin on GnRH-induced up-regulation of GnRH binding sites. After 2 days in culture, the cells were exposed to stimuli with or without test substances for 10 h, followed by evaluation ...

journal_title：Endocrinology

authors： Wang QF,Farnworth PG,Findlay JK,Burger HG

更新日期：1989-01-01 00:00:00

abstract：:Macrophages are known to release a lipophilic factor that stimulates testosterone production by Leydig cells. This macrophage-derived factor (MDF) is thought to be physiologically relevant, because removal of macrophages from the testis results in altered testosterone secretion and reduced fertility. The purpose of th...

journal_title：Endocrinology

authors： Nes WD,Lukyanenko YO,Jia ZH,Quideau S,Howald WN,Pratum TK,West RR,Hutson JC

更新日期：2000-03-01 00:00:00

abstract：:Male rats of five different strains (Simonsen albino, Wistar, Long-Evans, Holtzman Sprague-Dawley, and Charles River Sprague-Dawley) were tested for their response to the U.S. Biochemical Corp. Remington low iodine diet containing 15-18 microgram I/kg. Measurements made after the diet had been fed for 28-30 days indic...

journal_title：Endocrinology

authors： Okamura K,Taurog A,Krulich L

更新日期：1981-08-01 00:00:00

abstract：:Oxytocin (OT) is a hypothalamic nonapeptide that is synthesized as part of a larger precursor protein that also contains an approximately 10-kDa protein called neurophysin at its C-terminus. This precursor protein is trafficked through the regulated secretory pathway into secretory granules and then axonally transport...

journal_title：Endocrinology

authors： Zhang BJ,Kusano K,Zerfas P,Iacangelo A,Young WS 3rd,Gainer H

更新日期：2002-03-01 00:00:00

abstract：:Prolonged stimulation of cells by beta-adrenergic receptor agonists may lead to diminished responsiveness of the cells to subsequent activation by catecholamines. This phenomenon has been termed desensitization; the mechanism(s) for desensitization may involve an apparent loss in the number of beta-adrenergic receptor...

journal_title：Endocrinology

authors： Tsujimoto G,Manger WM,Hoffman BB

更新日期：1984-04-01 00:00:00

abstract：:In rat uterus and prostate, 7 alpha, 17 alpha-dimethyl-19-nortestosterone (DMNT) binds to the androgen receptor specifically and with high affinity. However, this steroid does not bind to glucocorticoid receptors, since it does not displace binding of [3H]triamcinolone acetonide in calf thymus cytosol. In calf uterine...

journal_title：Endocrinology

authors： Traish AM,Müller RE,Wotiz HH

更新日期：1986-04-01 00:00:00

abstract：:We previously characterized the transcriptional activity of the human CRH (hCRH) gene promoter in the mouse anterior pituitary cell line AtT20. Here, we show that phorbolester stimulated through the cAMP response element (CRE), located between -227 and -220 relative to the putative cap site, about 2.6-fold the express...

journal_title：Endocrinology

authors： Van LP

更新日期：1993-01-01 00:00:00

abstract：:Bone morphogenetic protein (BMP)-4 is a key mediator of anterior pituitary organogenesis. However, through inappropriate expression patterns, BMP-4 is also pathogenic in a pituitary adenoma subtype-specific context. In these cases, increase or decrease in BMP-4 in lactotroph- and corticotroph-derived adenomas, respect...

journal_title：Endocrinology

authors： Yacqub-Usman K,Duong CV,Clayton RN,Farrell WE

更新日期：2012-08-01 00:00:00

abstract：:Glucose stimulation of pancreatic beta-cells triggers electrical activity (slow waves of membrane potential with superimposed spikes) that is best monitored with intracellular microelectrodes. Closure of ATP-sensitive K+ channels underlies the depolarization to the threshold potential and participates in the increase ...

journal_title：Endocrinology

authors： Henquin JC

更新日期：1998-03-01 00:00:00