Variation in myometrial response to intravenous oxytocin administration at different times of the day in the pregnant rhesus monkey.

abstract：:At micromolar (pharmacological) concentrations, the action of tamoxifen on the proliferation of estrogen-dependent cells can be mediated not only by the estrogen receptor (ER), but also by other target molecules, such as protein kinase-C (PKC), which are easily inhibited by antiestrogens in cell-free experiments. By d...

journal_title：Endocrinology

authors： Astruc ME,Chabret C,Bali P,Gagne D,Pons M

更新日期：1995-03-01 00:00:00

abstract：:Progesterone (P(4)) signaling is critical for pregnancy. We previously showed that immunopilin FK506 binding protein (FKBP)52 serves as a cochaperone to optimize progesterone receptor (PR) function in the uterus, and its deficiency leads to P(4) resistance in a pregnancy stage-specific and genetic background-dependent...

journal_title：Endocrinology

authors： Hirota Y,Burnum KE,Acar N,Rabinovich GA,Daikoku T,Dey SK

更新日期：2012-05-01 00:00:00

abstract：:The glycoprotein FSH, a product of pituitary gonadotrope cells, regulates ovarian follicle development in females and spermatogenesis in males. FSH is a heterodimer of the common α gonadotropin subunit and the hormone-specific FSHβ subunit (a product of the Fshb gene). Using a conditional knockout approach (Cre-lox), ...

journal_title：Endocrinology

authors： Li Y,Schang G,Wang Y,Zhou X,Levasseur A,Boyer A,Deng CX,Treier M,Boehm U,Boerboom D,Bernard DJ

更新日期：2018-07-01 00:00:00

abstract：:We have recently reported that pretreatment with electroacupuncture (EA) at stomach meridian point 36 (St36) prevents the chronic cold-stress increase in the hypothalamus-pituitary-adrenal axis (HPA), an action that may be under central control. Given that treatment for stress-related symptoms usually begins after ons...

journal_title：Endocrinology

authors： Eshkevari L,Mulroney SE,Egan R,Lao L

更新日期：2015-10-01 00:00:00

abstract：:The antithyroid drug 6-propylthiouracil (PTU) was previously shown in our laboratory to have an unexpectedly prolonged inhibitory effect on iodination in the thyroid glands of rats. Eighteen hours after injection of a relatively small dose, iodination in the thyroid remained inhibited by more than 90%. We previously s...

journal_title：Endocrinology

authors： Taurog A,Dorris ML

更新日期：1989-06-01 00:00:00

abstract：:Breast cancer incidence increases in women receiving combined estrogen and progesterone therapy. Breast tumors show increased expression of the glucose transporter GLUT1. We determined the effect of these hormones on GLUT1-4 expression and deoxyglucose transport in ZR-75-1 breast cancer cells. Immunoblotting, immunocy...

journal_title：Endocrinology

authors： Medina RA,Meneses AM,Vera JC,Guzman C,Nualart F,Astuya A,García MA,Kato S,Carvajal A,Pinto M,Owen GI

更新日期：2003-10-01 00:00:00

abstract：:The 3'5'-cyclic GMP (cGMP) pathway is known to influence ovarian functions, including steroidogenesis, ovulation, and granulosa cell proliferation. We show here that cGMP-phosphodiesterase (PDE) activity increased in a gonadotropin-dependent manner more than 3-fold in the cumulus-oocyte complex (COC) after 24 h in vit...

journal_title：Endocrinology

authors： Sasseville M,Côté N,Gagnon MC,Richard FJ

更新日期：2008-11-01 00:00:00

abstract：UNLABELLED:Triple A syndrome is a rare, autosomal recessive cause of adrenal failure. Additional features include alacrima, achalasia of the esophageal cardia, and progressive neurodegenerative disease. The AAAS gene product is the nuclear pore complex protein alacrima-achalasia-adrenal insufficiency neurological disor...

journal_title：Endocrinology

authors： Prasad R,Metherell LA,Clark AJ,Storr HL

更新日期：2013-09-01 00:00:00

abstract：:Somatostatin-like immunoreactivity (SRIF-LI) has previously been demonstrated immunohistochemically in rat thyroid parafollicular cells. Studies were therefore performed to determine whether SRIF-LI was present in a transplantable medullary carcinoma of the thyroid (MCT) in the WAG/Rij strain of rat. SRIF-LI was found...

journal_title：Endocrinology

authors： Berelowitz M,Cibelius M,Szabo M,Frohman LA,Epstein S,Bell NH

更新日期：1980-11-01 00:00:00

abstract：:A midregion fragment of PTH-related protein (PTHrP), which is intensively conserved across species, has been identified as a secretory product of several different cell types, including keratinocytes and squamous carcinomas. As recent data suggest that a midregion PTHrP fragment may be biologically active, we hypothes...

journal_title：Endocrinology

authors： Orloff JJ,Ganz MB,Nathanson MH,Moyer MS,Kats Y,Mitnick M,Behal A,Gasalla-Herraiz J,Isales CM

更新日期：1996-12-01 00:00:00

abstract：:In rat uterus and prostate, 7 alpha, 17 alpha-dimethyl-19-nortestosterone (DMNT) binds to the androgen receptor specifically and with high affinity. However, this steroid does not bind to glucocorticoid receptors, since it does not displace binding of [3H]triamcinolone acetonide in calf thymus cytosol. In calf uterine...

journal_title：Endocrinology

authors： Traish AM,Müller RE,Wotiz HH

更新日期：1986-04-01 00:00:00

abstract：:Treatment of rat islets with the cytokine IL-1 results in the inhibition of mitochondrial function and insulin secretion, events that are mediated by beta-cell expression of iNOS [inducible nitric oxide (NO) synthase] and production of NO. beta-Cells recover from the inhibitory actions of NO, produced following 24 h i...

journal_title：Endocrinology

authors： Scarim AL,Nishimoto SY,Weber SM,Corbett JA

更新日期：2003-08-01 00:00:00

abstract：:Pulmonary alveolar type 2 cells act as a reservoir of stem cells which can be induced to proliferate during periods of lung growth and repair after lung injury. Despite the importance of this process, the mechanisms that regulate type 2 cell proliferation have not been well characterized. We show in this study that in...

journal_title：Endocrinology

authors： Mouhieddine OB,Cazals V,Maitre B,Le Bouc Y,Chadelat K,Clement A

更新日期：1994-07-01 00:00:00

abstract：:In rodents, soluble leptin receptor (SLR) may be generated by alternative splicing of ObR mRNA and/or as a cleavage product of ObR membrane-anchored receptors. In this study, we investigated the contribution of both processes on the generation of SLR in 3-, 8-, and 24-month-old Wistar rats fed ad libitum (AL) or under...

journal_title：Endocrinology

authors： Gallardo N,Arribas C,Villar M,Ros M,Carrascosa JM,Martínez C,Andrés A

更新日期：2005-11-01 00:00:00

abstract：:Control of trabecular bone volume is mediated by local events. Recently, it has been shown that the cytokines interleukin-1 (IL-1), tumor necrosis factor alpha (TNF alpha), and TNF beta [also called lymphotoxin (LT)] produced by immune cells all stimulate osteoclast activity, whereas the lymphokine interferon-gamma (I...

journal_title：Endocrinology

authors： Smith DD,Gowen M,Mundy GR

更新日期：1987-06-01 00:00:00

abstract：:Small amounts of TRH are present in the thyroid, and TRH has been shown in several studies to have a moderate direct inhibitory effect on TSH-stimulated thyroid hormone secretion. In a recent publication, however, data were presented to demonstrate that very low doses of TRH given in short pulses induce immediate incr...

journal_title：Endocrinology

authors： Iversen E,Laurberg P

更新日期：1988-02-01 00:00:00

abstract：:Adult female transgenic mice expressing the human GH (hGH) gene with mouse metallothionein-I promoter are sterile. To evaluate the hypothalamic-pituitary function in these animals, adult female transgenic mice and nontransgenic normal littermates were ovariectomized. On days 7 and 8 after ovariectomy, mice were inject...

journal_title：Endocrinology

authors： Chandrashekar V,Bartke A,Wagner TE

更新日期：1992-04-01 00:00:00

abstract：:Ovarian steroids act on unidentified neurons to trigger preovulatory secretion of GnRH. In the rat, important steroid target cells reside in the anterior medial preoptic nucleus (AMPN), a sexually dimorphic structure essential for stimulatory effects of ovarian steroids on LH secretion. The AMPN contains neurotensin (...

journal_title：Endocrinology

authors： Alexander MJ,Dobner PR,Miller MA,Bullock BP,Dorsa DM,Leeman SE

更新日期：1989-10-01 00:00:00

abstract：:Thyroid hormone produces a prompt, plasma membrane-mediated increase in several metabolic functions in the rat thymocyte. These effects of thyroid hormone require calcium and are inhibited by the beta-adrenergic antagonist alprenolol. In the present study, the interrelationship between thyroid hormone and adrenergic a...

journal_title：Endocrinology

authors： Segal J

更新日期：1988-05-01 00:00:00

abstract：:We have investigated the possibility that IGF-1 may play a role in the regulation of antler development. Plasma IGF-1 concentrations were measured throughout the first period of development of the pedicle and first antler of red deer (Cervus elaphus) to determine whether a relationship existed between growth of antler...

journal_title：Endocrinology

authors： Suttie JM,Gluckman PD,Butler JH,Fennessy PF,Corson ID,Laas FJ

更新日期：1985-02-01 00:00:00

abstract：:CRF dose-dependently enhanced corticosterone (B) secretion by rat adrenal slices including both cortex and medulla. Conversely, CRF did not exert any B response by fragments of adrenocortical autotransplants, which are completely deprived of chromaffin tissue. However, autotransplant quarters exhibited a dose-dependen...

journal_title：Endocrinology

authors： Andreis PG,Neri G,Mazzocchi G,Musajo F,Nussdorfer GG

更新日期：1992-07-01 00:00:00

abstract：:In primary cultures of sheep pituitary cells extracellular nucleotides stimulated rapid increases in inositol tris- and bisphosphate, accompanied by intracellular Ca2+ mobilization. A similar stimulation of inositol phosphate production by extracellular nucleotides was observed in rat and baboon pituitary cells. The i...

journal_title：Endocrinology

authors： Davidson JS,Wakefield IK,Sohnius U,van der Merwe PA,Millar RP

更新日期：1990-01-01 00:00:00

abstract：:Previous studies have shown that mice missing gp130, the common receptor subunit for many cytokines, die at or before birth with multiple skeletal abnormalities. Furthermore, interactions between PTH and gp130 signaling have suggested that gp130 signaling might influence calcium homeostasis. We, therefore, examined th...

journal_title：Endocrinology

authors： Shin HI,Divieti P,Sims NA,Kobayashi T,Miao D,Karaplis AC,Baron R,Bringhurst R,Kronenberg HM

更新日期：2004-03-01 00:00:00

abstract：:A sensitive radioimmunoassay is described for the measurement of plasma concentrations of canine growth hormone (cGH) as low as 0.25 ng/ml. The assay utilizes enzymatically iodinated cGH and the double antibody technique. The mean plasma concentration of growth hormone in the normal dog after overnight fast is 1.75 pl...

journal_title：Endocrinology

authors： Hampshire J,Altszuler N,Steele R,Greene LJ

更新日期：1975-03-01 00:00:00

abstract：:In bone, early events in inflammation involve the production and release of primary proinflammatory cytokines, such as interleukin-1 beta. By activation of target cells, these cytokines are thought to induce a second wave of cytokines, including monocyte chemoattractant protein-1 (MCP-1). MCP-1 is a cytokine that stim...

journal_title：Endocrinology

authors： Rahimi P,Wang CY,Stashenko P,Lee SK,Lorenzo JA,Graves DT

更新日期：1995-06-01 00:00:00

abstract：:Insulin-like growth factors I and II (IGF-I and -II) are polypeptides secreted by skeletal cells and are considered regulators of bone formation. IGF-I and -II were studied for their effects on collagen synthesis and degradation in cultures of intact fetal rat calvariae and on type I collagen transcript levels in oste...

journal_title：Endocrinology

authors： McCarthy TL,Centrella M,Canalis E

更新日期：1989-01-01 00:00:00

abstract：:The lactogen-dependent rat Nb2 lymphoma is a useful model to investigate PRL signaling pathways that lead to regulation of gene transcription. A primary mechanism coupled to PRL receptor (PRLR) activation in Nb2 cells involves phosphorylation by Jak-family tyrosine kinases of one or more signal transducers and activat...

journal_title：Endocrinology

authors： Borg KE,Zhang M,Hegge D,Stephen RL,Buckley DJ,Magnuson NS,Buckley AR

更新日期：1999-12-01 00:00:00

abstract：:The inhibitory effect of stress on reproductive function is potentially mediated by high concentrations of circulating glucocorticoids (GCs) acting via the GC receptor (GR). Gonadotropin-inhibitory hormone (GnIH) is a hypothalamic neuropeptide that inhibits gonadotropin secretion. GnIH may mediate stress-induced repro...

journal_title：Endocrinology

authors： Son YL,Ubuka T,Narihiro M,Fukuda Y,Hasunuma I,Yamamoto K,Belsham DD,Tsutsui K

更新日期：2014-05-01 00:00:00

abstract：:A central step in the development and sexual differentiation of the brain is the intraneuronal conversion of testosterone to estrogen. This conversion is catalyzed by an enzyme complex comprised of cytochrome P450 aromatase and the ubiquitous NADPH-dependent cytochrome P450 reductase. Brain aromatase activity is devel...

journal_title：Endocrinology

authors： Lauber ME,Lichtensteiger W

更新日期：1994-10-01 00:00:00

abstract：:The primate brain was thought to contain only the GnRH known as mammalian GnRH (mGnRH). This study investigates whether a second form of GnRH exists within the primate brain. We found that brain extracts from adult stumptail and rhesus monkeys contained two forms of GnRH that were similar to mGnRH and chicken GnRH-II ...

journal_title：Endocrinology

authors： Lescheid DW,Terasawa E,Abler LA,Urbanski HF,Warby CM,Millar RP,Sherwood NM

更新日期：1997-12-01 00:00:00