Transforming growth factor-alpha is a potential mediator of estrogen action in the mouse uterus.

abstract：:In order to elucidate the putative role of inhibin in regulation of spermatogenesis, expression of inhibin subunits was examined at defined stages of the cycle of the rat seminiferous epithelium. Twenty 2-mm segments of seminiferous tubules at stages XIII-I, II-VI, VII-VIII, and IX-XII were dissected using the transil...

journal_title：Endocrinology

authors： Bhasin S,Krummen LA,Swerdloff RS,Morelos BS,Kim WH,diZerega GS,Ling N,Esch F,Shimasaki S,Toppari J

更新日期：1989-02-01 00:00:00

abstract：:We report here the desensitization and internalization of the relaxin receptor (RXFP1) after agonist activation in both primary human decidual cells and HEK293 cells stably transfected with RXFP1. The importance of beta-arrestin 2 in these processes has also been demonstrated. Thus, in HEK-RXFP1 cells the desensitizat...

journal_title：Endocrinology

authors： Kern A,Bryant-Greenwood GD

更新日期：2009-05-01 00:00:00

abstract：:Extensive remodeling of the follicular extracellular matrix occurs during the process of ovulation. This remodeling involves the breakdown of collagen, which is regulated, in part, by the action of the metalloproteinase collagenase and its associated inhibitors. In the present study, follicular metalloproteinase inhib...

journal_title：Endocrinology

authors： Curry TE Jr,Mann JS,Estes RS,Jones PB

更新日期：1990-07-01 00:00:00

abstract：:The neuroendocrine basis for short-day induced testicular regression was studied in Syrian hamsters of the LSH/Ss Lak strain. Adult animals were maintained either under long or short days (14:10D or 6L:18D, respectively) and given single, daily ip injections of N-methyl-D-aspartate (NMDA) (25 mg/kg BW); control animal...

journal_title：Endocrinology

authors： Urbanski HF

更新日期：1990-11-01 00:00:00

abstract：:Intact handled rats were pretreated with the immunoglobulin G fractions from normal rabbit serum or antisera to ovine corticotropin-releasing factor (CRF) and/or vasopressin and subjected to restraint or formalin stress. The formalin-induced rise in plasma ACTH was reduced to 28% in rats pretreated with anti-CRF, to 5...

journal_title：Endocrinology

authors： Linton EA,Tilders FJ,Hodgkinson S,Berkenbosch F,Vermes I,Lowry PJ

更新日期：1985-03-01 00:00:00

abstract：:Thyroid hormones (TH) are actively taken up into target cells via TH-transmembrane transporters (THTT). Their activity and expression patterns define a layer of endocrine regulation that is poorly understood. Therefore, THTT are potential targets for interfering agents (endocrine disruptors) as well as for pharmacolog...

journal_title：Endocrinology

authors： Jayarama-Naidu R,Johannes J,Meyer F,Wirth EK,Schomburg L,Köhrle J,Renko K

更新日期：2015-07-01 00:00:00

abstract：:The estrogen receptor (ER) mixed agonists tamoxifen and raloxifene have been shown to protect against bone loss in ovariectomized rats. However, the mechanism by which these compounds manifest their activity in bone is unknown. We have used a series of in vitro screens to select for compounds that are mechanistically ...

journal_title：Endocrinology

authors： Willson TM,Norris JD,Wagner BL,Asplin I,Baer P,Brown HR,Jones SA,Henke B,Sauls H,Wolfe S,Morris DC,McDonnell DP

更新日期：1997-09-01 00:00:00

abstract：:Maternal immune tolerance is required for extravillous trophoblasts (EVTs) to invade the decidua without rejection. Endoplasmic reticulum aminopeptidase-1 (ERAP1) generates human leukocyte antigen (HLA) class I-adapted antigenic peptides, but its function in trophoblasts lacking classical HLA class I molecules remains...

journal_title：Endocrinology

authors： Shido F,Ito T,Nomura S,Yamamoto E,Sumigama S,Ino K,Itakura A,Hattori A,Tsujimoto M,Mizutani S,Kikkawa F

更新日期：2006-04-01 00:00:00

abstract：:Although the pituitary-grafted rat is a classic model of chronic PRL excess, the presence of somatotropes in grafted pituitary tissue indicates a potential for GH secretion. The current study was designed to investigate GH-releasing hormone (GRH)-induced GH secretion and beta-adrenergic inhibition of GH release in ani...

journal_title：Endocrinology

authors： Krieg RJ Jr,Johnson JH,Adler RA

更新日期：1989-11-01 00:00:00

abstract：:Endotoxin has been shown to stimulate GH secretion in human and sheep. However, changes in hypothalamic neurohormones involved in the GH regulation by endotoxin have never been studied in vivo. In sheep it is possible to collect hypophysial portal blood (HPB) and quantify GH-releasing hormone (GHRH) and somatostatin (...

journal_title：Endocrinology

authors： Briard N,Guillaume V,Frachebois C,Rico-Gomez M,Sauze N,Oliver C,Dutour A

更新日期：1998-06-01 00:00:00

abstract：:We previously reported that interleukin-1alpha (IL-1alpha)-induced activation of protein kinase C (PKC) via phosphatidylcholine-specific phospholipase C (PC-PLC) limits IL-6 synthesis induced by IL-1alpha itself in osteoblast-like MC3T3-E1 cells. In the present study, we further investigated the mechanism behind IL-1a...

journal_title：Endocrinology

authors： Miwa M,Kozawa O,Tokuda H,Uematsu T

更新日期：1999-11-01 00:00:00

abstract：:Angiotensin II is one of the main physiological regulators of aldosterone biosynthesis in the zona glomerulosa of the adrenal cortex. The hormone stimulates intracellular cholesterol mobilization to the mitochondrion for steroid biosynthesis. Here we have examined whether angiotensin II also modulates exogenous lipopr...

journal_title：Endocrinology

authors： Cherradi N,Bideau M,Arnaudeau S,Demaurex N,James RW,Azhar S,Capponi AM

更新日期：2001-10-01 00:00:00

abstract：:To probe the possible role of endogenous opiates in Sertoli cell proliferation during testicular development, the effect of interfering with beta-endorphin action either in vivo or in vitro was determined. The percent of Sertoli cells dividing was measured with quantitative autoradiography in [methyl 3H]-thymidine-exp...

journal_title：Endocrinology

authors： Orth JM

更新日期：1986-10-01 00:00:00

abstract：:Incubation with T3 results in a dose-dependent increase in growth rate of cultured GC cells, a GH-producing rat pituitary tumor cell line. The T3-induced increase in growth rate results mainly from shortening of the G1 period from 79.4 +/- 4.3 (SD) h in cells grown in T3-depleted medium (-T3) to 10.0 +/- 0.9 h. This e...

journal_title：Endocrinology

authors： DeFesi CR,Fels EC,Surks MI

更新日期：1985-05-01 00:00:00

abstract：:GH receptor (GHR) mediates the anabolic and metabolic effects of GH. We previously characterized a monoclonal antibody (anti-GHR(ext-mAb)) that reacts with subdomain 2 of the rabbit GHR extracellular domain (ECD) and is a conformation-specific inhibitor of GH signaling in cells bearing rabbit or human GHR. Notably, th...

journal_title：Endocrinology

authors： Jiang J,Wan Y,Wang X,Xu J,Harris JM,Lobie PE,Zhang Y,Zinn KR,Waters MJ,Frank SJ

更新日期：2011-12-01 00:00:00

abstract：:Granulosa cells isolated from the ovaries of pregnant mare serum gonadotropin (PMSG)-treated immature rats were cultured with relaxin or FSH. Both hormones increased the secretion of plasminogen activator into the culture medium. Relaxin caused a dose-related rise in plasminogen activator but did not increase cAMP or ...

journal_title：Endocrinology

authors： Too CK,Weiss TJ,Bryant-Greenwood GD

更新日期：1982-10-01 00:00:00

abstract：:A variety of transcription factors including Wilms tumor gene (Wt-1), steroidogenic factor 1 (Sf-1), dosage-sensitive sex reversal, adrenal hypoplasia congenita on the X-chromosome, Gene 1 (Dax-1), and pre-B-cell transcription factor 1 (Pbx1) have been defined as necessary for regular adrenocortical development. Howev...

journal_title：Endocrinology

authors： Lichtenauer UD,Duchniewicz M,Kolanczyk M,Hoeflich A,Hahner S,Else T,Bicknell AB,Zemojtel T,Stallings NR,Schulte DM,Kamps MP,Hammer GD,Scheele JS,Beuschlein F

更新日期：2007-02-01 00:00:00

abstract：:Immunohistochemical localization of two estrogen receptor (ER) subtypes, ER beta and ER alpha, was performed in neonatal, early postnatal, immature, and adult rats to determine whether ER alpha and ER beta are differentially expressed in the ovary. ER beta and ER alpha were visualized using a polyclonal anti-ER beta a...

journal_title：Endocrinology

authors： Sar M,Welsch F

更新日期：1999-02-01 00:00:00

abstract：:GH is the major regulator of circulating IGF-I, which, in return, controls pituitary GH secretion by negative feedback. IGF-binding protein-1 (IGFBP-1) is believed to modify this feedback through its effects on free IGF-I. In the present study we investigated the potential influence of IGFBP-1 on GH secretion in the a...

journal_title：Endocrinology

authors： Cingel-Ristic V,Van Neck JW,Frystyk J,Drop SL,Flyvbjerg A

更新日期：2004-09-01 00:00:00

abstract：:A growing body of information now supports the existence of a complete intraovarian insulin-like growth Factor I (IGF-I) system replete with ligands, receptors, and binding protein(s). However, studies concerned with the regulation of ovarian IGF-I gene expression remain scarce. It was thus the objective of this commu...

journal_title：Endocrinology

authors： Botero LF,Roberts CT Jr,LeRoith D,Adashi EY,Hernandez ER

更新日期：1993-06-01 00:00:00

abstract：:Although estrogens and estrogen receptors (ERs) are known to function in the male brain and reproductive tract, few studies have evaluated their involvement in the male hematopoietic and immune systems. This study was undertaken to determine the role of ERalpha in hematopoietic progenitor and B lymphocyte maturation. ...

journal_title：Endocrinology

authors： Thurmond TS,Murante FG,Staples JE,Silverstone AE,Korach KS,Gasiewicz TA

更新日期：2000-07-01 00:00:00

abstract：:The effects of dopamine on PRL secretion and lysosomal enzyme activity in anterior pituitary tissue from rats selected during various stages of the estrous cycle were examined under in vitro conditions. During the estrous cycle, there was a marked variation in the capacity of dopamine to stimulate the activity of the ...

journal_title：Endocrinology

authors： Nansel DD,Gudelsky GA,Reymond MJ,Porter JC

更新日期：1981-03-01 00:00:00

abstract：:Recent research progress indicates a close link between ghrelin, a natural ligand of GH secretagogues receptor (GHS-R), and both the metabolic balance and body composition. To clarify the involvement of ghrelin and GHS-R in the process of adipogenesis, we measured the expression of GHS-R and peroxisome proliferator-ac...

journal_title：Endocrinology

authors： Choi K,Roh SG,Hong YH,Shrestha YB,Hishikawa D,Chen C,Kojima M,Kangawa K,Sasaki S

更新日期：2003-03-01 00:00:00

abstract：:3-Iodothyronamine (3-T 1 AM) and thyronamine (T AM) are novel endogenous signaling molecules that exhibit great structural similarity to thyroid hormones but apparently antagonize classical thyroid hormone (T(3)) actions. Their proposed biosynthesis from thyroid hormones would require decarboxylation and more or less ...

journal_title：Endocrinology

authors： Piehl S,Heberer T,Balizs G,Scanlan TS,Smits R,Koksch B,Köhrle J

更新日期：2008-06-01 00:00:00

abstract：:Steady state levels of plasma membrane receptors (measured in radioligand assays) result from processes that contribute to the production of receptors (synthesis, recycling, and unmasking) as well as those that contribute to the loss of receptors (degradation, internalization, and inactivation). Accordingly, we have p...

journal_title：Endocrinology

authors： Braden TD,Conn PM

更新日期：1990-05-01 00:00:00

abstract：:11 beta-hydroxysteroid dehydrogenase (11 beta-OHSD) is thought to confer aldosterone specificity to mineralocorticoid target cells by protecting the mineralocorticoid receptor from occupancy by endogenous glucocorticoids. We have recently described a novel isoform of 11-OHSD in the renal aldosterone target cells (11 b...

journal_title：Endocrinology

authors： Náray-Fejes-Tóth A,Fejes-Tóth G

更新日期：1995-06-01 00:00:00

abstract：:Transforming growth factor-alpha (TGF alpha) has been localized to the anterior pituitary, specifically to the lactotroph and somatotroph cell populations, by our previous studies. Since pituitary lactotrophs are known to undergo growth in response to estrogens, we have used an estradiol-induced pituitary hyperplasia/...

journal_title：Endocrinology

authors： Borgundvaag B,Kudlow JE,Mueller SG,George SR

更新日期：1992-06-01 00:00:00

abstract：:This study was undertaken to identify uterine insulin-like growth factor-I (IGF-I) receptors and examine the regulation of these receptors throughout the estrous cycle and after 17 beta-estradiol (E2) administration to immature rats. We have demonstrated type I IGF receptors in crude uterine membranes by binding and c...

journal_title：Endocrinology

authors： Ghahary A,Murphy LJ

更新日期：1989-08-01 00:00:00

abstract：:To examine the physiological effects of norepinephrine (NE) in the paraventricular nucleus of the hypothalamus (PVH) on CRF gene expression and CRF release, NE was microinjected bilaterally into the PVH of conscious rats, and kinetic studies were performed on the levels of POMC messenger RNA (mRNA) in the anterior pit...

journal_title：Endocrinology

authors： Itoi K,Suda T,Tozawa F,Dobashi I,Ohmori N,Sakai Y,Abe K,Demura H

更新日期：1994-11-01 00:00:00

abstract：:Osteoblasts are known to produce osteoclast-stimulating activity (OSA). The aim of the current study was to relate the expression of OSA to the osteoblastic phenotype and examine its regulation by calciotropic hormones. The study was performed with the normal osteoblastic cell clone CRP 10/30 and the preosteoblastic c...

journal_title：Endocrinology

authors： Collin P,Guenther HL,Fleisch H

更新日期：1992-09-01 00:00:00