Thyronamines are isozyme-specific substrates of deiodinases.

abstract：:The effects of continuous high GH levels on GH signal transduction through the GH receptor (GHR)/Janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) pathway as well as the desensitization of this pathway by suppressors of cytokine signaling (SOCS) were studied in transgenic mice overexpres...

journal_title：Endocrinology

authors： González L,Miquet JG,Sotelo AI,Bartke A,Turyn D

更新日期：2002-02-01 00:00:00

abstract：:Fibroblast growth factor (FGF) 21, a unique, largely liver-derived endocrine member of the FGF superfamily, is often thought of as a fasting factor owing to its induction in rodents during starvation. However, FGF21 is not increased by fasting for periods of <7 days in humans; instead, it rises sharply after acute alc...

journal_title：Endocrinology

authors： Gillum MP

更新日期：2018-05-01 00:00:00

abstract：:A midregion fragment of PTH-related protein (PTHrP), which is intensively conserved across species, has been identified as a secretory product of several different cell types, including keratinocytes and squamous carcinomas. As recent data suggest that a midregion PTHrP fragment may be biologically active, we hypothes...

journal_title：Endocrinology

authors： Orloff JJ,Ganz MB,Nathanson MH,Moyer MS,Kats Y,Mitnick M,Behal A,Gasalla-Herraiz J,Isales CM

更新日期：1996-12-01 00:00:00

abstract：:Glucose release from the liver is mediated by hypothalamic norepinephrine (NE) neuronal activity, but glucose itself (or a metabolite of it) exerts negative feedback effects on central NE activity. The aim of the present study was to investigate a possible role for insulin in these central glucose homeostatic mechanis...

journal_title：Endocrinology

authors： Smythe GA,Bradshaw JE,Nicholson MV,Grunstein HS,Storlien LH

更新日期：1985-10-01 00:00:00

abstract：:We have recently identified gonadotropes as target cells for ATP action via ATP receptors of the P2U subtype. The present studies have used gonadotrope-derived alpha T3-1 cells to examine the possible signaling mechanisms subserving ATP action in gonadotropes. Addition of ATP produced a biphasic intracellular Ca2+ (Ca...

journal_title：Endocrinology

authors： Chen ZP,Kratzmeier M,Poch A,Xu S,McArdle CA,Levy A,Mukhopadhyay AK,Lightman SL

更新日期：1996-01-01 00:00:00

abstract：:Intracellular cargo transport relies on microtubules and motor proteins such as kinesins and dyneins. Currently we have ample knowledge of the mechanisms by which motor proteins propel themselves along the microtubules, but little is known about intracellular factors that regulate motor speed. Here we show that proadr...

journal_title：Endocrinology

authors： Larráyoz IM,Martínez A

更新日期：2012-04-01 00:00:00

abstract：:Androgens act to stimulate spermatogenesis through androgen receptors (ARs) on the Sertoli cells and peritubular myoid cells. Specific ablation of the AR in either cell type will cause a severe disruption of spermatogenesis. To determine whether androgens can stimulate spermatogenesis through direct action on the peri...

journal_title：Endocrinology

authors： O'Shaughnessy PJ,Verhoeven G,De Gendt K,Monteiro A,Abel MH

更新日期：2010-05-01 00:00:00

abstract：:The objectives of this study were to investigate the presence of immunoreactive GnRH (irGnRH) in scleractinian coral, Euphyllia ancora, study its seasonal variation, and evaluate its biological activity. irGnRH was detected and quantified in coral polyps. The biological activity of coral irGnRH was tested on pituitary...

journal_title：Endocrinology

authors： Twan WH,Hwang JS,Lee YH,Jeng SR,Yueh WS,Tung YH,Wu HF,Dufour S,Chang CF

更新日期：2006-01-01 00:00:00

abstract：:In vitro antiglucocorticoids (cortexolone and progesterone) were evaluated as in vivo antagonists of dexamethasone-induced increases in liver tyrosine amino transferase (TAT; EC 2.6.1.5), tryptophan oxygenase (TPO; EC 1.13.1.12), and glycogen deposition. Cortexolone antagonized the TPO and glycogen responses to dexame...

journal_title：Endocrinology

authors： Naylor PH,Gilani SS,Milholland RJ,Rosen F

更新日期：1980-07-01 00:00:00

abstract：:In bone, early events in inflammation involve the production and release of primary proinflammatory cytokines, such as interleukin-1 beta. By activation of target cells, these cytokines are thought to induce a second wave of cytokines, including monocyte chemoattractant protein-1 (MCP-1). MCP-1 is a cytokine that stim...

journal_title：Endocrinology

authors： Rahimi P,Wang CY,Stashenko P,Lee SK,Lorenzo JA,Graves DT

更新日期：1995-06-01 00:00:00

abstract：:Luteinizing hormone/chorionic gonadotropin receptor (LHR) expression in the ovary is regulated by a messenger RNA (mRNA) binding protein, which specifically binds to the coding region of LHR mRNA. We have shown that miR-122, a short noncoding RNA, mediates LHR mRNA levels by modulating the expression of LHR mRNA-bindi...

journal_title：Endocrinology

authors： Menon B,Guo X,Garcia N,Gulappa T,Menon KMJ

更新日期：2018-05-01 00:00:00

abstract：:Nitrogenous compounds were studied for their effect on cGMP levels in the thyroid. Several agents, including sodium nitrite and hydroxylamine, could generate a rise of over 100-fold in cGMP. At a concentration of 20 mM, HN2OH and NaNO2 significantly reduced cAMP levels previously generated by 0.5 mU/ml TSH. If the sli...

journal_title：Endocrinology

authors： Spaulding SW

更新日期：1979-09-01 00:00:00

abstract：:Four 1-yr-old, i.e. immature, monkeys (M. fascicularis) were treated with testosterone. For the first 21 weeks, they received testosterone capsules sc; thereafter for the remainder of 1 yr, they received weekly injections of 125 mg testosterone enanthate. Four similarly aged monkeys served as untreated controls. The t...

journal_title：Endocrinology

authors： Marshall GR,Wickings EJ,Nieschlag E

更新日期：1984-06-01 00:00:00

abstract：:2,5-Hexanedione (2,5-HD) exposure in the rat produces irreversible testicular atrophy, a model of human male infertility that can be used for mechanistic and therapeutic studies. Following testicular injury by 2,5-HD, stem cell factor (SCF), a Sertoli cell-derived growth factor that binds the c-kit receptor on spermat...

journal_title：Endocrinology

authors： Blanchard KT,Lee J,Boekelheide K

更新日期：1998-01-01 00:00:00

abstract：:The scaffolding protein, protein targeting to glycogen (PTG), orchestrates the signaling of several metabolic enzymes involved in glycogen synthesis. However, little is known concerning the regulation of PTG itself. In this study, we have cloned and characterized the mouse promoter of PTG. We identified multiple FoxA2...

journal_title：Endocrinology

authors： Cheng A,Zhang M,Crosson SM,Bao ZQ,Saltiel AR

更新日期：2006-07-01 00:00:00

abstract：:Diets lacking soy and alpha-alpha derivatives that are considered to be estrogen-free by standard bioassays (uterotrophic assay and vaginal opening) have been revealed to contain considerable amounts of compounds able to transcriptionally activate the estrogen receptors (ERs) and stimulate luciferase expression in sev...

journal_title：Endocrinology

authors： Ciana P,Brena A,Sparaciari P,Bonetti E,Di Lorenzo D,Maggi A

更新日期：2005-12-01 00:00:00

abstract：:We have established immortalized human granulosa cells by triple transfection of primary cells obtained from in vitro fertilization patients with SV40 DNA, Ha-ras oncogene, and a temperature sensitive (ts) mutant of the tumor suppressor gene p53 (p53val135). Forty-one clones were isolated, and their steroidogenic resp...

journal_title：Endocrinology

authors： Hosokawa K,Dantes A,Schere-Levy C,Barash A,Yoshida Y,Kotsuji F,Vlodavsky I,Amsterdam A

更新日期：1998-11-01 00:00:00

abstract：:In fish spermatogenesis, the main action of progestins is generally regarded as the induction of sperm maturation. Our previous in vitro study demonstrated that a progestin, 17alpha,20beta-dihydroxy-4-pregnen-3-one (DHP), induced the initiation of meiosis in spermatogenesis in the Japanese eel (Anguilla japonica). In ...

journal_title：Endocrinology

authors： Ozaki Y,Higuchi M,Miura C,Yamaguchi S,Tozawa Y,Miura T

更新日期：2006-11-01 00:00:00

abstract：:The effects of GH and PTH on cancellous histomorphometry were determined in the proximal tibial metaphysis of hypophysectomized (HYPOX) sexually mature female rats. HYPOX resulted in uterine atrophy and a loss in body weight. Longitudinal bone growth ceased and bone formation was greatly reduced. There were decreases ...

journal_title：Endocrinology

authors： Schmidt IU,Dobnig H,Turner RT

更新日期：1995-11-01 00:00:00

abstract：:GH is secreted in a pulsatile manner, the pattern of which plays an important role in the regulation of growth and metabolism. Sex steroids are also known to participate in metabolic regulation. The present study was undertaken to elucidate the relationship between changes in GH pulsatility and metabolic transition du...

journal_title：Endocrinology

authors： Yonezawa T,Mogi K,Li JY,Sako R,Yamanouchi K,Nishihara M

更新日期：2005-06-01 00:00:00

abstract：:Most studies of lipoprotein requirements for steroid secretion by the adrenal have examined the mixed cell population of the whole gland; none have examined lipoprotein requirements of guinea pig adrenocortical cells. In this study the effect of exogenous lipoprotein on the ability of cells from each of the different ...

journal_title：Endocrinology

authors： Black VH

更新日期：1987-02-01 00:00:00

abstract：:The receptor for the orexigenic peptide, ghrelin, is one of the most constitutively active 7TM receptors known, as demonstrated under in vitro conditions. Change in expression of a constitutively active receptor is associated with change in signaling independent of the endogenous ligand. In the following study, we fou...

journal_title：Endocrinology

authors： Petersen PS,Woldbye DP,Madsen AN,Egerod KL,Jin C,Lang M,Rasmussen M,Beck-Sickinger AG,Holst B

更新日期：2009-11-01 00:00:00

abstract：:MCRs of testosterone (T) and 5 alpha-dihydrotestosterone (DHT) were determined in the morning and evening in four chronically chaired adult rhesus monkeys (Macaca mulatta) by means of steady state infusion of [4-14C]testosterone and [1,2-3H]dihydrotestosterone. Morning and evening MCRs were comparable for both T and D...

journal_title：Endocrinology

authors： Sholl SA,Toivola PT,Robinson JA

更新日期：1979-08-01 00:00:00

abstract：:We have recently identified, characterized, and cloned a luteal microsomal 32-kDa phosphoprotein that we named PRAP (for PRL-receptor associated protein), and we have demonstrated that PRAP binds to the intracellular domain of the short but not the long form of the PRL receptor. In this study, we used PRAP cDNA to exa...

journal_title：Endocrinology

authors： Duan WR,Parmer TG,Albarracin CT,Zhong L,Gibori G

更新日期：1997-08-01 00:00:00

abstract：:Tumor progression largely depends on blood supply and neovessel formation, and angiogenesis is emerging as a promising target for cancer therapy. Vascular endothelial growth factor (VEGF), a major proangiogenic molecule, stimulates angiogenesis via promoting endothelial proliferation, survival and migration. VEGF has ...

journal_title：Endocrinology

authors： Ye C,Feng C,Wang S,Wang KZ,Huang N,Liu X,Lin Y,Li M

更新日期：2004-02-01 00:00:00

abstract：:Even though functional CRH receptors have been identified in several brain regions by ligand binding, the identity of brain areas expressing the CRH receptor gene has not been described. The recent cloning of the rat CRH receptor gene has permitted us to conduct an in situ hybridization histochemistry study to localiz...

journal_title：Endocrinology

authors： Wong ML,Licinio J,Pasternak KI,Gold PW

更新日期：1994-11-01 00:00:00

abstract：:We have investigated the interaction between hypothalamic ACTH secretagogues and adrenocortical glucocorticoids in rat anterior pituitary tissue using an in vitro perifusion system. Repeated 5 min pulses of 41-residue CRF (CRF-41) or arginine vasopressin (AVP) were applied at 1 h intervals for up to 7 h. Administratio...

journal_title：Endocrinology

authors： Shipston MJ,Antoni FA

更新日期：1992-04-01 00:00:00

abstract：:Daily nocturnal (N) and diurnal (D) surges of PRL are characteristic of a pseudopregnancy (psp) induced by cervical stimulation (CS). These semicircadian surges persist for 13-14 days, after which time they cease, and psp ends. The purpose of this study was to describe the involvement of the ovarian steroids in the ma...

journal_title：Endocrinology

authors： Gorospe WC,Freeman ME

更新日期：1981-04-01 00:00:00

abstract：:Acute leptin increase as well as endogenous hyperleptinemia evoked by high-fat diets (HF) activate fatty acid metabolism in nonadipose tissues. This supports the notion that hyperleptinemia is pivotal to prevent/delay steatosis during periods of positive energy balance. We have previously shown that long-term HF spare...

journal_title：Endocrinology

authors： Guzmán-Ruiz R,Somoza B,Gil-Ortega M,Merino B,Cano V,Attané C,Castan-Laurell I,Valet P,Fernández-Alfonso MS,Ruiz-Gayo M

更新日期：2010-03-01 00:00:00

abstract：:MRL-lpr/lpr mice manifest a systemic lupus-like autoimmune disease. As part of this syndrome, the mice spontaneously develop autoimmune thyroiditis, which is morphologically and biochemically similar to human autoimmune thyroiditis. In this study we investigated whether thyroid tissue obtained from sites of chronic in...

journal_title：Endocrinology

authors： Green LM,Lazarus JP,LaBue M,Shah MM

更新日期：1995-08-01 00:00:00