Dopamine receptor activation inhibits estrogen-stimulated transforming growth factor-alpha gene expression and growth in anterior pituitary, but not in uterus.

abstract：:The present study was undertaken to investigate the effect of the Hyp mutation and diet-induced hyperparathyroidism on renal responsiveness to PTH and forskolin and to determine whether the renal brush border membrane phosphate transport defect is expressed in the vitamin D- and calcium-deficient Hyp mouse. Our result...

journal_title：Endocrinology

authors： Tenenhouse HS,Veksler A

更新日期：1986-03-01 00:00:00

abstract：:We report here the desensitization and internalization of the relaxin receptor (RXFP1) after agonist activation in both primary human decidual cells and HEK293 cells stably transfected with RXFP1. The importance of beta-arrestin 2 in these processes has also been demonstrated. Thus, in HEK-RXFP1 cells the desensitizat...

journal_title：Endocrinology

authors： Kern A,Bryant-Greenwood GD

更新日期：2009-05-01 00:00:00

abstract：:The metabolism of 25-hydroxycholesterol (25-OH-cholesterol) to progestins by mitochondria and dispersed cells prepared from ovaries of PMSG-hCG-primed rats was studied. Mitochondria converted [3H]25-OH-cholesterol into [3H]pregnenolone and [3H]progesterone. Unlabeled 25-OH-cholesterol also stimulated mitochondrial ste...

journal_title：Endocrinology

authors： Toaff ME,Schleyer H,Strauss JF 3rd

更新日期：1982-12-01 00:00:00

abstract：:Human pituitary prolactin (hPRL) contains a single major component. Upon iodination by a lactoperoxidase procedure approximately 50% of this component remains ulaltered in molecular size and net charge by the criteria of quantitative polyacrylamide gel electrophoresis (PAGE). Aminiotic fluid hPRL contains two componen...

journal_title：Endocrinology

authors： Rogol AD,Chrambach A

更新日期：1975-08-01 00:00:00

abstract：:We investigated the effects of the peripheral administration of 17 beta-estradiol (E2), estrone (E1), and the catecholestrogens, 2-hydroxyestradiol (2-OHE2) and 2-hydroxyestrone, (2-OHE1), on anterior pituitary gland PRL release in the prepuberal rat. Steroids in oil were injected sc into 25-day-old female and 35- to ...

journal_title：Endocrinology

authors： Rodriguez-Sierra JF,Blake CA

更新日期：1982-02-01 00:00:00

abstract：:High fat feeding is associated with impaired insulin action, an obese body composition, and down-regulation of glucose transporter-4 (GLUT4) expression in adipocytes. We recently showed that overexpression of GLUT4 selectively in adipocytes of transgenic mice using the aP2 (fatty acid-binding protein) promoter/enhance...

journal_title：Endocrinology

authors： Gnudi L,Tozzo E,Shepherd PR,Bliss JL,Kahn BB

更新日期：1995-03-01 00:00:00

abstract：:In the present study we have examined the effects of FSH, forskolin, and (Bu)2cAMP on messenger RNA (mRNA) levels for all known subunits of cAMP-dependent protein kinase in rat Sertoli cells, using newly developed complementary DNA (cDNA) probes. mRNAs for the three regulatory subunits [RI alpha, RII51, (RII beta), an...

journal_title：Endocrinology

authors： Oyen O,Sandberg M,Eskild W,Levy FO,Knutsen G,Beebe S,Hansson V,Jahnsen T

更新日期：1988-06-01 00:00:00

abstract：:Recently, California condors (Gymnogyps californianus) have been reintroduced to coastal regions of California where they feed on marine mammal carcasses. There is evidence that coastal-dwelling condors experience reproductive issues, such as eggshell thinning, likely resulting from exposure to endocrine-disrupting ch...

journal_title：Endocrinology

authors： Felton RG,Steiner CC,Durrant BS,Keisler DH,Milnes MR,Tubbs CW

更新日期：2015-12-01 00:00:00

abstract：:Androgens and estrogens play major roles in cell differentiation, cell growth, and peptide secretion in steroid target tissues. In addition to the binding of these hormones to their receptors, formation and metabolism are important in the action of steroids. Metabolism of the potent steroid hormones includes glucuroni...

journal_title：Endocrinology

authors： Turgeon D,Carrier JS,Lévesque E,Hum DW,Bélanger A

更新日期：2001-02-01 00:00:00

abstract：:FSH and IGF-I are both important determinants of testicular development and Sertoli cell function. The present studies were performed to determine the actions of FSH and IGF-I on PI3K/AKT protein kinase signaling in immature rat Sertoli cells. Primary cultures of rat Sertoli cells were prepared from 10-d-old rats. Aft...

journal_title：Endocrinology

authors： Khan SA,Ndjountche L,Pratchard L,Spicer LJ,Davis JS

更新日期：2002-06-01 00:00:00

abstract：:Gonadal differentiation is dependent upon a cascade of molecular and morphological events. Steroidogenic factor 1 (SF-1) and DAX-1 have been implicated in this process. A SF-1 binding site has been reported to be present on the DAX-1 gene. We therefore used immunocytochemistry to determine whether these two transcript...

journal_title：Endocrinology

authors： Majdic G,Saunders PT

更新日期：1996-08-01 00:00:00

abstract：:Historically, much of the research on health effects of environmental pollutants focused on ascertaining whether compounds were carcinogenic. More recent findings show that environmental contaminants also exert insidious effects by disrupting hormone action. Of particular concern are findings that developmental exposu...

journal_title：Endocrinology

authors： Petersen SL,Krishnan S,Hudgens ED

更新日期：2006-06-01 00:00:00

abstract：:Aggression enables individuals to obtain and retain limited resources. Studies of the neuroendocrine regulation of aggression have focused on territorial and reproductive contexts. By contrast, little is understood concerning the neuroendocrine regulation of aggression over other resources, such as food. Here, we deve...

journal_title：Endocrinology

authors： Fokidis HB,Prior NH,Soma KK

更新日期：2013-11-01 00:00:00

abstract：:LH treatment of isolated medium (3- to 7-mm) follicles from porcine ovaries stimulated pregnenolone synthesis by mitochondria isolated from these tissues. This LH stimulation of pregnenolone synthesis was observed regardless of whether exogenous cholesterol was added to the mitochondrial assay system, suggesting that ...

journal_title：Endocrinology

authors： Neymark MA,Bieszczad RR,Dimino MJ

更新日期：1984-02-01 00:00:00

abstract：:The multifunctional cytokine, transforming growth factor-beta (TGF beta), is found in many tissues in a latent or inactive form. The nature and composition of the latent complex can vary depending on tissue type. The release of active TGF beta from its latent complex is a potentially important mechanism for regulation...

journal_title：Endocrinology

authors： Bonewald LF,Oreffo RO,Lee CH,Park-Snyder S,Twardzik D,Mundy GR

更新日期：1997-02-01 00:00:00

abstract：:In the bovine ovary, thecal cells are the only cell type capable of expressing the CYP17 gene in response to LH. With the onset of ovulation and luteinization in the cow, there is complete loss of P450c17alpha expression. To characterize the molecular mechanisms involved in tissue-specific regulation of the CYP17 gene...

journal_title：Endocrinology

authors： Borroni R,Liu Z,Simpson ER,Hinshelwood MM

更新日期：1997-05-01 00:00:00

abstract：:The effects of short term (1-month) and life-long 60% ad libitum food restriction on the adrenocortical response to restraint stress were compared in young and aged Fischer 344 rats. In rats restricted for 1 month (study 1), the adrenocortical response differed as a function of age. In 8-month-old animals, the initial...

journal_title：Endocrinology

authors： Stewart J,Meaney MJ,Aitken D,Jensen L,Kalant N

更新日期：1988-10-01 00:00:00

abstract：:It is well established that TRH exerts a stimulatory effect on the secretion of both TSH and PRL. Clinically, hyperprolactinemia is usually present in hypothyroid women, but not men. In experimental studies, results vary because of the sexes, and treatments of animals differ. The purpose of this study was to further i...

journal_title：Endocrinology

authors： Pan JT,Chen CW

更新日期：1990-06-01 00:00:00

abstract：:Five studies are reported which were designed to define the effects of an estrogen and a progestogen, alone and in combination, on tissue concentrations (heart, kidney, and liver) of two trace metals (zinc, copper) and four bulk cations (sodium, potassium, calcium, magnesium). Male rats received Premarin (0.08 mg) and...

journal_title：Endocrinology

authors： Yunice AA,Lindeman RD

更新日期：1975-11-01 00:00:00

abstract：:Thyroid hormone and retinoic acid (RA) are essential for normal neural development in vivo, yet all in vitro differentiation strategies of embryonic stem (ES) cells use only RA. We developed a novel differentiation strategy of mouse ES cells using T(3). A dominant-negative knock-in point mutation (P398H) was introduce...

journal_title：Endocrinology

authors： Liu YY,Tachiki KH,Brent GA

更新日期：2002-07-01 00:00:00

abstract：:In preovulatory ovarian follicles, the oocyte is maintained in meiotic prophase arrest by natriuretic peptide precursor C (NPPC) and its receptor natriuretic peptide receptor 2 (NPR2). LH treatment results in the decrease of NPR2 guanylyl cyclase activity that promotes resumption of meiosis. We investigated the regula...

journal_title：Endocrinology

authors： Wang Y,Kong N,Li N,Hao X,Wei K,Xiang X,Xia G,Zhang M

更新日期：2013-09-01 00:00:00

abstract：:The response of fat tissue to GH or insulin-like growth factor I (IGF-I) differs between humans with hypopituitarism and those with exogenous obesity; the effects of combined GH and IGF-I administration have not been compared in these two situations. In GH-deficient dwarf rats (who have a primary GH deficiency), the e...

journal_title：Endocrinology

authors： Dubuis JM,Deal C,Tsagaroulis P,Clark RG,Van Vliet G

更新日期：1996-07-01 00:00:00

abstract：:The present work extends our previous report that the intracerebroventricular (i.c.v.) injection of interleukin-1beta(IL-1beta, 80 ng) significantly blunted the testosterone response to 1 U/kg human CG (hCG), an effect that we attributed to the stimulation of inhibitory pathways connecting the hypothalamus to the test...

journal_title：Endocrinology

authors： Ogilvie K,Rivier C

更新日期：1998-07-01 00:00:00

abstract：:After hormonal ablation, 90% of the secretory epithelial cells of the prostate undergo apoptosis, and the remaining cells are reorganized as the tissue is remodeled. Using differential display RT-PCR of total RNA extracted from the rat ventral prostate before and 4 days after castration, we have cloned and sequenced a...

journal_title：Endocrinology

authors： Morrissey C,Bennett S,Nitsche E,Guenette RS,Wong P,Tenniswood M

更新日期：1999-07-01 00:00:00

abstract：:Male rats, kept under a lighting condition of 14-h light, 10-h dark, were subjected to scheduled feeding regimens. Food was available either in the early light phase or the early dark phase. The 24-h rhythms of serum corticosterone and of N-acetylserotonin (NAS) and melatonin (MT) in the pineal and serum were determin...

journal_title：Endocrinology

authors： Ho AK,Burns TG,Grota LJ,Brown GM

更新日期：1985-05-01 00:00:00

abstract：:Incubation with T3 results in a dose-dependent increase in growth rate of cultured GC cells, a GH-producing rat pituitary tumor cell line. The T3-induced increase in growth rate results mainly from shortening of the G1 period from 79.4 +/- 4.3 (SD) h in cells grown in T3-depleted medium (-T3) to 10.0 +/- 0.9 h. This e...

journal_title：Endocrinology

authors： DeFesi CR,Fels EC,Surks MI

更新日期：1985-05-01 00:00:00

abstract：:The effects of retinoic acids (RAs) on development of seminal vesicles (SVs) of neonatal mice were investigated in vitro. SVs from 0-day-old male mice were cultured for 2-6 days in serum-free, chemically defined medium containing transferrin and BSA supplemented with 5alpha-dihydrotestosterone (DHT; 10(-8) M) and insu...

journal_title：Endocrinology

authors： Tanji N,Yokoyama M,Takeuchi M,Terada N,Dahiya R,Cunha GR

更新日期：1996-07-01 00:00:00

abstract：:The mineralocorticoid receptor (MR), a member of the nuclear receptor superfamily of transcription factors, is activated by aldosterone and mediates its natriferic action in tight epithelia. MR is also expressed in nonepithelial tissues. Importantly, it mediates the deleterious effects of inappropriately high aldoster...

journal_title：Endocrinology

authors： Aguilar-Sánchez C,Hernández-Díaz I,Lorenzo-Díaz F,Navarro JF,Hughes TE,Giraldez T,Alvarez de la Rosa D

更新日期：2012-07-01 00:00:00

abstract：:A side population (SP) has been identified in a number of tissues, where it typically represents a small population enriched in stem/progenitor cells. In this study we show that the adult mouse anterior pituitary (AP) also contains a characteristic SP displaying verapamil-sensitive Hoechst dye efflux capacity. A major...

journal_title：Endocrinology

authors： Chen J,Hersmus N,Van Duppen V,Caesens P,Denef C,Vankelecom H

更新日期：2005-09-01 00:00:00

abstract：:Synthesis of uteroglobin in rabbit uterine epithelial cells during early pregnancy is induced by progesterone and apparently suppressed by estrogen. To assess whether the steroid hormones exert regulatory effects on the expression of the uteroglobin gene, we performed transcriptional rate assays in endometrial nuclei ...

journal_title：Endocrinology

authors： Shen XZ,Tsai MJ,Bullock DW,Woo SL

更新日期：1983-03-01 00:00:00