Catecholestrogens and release of anterior pituitary gland hormones. II. Prolactin.

abstract：:The aim of our study was to isolate and identify novel proteins that are involved in the process of ovulation. To achieve this goal we used the technique of proteome analysis. Comparison of ovary protein patterns, obtained by high resolution two-dimensional gel electrophoresis from recombinant FSH (rFSH)- and rFSH + h...

journal_title：Endocrinology

authors： Brockstedt E,Peters-Kottig M,Badock V,Hegele-Hartung C,Lessl M

更新日期：2000-07-01 00:00:00

abstract：:The fragile X syndrome is the most frequent hereditary form of mental retardation. This X-linked disorder is, in most cases, caused by an unstable and expanding trinucleotide CGG repeat located in the 5'-untranslated region of the gene involved, the fragile X mental retardation 1 (FMR1) gene. Expansion of the CGG repe...

journal_title：Endocrinology

authors： Slegtenhorst-Eegdeman KE,de Rooij DG,Verhoef-Post M,van de Kant HJ,Bakker CE,Oostra BA,Grootegoed JA,Themmen AP

更新日期：1998-01-01 00:00:00

abstract：:An immunomodulatory role for LHRH was suggested when we reported the presence of immunoactive and bioactive LHRH and its mRNA in rat splenic and thymic lymphocytes. In this paper we report that human peripheral T-cells as well as its subsets CD4+ and CD8+ contained immunoactive and bioactive LHRH. Furthermore, analysi...

journal_title：Endocrinology

authors： Azad N,La Paglia N,Jurgens KA,Kirsteins L,Emanuele NV,Kelley MR,Lawrence AM,Mohagheghpour N

更新日期：1993-07-01 00:00:00

abstract：:The present study was undertaken to identify the mechanisms underlying the effect of insulin-like growth factor (IGF-I) on LH receptor in rat granulosa cells. Treatment with FSH, as expected, produced a substantial increase in LH receptor messenger RNA (mRNA) level, and concurrent treatment with increasing concentrati...

journal_title：Endocrinology

authors： Hirakawa T,Minegishi T,Abe K,Kishi H,Ibuki Y,Miyamoto K

更新日期：1999-11-01 00:00:00

abstract：:The plasma osteocalcin (OC) concentration correlates with histological parameters of bone formation and has been used as an index of osteoblast activity. Although the rate of OC synthesis is likely to be a major determinant of the plasma OC level, the contribution of other processes, for example, OC plasma clearance, ...

journal_title：Endocrinology

authors： Fortune CL,Farrugia W,Tresham J,Scoggins BA,Wark JD

更新日期：1989-06-01 00:00:00

abstract：:Leptin enhances the glucose utilization in most insulin target tissues and paradoxically decreases it in white adipose tissue (WAT), but knowledge of the mechanisms underlying the inhibitory effect of central leptin on the insulin-dependent glucose uptake in WAT is limited. After 7 d intracerebroventricular leptin tre...

journal_title：Endocrinology

authors： Bonzón-Kulichenko E,Fernández-Agulló T,Moltó E,Serrano R,Fernández A,Ros M,Carrascosa JM,Arribas C,Martínez C,Andrés A,Gallardo N

更新日期：2011-04-01 00:00:00

abstract：:The estrogen receptor (ER) mixed agonists tamoxifen and raloxifene have been shown to protect against bone loss in ovariectomized rats. However, the mechanism by which these compounds manifest their activity in bone is unknown. We have used a series of in vitro screens to select for compounds that are mechanistically ...

journal_title：Endocrinology

authors： Willson TM,Norris JD,Wagner BL,Asplin I,Baer P,Brown HR,Jones SA,Henke B,Sauls H,Wolfe S,Morris DC,McDonnell DP

更新日期：1997-09-01 00:00:00

abstract：:The iodothyronine deiodinases, D1, D2, and D3, all contain selenium (Se) in the form of selenocysteine at their active sites, and they play crucial roles in determining the circulating and intracellular levels of the active thyroid hormone (TH), T3. However, not only are serum T3 levels normal in Se-deficient rats but...

journal_title：Endocrinology

authors： Bates JM,Spate VL,Morris JS,St Germain DL,Galton VA

更新日期：2000-07-01 00:00:00

abstract：:The action of sex steroids on the growth and differentiation of target tissues requires the presence of specific intracellular receptors. We compared the distribution of cells containing estrogen receptor (ER) and/or progesterone receptor (PR) in rabbit uterus by immunohistochemistry using monoclonal antibodies direct...

journal_title：Endocrinology

authors： Zaino RJ,Clarke CL,Feil PD,Satyaswaroop PG

更新日期：1989-11-01 00:00:00

abstract：:A plasma fraction rich in thyroid hormone-binding globulin (hTBG, human thyropexin) was injected iv into rabbits in order to see whether thyroid hormone concentrations in plasma would increase by return of T3 and T4 from the extravascular space. For this purpose, both [125I]T3 and [131I]T4 were simultaneously injected...

journal_title：Endocrinology

authors： Wahl R,Schmidberger H,Fessler E,Heinzel W,Schenzle D,Bohner J,Kallee E

更新日期：1989-03-01 00:00:00

abstract：:Histamine has been shown to be involved in atherosclerosis and coronary heart disease. Little information is available regarding the effects of histamine on lipoprotein metabolism. In the current study, we investigated the effects of histamine on the expression of hepatic low density lipoprotein (LDL) receptors and on...

journal_title：Endocrinology

authors： Liao W,Rudling M,Angelin B

更新日期：1997-05-01 00:00:00

abstract：:Whole saliva collected from rat, mouse, and human sources was found to contain high concentrations of transforming growth factor-alpha (TGF alpha) when analyzed by RIA. The concentrations of TGF alpha in unstimulated human saliva (age, 30-45 yr; n = 10; 1.5 +/- 3.1 nM) was reduced with age (age, 55-70 yr; n = 10; 0.4 ...

journal_title：Endocrinology

authors： Humphreys-Beher MG,Macauley SP,Chegini N,van Setten G,Purushotham K,Stewart C,Wheeler TT,Schultz GS

更新日期：1994-02-01 00:00:00

abstract：:A detailed understanding of the mechanism of action of estrogen on bones is still lacking. The present study was designed to examine possible modulation by 17 beta-estradiol (E2) on the effects of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] and on vitamin D receptors (VDR) in the ROS 17/2.8 osteoblast-like cell line. Cell...

journal_title：Endocrinology

authors： Liel Y,Kraus S,Levy J,Shany S

更新日期：1992-05-01 00:00:00

abstract：:Commercially available preparations of natural porcine glucose-dependent insulinotropic polypeptide (GIP) were subjected to reverse phase HPLC. The material was found to give rise to 4 peaks which were characterized by HPLC-retention time and N-terminal sequence analysis. They represented: intact porcine GIP(1-42), 58...

journal_title：Endocrinology

authors： Schmidt WE,Siegel EG,Kümmel H,Gallwitz B,Creutzfeldt W

更新日期：1987-02-01 00:00:00

abstract：:The present studies were performed to determine whether the major biologically active metabolite of vitamin D3, 1,25-dihydroxycholecalciferol [1,25(OH)2D3], could influence the activities of rat colonic particulate guanylate cyclase and adenylate cyclase. To address these issues, colonocytes were harvested from Spragu...

journal_title：Endocrinology

authors： Khare S,Wilson DM,Tien XY,Dudeja PK,Wali RK,Sitrin MD,Brasitus TA

更新日期：1993-11-01 00:00:00

abstract：:There is growing international interest in how environmental conditions experienced during development can shape adult phenotypes and the extent to which such induced changes are adaptive. One physiological system that links an individual to changes in environmental circumstances during development is the hypothalamic...

journal_title：Endocrinology

authors： Spencer KA,Evans NP,Monaghan P

更新日期：2009-04-01 00:00:00

abstract：:To evaluate the possible existence of masked gonadotropin receptors in the corpus luteum, we characterized the effects of alcohols and neuraminidase on [125I]iodohuman LH binding to in vitro preparations of luteal tissue from the rhesus monkey and pseudopregnant rat. The presence of 1-8% (vol/vol) ethanol enhanced spe...

journal_title：Endocrinology

authors： Danforth DR,Stouffer RL

更新日期：1985-08-01 00:00:00

abstract：:Hepatic synthesis of alpha 2u-globulin and its mRNA in the male rat is dependent on androgen, glucocorticoid, T4, insulin, and GH. Some of these hormones may act directly on the liver, while others may influence alpha 2u-globulin synthesis through indirect physiological changes. In the present study the specific role ...

journal_title：Endocrinology

authors： Murty CV,Rao KV,Roy AK

更新日期：1987-11-01 00:00:00

abstract：:GH is the major regulator of circulating IGF-I, which, in return, controls pituitary GH secretion by negative feedback. IGF-binding protein-1 (IGFBP-1) is believed to modify this feedback through its effects on free IGF-I. In the present study we investigated the potential influence of IGFBP-1 on GH secretion in the a...

journal_title：Endocrinology

authors： Cingel-Ristic V,Van Neck JW,Frystyk J,Drop SL,Flyvbjerg A

更新日期：2004-09-01 00:00:00

abstract：:TRH is a potent stimulator of pituitary TSH release, but its function in the physiological regulation of thyroid activity is still controversial. The purpose of the present study was to investigate TRH and catecholamine secretion into hypophysial portal blood of hypothyroid and hyperthyroid rats, and in rats bearing p...

journal_title：Endocrinology

authors： Rondeel JM,de Greef WJ,van der Schoot P,Karels B,Klootwijk W,Visser TJ

更新日期：1988-07-01 00:00:00

abstract：:Neuropeptide Y (NPY) peptide concentrations in the arcuate nucleus have recently been shown to be modulated by gonadal steroids in the male rat. The present study was designed to determine whether NPY messenger RNA (mRNA)-synthesizing cells in the arcuate nucleus (Arc) of the male rat are regulated by testosterone (T)...

journal_title：Endocrinology

authors： Urban JH,Bauer-Dantoin AC,Levine JE

更新日期：1993-01-01 00:00:00

abstract：:The circadian rhythm of glucocorticoids affects diverse physiological systems, including stress responses and the coordination of rhythmic functions in peripheral and central tissues. Circadian clocks are considered to be important coordinators of glucocorticoid release and loss of the core clock component Brain and m...

journal_title：Endocrinology

authors： Dumbell R,Leliavski A,Matveeva O,Blaum C,Tsang AH,Oster H

更新日期：2016-11-01 00:00:00

abstract：:Recombinant interleukin-1 alpha and -beta (Il-1 alpha and -beta) have been evaluated for their abilities to stimulate ACTH and catecholamine secretion in the intact adult male rat. Additionally, the role of adrenergic-dependent pathways in mediating Il-1-induced ACTH release has been assessed. The iv or intracerebrove...

journal_title：Endocrinology

authors： Rivier C,Vale W,Brown M

更新日期：1989-12-01 00:00:00

abstract：:Stress-responsive neurons of the hypothalamic paraventricular nucleus (PVN) show functional plasticity and adapt to repeated restraint (RR) stress. To investigate whether neuronal adaptation to the homotypic stress also affects their response to a heterotypic stressor, we used in situ hybridization with intronic and e...

journal_title：Endocrinology

authors： Ma XM,Lightman SL,Aguilera G

更新日期：1999-08-01 00:00:00

abstract：:Although nicotinic cholinergic agonists have functional effects on PC 12 cells, radioligand-binding sites have not been detected. We, therefore, studied PC 12 cells incubated in the presence of nerve growth factor (NGF) and determined that specific [3H]nicotine-binding sites were induced approximately 2.5-fold in the ...

journal_title：Endocrinology

authors： Madhok TC,Sharp BM

更新日期：1992-02-01 00:00:00

abstract：:This study was designed to test the hypothesis that systemic immune challenge with endotoxin inhibits the reproductive axis centrally by suppressing GnRH pulsatile release into hypophyseal portal blood. Using alert, normally behaving, ovariectomized ewes, we sampled hypophyseal portal blood at 10-min intervals beginni...

journal_title：Endocrinology

authors： Battaglia DF,Bowen JM,Krasa HB,Thrun LA,Viguié C,Karsch FJ

更新日期：1997-10-01 00:00:00

abstract：:In the spiny dogfish (Squalus acanthias), germ cells and adjacent steroidogenic elements are topographically segregated within the testis according to stage of development. In the experiments reported here, we have taken advantage of this favorable anatomical arrangement to demonstrate stage-specific variations in ste...

journal_title：Endocrinology

authors： Callard GV,Pudney JA,Mak P,Canick JA

更新日期：1985-10-01 00:00:00

abstract：:Granulosa cells isolated from the ovaries of pregnant mare serum gonadotropin (PMSG)-treated immature rats were cultured with relaxin or FSH. Both hormones increased the secretion of plasminogen activator into the culture medium. Relaxin caused a dose-related rise in plasminogen activator but did not increase cAMP or ...

journal_title：Endocrinology

authors： Too CK,Weiss TJ,Bryant-Greenwood GD

更新日期：1982-10-01 00:00:00

abstract：:T(4) activation into T(3) is catalyzed by type 2 deiodinase (D2) in the brain. The rapid induction of D2 in astrocytes by transient brain ischemia has prompted us to explore the effects of hypoxia on D2 in cultures of astrocytes. Hypoxia (2.5% O(2)) of cultured astrocytes increased D2 activity, alone or in association...

journal_title：Endocrinology

authors： Lamirand A,Mercier G,Ramaugé M,Pierre M,Courtin F

更新日期：2007-10-01 00:00:00

abstract：:GH is believed to play a role in promoting insulin resistance in patients with diabetes and with GH excess. The means by which GH produces insulin resistance may be through direct suppression of glucose metabolism in target cells (insulin-independent) or by interfering with the ability of insulin to stimulate glucose ...

journal_title：Endocrinology

authors： Foster CM,Hale PM,Jing HW,Schwartz J

更新日期：1988-08-01 00:00:00