Abstract:
:Histamine has been shown to be involved in atherosclerosis and coronary heart disease. Little information is available regarding the effects of histamine on lipoprotein metabolism. In the current study, we investigated the effects of histamine on the expression of hepatic low density lipoprotein (LDL) receptors and on plasma lipoproteins in the rat. Injection of compound 48/80 (C48/80, a histamine releaser) or histamine reduced hepatic LDL receptor expression, but not LDL receptor messenger RNA levels. Oral administration of polymyxin B (an antiendotoxin antibiotic and a histamine releaser) before the injection of C48/80 or histamine did not attenuate their effects. Polymyxin B itself had effects similar to those of C48/80 and histamine on LDL receptors. These results suggest that the effects of histamine are not mediated by the induction of gut-derived endotoxemia. Histamine H2 agonists (dimaprit and impromidine), but not H1 agonists (2-methylhistamine and 2-thiazolylethylamine), also reduced hepatic LDL receptor expression. The suppressive effect of C48/80 on hepatic LDL receptor expression was not attenuated by either the H1 antagonist (chlorpheniramine) or the H2 antagonist (cimetidine). Administration of C48/80 also reduced plasma high density lipoprotein (HDL) cholesterol. The H1 antagonist (chlorpheniramine), but not the H2 antagonist (cimetidine), almost completely reversed the effect of C48/80 on plasma HDL cholesterol. In conclusion, histamine suppresses hepatic LDL receptor expression via a non-H1 receptor-mediated pathway, and histamine reduces plasma HDL cholesterol via an H1 receptor-mediated pathway.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Liao W,Rudling M,Angelin Bdoi
10.1210/endo.138.5.5115subject
Has Abstractpub_date
1997-05-01 00:00:00pages
1863-70issue
5eissn
0013-7227issn
1945-7170journal_volume
138pub_type
杂志文章相关文献
ENDOCRINOLOGY文献大全abstract::Effects of thyroidectomy on Fos-like immunoreactivity (IR) in the rat brain were examined using single and double-label immunocytochemical techniques. In particular, the possibility that Fos might be involved in thyroid hormone regulation of thyrotropin releasing hormone (TRH)-containing neurons located in the parvoce...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-129-6-3208
更新日期:1991-12-01 00:00:00
abstract::Antisera to porcine relaxin were produced in rabbits injected with different fractions that had been separated by polyacrylamide gel electrophoresis (PAGE). Analyses by agar double immunodiffusion demonstrated that the different fractions of relaxin separated by PAGE have similar antigenic sites and the individual fra...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-101-3-679
更新日期:1977-09-01 00:00:00
abstract::The BB/Wor rat develops spontaneous autoimmune diabetes mellitus and also frequently develops lymphocytic thyroiditis. To clarify the role of T cell lymphopenia and the major histocompatibility complex (MHC) in the development of these autoimmune disorders, we studied back-cross animals between the inbred thyroiditis ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.136.12.7588330
更新日期:1995-12-01 00:00:00
abstract::We have recently found that, in the frog adrenal gland, endozepines are present in chromaffin cells and we have shown that the triakontatetraneuropeptide TTN is a potent stimulator of corticosteroid secretion in vitro. In the present study, we have investigated the transduction mechanisms mediating the corticotropic e...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.141.1.7228
更新日期:2000-01-01 00:00:00
abstract::To determine whether 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] regulates PTH secretion, we have tested its effects in both short term incubations (30-120 min) and long term primary cell cultures (24-96 h) of bovine parathyroid cells. In short term incubations, 10(-11)-10(-7) M 1,25-(OH)2D3 had no consistent effect on PT...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-117-5-2114
更新日期:1985-11-01 00:00:00
abstract::The direct actions of kit-ligand/stem cell factor (KL) in developing ovarian follicles were investigated. Previous studies have shown that granulosa cells express KL that can support oocyte development. The current study demonstrates that KL can also act directly on theca cells to promote cellular growth and different...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.138.9.5368
更新日期:1997-09-01 00:00:00
abstract::In GH4C1 cells, membrane depolarization induces a rapid and sustained increase in the cytosolic free calcium concentration ([Ca2+]i). In the present study we have investigated the role of [Ca2+]i in the regulation of basal intracellular pH (pHi). Depolarizing GH4C1 cells in buffer containing 0.4 mM extracellular Ca2+ ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.130.2.1733720
更新日期:1992-02-01 00:00:00
abstract::Nitric oxide (NO) has emerged as a potent regulator useful in alleviating estrogen deficiency bone loss. Osteoprotegerin (OPG) and receptor activator of nuclear factor-kappaB ligand (RANKL) play important roles in regulating osteoclastogenesis. Although recent studies have reported NO donor attenuation of bone loss, t...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2003-1074
更新日期:2004-05-01 00:00:00
abstract::Little is known about the mechanisms of action of polypeptide hormones on chromatin structure and nuclear function. We have employed micrococcal nuclease to examine the effect of TSH on the accessibility of DNA in thyroid nuclei. Brief digestion of nuclear suspensions with 0.05-0.2 U/ml micrococcal nuclease at 26-28 C...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-110-6-2118
更新日期:1982-06-01 00:00:00
abstract::Previous studies showed that epidermal growth factor (EGF) and TGFalpha mimic the action of LH on the resumption of oocyte maturation. We tested whether EGF-like agents, such as amphiregulin (AR), epiregulin (ER), and betacellulin (BTC), also mediate the LH stimulation of the ovulatory response in the rat. LH induced ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2004-0588
更新日期:2005-01-01 00:00:00
abstract::The effects of nerve activation and of the catecholamines epinephrine and norepinephrine on adrenal corticosteroid release were investigated in intact isolated perfused pig adrenals with preserved nerve supply. To study the contact zones of medullary and cortical tissues, porcine adrenals were examined on the histolog...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-127-2-900
更新日期:1990-08-01 00:00:00
abstract::The central characteristic of uterine fibroids is excessive deposition of extracellular matrix (ECM), which contributes to fibroid growth and bulk-type symptoms. Despite this, very little is known about patterns of ECM protein expression in fibroids and whether these are influenced by the most common genetic anomalies...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-03018
更新日期:2018-02-01 00:00:00
abstract::Stat proteins are SH2 domain-containing transcription factors that are activated by various cytokines and growth factors. In a previous work, we have identified Stat 5B as a substrate of the insulin receptor based on yeast two-hybrid and mammalian cell transfection studies. In the present study, we have approached the...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.141.6.7496
更新日期:2000-06-01 00:00:00
abstract::Increased toxicant exposure and resultant environmentally induced diseases are a tradeoff of industrial productivity. Dioxin [2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD)], a ubiquitous byproduct, is associated with a spectrum of diseases including endometriosis, a common, chronic disease in women. TCDD activates cytoch...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-00860
更新日期:2018-01-01 00:00:00
abstract::The ALP1 [aci-reductone dioxygenase (ARD)-like protein 1] gene was identified in a comprehensive cDNA subtraction aimed at identifying genes regulated by androgens in the rat ventral prostate. ALP1 is homologous to the ARD/ARD' that were discovered in Klebsiella pneumoniae as enzymes that have the same polypeptide seq...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2003-0947
更新日期:2004-04-01 00:00:00
abstract::Glucocorticoids induce tyrosine aminotransferase (TAT) in hepatoma cells. We have previously shown that both the concentration of the agonist dexamethasone (Dex) required for half-maximal induction (EC50) and the amount of agonist activity produced by the antagonist dexamethasone 21-mesylate (Dex-Mes), expressed as a ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.130.4.1347740
更新日期:1992-04-01 00:00:00
abstract::Two receptors (CRH receptor type 1 and CRH receptor type 2) have been identified for the stress-induced neuropeptide, CRH and related peptides, urocortin, and urocortin II. We previously found marked down-regulation of cardiac CRH receptor type 2 expression following administration of bacterial endotoxin, lipopolysacc...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.142.8.8342
更新日期:2001-08-01 00:00:00
abstract::We have investigated the role of protein kinase C (PKC) isoenzymes in the differential growth regulation of human pancreatic carcinoma cell lines by all-trans retinoic acid (RA). RA treatment results in dose-dependent stimulation of anchorage-independent growth in AsPc1 cells and growth inhibition in Capan 2 cells. Bo...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.137.8.8754760
更新日期:1996-08-01 00:00:00
abstract::The structural requirements for the inhibition of net bone collagen synthesis by parathyroid hormone (PTH) in vitro have been examined by study of the effects of selected fragments and analogs of bovine PTH (bPTH) upon the incorporation of [3H]proline into collagenase-digestible and -nondigestible proteins by neonatal...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-108-1-103
更新日期:1981-01-01 00:00:00
abstract::Metastasis of various malignant cells is inversely related to the abundance of the Nm23-H1 protein. The role of estrogens in tumor metastasis has now been investigated by examining the effect of E2 on the expression of the Nm23-H1 gene. Three human breast carcinoma cell lines, in which endogenous ERalpha is expressed ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.143.2.8620
更新日期:2002-02-01 00:00:00
abstract::The purpose of this investigation was to use an approach targeted specifically on endogenous relaxin to determine the influence of relaxin on birth in the rat. To that end, a monoclonal antibody specific for rat relaxin, designated MCA1, was used to passively neutralize endogenous relaxin in intact pregnant rats. MCA1...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-123-5-2479
更新日期:1988-11-01 00:00:00
abstract::The dynamics of dopamine (DA) action on PRL release was studied in superfused rat anterior pituitary cell aggregates, cultured for for 5 days either in conventional or in serum-free defined medium. In aggregates cultured in conventional medium 0.1-1 nM DA applied for 20 min provoked a rapid and concentration-dependent...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-114-4-1371
更新日期:1984-04-01 00:00:00
abstract::Brain-derived neurotropic factor (BDNF) is a member of the nerve growth factor family that is important for neuronal survival and plasticity. We recently demonstrated that stress decreases BDNF messenger RNA (mRNA) levels in the hippocampus, which raises the possibility that BDNF may play a role in regulation of the h...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.136.9.7649080
更新日期:1995-09-01 00:00:00
abstract::The experimental induction of puberty by GnRH administration to prepubertal lambs increases serum bioactive FSH (B-FSH) as measured in the rat Sertoli cell aromatase induction bioassay. Serum immunoreactive FSH (I-FSH) levels are unchanged. The increase in serum B-FSH is associated with an increase in the proportion o...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.132.4.8462450
更新日期:1993-04-01 00:00:00
abstract::Both Snell (Pit-1(dw) or (dwj), dw/dw) and Ames (Prophet of Pit-1(df), df/df) dwarf mice fail to produce prolactin (PRL) as well as GH due to deficient transcription factor Pit-1 activity and have reduced numbers of hypothalamic PRL-inhibiting area A12 tuberoinfundibular dopaminergic (TIDA) neurons. It has been report...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2004-0931
更新日期:2004-12-01 00:00:00
abstract::The present study employed the dehydroepiandrosterone (DHA) loading test to determine if the placenta in baboons remains functional following fetectomy. A bolus iv injection of 100 mg DHA was given to 4 baboons prior to and at various intervals following fetectomy at midgestation. Blood samples were withdrawn over a 4...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-116-2-843
更新日期:1985-02-01 00:00:00
abstract::11 beta-Hydroxysteroid dehydrogenase (11 beta HSI) is an enzyme complex responsible for the conversion of hormonally active cortisol to inactive cortisone; two isoforms of the enzyme have been cloned and characterized. Clinical observations from patients with the hypertensive syndrome apparent mineralocorticoid excess...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.138.3.4994
更新日期:1997-03-01 00:00:00
abstract::Estrogens stimulate cell proliferation in typical estrogen-responsive tissues including the anterior pituitary gland. Here we report that 17-beta estradiol (E2) has estrogen receptor-mediated mitogenic and antimitogenic actions on rat lactotrophs in primary culture, depending on the cell context. E2 did not affect bas...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.143.7.8915
更新日期:2002-07-01 00:00:00
abstract::To determine the effect of aromatase inhibitors on peripheral aromatization, male rhesus monkeys were infused with [7-3H]androstenedione and [4-14C]estrone before and during treatment with 4-hdyroxy-androstene-3,17-dione (50 mg/kg each; four monkeys) or 4-acetoxy-androstene-3,17-dione (700 mg each; two monkeys). In al...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-106-1-19
更新日期:1980-01-01 00:00:00
abstract::Previous studies established a positive relationship between oocyte competence and follistatin mRNA abundance. Herein, we used the bovine model to test the hypothesis that follistatin plays a functional role in regulation of early embryogenesis. Treatment of early embryos with follistatin during in vitro culture (befo...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2008-1574
更新日期:2009-05-01 00:00:00