1,25-Dihydroxyvitamin D3 suppresses parathyroid hormone secretion from bovine parathyroid cells in tissue culture.

abstract：:Pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) is a neuropeptide related to vasoactive intestinal peptide-secretin-glucagon which stimulates adenylate cyclase in cultured rat pituitary cells and stimulates LH and FSH release in vitro and in vivo. Because the cAMP-protein kinase-A pathway regulates the...

journal_title：Endocrinology

authors： Tsujii T,Ishizaka K,Winters SJ

更新日期：1994-09-01 00:00:00

abstract：:Aberrant expression of ectopic G protein-coupled receptors (GPCRs) in adrenal cortex tissue has been observed in several cases of ACTH-independent macronodular adrenal hyperplasias and adenomas associated with Cushing's syndrome. Although there is clear clinical evidence for the implication of these ectopic receptors ...

journal_title：Endocrinology

authors： Mazzuco TL,Chabre O,Sturm N,Feige JJ,Thomas M

更新日期：2006-02-01 00:00:00

abstract：:Progesterone has the capacity to suppress hypothalamic dopaminergic neuronal activity on proestrous afternoon and prolong or amplify the preovulatory prolactin surge in rats. In the present study, we examined enzyme activity and phosphorylation state of tyrosine hydroxylase (TH) in the stalk-median eminence of cycling...

journal_title：Endocrinology

authors： Liu B,Arbogast LA

更新日期：2008-04-01 00:00:00

abstract：:GHRH stimulates GH secretion in chickens as in mammals. However, nothing is known about the chicken GHRH receptor (GHRH-R). Here we report the cDNA sequence of chicken GHRH-R. Comparison of the cDNA sequence with the chicken genome localized the GHRH-R gene to chicken chromosome 2 and indicated that the chicken GHRH-R...

journal_title：Endocrinology

authors： Porter TE,Ellestad LE,Fay A,Stewart JL,Bossis I

更新日期：2006-05-01 00:00:00

abstract：:Kisspeptin, encoded by the Kiss1 gene, binds to a specific G protein-coupled receptor (kisspeptin1 receptor) to regulate the central reproductive axis. Kisspeptin has also been reported to be expressed in peripheral tissues, including the testes. However, factors regulating testicular kisspeptin and its role in reprod...

journal_title：Endocrinology

authors： Salehi S,Adeshina I,Chen H,Zirkin BR,Hussain MA,Wondisford F,Wolfe A,Radovick S

更新日期：2015-04-01 00:00:00

abstract：:The present study investigated whether activation of the hexosamine biosynthesis pathway might mediate at least in part the high glucose effect on angiotensinogen (ANG) gene expression and immortalized renal proximal tubular cell (IRPTC) hypertrophy. IRPTC were cultured in monolayer. ANG, renin, and beta-actin mRNA ex...

journal_title：Endocrinology

authors： Hsieh TJ,Fustier P,Zhang SL,Filep JG,Tang SS,Ingelfinger JR,Fantus IG,Hamet P,Chan JS

更新日期：2003-10-01 00:00:00

abstract：:Variation in the onset of puberty among inbred strains of mice suggests that quantitative trait loci (QTLs) affect neurological and hormonal aspects of sexual maturation. Taking a novel approach toward identifying factors that regulate the hypothalamic-pituitary-gonadal (HPG) axis, we evaluated pubertal timing [as ass...

journal_title：Endocrinology

authors： Krewson TD,Supelak PJ,Hill AE,Singer JB,Lander ES,Nadeau JH,Palmert MR

更新日期：2004-10-01 00:00:00

abstract：:Canine renal cortical PTH receptors were solubilized after occupancy of membrane-associated receptors with the agonist ligand [125I]bovine (b) PTH-(1-34). Stabilization of binding during solubilization required the use of high concentrations of BSA (optimally 5%) and appropriate detergents (0.5% 3-[(3-cholamidopropyl)...

journal_title：Endocrinology

authors： Nissenson RA,Mann E,Winer J,Teitelbaum AP,Arnaud CD

更新日期：1986-03-01 00:00:00

abstract：:A basic somatomedin preparation results in a 2-fold stimulation of incorporation of both [3H]leucine into protein and 35SO4 into glycosaminoglycans by cultured chick sternal chondrocytes. The stimulation is seen in the presence of 20 mM 4-methylumbelliferyl-beta-D-xyloside alone but is not observable in the presence o...

journal_title：Endocrinology

authors： Kemp SF,Hintz RL

更新日期：1980-03-01 00:00:00

abstract：:Transcription activator-like effector nucleases (TALENs) are a powerful approach for targeted genome editing and have been proved to be effective in several organisms. In this study, we reported that TALENs can induce somatic mutations in Nile tilapia, an important species for worldwide aquaculture, with reliably high...

journal_title：Endocrinology

authors： Li MH,Yang HH,Li MR,Sun YL,Jiang XL,Xie QP,Wang TR,Shi HJ,Sun LN,Zhou LY,Wang DS

更新日期：2013-12-01 00:00:00

abstract：:To understand the physiological role of ghrelin, it is crucial to study both the actions of ghrelin and the regulation of ghrelin secretion. Although ghrelin actions have been extensively revealed, the direct factors regulating ghrelin secretion by ghrelin-producing cells (X/A-like cells), however, is not fully unders...

journal_title：Endocrinology

authors： Iwakura H,Ariyasu H,Hosoda H,Yamada G,Hosoda K,Nakao K,Kangawa K,Akamizu T

更新日期：2011-07-01 00:00:00

abstract：:It is known that the circadian rhythm in hepatic phosphoenolpyruvate carboxykinase expression (a limiting catalytic step of gluconeogenesis) and hepatic glucose production is maintained by both daily oscillation in autonomic inputs to the liver and night feeding behavior. However, increased glycemia and reduced melato...

journal_title：Endocrinology

authors： Nogueira TC,Lellis-Santos C,Jesus DS,Taneda M,Rodrigues SC,Amaral FG,Lopes AM,Cipolla-Neto J,Bordin S,Anhê GF

更新日期：2011-04-01 00:00:00

abstract：:Estrogen deficiency causes bone loss by increasing the number of bone-resorbing osteoclasts. Selective p38α MAPK inhibitors prevent bone-wasting effects of estrogen withdrawal but implicated mechanisms remain to be identified. Here, we show that inactivation of the p38α-encoding gene in osteoblast lineage cells with t...

journal_title：Endocrinology

authors： Thouverey C,Caverzasio J

更新日期：2015-12-01 00:00:00

abstract：:Previous experiments showed that LSH/SsLak female hamsters cease ovarian cyclicity after 2-4 weeks of short photoperiod (SP) treatment. This study was designed to reveal early hormonal and histological changes on day 1 of the estrous cycle (estrus) in SP-treated animals and changes brought about by the SP-induced acyc...

journal_title：Endocrinology

authors： Hauser UE,Benson B

更新日期：1987-01-01 00:00:00

abstract：:To evaluate the possible existence of masked gonadotropin receptors in the corpus luteum, we characterized the effects of alcohols and neuraminidase on [125I]iodohuman LH binding to in vitro preparations of luteal tissue from the rhesus monkey and pseudopregnant rat. The presence of 1-8% (vol/vol) ethanol enhanced spe...

journal_title：Endocrinology

authors： Danforth DR,Stouffer RL

更新日期：1985-08-01 00:00:00

abstract：:Sclerostin (SOST), a member of the cystine-knot superfamily, is essential for proper skeletogenesis because a loss-of-function mutation in the SOST gene results in sclerosteosis featured with massive bone growth in humans. To understand the function of SOST in developmental skeletal tissue formation, we examined SOST ...

journal_title：Endocrinology

authors： Ohyama Y,Nifuji A,Maeda Y,Amagasa T,Noda M

更新日期：2004-10-01 00:00:00

abstract：:Kisspeptins are hypothalamic neuropeptides encoded by KISS1 and recently described as major regulators of GnRH release from hypothalamic neurons. Although 17beta-estradiol (E2)-induced up-regulation of KISS1 expression has been documented in anteroventral periventricular nucleus neurons, E2 down-regulates KISS1 expres...

journal_title：Endocrinology

authors： Huijbregts L,de Roux N

更新日期：2010-08-01 00:00:00

abstract：:The binding characteristics of Sertoli Cell Factor (SCF) to the anterior pituitaries were examined using tissue homogenates and cultured cells. Tritium-labeled SCF (3H-SCF), synthesized by rat Sertoli cells in vitro in the presence of 3H-leucine and partly purified by Sephadex gel chromatography, was used to the ligan...

journal_title：Endocrinology

authors： Steinberger A,Seethalakshmi L,Kessler M,Steinberger E

更新日期：1982-08-01 00:00:00

abstract：:Agouti-related protein (AgRP) expressed in the arcuate nucleus is a potent orexigenic neuropeptide, which increases food intake and reduces energy expenditure resulting in increases in body weight (BW). Glucocorticoids, key hormones that regulate energy balance, have been shown in rodents to regulate the expression of...

journal_title：Endocrinology

authors： Shibata M,Banno R,Sugiyama M,Tominaga T,Onoue T,Tsunekawa T,Azuma Y,Hagiwara D,Lu W,Ito Y,Goto M,Suga H,Sugimura Y,Oiso Y,Arima H

更新日期：2016-04-01 00:00:00

abstract：:Studies were performed to characterize the identity of the factors present in calf serum that stimulate endothelin (ET) production by vascular endothelial cells in culture. Two putative candidates responsible for the ET-releasing activity present in serum are members of the transforming growth factor-beta (TGF beta) s...

journal_title：Endocrinology

authors： Brown MR,Vaughan J,Jimenez LL,Vale W,Baird A

更新日期：1991-11-01 00:00:00

abstract：:Pancreatic beta-cells and HIT-T15 cells exhibit oscillations of cytosolic calcium ([Ca2+]i) that are dependent on glucose metabolism and appear to trigger pulsatile insulin secretion. Significantly, differences in the pattern of this [Ca2+]i oscillatory activity may have important implications for our understanding of...

journal_title：Endocrinology

authors： Leech CA,Holz GG 4th,Habener JF

更新日期：1994-07-01 00:00:00

abstract：:Female rats were ovariectomized and either sham-pinealectomized or pinealectomized on day 24 of age and exposed to a photoperiod of 12 h light: 12 h dark. In vivo and in vitro measures of adrenocortical function were made at 6, 7, and 8 weeks of age (18, 25, and 32 days post-pinealectomy, respectively). Pinealectomy d...

journal_title：Endocrinology

authors： Ogle TF,Kitay JI

更新日期：1976-01-01 00:00:00

abstract：:Effect of cytosolic 3,5,3'-triiodo-L-thyronine (T3)-binding protein (CTBP) on [125I]T3 binding to nuclei was investigated in vitro. CTBP and nuclei were prepared from rat kidney. CTBP was inactivated by incubating with charcoal and activated by incubating with NADPH or with NADP and dithiothreitol. Two complexes of CT...

journal_title：Endocrinology

authors： Hashizume K,Miyamoto T,Kobayashi M,Suzuki S,Ichikawa K,Yamauchi K,Ohtsuka H,Takeda T

更新日期：1989-06-01 00:00:00

abstract：:The guinea pig adrenal cortex is grossly composed of two regions: an outer, yellow zone and an inner, brown zone. These zones, which represent 33% and 66% of the total adrenocortical volume, respectively, can be separated by blunt dissection. It has been previously reported that specific pregnenolone and pregnenolone ...

journal_title：Endocrinology

authors： Strott CA,Goff AK,Lyons CD

更新日期：1981-12-01 00:00:00

abstract：:The type 1 PTH/PTH-related peptide receptor (PTH1R) is a class B G protein-coupled receptor that demonstrates immunoreactivity in the nucleus as well as cytoplasm of target cells. Our previous studies on the PTH1R have shown that it associates with the importin family of transport regulatory proteins. To investigate t...

journal_title：Endocrinology

authors： Pickard BW,Hodsman AB,Fraher LJ,Watson PH

更新日期：2007-05-01 00:00:00

abstract：:In the present work we describe homologous desensitization of gonadotropin release from pituitary cells in response to short-term exposure to GnRH. Like the release process itself, desensitization requires receptor occupancy by an agonist. In contrast, however, inhibition of LH release by chelation of extracellular ca...

journal_title：Endocrinology

authors： Smith WA,Conn PM

更新日期：1983-01-01 00:00:00

abstract：:Dihydrotestosterone (DHT) concentration was measured in prostatic tissue obtained from castrate or intact beagles treated with androgens and/or estradiol-17 beta. Also DHT concentration was measured in prostatic tissue of beagles ranging from 0.7-9.2 yr; some with and others without spontaneously occurring benign pros...

journal_title：Endocrinology

authors： Ewing LL,Berry SJ,Higginbottom EG

更新日期：1983-12-01 00:00:00

abstract：:In vitro antiglucocorticoids (cortexolone and progesterone) were evaluated as in vivo antagonists of dexamethasone-induced increases in liver tyrosine amino transferase (TAT; EC 2.6.1.5), tryptophan oxygenase (TPO; EC 1.13.1.12), and glycogen deposition. Cortexolone antagonized the TPO and glycogen responses to dexame...

journal_title：Endocrinology

authors： Naylor PH,Gilani SS,Milholland RJ,Rosen F

更新日期：1980-07-01 00:00:00

abstract：:We previously reported that RU486 can reverse progesterone (P)-induced suppression of the estrogen receptor (ER) in the uterus of pregnant rhesus monkeys, but we did not determine whether estrogen (E) could act through its receptor in the presence of P and RU486. To pursue this question, we treated spayed rhesus monke...

journal_title：Endocrinology

authors： Slayden OD,Hirst JJ,Brenner RM

更新日期：1993-04-01 00:00:00

abstract：:In the rat a GH-binding protein (GHBP) exists that is derived from the GH receptor gene by an alternative messenger RNA splicing mechanism such that the transmembrane and intracellular domains of the GH receptor are replaced by a hydrophilic carboxy terminus. Previous immunohistochemical studies detailing the localiza...

journal_title：Endocrinology

authors： Lobie PE,García-Aragón J,Wang BS,Baumbach WR,Waters MJ

更新日期：1992-05-01 00:00:00