The action of somatomedin on glycosaminoglycan synthesis in cultured chick chondrocytes.

abstract：:Treatment of 5-day cyclic rats with 10 or 100 microgram estradiol benzoate on the day of estrus induced a luteal phase in all animals studied. On the other hand, an injection with 1 microgram estradiol benzoate given on the same day failed to induce pseudopregnancy. When 10 mg progesterone were injected on the day of ...

journal_title：Endocrinology

authors： de Greef WJ,Zeilmaker GH

更新日期：1979-07-01 00:00:00

abstract：:Angiotensin-II (Ang-II), K+, and ACTH are important stimulators of aldosterone secretion that require Ca2+ influx to be active. However, Ang-II and K+ are linked to the Ca2+ messenger system, while ACTH is coupled to the cAMP pathway. Peripheral-type binding sites for benzodiazepines are particularly abundant in stero...

journal_title：Endocrinology

authors： Python CP,Rossier MF,Vallotton MB,Capponi AM

更新日期：1993-04-01 00:00:00

abstract：:Rat reticulocytes contain a cytosol activator protein (RCAP) that augments hormone-sensitive adenylate cyclase activity in the rat reticulocyte and other systems. In a previous publication, using a highly purified preparation of RCAP, we reported that the stimulatory guanine nucleotide-binding protein (Ns) was require...

journal_title：Endocrinology

authors： Shane E,Yeh M,Feigin AS,Owens JM,Bilezikian JP

更新日期：1985-07-01 00:00:00

abstract：:Amiodarone, a potent antiarrhythmic drug, contains 37.2% iodine by weight and may induce either hypo- or hyperthyroidism. The high iodine content of amiodarone may be responsible for both complications, but a cytotoxic effect of the drug on the thyroid resulting in thyroiditis has been reported. In the present study t...

journal_title：Endocrinology

authors： Chiovato L,Martino E,Tonacchera M,Santini F,Lapi P,Mammoli C,Braverman LE,Pinchera A

更新日期：1994-05-01 00:00:00

abstract：:The effects of increasing concentrations of leucine (0.2, 2.0, and 15.0 mmol/liter) on glucagon secretion from the perfused rat pancreas were examined at various glucose levels (0, 3.3, or 8.3 mmol/liter) and in the absence or presence of either arginine (5.0 mmol/liter) or glutamine (10.0 mmol/liter). At a low glucos...

journal_title：Endocrinology

authors： Leclercq-Meyer V,Marchand J,Woussen-Colle MC,Giroix MH,Malaisse WJ

更新日期：1985-03-01 00:00:00

abstract：:In vivo and in vitro evidence indicates that FSH is a primary regulator of testicular inhibin production. However, recent reports suggest that LH may also promote inhibin secretion in vivo. To investigate whether LH regulates inhibin subunit messenger RNA (mRNA) expression as well, we examined the effects of hypophyse...

journal_title：Endocrinology

authors： Krummen LA,Morelos BS,Bhasin S

更新日期：1990-09-01 00:00:00

abstract：:Specific polyclonal antisera to the rat estrogen receptor (rER) were developed using a synthetic peptide as the antigen. The peptide corresponds to amino acids 270-284 deduced from the cloned rER cDNA and has no homology to other steroid hormone receptors. Antipeptide antisera raised in rabbits specifically recognize ...

journal_title：Endocrinology

authors： Furlow JD,Ahrens H,Mueller GC,Gorski J

更新日期：1990-09-01 00:00:00

abstract：:The GH/IGF-I axis has both pre- and postpubertal metabolic effects. However, the differential effects of GH and/or IGF-I on animal physiology or the plasma proteome are still being unraveled. In this report, we analyzed several physiological effects along with the plasma proteome after treatment of mice with recombina...

journal_title：Endocrinology

authors： Ding J,List EO,Bower BD,Kopchick JJ

更新日期：2011-10-01 00:00:00

abstract：:The regression of the tadpole tail is under the direct control of the thyroid hormones and offers a unique system for the study of the action of these hormones. We have examined the binding of L-triiodothyronine (T3) and L-thyroxine (T4) in vitro using tail fin bricks which included epidermal and connective cells. The...

journal_title：Endocrinology

authors： Yoshizato K,Kistler A,Frieden E

更新日期：1975-10-01 00:00:00

abstract：:Synthetic glucocorticoids (GCs), including dexamethasone (DEX), are powerful anti-inflammatory drugs. Long-term use of GCs, however, can result in metabolic side effects such as hyperglycemia, hepatosteatosis, and insulin resistance. The GC receptor (GR) and liver X receptors (LXRα and LXRβ) regulate overlapping genes...

journal_title：Endocrinology

authors： Patel R,Magomedova L,Tsai R,Angers S,Orellana A,Cummins CL

更新日期：2017-04-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is the most frequent chronic liver disease in the United States and is strongly associated with hepatic insulin resistance. We examined whether the thyroid hormone receptor-α (Thra) would be a potential therapeutic target to prevent diet-induced NAFLD and insulin resistance. Fo...

journal_title：Endocrinology

authors： Jornayvaz FR,Lee HY,Jurczak MJ,Alves TC,Guebre-Egziabher F,Guigni BA,Zhang D,Samuel VT,Silva JE,Shulman GI

更新日期：2012-02-01 00:00:00

abstract：:The present study assesses the relationship between G-proteins and protein kinase-C (PKC) in the gonadotrope. Cells were depleted of PKC with 1 microM phorbol 12-myristate 13-acetate for 12 h, followed by medium 199-BSA for 6 h before treatment with vehicle, pertussis toxin (PTX), cholera toxin (CTX), or (Bu)2cAMP (dB...

journal_title：Endocrinology

authors： Barnes SJ,Conn PM

更新日期：1993-12-01 00:00:00

abstract：:Estrogen formation is catalyzed by the aromatase cytochrome P450 (P450AROM) enzyme. Aromatase activity has been detected in several regions in the rat brain. In the present study, we used peptide-generated polyclonal antibodies raised against a 20-amino acid synthetic fragment of the rat P450AROM protein (as deduced f...

journal_title：Endocrinology

authors： Sanghera MK,Simpson ER,McPhaul MJ,Kozlowski G,Conley AJ,Lephart ED

更新日期：1991-12-01 00:00:00

abstract：:Previous experiments showed that LSH/SsLak female hamsters cease ovarian cyclicity after 2-4 weeks of short photoperiod (SP) treatment. This study was designed to reveal early hormonal and histological changes on day 1 of the estrous cycle (estrus) in SP-treated animals and changes brought about by the SP-induced acyc...

journal_title：Endocrinology

authors： Hauser UE,Benson B

更新日期：1987-01-01 00:00:00

abstract：:A member of the interferon-inducible p200 family of proteins, p204, has recently been reported to function in the development of many mesoderm-derived tissues, such as bone, muscle, and cartilage. However, no published study has yet investigated the role of p204 in adipogenesis. Our preliminary experiments showed that...

journal_title：Endocrinology

authors： Xiao J,Sun B,Cai GP

更新日期：2010-07-01 00:00:00

abstract：:Stimulation of rat granulosa cell aromatase activity by FSH has recently been used as a sensitive biological end point to develop an in vitro FSH bioassay. The present report provides a detailed validation and application of this assay. In the presence of androstenedione and diethylstilbestrol, FSH stimulated estrogen...

journal_title：Endocrinology

authors： Jia XC,Hsueh AJ

更新日期：1986-10-01 00:00:00

abstract：:The effects of FSH, hCG, and PRL on the activity of 20 alpha-hydroxysteroid dehydrogenase (20 alpha-SDH) of separate ovarian components of hypophysectomized, diethylstilbestrol-treated rats were studied. Enzyme activity was found to reside mainly in granulosa cells. FSH induced an increase in enzyme activity. A prepar...

journal_title：Endocrinology

authors： Eckstein B,Nimrod A

更新日期：1979-03-01 00:00:00

abstract：:Carbonyl cyanide trifluoromethoxyphenylhydrazone (FCCP), a protonophore, and methylamine, a weak base, agents that dissipate hydrogen gradients across cellular membranes, were used to probe the coupling of hydrogen gradients to the processing and secretion of the glycoprotein hormone hCG by human choriocarcinoma cells...

journal_title：Endocrinology

authors： Peters BP,Krzesicki RF,Perini F,Ruddon RW

更新日期：1986-07-01 00:00:00

abstract：:Androgens play a critical role in the development and progression of prostate cancer (PCa), and androgen deprivation therapy via surgical or medical castration is front-line therapy for patients with advanced PCa. However, intratumoral testosterone levels are elevated in metastases from patients with castration-resist...

journal_title：Endocrinology

authors： Cho E,Montgomery RB,Mostaghel EA

更新日期：2014-11-01 00:00:00

abstract：:We have examined the effects of a new synthetic inhibitor of mammalian tissue collagenase, CI-1 (N-[3-N-(benzyloxycarbonyl)amino-1-(R)carboxypropyl]L-leucyl-O-methyl-L- tyrosine N-methylamide; G. D. Searle SC 40827), and a general metalloproteinase inhibitor, 1,10-phenanthroline, on ovulation, as judged by the observa...

journal_title：Endocrinology

authors： Brännström M,Woessner JF Jr,Koos RD,Sear CH,LeMaire WJ

更新日期：1988-05-01 00:00:00

abstract：:We previously reported that interleukin-1alpha (IL-1alpha)-induced activation of protein kinase C (PKC) via phosphatidylcholine-specific phospholipase C (PC-PLC) limits IL-6 synthesis induced by IL-1alpha itself in osteoblast-like MC3T3-E1 cells. In the present study, we further investigated the mechanism behind IL-1a...

journal_title：Endocrinology

authors： Miwa M,Kozawa O,Tokuda H,Uematsu T

更新日期：1999-11-01 00:00:00

abstract：:The relationship between progesterone and prostaglandin (PG) secretion in the pseudopregnant rabbit corpus luteum was investigated using isolated in vitro perfused ovaries. Progesterone and PG secretion were measured on days 1, 11, and 18 of hCG-induced pseudopregnancy. The mean progesterone secretion increased signif...

journal_title：Endocrinology

authors： Dharmarajan AM,Sueoka K,Miyazaki T,Atlas SJ,Ghodgaonkar RB,Dubin NH,Zirkin BR,Wallach EE

更新日期：1989-03-01 00:00:00

abstract：:Thyroid hormones are essential for normal development and metabolism. Their synthesis requires transport of iodide into thyroid follicles. The mechanisms involving the apical efflux of iodide into the follicular lumen are poorly elucidated. The discovery of mutations in the SLC26A4 gene in patients with Pendred syndro...

journal_title：Endocrinology

authors： Pesce L,Bizhanova A,Caraballo JC,Westphal W,Butti ML,Comellas A,Kopp P

更新日期：2012-01-01 00:00:00

abstract：:Ghrelin is a growth hormone-releasing peptide recently discovered in the stomach of rat and human as an endogenous ligand for growth hormone-secretagogue receptor. In the present study, a full-length cDNA for mouse ghrelin has been cloned from the stomach using the oligo-capping and rapid amplification methods, and th...

journal_title：Endocrinology

authors： Tanaka M,Hayashida Y,Iguchi T,Nakao N,Nakai N,Nakashima K

更新日期：2001-08-01 00:00:00

abstract：:Two surges of PRL designated as nocturnal (N) and diurnal (D) are observed during early pregnancy. The present study was undertaken to determine the involvement of serotonin (5-HT) in regulating these PRL surges. On day 7 of pregnancy intracarotid catheters were implanted, and blood samples were obtained at 0200 and 0...

journal_title：Endocrinology

authors： Mistry A,Voogt JL

更新日期：1989-12-01 00:00:00

abstract：:Is it well known that LHRH agonists can inhibit testicular functions by gonadal desensitization secondary to endogenous LH release and that a direct action at the gonadal level has also been demonstrated. Since an excess of anti-LH serum can be used, as an alternative to hypophysectomy, to neutralize the influence of ...

journal_title：Endocrinology

authors： Séguin C,Bélanger A,Labrie F,Hansel W

更新日期：1982-02-01 00:00:00

abstract：:Although the extent of proptosis in exophthalmic Graves' disease has been measured directly and shown to correlate with serum content of a bioassayable exophthalmus-producing factor (EPS;1), a comparable relationship in an experimental model has not been reported. Progressive exophthalmos, measured from photographs an...

journal_title：Endocrinology

authors： Valk TW,Taylor RE Jr,Barker SB

更新日期：1975-01-01 00:00:00

abstract：:The level of fructose 2,6-bisphosphate (F2,6P2), a potent stimulator of 6-phosphofructo-1-kinase and inhibitor of fructose 1,6-bisphosphatase, was measured in three different muscle types (tensor fascia latae, biceps femoris, and soleus) and in the liver of normal and diabetic rats. The mean (+/- SEM) content of F2,6P...

journal_title：Endocrinology

authors： Dall'Aglio E,Reaven GM,Azhar S

更新日期：1986-01-01 00:00:00

abstract：:Mesenchymal stroma/stem cells (MSCs) exist in adult tissues, such as adipose tissue and bone marrow, and differentiate into cells of multiple lineages. In previous studies, we found that MSCs differentiate into steroidogenic cells by forced expression of steroidogenic factor 1 (SF-1)/adrenal 4 binding protein (Ad4BP),...

journal_title：Endocrinology

authors： Tanaka T,Aoyagi C,Mukai K,Nishimoto K,Kodama S,Yanase T

更新日期：2020-03-01 00:00:00

abstract：:Experimental evidence indicates that the neonatal gonadal steroid environment is an important determinant of the sexual dimorphism of GH secretion and body growth. However, the influence of the sex steroids in GH control during adult life and their mechanism/site of action are largely unknown. In the present study we ...

journal_title：Endocrinology

authors： Painson JC,Thorner MO,Krieg RJ,Tannenbaum GS

更新日期：1992-01-01 00:00:00