Chromosomes 6 and 13 harbor genes that regulate pubertal timing in mouse chromosome substitution strains.

abstract：:Although factors that regulate cAMP and steroid production in granulosa cells of hen preovulatory follicles have been well studied, much less is known of the mechanisms that control steroidogenesis in the adjacent thecal layer. These studies were conducted to examine the involvement and interaction of cAMP and protein...

journal_title：Endocrinology

authors： Tilly JL,Johnson AL

更新日期：1989-09-01 00:00:00

abstract：:We previously reported the existence of a descending multisynaptic, pituitary-independent, neural pathway between the hypothalamus and the testes in the male rat. Stimulation of this pathway by the intracerebroventricular (icv) injection of IL-1beta or corticotropin-releasing factor blunts the testosterone (T) respons...

journal_title：Endocrinology

authors： Selvage DJ,Lee SY,Parsons LH,Seo DO,Rivier CL

更新日期：2004-04-01 00:00:00

abstract：:We have used in situ hybridization histochemistry to investigate interactions between the thyroid and adrenal axes in the rat. Propylthiouracil (PTU)-induced hypothyroidism caused a significant reduction in CRH gene transcripts in the paraventricular nucleus of male rats, with a concomitant decrease in both POMC gene ...

journal_title：Endocrinology

authors： Shi ZX,Levy A,Lightman SL

更新日期：1994-03-01 00:00:00

abstract：:Activin A is a member of the transforming growth factor-beta family of growth factors and a potent regulator of cellular activity. A number of binding proteins for activin A have been identified, including alpha 2-macroglobulin (alpha 2M). Alpha 2M has several conformational states that are known to have different gro...

journal_title：Endocrinology

authors： Niemuller CA,Randall KJ,Webb DJ,Gonias SL,LaMarre J

更新日期：1995-12-01 00:00:00

abstract：:Kisspeptins are hypothalamic neuropeptides encoded by KISS1 and recently described as major regulators of GnRH release from hypothalamic neurons. Although 17beta-estradiol (E2)-induced up-regulation of KISS1 expression has been documented in anteroventral periventricular nucleus neurons, E2 down-regulates KISS1 expres...

journal_title：Endocrinology

authors： Huijbregts L,de Roux N

更新日期：2010-08-01 00:00:00

abstract：:Leptin, a circulating 16-kDa protein secreted by adipocytes, decreases body weight by reducing food intake and enhancing energy utilization. Leptin receptors that share homology to the glycoprotein gp130 have been recently cloned. In addition, differentially spliced leptin receptor messenger RNAs have been identified....

journal_title：Endocrinology

authors： Liu C,Liu XJ,Barry G,Ling N,Maki RA,De Souza EB

更新日期：1997-08-01 00:00:00

abstract：:To study conversion of 3,5,3'-triiodothyroinine (T3) and 3,3',5'-triiodothyronine (rT3) to 3,3'-diiodothyronine (T2) in vitro, T3 or rT3 was incubated at pH 7.35 with homogenates of several rat tissues (liver, kidney, muscle, heart, ling, spleen, intestines, and brain) for 15 min at 37 C. The T2 generated during incub...

journal_title：Endocrinology

authors： Chopra IJ,Wu SY,Nakamura Y,Solomon DH

更新日期：1978-04-01 00:00:00

abstract：:Experimental evidence indicates that the neonatal gonadal steroid environment is an important determinant of the sexual dimorphism of GH secretion and body growth. However, the influence of the sex steroids in GH control during adult life and their mechanism/site of action are largely unknown. In the present study we ...

journal_title：Endocrinology

authors： Painson JC,Thorner MO,Krieg RJ,Tannenbaum GS

更新日期：1992-01-01 00:00:00

abstract：:Cytosols of whole testicular homogenates from the Syrian golden hamster contained specific binding sites for [3H]triamcinolone acetonide that exhibited limited capacity and high affinity binding characteristic of glucocorticoid receptors in other target tissues. The receptor complex sedimented as an 8.6S binder in low...

journal_title：Endocrinology

authors： Ortlip SA,Li SA,Li JJ

更新日期：1981-11-01 00:00:00

abstract：:Stimulation of mitogenesis in rat Nb2 node lymphoma cells by human (h) PRL was inhibited by inhibitors of Na+/H+ exchange (viz. amiloride and its analogs) and inhibitors of protein kinases (isoquinolinesulfonamide derivatives). The most potent were ethylisopropylamiloride (EP-Am) (IC50, 13 microM) and H-7, selective f...

journal_title：Endocrinology

authors： Too CK,Walker A,Murphy PR,Cragoe EJ Jr,Jacobs HK,Friesen HG

更新日期：1987-10-01 00:00:00

abstract：:As a metabolic sensor, the serine/threonine protein kinase AMP-activated protein kinase (AMPK) promotes the adaptation of cells to signals arising from nutrients, hormones, and growth factors. The ability of IGF-I to stimulate protein synthesis is suppressed by AMPK, therefore, these studies were undertaken to determi...

journal_title：Endocrinology

authors： Ning J,Xi G,Clemmons DR

更新日期：2011-08-01 00:00:00

abstract：:Diabetics have at least twice the risk of stroke and may show performance deficit in a wide range of cognitive domains. The mechanisms underlying this gradually developing end-organ damage may involve both vascular changes and direct damage to neuronal cells as a result of overproduction of superoxide by the respirato...

journal_title：Endocrinology

authors： Aragno M,Mastrocola R,Medana C,Restivo F,Catalano MG,Pons N,Danni O,Boccuzzi G

更新日期：2005-12-01 00:00:00

abstract：:We examined whether mitogen-activated protein (MAP) kinase was activated by stimulation of the cAMP pathway and whether MAP kinase activation was involved in synthesis of PRL and GH in GH(3) cells. Treatment of the cells with a cAMP analog, 8-(4-chlorophenylthio)cAMP (CPT-cAMP), activated MAP kinase and increased PRL ...

journal_title：Endocrinology

authors： Yonehara T,Kanasaki H,Yamamoto H,Fukunaga K,Miyazaki K,Miyamoto E

更新日期：2001-07-01 00:00:00

abstract：:Treatment of 5-day cyclic rats with 10 or 100 microgram estradiol benzoate on the day of estrus induced a luteal phase in all animals studied. On the other hand, an injection with 1 microgram estradiol benzoate given on the same day failed to induce pseudopregnancy. When 10 mg progesterone were injected on the day of ...

journal_title：Endocrinology

authors： de Greef WJ,Zeilmaker GH

更新日期：1979-07-01 00:00:00

abstract：:Polypeptide YY(3-36) (PYY(3-36)) is a gastrointestinal secreted molecule, agonist of neuropeptide Y (NPY) receptor subtypes Y2 and Y5, recently involved in the control of food intake. Notably, several factors with key roles in energy homeostasis conduct pleiotropic effects upon the reproductive axis. However, whether ...

journal_title：Endocrinology

authors： Fernandez-Fernandez R,Aguilar E,Tena-Sempere M,Pinilla L

更新日期：2005-03-01 00:00:00

abstract：:Male and female Holtzman rats were raised from weaning on a vitamin D-deficient diet (-D). Control (+D) animals were raised on the same diet and orally given 70 IU vitamin D3 twice each week. Serum Ca levels fell at the same rate in -D males and females. In contrast, serum parathyroid hormone increased more rapidly in...

journal_title：Endocrinology

authors： Thomas ML,Forte LR

更新日期：1981-11-01 00:00:00

abstract：:Obesity is associated with systemic inflammation and elevated levels of TNFα, leading to impaired glucose tolerance. In humans, obesity is also associated with reduced nutrient-stimulated secretion of the intestinal incretin hormone, glucagon-like peptide-1 (GLP-1). We hypothesized that TNFα plays a direct role in the...

journal_title：Endocrinology

authors： Gagnon J,Sauvé M,Zhao W,Stacey HM,Wiber SC,Bolz SS,Brubaker PL

更新日期：2015-11-01 00:00:00

abstract：:Calcineurin-nuclear factor of activated T cells signaling controls the differentiation and function of osteoclasts and osteoblasts, and regulator of calcineurin-2 (Rcan2) is a physiological inhibitor of this pathway. Rcan2 expression is regulated by T(3), which also has a central role in skeletal development and bone ...

journal_title：Endocrinology

authors： Bassett JH,Logan JG,Boyde A,Cheung MS,Evans H,Croucher P,Sun XY,Xu S,Murata Y,Williams GR

更新日期：2012-07-01 00:00:00

abstract：:Up to now, no relevant tumor antigen has been identified in medullary thyroid carcinoma (MTC). The aim of the present study was to prove the concept of an immunization with an amino acid-modified calcitonin (CT) for the treatment of MTC in a transgenic mouse model. Amino acid-modified (human) CT has been chosen for va...

journal_title：Endocrinology

authors： Wuttke M,Papewalis C,Meyer Y,Kessler C,Jacobs B,Willenberg HS,Schinner S,Kouatchoua C,Baehring T,Scherbaum WA,Schott M

更新日期：2008-11-01 00:00:00

abstract：:The castration-induced regression and testosterone stimulated regrowth of the vasculature in the rat ventral prostate lobe were studied using stereological techniques. Seven days after castration, the endothelial cell proliferation rate (bromodeoxyuridine labeling index); the total weights of blood vessel walls, blood...

journal_title：Endocrinology

authors： Franck-Lissbrant I,Häggström S,Damber JE,Bergh A

更新日期：1998-02-01 00:00:00

abstract：:Selective inhibitors of sodium glucose cotransporter-2 (SGLT2) are widely used for the treatment of type 2 diabetes and act primarily to lower blood glucose by preventing glucose reabsorption in the kidney. However, it is controversial whether these agents also act on the pancreatic islet, specifically the α cell, to ...

journal_title：Endocrinology

authors： Dai C,Walker JT,Shostak A,Bouchi Y,Poffenberger G,Hart NJ,Jacobson DA,Calcutt MW,Bottino R,Greiner DL,Shultz LD,McGuinness OP,Dean ED,Powers AC

更新日期：2020-08-01 00:00:00

abstract：:NADPH-cytochrome P-450 reductase (EC 1.6.2.4), the enzyme involved in progesterone 17-hydroxylation, was purified to apparent homogeneity by detergent solubilization of the microsomal fractions of liver and testis from untreated rats. The enzymes from these two tissues were then compared with regard to several paramet...

journal_title：Endocrinology

authors： Hales DB,Betz G

更新日期：1986-08-01 00:00:00

abstract：:Twelve weeks of high-fat diet feeding causes ghrelin resistance in arcuate neuropeptide Y (NPY)/agouti-related protein (AgRP) neurons. In the current study, we investigated whether diet-induced weight loss could restore NPY/AgRP neuronal responsiveness to ghrelin and whether ghrelin mediates rebound weight gain after ...

journal_title：Endocrinology

authors： Briggs DI,Lockie SH,Wu Q,Lemus MB,Stark R,Andrews ZB

更新日期：2013-02-01 00:00:00

abstract：:IGF-I is an endocrine and paracrine regulator of skeletal homeostasis, principally by virtue of its anabolic effects on osteoblastic cells. In the current study, we examined the intracellular signaling pathways by which IGF-I promotes proliferation and survival in SaOS-2 human osteoblastic cells. Inhibition of each of...

journal_title：Endocrinology

authors： Grey A,Chen Q,Xu X,Callon K,Cornish J

更新日期：2003-11-01 00:00:00

abstract：:Age-associated changes in the reproductive hormones-the gonadal steroid hormones and the gonadotropins-have been identified as potential risk factors for Alzheimer's disease (AD). However, levels of gonadotropins and estrogens are closely linked in vivo, and it has proven difficult to separate the effects of gonadotro...

journal_title：Endocrinology

authors： Barron AM,Verdile G,Taddei K,Bates KA,Martins RN

更新日期：2010-11-01 00:00:00

abstract：:In the present study, we investigated the role of the multidrug resistance (mdr) P-glycoprotein (Pgp) at the blood-brain barrier in the control of access of cortisol and corticosterone to the mouse and human brain. [(3)H]Cortisol poorly penetrated the brain of adrenalectomized wild-type mice, but the uptake was 3.5-fo...

journal_title：Endocrinology

authors： Karssen AM,Meijer OC,van der Sandt IC,Lucassen PJ,de Lange EC,de Boer AG,de Kloet ER

更新日期：2001-06-01 00:00:00

abstract：:GH is considered to play a role in the pathogenesis of diabetic retinopathy, causing neovascularization in the retina. The present study was conducted to assess the possibility that GH may play a role in ocular development by determining whether GH is expressed in the eye of the chicken during development. In the 17-d...

journal_title：Endocrinology

authors： Takeuchi S,Haneda M,Teshigawara K,Takahashi S

更新日期：2001-12-01 00:00:00

abstract：:PRL and placental lactogen (PL) play key roles in maintaining the rodent corpus luteum through pregnancy. Suppressors of cytokine signaling (SOCS) have been shown to decrease cell sensitivity to cytokines, including PRL, and so here we have addressed the issue of whether luteolysis induced by prostaglandin F(2alpha) (...

journal_title：Endocrinology

authors： Curlewis JD,Tam SP,Lau P,Kusters DH,Barclay JL,Anderson ST,Waters MJ

更新日期：2002-10-01 00:00:00

abstract：:Recent studies have demonstrated that passive immunization of neonatal rats to GRF inhibited their somatic growth through the suppression of GH secretion. In this study, we investigated the changes in pituitary GRF receptor (GRFR) expression in GRF antibody (GRF-ab) treated rats. Neonatal rats were treated from day 1 ...

journal_title：Endocrinology

authors： Horikawa R,Hellmann P,Cella SG,Torsello A,Day RN,Muller EE,Thorner MO

更新日期：1996-06-01 00:00:00

abstract：:Maternal obesity during pregnancy increases the risk of obesity in the offspring. Several observations have pointed to a causative role for the proinflammatory cytokine IL-6, but whether it is present in the fetal circulation and how it acts on the developing fetus are unclear. We first observed that postnatal day 0 o...

journal_title：Endocrinology

authors： Sanders TR,Kim DW,Glendining KA,Jasoni CL

更新日期：2014-07-01 00:00:00