Serum prolactin concentrations during hormonally induced pseudopregnancy in the rat.

abstract：:We have studied whether activation of cell adhesion kinase beta (CAKbeta) is involved in stretch-induced signaling pathway in cultured rat vascular smooth muscle cells. Cyclic stretch (1 Hz) induced a rapid (within 1 min) phosphorylation of CAKbeta, whose effect was time and strength dependent. Both Ca(2+) and Na(+) i...

journal_title：Endocrinology

authors： Iwasaki H,Yoshimoto T,Sugiyama T,Hirata Y

更新日期：2003-06-01 00:00:00

abstract：:Decidual/trophoblast PRL-related protein (d/tPRP) is a member of the PRL gene family and is dually expressed in uterine and placental tissues in a highly coordinated pattern during pregnancy. In the present study, we describe the isolation and characterization of the d/tPRP gene. A lambda DASH II Wistar-Kyoto rat geno...

journal_title：Endocrinology

authors： Orwig KE,Dai G,Rasmussen CA,Soares MJ

更新日期：1997-06-01 00:00:00

abstract：:Prostacyclin (PGI2) (1-5 micrograms in 3 microliters 0.05 M Tris/HCl buffer, pH 7.5) and its stable metabolite, 6-oxo-PGF1 alpha, were microinjected into the third ventricle of ovariectomized rats, and plasma FSH, GH, PRL, and TSH levels were measured by RIA. Control animals received 3 microliters buffer. Injection of...

journal_title：Endocrinology

authors： Ottlecz A,Samson WK,McCann SM

更新日期：1984-02-01 00:00:00

abstract：:Mammary gland explants from mature virgin mice, rats, and rabbits exhibit an increased rate of both DNA and casein syntheses when cultured in the presence of specific combinations of insulin, hydrocortisone, and PRL. If cytosine arabinoside, a potent inhibitor of DNA synthesis, is added to the culture medium, casein s...

journal_title：Endocrinology

authors： Nicholas KR,Bolander FF Jr,Sankaran L,Topper YJ

更新日期：1983-03-01 00:00:00

abstract：:We examined the gene expression of V-1, a novel soluble protein with the cdc10/SWI6 motif, in pseudopregnant rat ovaries. Northern blot analysis on days 1, 5, and 11 of pseudopregnancy revealed an approximately 2-fold increase in the V-1 messenger RNA (mRNA) expression level on day 5 to that on day 1, and no significa...

journal_title：Endocrinology

authors： Song SY,Asakai R,Kenmotsu N,Taoka M,Isobe T,Yamakuni T

更新日期：1996-04-01 00:00:00

abstract：:In various forms of shock, TRH is equivalent to naloxone in reversing the hypotension and improving the survival rate. The present findings indicate that in spontaneously hypertensive rats (SHR), TRH has another naloxone-like effect in antagonizing the antihypertensive response to clonidine and alpha-methyldopa. When ...

journal_title：Endocrinology

authors： Kunos G,Newman F,Farsang C,Ungar W

更新日期：1984-12-01 00:00:00

abstract：:Gastrin is natriuretic, but its renal molecular targets and signal transduction pathways are not fully known. In this study, we confirmed the existence of CCKBR (a gastrin receptor) in male human renal proximal tubule cells and discovered that gastrin induced S6 phosphorylation, a downstream component of the phosphati...

journal_title：Endocrinology

authors： Liu T,Jose PA

更新日期：2013-02-01 00:00:00

abstract：:The hypothalamic peptide, pituitary adenylate cyclase-activating polypeptide (PACAP), can efficiently increase cAMP levels in pituitary cells and release a number of pituitary hormones, suggesting an important physiological role for this peptide in pituitary function. Exposure of GH3 rat pituitary cells to PACAP resul...

journal_title：Endocrinology

authors： Coleman DT,Chen X,Sassaroli M,Bancroft C

更新日期：1996-04-01 00:00:00

abstract：:Kisspeptins, products of the KiSS-1 gene with ability to bind G protein-coupled receptor 54 (GPR54), have been recently identified as major gatekeepers of reproductive function with ability to potently activate the GnRH/LH axis. Yet, despite the diversity of functional states of the female gonadotropic axis, pharmacol...

journal_title：Endocrinology

authors： Roa J,Vigo E,Castellano JM,Navarro VM,Fernández-Fernández R,Casanueva FF,Dieguez C,Aguilar E,Pinilla L,Tena-Sempere M

更新日期：2006-06-01 00:00:00

abstract：:Mouse uterine estrogen receptor (ER) was purified about 11,000-fold from normal mouse uteri by affinity chromatography. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the purified ER demonstrated a major component of 65,000 mol wt with minor fragments of the 54,000- and 37,000-dalton species, as judged b...

journal_title：Endocrinology

authors： Horigome T,Golding TS,Quarmby VE,Lubahn DB,McCarty K Sr,Korach KS

更新日期：1987-12-01 00:00:00

abstract：:The effect of TSH stimulation on cellular (c)-myc mRNA content in cultured thyroid cells was examined by Northern blot analysis. Polyadenylated mRNA was prepared from quiescent FRTL-5 rat thyroid cells and from cells stimulated by TSH for 8 h. A major 2.1 kilobase (kb) transcript was enhanced 5.5-fold by TSH. (Bu)2cAM...

journal_title：Endocrinology

authors： Dere WH,Hirayu H,Rapoport B

更新日期：1985-11-01 00:00:00

abstract：:The multifunctional cytokine, transforming growth factor-beta (TGF beta), is found in many tissues in a latent or inactive form. The nature and composition of the latent complex can vary depending on tissue type. The release of active TGF beta from its latent complex is a potentially important mechanism for regulation...

journal_title：Endocrinology

authors： Bonewald LF,Oreffo RO,Lee CH,Park-Snyder S,Twardzik D,Mundy GR

更新日期：1997-02-01 00:00:00

abstract：:To test the role of gene expression of the classical ER (ER alpha) in the inhibitory effects of E on food intake and body weight, we ovariectomized and administered E2 benzoate (75 pg/d) or vehicle to wild-type (WT) mice and mice with a null mutation of ER alpha (alpha ERKO). Mice were ovariectomized at age 9 wk, at w...

journal_title：Endocrinology

authors： Geary N,Asarian L,Korach KS,Pfaff DW,Ogawa S

更新日期：2001-11-01 00:00:00

abstract：:A substantial body of experimental evidence indicates that serotonin (5-HT) and several synthetic 5-HT receptor agonists activate the hypothalamic-pituitary-adrenal (HPA) axis. To explore the mechanism(s) by which 5-HT or 5-HT agonists enhance the activity of the HPA axis in vitro, we examined the stimulatory effects ...

journal_title：Endocrinology

authors： Calogero AE,Bagdy G,Szemeredi K,Tartaglia ME,Gold PW,Chrousos GP

更新日期：1990-04-01 00:00:00

abstract：:The concentrations and contents of vasoactive intestinal peptide (VIP) and cholecystokinin (CCK) in the brain and of these peptides along with secretin and glucagon-like immunoreactivity (GLI) in the gut were compared in a group of 16 5-day fasted adult Sprague-Dawley rats with the corresponding peptides in a group of...

journal_title：Endocrinology

authors： Zheng B,Eng J,Yalow RS

更新日期：1987-02-01 00:00:00

abstract：:A mitochondrial fraction prepared from homogenates of rat hypothalamic tissue was found by means of electron microscopy to be enriched with synaptosomes. The release of luteinizing hormone releasing hormone (LHRH) and thyrotropin releasing hormone (TRH) from this preparation was investigated. After incubation, the syn...

journal_title：Endocrinology

authors： Warberg J,Eskay RL,Barnea A,Reynolds RC,Porter JC

更新日期：1977-03-01 00:00:00

abstract：:Linear growth results from proliferation and differentiation of chondrocytes within the growth plates and is regulated, in part, by the insulin-like growth factors (IGFs). IGF binding proteins (IGFBPs) also appear to play a significant, but yet unclear, role. To examine IGFBP production by chondrocytes, we isolated bo...

journal_title：Endocrinology

authors： Olney RC,Smith RL,Kee Y,Wilson DM

更新日期：1993-08-01 00:00:00

abstract：:Prostaglandin (PG) E2 (PGE(2)) plays a central role in the regulation of smooth muscle contractions. Classically, PGE(2) stimulates contractions via EP1 and EP3 receptors, whereas EP2 and EP4 maintain quiescence. Labor involves a change from myometrial quiescence to contractions with a shift from anti- to proinflammat...

journal_title：Endocrinology

authors： Kandola MK,Sykes L,Lee YS,Johnson MR,Hanyaloglu AC,Bennett PR

更新日期：2014-02-01 00:00:00

abstract：:The estrogenic and antiestrogenic actions of the geometric isomers of tamoxifen and 4-hydroxytamoxifen were determined in a PRL synthesis assay using primary cultures of dispersed immature rat pituitary gland cells. 4-Hydroxytamoxifen was 100 times more potent as an antiestrogen than tamoxifen. The cis isomer of tamox...

journal_title：Endocrinology

authors： Jordan VC,Koch R,Langan S,McCague R

更新日期：1988-04-01 00:00:00

abstract：:The specific biological function of the cell surface or membrane-bound isoform of colony-stimulating factor-1 (mCSF-1) is not well understood. To help define the role of this isoform in bone, we developed a transgenic mouse in which targeted expression of human mCSF-1 in osteoblasts was achieved under the control of t...

journal_title：Endocrinology

authors： Yao GQ,Wu JJ,Sun BH,Troiano N,Mitnick MA,Insogna K

更新日期：2003-08-01 00:00:00

abstract：:The participation of growth factors in wound healing and tissue repair has been well established. Previous studies demonstrated that the expression of keratinocyte growth factor (KGF) was greatly elevated shortly after injury and that topical application of KGF accelerated healing. Steroidal antiinflammatory agents, s...

journal_title：Endocrinology

authors： Chedid M,Hoyle JR,Csaky KG,Rubin JS

更新日期：1996-06-01 00:00:00

abstract：:The hormonal requirements for lactogenesis were investigated using explant cultures of mammary tissue obtained from cows at 30-40 days prepartum. Hormones used were insulin, hydrocortisone, and prolactin, and parameters examined were radioactive acetate incorporation into fatty acids, secretory response ratings, and h...

journal_title：Endocrinology

authors： Collier RJ,Bauman DE,Hays RL

更新日期：1977-04-01 00:00:00

abstract：:Aromatase-deficient (ArKO) mice are deficient in estrogens due to deletion of the aromatase gene. We hypothesized that there may be changes in the cardiovascular system of ArKO mice because of evidence linking estrogens with improved cardiovascular outcomes and the induction of the glucocorticoid-metabolizing enzyme, ...

journal_title：Endocrinology

authors： Head GA,Obeyesekere VR,Jones ME,Simpson ER,Krozowski ZS

更新日期：2004-09-01 00:00:00

abstract：:Type 3 deiodinase (D3), the physiologic inactivator of thyroid hormones, is induced during tissue injury and regeneration. This has led to the hypotheses that D3 impacts injury tolerance by reducing local T3 signaling and contributes to the fall in serum triiodothyronine (T3) observed in up to 75% of sick patients (te...

journal_title：Endocrinology

authors： Castroneves LA,Jugo RH,Maynard MA,Lee JS,Wassner AJ,Dorfman D,Bronson RT,Ukomadu C,Agoston AT,Ding L,Luongo C,Guo C,Song H,Demchev V,Lee NY,Feldman HA,Vella KR,Peake RW,Hartigan C,Kellogg MD,Desai A,Salvatore D

更新日期：2014-10-01 00:00:00

abstract：:Pituitary GH secretion is pulsatile in man and the rat, but evidence of pulsatility in the GH-dependent somatomedins (insulin-like growth factors) has not been described. In this study serum immunoreactive somatomedin-C periodicity was examined in 10 chronically cannulated unstressed rats. Blood samples were taken at ...

journal_title：Endocrinology

authors： Baxter RC,Zaltsman Z,Oliver JR,Willoughby JO

更新日期：1983-08-01 00:00:00

abstract：:As ovariectomy induces obesity in rats, we have investigated the influence of ovariectomy and hormone replacement on the proliferation and differentiation capacities of rat cultured preadipocytes removed from different fat depots (femoral sc, parametrial, and perirenal). Ovariectomy induced increased proliferation and...

journal_title：Endocrinology

authors： Lacasa D,Garcia E,Agli B,Giudicelli Y

更新日期：1997-07-01 00:00:00

abstract：:In previous studies it was shown that bovine GH (bGH) suppressed and glucagon stimulated the level of 24- and 30- to 34-kilodalton insulin-like growth factor-binding proteins (IGFBPs) in the media of cultured rat hepatocytes. In the present study we have evaluated the regulation of IGFBP-1 gene expression in primary r...

journal_title：Endocrinology

authors： Kachra Z,Yang CR,Murphy LJ,Posner BI

更新日期：1994-11-01 00:00:00

abstract：:To assess the consequences of prolonged exposure to elevated levels of LH/human chorionic gonadotropin (hCG) in the female, we developed a transgenic (TG) mouse model (hCGbeta+) that overexpresses the hCGbeta-subunit cDNA. Because of the promoter used, ubiquitin C, the transgene is expressed in multiple tissues, inclu...

journal_title：Endocrinology

authors： Rulli SB,Kuorelahti A,Karaer O,Pelliniemi LJ,Poutanen M,Huhtaniemi I

更新日期：2002-10-01 00:00:00

abstract：:Studies were carried out to determine the origin of the immediate increase in plasma calcium following acute calcitonin deficiency in mature rats. Animals were pre-labelled with 45calcium 24 hours and 4 weeks before thyroparathyroidectomy (TPTX) and 1 hour, 24 hours, 2 and 4 weeks before nephrectomy and TPTX and bled ...

journal_title：Endocrinology

authors： Kalu DN,Hadji-Georgopoulos A,Foster GV

更新日期：1976-02-01 00:00:00

abstract：:The purpose of this investigation was to use an approach targeted specifically on endogenous relaxin to determine the influence of relaxin on birth in the rat. To that end, a monoclonal antibody specific for rat relaxin, designated MCA1, was used to passively neutralize endogenous relaxin in intact pregnant rats. MCA1...

journal_title：Endocrinology

authors： Guico-Lamm ML,Sherwood OD

更新日期：1988-11-01 00:00:00