Activation of cell adhesion kinase beta by mechanical stretch in vascular smooth muscle cells.

abstract：:One day of fasting suppresses pulsatile LH secretion in adult male rhesus monkeys. In the present study, we determined whether the hypothalamic-pituitary-adrenal (HPA) axis is activated by 1 day of fasting, and if there is any evidence that an increase in the activity of the HPA axis causes the fasting-induced suppres...

journal_title：Endocrinology

authors： Helmreich DL,Mattern LG,Cameron JL

更新日期：1993-06-01 00:00:00

abstract：:We have investigated the adrenergic control of mitogen-activated protein kinase (MAPK) activity in brown adipocytes. Cold exposure in rats led to an activation of MAPK in brown adipose tissue, as determined by the gel mobility shift assay and in-gel kinase assay. In contrast, no activation was seen after surgical symp...

journal_title：Endocrinology

authors： Shimizu Y,Tanishita T,Minokoshi Y,Shimazu T

更新日期：1997-01-01 00:00:00

abstract：:Prolactin (Prl) secreting cells in a mixed pituitary cell culture form microscopically-identifiable plaques (zones of hemolysis around the lactotropes) when incubated in a monolayer with staphylococcal protein-A-coated ovine erythrocytes in the presence of Prl antiserum and complement. Plaques form first at 15-30 min ...

journal_title：Endocrinology

authors： Neill JD,Frawley LS

更新日期：1983-03-01 00:00:00

abstract：:The importance of locally produced insulin-like growth factor-I (IGF-I) in connective tissues has recently been recognized. It has been postulated that the action of anabolic hormones on bone may be mediated through local IGF-I release. However, whether IGF-I can also be modulated by other locally acting cytokines has...

journal_title：Endocrinology

authors： Elford PR,Lamberts SW

更新日期：1990-10-01 00:00:00

abstract：:These studies have examined the ontogeny of specific GH- and PRL-binding proteins in rabbit liver cytosol across the fetal, early neonatal, and adult periods. The precise hormonal specificity of binding of the somatotropic/lactogenic ligand, [125I]human GH, was determined by displacement with monoclonal antibodies aga...

journal_title：Endocrinology

authors： Ymer SI,Stevenson JL,Herington AC

更新日期：1989-07-01 00:00:00

abstract：:The role of adrenergic stimulation in the regulation of mitogen-activated protein kinase (MAPK) in rat pinealocytes was investigated by measuring phosphorylated MAPK using Western blot analysis and a MAPK enzymatic assay. Stimulation with the endogenous neurotransmitter, norepinephrine (NE; a mixed alpha- and beta-adr...

journal_title：Endocrinology

authors： Ho AK,Chik CL

更新日期：2000-12-01 00:00:00

abstract：:The temporal aspects of gonadotropin release were studied in infantile (14-day-old) female rats. Blood samples were collected using vena cava cannulae at 10-, 15-, 20-, or 30-min intervals and assayed for either LH alone or for both LH and FSH. Within individual animals, blood LH levels exhibited a degree of variabili...

journal_title：Endocrinology

authors： Frawley LS,Henricks DM

更新日期：1979-11-01 00:00:00

abstract：:Dihydrotestosterone (DHT) concentration was measured in prostatic tissue obtained from castrate or intact beagles treated with androgens and/or estradiol-17 beta. Also DHT concentration was measured in prostatic tissue of beagles ranging from 0.7-9.2 yr; some with and others without spontaneously occurring benign pros...

journal_title：Endocrinology

authors： Ewing LL,Berry SJ,Higginbottom EG

更新日期：1983-12-01 00:00:00

abstract：:Xenoestrogens from synthetic or natural origin represent an increasing risk of disrupted endocrine functions including the physiological activity of the hypothalamo-pituitary-gonad axis. Ethinyl estradiol (EE2) is a synthetic estrogen used in contraceptive pills, whereas zearalenone (ZEA) is a natural mycoestrogen fou...

journal_title：Endocrinology

authors： Kriszt R,Winkler Z,Polyák Á,Kuti D,Molnár C,Hrabovszky E,Kalló I,Szőke Z,Ferenczi S,Kovács KJ

更新日期：2015-11-01 00:00:00

abstract：:The PTH activates both adenylate cyclase and a mechanism that increases membrane-associated protein kinase-C (PKC) activity. To define the hormone's PKC activation domain we have used a panel of PTH fragments and ROS 17/2 rat osteosarcoma cells as the target cells. PTH equally and maximally increased PKC activity in R...

journal_title：Endocrinology

authors： Jouishomme H,Whitfield JF,Chakravarthy B,Durkin JP,Gagnon L,Isaacs RJ,MacLean S,Neugebauer W,Willick G,Rixon RH

更新日期：1992-01-01 00:00:00

abstract：:Basal hypothalamic deafferentation abolished the nycthemeral rhythm of both plasma TSH and corticosterone. ...

journal_title：Endocrinology

authors： Fukuda H,Greer MA

更新日期：1975-09-01 00:00:00

abstract：:We have previously described FSH receptor-mediated influx of 45Ca++ in cultured Sertoli cells from immature rats and receptor-enriched proteoliposomes via activation of voltage-sensitive and voltage-independent calcium channels. We have further shown that this effect of FSH does not require cholera toxin- or pertussis...

journal_title：Endocrinology

authors： Grasso P,Santa-Coloma TA,Reichert LE Jr

更新日期：1991-06-01 00:00:00

abstract：:In the present study we have used a high affinity photoaffinity label (PAL) agonist (pGlu-His-Trp-Ser-125I-iodoTyr-D-Lys(para-N3-Benzoyl)-Leu-Arg-P roNHEt) and a PAL antagonist (NAcD2Nal-D4ClPhe-D3Pal-Ser-125I-iodo-NMeTyr-D-L ys(para-N3-Benzoyl)Leu-Lys(Isp) - Pro-D-Ala-NH2) to covalently label the GnRH receptor. Rat p...

journal_title：Endocrinology

authors： Janovick JA,Haviv F,Fitzpatrick TD,Conn PM

更新日期：1993-08-01 00:00:00

abstract：:Insulinopenic diabetes mellitus in the rat is associated with reduced circulating levels of insulin-like growth factor-I (IGF-I), resulting primarily from decreased IGF-I synthesis in liver and extrahepatic sites. Plasma GH levels in these animals are also suppressed, with loss of episodic secretion and decreased pitu...

journal_title：Endocrinology

authors： Olchovsky D,Bruno JF,Gelato MC,Song J,Berelowitz M

更新日期：1991-02-01 00:00:00

abstract：:The glycoprotein FSH, a product of pituitary gonadotrope cells, regulates ovarian follicle development in females and spermatogenesis in males. FSH is a heterodimer of the common α gonadotropin subunit and the hormone-specific FSHβ subunit (a product of the Fshb gene). Using a conditional knockout approach (Cre-lox), ...

journal_title：Endocrinology

authors： Li Y,Schang G,Wang Y,Zhou X,Levasseur A,Boyer A,Deng CX,Treier M,Boehm U,Boerboom D,Bernard DJ

更新日期：2018-07-01 00:00:00

abstract：:Osteocalcin (OC), a bone specific protein expressed during differentiation and mineralization of the bone extracellular matrix, is down-regulated upon treatment with transforming growth factor (TGF)-beta 1. To address the potential role of OC gene expression in relation to TGF-beta 1 regulation of bone formation and r...

journal_title：Endocrinology

authors： Banerjee C,Stein JL,Van Wijnen AJ,Frenkel B,Lian JB,Stein GS

更新日期：1996-05-01 00:00:00

abstract：:Besides its role in body weight control leptin may also act as a vasoactive hormone. This study was designed to investigate whether leptin modifies angiotensin II (ANG II)-induced vascular responses. The expression of functional leptin receptors (OB-Rb) was detected in vascular smooth muscle cells (VSMCs) from adult W...

journal_title：Endocrinology

authors： Fortuño A,Rodríguez A,Gómez-Ambrosi J,Muñiz P,Salvador J,Díez J,Frühbeck G

更新日期：2002-09-01 00:00:00

abstract：:Many New World primate species have elevated circulating free plasma cortisol concentrations, target tissue resistance to cortisol, and no evidence of sodium retention. A representative New World primate, the squirrel monkey (Saimiri sciureus), has plasma cortisol concentrations above those necessary to cause complete...

journal_title：Endocrinology

authors： Chrousos GP,Loriaux DL,Brandon D,Shull J,Renquist D,Hogan W,Tomita M,Lipsett MB

更新日期：1984-07-01 00:00:00

abstract：:Immunoaffinity adsorption techniques, utilizing specific antisera for hCG and its subunits bound to Sepharose 4B, have been employed to separate hCG alpha beta dimer and free subunits of hCG. As previously reported by this and a number of other laboratories, trophoblast cells (in vivo and in vitro) produce free alpha ...

journal_title：Endocrinology

authors： Cole LA,Hartle RJ,Laferla JJ,Ruddon RW

更新日期：1983-09-01 00:00:00

abstract：:The marked up-regulation of oxytocin (OT) receptors in rabbit amnion at term was reproduced in cultured amnion cells by raising intracellular cAMP levels. (Bu)2AMP, forskolin, or cholera toxin caused 2- to 8-fold increases in specific binding of iodinated OT antagonist. The rise in OT receptors involves activation of ...

journal_title：Endocrinology

authors： Hinko A,Soloff MS

更新日期：1993-01-01 00:00:00

abstract：:Thyroid cell growth and function are regulated by hormones and growth factors binding to cell surface receptors that are coupled via G proteins, Gs and Gq, to the adenylyl cyclase and phospholipase C signal transduction systems, respectively. Activating mutations of the TSH receptor and G alpha s have been documented ...

journal_title：Endocrinology

authors： Zeiger MA,Saji M,Gusev Y,Westra WH,Takiyama Y,Dooley WC,Kohn LD,Levine MA

更新日期：1997-08-01 00:00:00

abstract：:Estrogens bind to two nuclear estrogen receptor (ER) subtypes, ERα and ERβ, which are expressed in differing amounts in various tissues. The endogenous estrogen, 17β-estradiol (E2), binds to both subtypes with nearly equal affinity and is the prototypical agonist. Selective estrogen receptor modulators (SERMs) may bin...

journal_title：Endocrinology

authors： Starkey NJE,Li Y,Drenkhahn-Weinaug SK,Liu J,Lubahn DB

更新日期：2018-05-01 00:00:00

abstract：:Male rats of five different strains (Simonsen albino, Wistar, Long-Evans, Holtzman Sprague-Dawley, and Charles River Sprague-Dawley) were tested for their response to the U.S. Biochemical Corp. Remington low iodine diet containing 15-18 microgram I/kg. Measurements made after the diet had been fed for 28-30 days indic...

journal_title：Endocrinology

authors： Okamura K,Taurog A,Krulich L

更新日期：1981-08-01 00:00:00

abstract：:Des-acyl ghrelin (DAG), the most abundant form of ghrelin in humans, has been found to reduce arterial blood pressure and prevent cardiac and endothelial cell apoptosis. Despite this, data regarding its direct effect on cardiac function and coronary blood flow, as well as the related involvement of autonomic nervous s...

journal_title：Endocrinology

authors： Grossini E,Raina G,Farruggio S,Camillo L,Molinari C,Mary D,Walker GE,Bona G,Vacca G,Moia S,Prodam F,Surico D

更新日期：2016-06-01 00:00:00

abstract：:Prolactinomas are the most prevalent functional pituitary adenomas. Dopamine D2 receptor (D2R) agonists, such as bromocriptine are the first line of therapy; however, drug intolerance/resistance to D2R agonists exists. Apart from D2R agonists, there is no established medical therapy for prolactinomas; therefore, ident...

journal_title：Endocrinology

authors： Miller M,Chen S,Woodliff J,Kansra S

更新日期：2008-08-01 00:00:00

abstract：:Benign prostatic hyperplasia is a nonmalignant enlargement of the prostate that commonly occurs in older men. We show that liver X receptor (Lxr)-α knockout mice (lxrα(-/-)) develop ventral prostate hypertrophy, correlating with an overaccumulation of secreted proteins in prostatic ducts and an alteration of vesicular...

journal_title：Endocrinology

authors： Viennois E,Esposito T,Dufour J,Pommier A,Fabre S,Kemeny JL,Guy L,Morel L,Lobaccaro JM,Baron S

更新日期：2012-07-01 00:00:00

abstract：:Pancreatic islets express the superoxide-producing nicotinamide adenine dinucleotide phosphate (NADPH) oxidase system, but its role remains unknown. To address this, we studied the mechanisms of impaired insulin secretion induced by diphenyleneiodium (DPI), an NADPH oxidase inhibitor. We investigated the effects of DP...

journal_title：Endocrinology

authors： Imoto H,Sasaki N,Iwase M,Nakamura U,Oku M,Sonoki K,Uchizono Y,Iida M

更新日期：2008-11-01 00:00:00

abstract：:The divergent commitment of ovarian granulosa cells to either proliferation and differentiation or programmed cell death directly reflects the process of follicular dominance and atresia. This process is regulated by FSH and local paracrine factors. To further analyze the role of FSH and intraovarian factors in follic...

journal_title：Endocrinology

authors： Li R,Phillips DM,Moore A,Mather JP

更新日期：1997-07-01 00:00:00

abstract：:Our previous work suggests that persistent protein malnutrition in immature domestic fowl (Gallus gallus domesticus) alters ACTH-adrenocortical cell interaction, possibly including ACTH receptors. To investigate this possibility, we measured some ACTH receptor parameters in isolated adrenocortical cells from normal an...

journal_title：Endocrinology

authors： Carsia RV,Weber H

更新日期：1988-02-01 00:00:00

abstract：:The development of white adipose tissue involves both the hypertrophy of existing adipocytes and the proliferation and differentiation of preadipocytes. Adipogenic differentiation is inhibited by TGFβ signaling through Smad2/3, and IGF binding protein-3 (IGFBP-3) is also known to activate Smad2/3 signaling in some cel...

journal_title：Endocrinology

authors： de Silva HC,Firth SM,Twigg SM,Baxter RC

更新日期：2012-10-01 00:00:00