Thyrotropin releasing hormone and naloxone attenuate the antihypertensive action of central alpha 2-adrenoceptor stimulation through different mechanisms.

abstract：:The administration of testosterone cypionate (0.4 mg/kg BW . day) to castrated male dogs caused a doubling of prostate weight within 4 weeks and an increase in the content of testosterone and dihydrotestosterone in the prostate. When the 5 alpha-reductase inhibitor 17-N,N-diethylcarbamoyl-4-methyl-4-aza-5 alpha-andros...

journal_title：Endocrinology

authors： Wenderoth UK,George FW,Wilson JD

更新日期：1983-08-01 00:00:00

abstract：:The administration of testosterone via Silastic capsules has been shown previously to maintain advanced spermatid number quantitatively in intact rats in which LH but not FSH was suppressed, but not in hypophysectomized rats, indicating that pituitary factors in addition to LH are required for the quantitative mainten...

journal_title：Endocrinology

authors： Awoniyi CA,Zirkin BR,Chandrashekar V,Schlaff WD

更新日期：1992-06-01 00:00:00

abstract：:Studies were carried out to determine the regional central nervous system and species specificity of the previously observed [125I]iodoavian pancreatic polypeptide ( [125I]iodo-APP) specific binding to chick brain membranes. The avian species examined were chicken, pigeon, duck, quail, chukar, and pheasant. In all spe...

journal_title：Endocrinology

authors： Adamo ML,Hazelwood RL

更新日期：1984-03-01 00:00:00

abstract：:Prolactin (PRL) receptors are expressed in a broad range of human cell types and in a majority of human breast and prostate cancers. Experimentally, normal and malignant human cells are typically cultured in vitro in media containing bovine PRL (bPRL) from fetal bovine serum or as xenotransplants in vivo in the presen...

journal_title：Endocrinology

authors： Utama FE,Tran TH,Ryder A,LeBaron MJ,Parlow AF,Rui H

更新日期：2009-04-01 00:00:00

abstract：:Effects of thyroid hormone on proteoglycan degradation in various regions of cartilage were investigated. In propylthiouracil-treated rats with hypothyroidism, proteoglycan degradation in epiphyseal cartilage during endochondral ossification was markedly suppressed. However, injections of T(4) reversed this effect of ...

journal_title：Endocrinology

authors： Makihira S,Yan W,Murakami H,Furukawa M,Kawai T,Nikawa H,Yoshida E,Hamada T,Okada Y,Kato Y

更新日期：2003-06-01 00:00:00

abstract：:Slices of normal mammary tissue from pregnant and lactating mice and slices of neoplastic (MXT) mouse mammary tissue were superfused with estradiol (E2) and estrone (E1) each labeled with a different isotope. Isotope concentrations in tissue and perfusate at the steady state were used to calculate fractions and rates ...

journal_title：Endocrinology

authors： De Ryck LM,Raus JC

更新日期：1983-07-01 00:00:00

abstract：:Whereas the stimulatory effect of interleukin-6 (IL-6) on the hypothalamic-pituitary-adrenal (HPA) axis is well established, its mode of action in this axis has yet to be fully elucidated. To further study the role of IL-6 in the HPA axis, we compared the expression of IL-6 messenger RNA (mRNA) in the rat hypothalamus...

journal_title：Endocrinology

authors： Muramami N,Fukata J,Tsukada T,Kobayashi H,Ebisui O,Segawa H,Muro S,Imura H,Nakao K

更新日期：1993-12-01 00:00:00

abstract：:A complementary DNA, uterine-ovarian-specific gene 44 (UO-44), has been isolated from tamoxifen-induced rat uterine complementary DNA library using differential display techniques. UO-44 transcripts are found to be abundant in the uterus and ovary. UO-44 gene expression in the uterus is strictly regulated by estrogens...

journal_title：Endocrinology

authors： Huynh H,Ng CY,Lim KB,Ong CK,Ong CS,Tran E,Tuyen Nguyen TT,Chan TW

更新日期：2001-07-01 00:00:00

abstract：:A relationship between the actions of TSH and IGF-1 was first recognized several decades ago. The close physical and functional associations between their respective receptors (TSHR and IGF-1R) has been described more recently in thyroid epithelium and human orbital fibroblasts as has the noncanonical behavior of IGF-...

journal_title：Endocrinology

authors： Atkins SJ,Lentz SI,Fernando R,Smith TJ

更新日期：2015-12-01 00:00:00

abstract：:Under acute stress conditions in the rat, there is rapid and transient increase in circulating prolactin (PRL). This leads to an elevated expression of the long form of PRLR (PRLR-L) first in the hypothalamus and the choroid plexus. This increase in PRL is involved in the inhibition of stress-induced hypocalcemia and ...

journal_title：Endocrinology

authors： Fujikawa T,Tamura K,Kawase T,Mori Y,Sakai RR,Sakuma K,Yamaguch A,Ogata M,Soya H,Nakashima K

更新日期：2005-08-01 00:00:00

abstract：:The effects of pentobarbital (Pnt) treatment on the progesterone (P)-induced afternoon increase in the medial basal hypothalamic (MBH) LHRH and serum LH and FSH levels in ovariectomized estradiol benzoate-primed rats were studied. Pnt injection before P blocked the afternoon rise in serum gonadotropins but failed to a...

journal_title：Endocrinology

authors： Kalra SP,Simpkins JW,Kalra PS

更新日期：1981-04-01 00:00:00

abstract：:The brain has traditionally been considered to be a target site of peripheral steroid hormones. By contrast, new findings over the past decade have shown that the brain itself also has the capability of forming steroids de novo, the so-called neurosteroids. De novo neurosteroidogenesis in the brain from cholesterol is...

journal_title：Endocrinology

authors： Tsutsui K

更新日期：2008-06-01 00:00:00

abstract：:We have shown that nonlactogenic rat (r) GH is far more potent than rPRL in inducing rat mammary development. To determine the relative roles of GH and PRL in mammary development and their mechanisms of action, we have compared the abilities of a group of native and mutant GHs, PRLs, and placental lactogens (PLs) to i...

journal_title：Endocrinology

authors： Feldman M,Ruan W,Cunningham BC,Wells JA,Kleinberg DL

更新日期：1993-10-01 00:00:00

abstract：:T3 and rT3 production rates in the fetus account for roughly only a third of the total T4 production rate; thus, the fate of the majority of T4 produced in the fetus is unknown (the "T4 disposal gap"). We developed sensitive and specific T4 sulfate (T4S) and T3 sulfate (T3S) RIAs to investigate the roles of these comp...

journal_title：Endocrinology

authors： Wu S,Polk D,Wong S,Reviczky A,Vu R,Fisher DA

更新日期：1992-10-01 00:00:00

abstract：:A novel transcript of the GH gene has been identified in ocular tissues of chick embryos. It is, however, unknown whether this transcript (small chicken GH, scGH) is translated. This possibility was therefore assessed. The expression of scGH mRNA was confirmed by RT-PCR, using primers that amplified a 426-bp cDNA of i...

journal_title：Endocrinology

authors： Baudet ML,Martin B,Hassanali Z,Parker E,Sanders EJ,Harvey S

更新日期：2007-01-01 00:00:00

abstract：:Analogs of the seco-steroid hormone, 1,25-dihydroxyvitamin D3 [1,25-(OH)-2D3] can preferentially stimulate genomic or nongenomic signaling pathways in osteoblasts. In this study, we used 1,25-(OH)2D3 analogs and voltage-sensitive Ca2+ channel (VSCC) ligands, including dihydropyridines (Bay K 8644 and nitrendipine), in...

journal_title：Endocrinology

authors： Khoury R,Ridall AL,Norman AW,Farach-Carson MC

更新日期：1994-12-01 00:00:00

abstract：:Morphological plasticity in response to estradiol is a hallmark of astrocytes in the arcuate nucleus. The functional consequences of these morphological changes have remained relatively unexplored. Here we report that in the arcuate nucleus estradiol significantly increased the protein levels of the two enzymes in the...

journal_title：Endocrinology

authors： Blutstein T,Baab PJ,Zielke HR,Mong JA

更新日期：2009-07-01 00:00:00

abstract：:GH has physiological functions in many tissues, but the cellular targets for direct effects of GH remain ill defined in complex tissues such as the growth plate in which the contribution of direct vs. indirect actions of GH remains controversial. The Janus kinase (Jak)-signal transducer and activator of transcription ...

journal_title：Endocrinology

authors： Gevers EF,Hannah MJ,Waters MJ,Robinson IC

更新日期：2009-08-01 00:00:00

abstract：:The original objective of this study was to use available distribution volume (V) and deca constant (k) estimates for rat LH and FSH to determine the amounts of these hormones synthesized and released during a dynamic secretory event, the postpartum preovulatory surge. The problem was approached by 1) determining the ...

journal_title：Endocrinology

authors： Diebel ND,Bogdanove EM

更新日期：1978-09-01 00:00:00

abstract：:Intravascular injections of adrenocorticotropic hormone in hypophysectomized rats were approximately 3 times more effective in stimulating increases in plasma corticosteroid concentration when given at the offset rather than the onset of the daily photoperiod (12 h:12 h light-dark cycle). Reversal of the photoperiodic...

journal_title：Endocrinology

authors： Ottenweller JE,Meier AH,Ferrell BR,Horseman ND,Proctor A

更新日期：1978-11-01 00:00:00

abstract：:Equine CG (eCG) both radioiodinated and unlabeled, was injected iv into male rats, and the disappearance of the hormone from the circulation was studied. The uptake and inactivation of the hormone by various tissues was also examined. The disappearance curve of eCG consisted of two exponential components with apparent...

journal_title：Endocrinology

authors： Aggarwal BB,Papkoff H

更新日期：1981-10-01 00:00:00

abstract：:The SMRT coregulator functions as a dual coactivator and corepressor for estrogen receptor-α (ERα) in a gene-specific manner, and in several studies its elevated expression correlates with poor outcome for breast cancer patients. A specific role of SMRT in breast cancer progression has not been elucidated, but SMRT kn...

journal_title：Endocrinology

authors： Blackmore JK,Karmakar S,Gu G,Chaubal V,Wang L,Li W,Smith CL

更新日期：2014-09-01 00:00:00

abstract：:It has previously been established that neuropeptide-Y (NPY) is a potent inhibitor of alpha MSH release from the pars intermedia of the amphibian Xenopus laevis. The location of binding sites for NPY in the pars intermedia of the pituitary has now been studied with light microscopic autoradiography, using a dispersed ...

journal_title：Endocrinology

authors： De Rijk EP,Cruijsen PM,Jenks BG,Roubos EW

更新日期：1991-02-01 00:00:00

abstract：:A biologically active form of the epidermal growth factor (EGF) precursor has been detected in human fluids and secretions. The secreted protein identified in human urine and milk has an apparent molecular mass of 160-170 kilodaltons and exhibits an affinity for the glycosaminoglycan heparin. More importantly, the sec...

journal_title：Endocrinology

authors： Mroczkowski B,Reich M

更新日期：1993-01-01 00:00:00

abstract：:Because of the importance of estrogen in osteoporosis, the effects of decreased estrogen production using sensitive measurements of bone mineral metabolism were studied in oophorectomized rats. Serum levels of ionized calcium, bone gla protein (BGP), vitamin D metabolites (25-hydroxyvitamin D and 1,25-dihydroxyvitamin...

journal_title：Endocrinology

authors： Ismail F,Epstein S,Fallon MD,Thomas SB,Reinhardt TA

更新日期：1988-02-01 00:00:00

abstract：:3-Iodothyronamine (T(1)AM) is an endogenous thyroid hormone derivative with unknown biosynthetic origins. Structural similarities have led to the hypothesis that T(1)AM is an extrathyroidal metabolite of T(4). This study uses an isotope-labeled T(4) [heavy-T(4) (H-T(4))] that can be distinguished from endogenous T(4) ...

journal_title：Endocrinology

authors： Hackenmueller SA,Marchini M,Saba A,Zucchi R,Scanlan TS

更新日期：2012-11-01 00:00:00

abstract：:Mutations in Na(+)-glucose transporters (SGLT)-2 and hepatocyte nuclear factor (HNF)-1alpha genes have been related to renal glycosuria and maturity-onset diabetes of the young 3, respectively. However, the expression of these genes have not been investigated in type 1 and type 2 diabetes. Here in kidney of diabetic r...

journal_title：Endocrinology

authors： Freitas HS,Anhê GF,Melo KF,Okamoto MM,Oliveira-Souza M,Bordin S,Machado UF

更新日期：2008-02-01 00:00:00

abstract：:Circulating levels of the pancreatic beta-cell peptide hormone amylin and the gut peptide PYY[3-36] increase after nutrient ingestion. Both have been implicated as short-term signals of meal termination with anorexigenic and weight-reducing effects. However, their combined effects are unknown. We report that the combi...

journal_title：Endocrinology

authors： Roth JD,Coffey T,Jodka CM,Maier H,Athanacio JR,Mack CM,Weyer C,Parkes DG

更新日期：2007-12-01 00:00:00

abstract：:The present study was undertaken to investigate the role of angiotensin II (Ang II) in ovulation and ovarian steroidogenesis and prostaglandin (PG) production via the Ang II receptors in rabbit ovaries. In in vitro perfused rabbit ovaries, PD123319, a selective nonpeptide antagonist for AT2 receptors, reduced the Ang ...

journal_title：Endocrinology

authors： Yoshimura Y,Karube M,Aoki H,Oda T,Koyama N,Nagai A,Akimoto Y,Hirano H,Nakamura Y

更新日期：1996-04-01 00:00:00

abstract：:Nonesterified fatty acids (NEFAs) have been recently shown in the rat to be involved in steroid hormone expression, having effects on plasma transport and intracellular activity. This study examines the influence of saturated and unsaturated NEFAs on estradiol (E2) binding to cytosol from human uterus, breast, and mel...

journal_title：Endocrinology

authors： Benassayag C,Vallette G,Hassid J,Raymond JP,Nunez EA

更新日期：1986-01-01 00:00:00