Evidence that the growth hormone receptor mediates differentiation and development of the mammary gland.

abstract：:Clinically, approximately 30% of women who receive synthetic glucocorticoids (sGC) for risk of preterm labor carry to term. In vitro studies have shown that sGC acutely regulate the placental system A amino acid transporter, but there are no comparable data in vivo. Hence, the objective of our study was to examine the...

journal_title：Endocrinology

authors： Audette MC,Challis JR,Jones RL,Sibley CP,Matthews SG

更新日期：2011-09-01 00:00:00

abstract：:Profound somatotroph hypoplasia in the dwarf (dw/dw) rat is accompanied by an estrogen-dependent induction of prolactin secretion by the GH secretagogue, GHRP-6. Using electron microscopy, we demonstrated that the reduction in the somatotroph population in the dw/dw pituitary is accompanied by the presence of a morpho...

journal_title：Endocrinology

authors： Huerta-Ocampo I,Christian HC,Thompson NM,El-Kasti MM,Wells T

更新日期：2005-11-01 00:00:00

abstract：:The effects of estradiol valerate and constant light exposure on the histological appearance of the arcuate nucleus were assessed in female rats. Both of these treatments caused significant increases in the numbers of reactive microglial cells and astrocytic granules in the nucleus. Ovariectomy before either treatment...

journal_title：Endocrinology

authors： Brawer JR,Schipper H,Naftolin F

更新日期：1980-07-01 00:00:00

abstract：:The dynamics of dopamine (DA) action on PRL release was studied in superfused rat anterior pituitary cell aggregates, cultured for for 5 days either in conventional or in serum-free defined medium. In aggregates cultured in conventional medium 0.1-1 nM DA applied for 20 min provoked a rapid and concentration-dependent...

journal_title：Endocrinology

authors： Denef C,Baes M,Schramme C

更新日期：1984-04-01 00:00:00

abstract：:The expression of short-chain fatty acid receptors GPR41/FFAR3 and GPR43/ free fatty acid receptor 2 (FFAR2) was studied in the gastrointestinal tract of transgenic monomeric red fluorescent protein (mRFP) reporter mice. In the stomach free fatty acid receptor 3 (FFAR3)-mRFP was expressed in a subpopulation of ghrelin...

journal_title：Endocrinology

authors： Nøhr MK,Pedersen MH,Gille A,Egerod KL,Engelstoft MS,Husted AS,Sichlau RM,Grunddal KV,Poulsen SS,Han S,Jones RM,Offermanns S,Schwartz TW

更新日期：2013-10-01 00:00:00

abstract：:Stearoyl-CoA desaturase-1 (SCD-1) plays a pivotal role in an increase of triglyceride by an excess of dietary carbohydrate intake. Dietary carbohydrates increase SCD-1 gene expression in liver by sterol response element binding protein (SREBP)-1c-dependent and SREBP-1c -independent pathways. Previous report demonstrat...

journal_title：Endocrinology

authors： Hashimoto K,Ishida E,Miura A,Ozawa A,Shibusawa N,Satoh T,Okada S,Yamada M,Mori M

更新日期：2013-01-01 00:00:00

abstract：:To investigate further brain-pituitary-gonadal interrelationships we have generated mice in which the gene encoding the FSH receptor has been disrupted. Female FSH receptor knockout (FSHRKO) mice were infertile. The ovaries were significantly reduced in size, with follicular development arrested at the preantral stage...

journal_title：Endocrinology

authors： Abel MH,Wootton AN,Wilkins V,Huhtaniemi I,Knight PG,Charlton HM

更新日期：2000-05-01 00:00:00

abstract：:To define the specific role of IGF-I receptor (IGF-IR) in adipogenic and thermogenic differentiation of brown adipocytes during late fetal life, we have established immortalized brown adipocyte cell lines from fetuses of IGF-IR-deficient mice (IGF-IR(-/-)) as well as from wild-type mice (IGF-IR(+/+)). IGF-IR(-/-) cell...

journal_title：Endocrinology

authors： Mur C,Arribas M,Benito M,Valverde AM

更新日期：2003-02-01 00:00:00

abstract：:In a previous study we found that PTH stimulated bone resorption and release of insulin-like growth factor-I (IGF-I) and IGF-II from cultured neonatal mouse calvaria. Since IGF-I and IGF-II stimulate osteoblast proliferation and collagen synthesis, these results suggested that increased release of IGFs during resorpti...

journal_title：Endocrinology

authors： Linkhart TA,Keffer MJ

更新日期：1991-03-01 00:00:00

abstract：:Differences in the catalytic activity of the placental and gonadal isozymes of porcine aromatase cytochrome P450 (P450arom) were examined in cell lines exhibiting stable expression of recombinant enzyme. Cell lines were selected that expressed high, but similar, immunodetectable levels of each isozyme based on Western...

journal_title：Endocrinology

authors： Corbin CJ,Trant JM,Walters KW,Conley AJ

更新日期：1999-11-01 00:00:00

abstract：:The anterior pituitary (AP) is made of five different cell types. The relative abundance and phenotype of AP cells may change in different physiological situations as an expression of pituitary plasticity. Here, we analyze in detail the phenotype of mouse corticotropes and the effects of acute cold stress on AP cell p...

journal_title：Endocrinology

authors： Senovilla L,Núñez L,Villalobos C,García-Sancho J

更新日期：2008-05-01 00:00:00

abstract：:Effects of thyroid hormone on proteoglycan degradation in various regions of cartilage were investigated. In propylthiouracil-treated rats with hypothyroidism, proteoglycan degradation in epiphyseal cartilage during endochondral ossification was markedly suppressed. However, injections of T(4) reversed this effect of ...

journal_title：Endocrinology

authors： Makihira S,Yan W,Murakami H,Furukawa M,Kawai T,Nikawa H,Yoshida E,Hamada T,Okada Y,Kato Y

更新日期：2003-06-01 00:00:00

abstract：:We previously demonstrated that the mitochondrial peripheral-type benzodiazepine receptor (PBR) is coupled to hormone-activated steroidogenesis by regulating the intramitochondrial cholesterol transport, the rate-determining step of steroid biosynthesis. In the present study we examined whether PBR is the site of horm...

journal_title：Endocrinology

authors： Boujrad N,Gaillard JL,Garnier M,Papadopoulos V

更新日期：1994-10-01 00:00:00

abstract：:We have previously reported that the acute injection of interleukin-1 beta (IL-1 beta) into the brain ventricles of intact female rats promptly decreases LHRH release and inhibits gene expression of this peptide in the medial preoptic area (MPOA). The present studies were therefore designed to determine whether contin...

journal_title：Endocrinology

authors： Rivest S,Lee S,Attardi B,Rivier C

更新日期：1993-12-01 00:00:00

abstract：:Adult Leydig cells are derived from proliferating stem/progenitor Leydig cells in the infant testis and subsequent differentiation to steroidogenic cells in adult mice. Leydig cell proliferation in the infant testis occurs primarily in response to increased levels of LH that induce Leydig cell expression of neuregulin...

journal_title：Endocrinology

authors： Umehara T,Kawashima I,Kawai T,Hoshino Y,Morohashi KI,Shima Y,Zeng W,Richards JS,Shimada M

更新日期：2016-12-01 00:00:00

abstract：:GH feeds back at the level of the central nervous system to alter the release of somatostatin and GRF, resulting in altered GH release. The purpose of this study was to see whether the concentration of GH, impinging directly on the somatotrophs of the adenohypophysis, would alter the responsiveness of the somatotrophs...

journal_title：Endocrinology

authors： Kraicer J,Lussier B,Moor BC,Cowan JS

更新日期：1988-04-01 00:00:00

abstract：:Mice with somatotrope-specific deletion of the Janus kinase binding site in leptin receptors are GH deficient as young adults and become obese by 6 months of age. This study focused on the metabolic status of young (3-4.5 month old) preobese mutant mice. These mutants had normal body weights, lean body mass, serum lep...

journal_title：Endocrinology

authors： Akhter N,Odle AK,Allensworth-James ML,Haney AC,Syed MM,Cozart MA,Chua S,Kineman R,Childs GV

更新日期：2012-10-01 00:00:00

abstract：:L-Triiodothyronine in vitro increased the uptake of the non-metabolizable amino acid, alpha-aminoisobutyrate, into isolated rat thymocytes. This effect was evident at extracellular free hormone concentrations of 10-7 to 5 times 10-8M and was due to a marked inhibition of amino acid efflux. In contrast, insulin and dib...

journal_title：Endocrinology

authors： Goldfine ID,Simons CG,Ingbar SH

更新日期：1975-03-01 00:00:00

abstract：:PTH-related protein (PTHrP) is the principle mediator of the syndrome of humoral hypercalcemia of malignancy and has potential paracrine actions on smooth muscle, epithelial cell growth, and placental calcium transport. The human PTHrP gene is complex: a combination of three promoters, one 5' alternative splicing even...

journal_title：Endocrinology

authors： Southby J,Murphy LM,Martin TJ,Gillespie MT

更新日期：1996-04-01 00:00:00

abstract：:Morphoregulator genes like members of the Hox gene family regulate uterine development and are associated with endocrine-related processes such as endometrial proliferation and differentiation in the adult uterus. Exposure to neonatal endocrine disruptors could affect signaling events governed by Hox genes, altering t...

journal_title：Endocrinology

authors： Varayoud J,Ramos JG,Bosquiazzo VL,Muñoz-de-Toro M,Luque EH

更新日期：2008-11-01 00:00:00

abstract：:The adipose conversion of 3T3-L1 fibroblasts depends on serum factors, one of which has been identified as GH. Human serum extracts obtained by heat treatment do not contain intact GH, as shown by RIA, but still support adipose conversion. After organic solvent extraction followed by reversed phase HPLC, two adipogeni...

journal_title：Endocrinology

authors： Schiwek DR,Löffler G

更新日期：1987-02-01 00:00:00

abstract：:The ability of cells to directly respond to glucocorticoids and aldosterone is a function of GR and MR expression, and coexpression of 11beta-hydroxysteroid dehydrogenases (11betaHSDs), which convert glucocorticoids and their 11-ketometabolites into either receptor inactive or active derivatives. The aim of the presen...

journal_title：Endocrinology

authors： Sheppard KE,Autelitano DJ

更新日期：2002-01-01 00:00:00

abstract：:Leptin has been shown to activate multiple signaling molecules in cultured cells, including Janus kinase-2, STAT (signal transducer and activator of transcription) proteins, and mitogen-activated protein kinase, and to stimulate the DNA-binding activity of STAT3 in mouse hypothalamus. In this study, the activation of ...

journal_title：Endocrinology

authors： McCowen KC,Chow JC,Smith RJ

更新日期：1998-11-01 00:00:00

abstract：:11beta-hydroxysteroid dehydrogenases (11betaHSDs) catalyze interconversion of 11-hydroxy-glucocorticoids with inactive 11-keto metabolites. In blood vessel walls, loss of 11betaHSD1 is thought to reduce local glucocorticoid concentrations, reducing the progression of atheroma and enhancing angiogenesis. Conversely, on...

journal_title：Endocrinology

authors： Dover AR,Hadoke PW,Macdonald LJ,Miller E,Newby DE,Walker BR

更新日期：2007-01-01 00:00:00

abstract：:Studying the mechanisms for the complex pathogenesis of polycystic ovary syndrome (PCOS) requires animal models with endocrine, reproductive, and metabolic features of the syndrome. Hyperandrogenism seems to be a central factor in PCOS, leading to anovulation and insulin resistance. In female rats, continuous administ...

journal_title：Endocrinology

authors： Maliqueo M,Sun M,Johansson J,Benrick A,Labrie F,Svensson H,Lönn M,Duleba AJ,Stener-Victorin E

更新日期：2013-01-01 00:00:00

abstract：:Dispersed cells from whole testes or from isolated interstitial tissue of mature rats, yielded two distinct populations of Leydig cells when subjected to centrifugation in a 0-40% metrizamide gradient. One population (I) was found in a fractions with a density of 1.085-1.117 g/cm3, and the other population (II) was fo...

journal_title：Endocrinology

authors： Payne AH,Downing JR,Wong KL

更新日期：1980-05-01 00:00:00

abstract：:The consumption of refined sugars continues to pose a significant health risk. However, nearly nothing is known about the effects of sugar intake by healthy women on the oocyte or embryo. Using rhesus monkeys, we show that low-dose sucrose intake over a 6-month period has an impact on the oocyte with subsequent effect...

journal_title：Endocrinology

authors： Chaffin CL,Latham KE,Mtango NR,Midic U,VandeVoort CA

更新日期：2014-07-01 00:00:00

abstract：:GnRH release in the median eminence (ME) is the central output for control of reproduction. GnRH processes in the preoptic area (POA) also release GnRH. We examined region-specific regulation of GnRH secretion using fast-scan cyclic voltammetry to detect GnRH release in brain slices from adult male mice. Blocking endo...

journal_title：Endocrinology

authors： Glanowska KM,Moenter SM

更新日期：2015-01-01 00:00:00

abstract：:Hyperaldosteronism is linked to the development and progression of several different cardiovascular diseases. Angiotensin (Ang) II increases aldosterone secretion and adrenal blood flow. Ang II peptide fragments are produced by various peptidases, and these Angs have diverse and vital physiologic roles. Due to the unc...

journal_title：Endocrinology

authors： Kopf PG,Campbell WB

更新日期：2013-12-01 00:00:00

abstract：:Thyroid hormone is essential for normal proliferation and differentiation of chondrocytes. Thus, untreated congenital hypothyroidism is marked by severe short stature. The monocarboxylate transporter 8 (MCT8) is a highly specific transporter for thyroid hormone. The hallmarks of Allan-Herndon-Dudley syndrome, caused b...

journal_title：Endocrinology

authors： Abe S,Namba N,Abe M,Fujiwara M,Aikawa T,Kogo M,Ozono K

更新日期：2012-08-01 00:00:00