Abstract:
:The effects of estradiol valerate and constant light exposure on the histological appearance of the arcuate nucleus were assessed in female rats. Both of these treatments caused significant increases in the numbers of reactive microglial cells and astrocytic granules in the nucleus. Ovariectomy before either treatment prevented the glial reaction, indicating that the experimental manipulations triggered the secretion of an ovarian product which appears to be selectively toxic to the arcuate nucleus. The fact that monthly injections of estradiol valerate in male rats produced the same profile of degeneration in the arcuate nucleus suggests that the neuropathological agent may itself be estradiol. Ovariectomy also significantly reduced arcuate microglial reactivity associated with normal aging, which suggests that cyclic surges of endogenous estradiol may be capable of gradually producing an arcuate lesion. This phenomenon may accout for the hypothalamic reproductive failure associated with normal aging in the rat.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Brawer JR,Schipper H,Naftolin Fdoi
10.1210/endo-107-1-274subject
Has Abstractpub_date
1980-07-01 00:00:00pages
274-9issue
1eissn
0013-7227issn
1945-7170journal_volume
107pub_type
杂志文章相关文献
ENDOCRINOLOGY文献大全abstract::In vivo and in vitro evidence indicates that FSH is a primary regulator of testicular inhibin production. However, recent reports suggest that LH may also promote inhibin secretion in vivo. To investigate whether LH regulates inhibin subunit messenger RNA (mRNA) expression as well, we examined the effects of hypophyse...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-127-3-1097
更新日期:1990-09-01 00:00:00
abstract::To determine the effect of aromatase inhibitors on peripheral aromatization, male rhesus monkeys were infused with [7-3H]androstenedione and [4-14C]estrone before and during treatment with 4-hdyroxy-androstene-3,17-dione (50 mg/kg each; four monkeys) or 4-acetoxy-androstene-3,17-dione (700 mg each; two monkeys). In al...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-106-1-19
更新日期:1980-01-01 00:00:00
abstract::In osteoblasts, retinoic acid (RA) modulates the synthesis of various proteins, including collagen. However, little is known about the effects of RA on the regulation of interstitial collagenase synthesis and collagen degradation. After treatment of primary osteoblast-enriched (Ob) cells from fetal rat calvariae with ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.134.6.8194470
更新日期:1994-06-01 00:00:00
abstract::Groups of female ferrets born in the laboratory received sc Silastic capsules containing testosterone (T), 5 alpha-dihydrotestosterone (DHT), 17 beta-estradiol (E), or no steroid for 15 days beginning on the day of birth; an additional group of male ferrets received empty sc capsules neonatally. All ferrets were gonad...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-111-3-773
更新日期:1982-09-01 00:00:00
abstract::GH is secreted in a pulsatile manner, the pattern of which plays an important role in the regulation of growth and metabolism. Sex steroids are also known to participate in metabolic regulation. The present study was undertaken to elucidate the relationship between changes in GH pulsatility and metabolic transition du...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2004-1434
更新日期:2005-06-01 00:00:00
abstract::The ability of the adult pancreas to generate new insulin (beta) cells has been controversial because of difficulties in unequivocally identifying the precursor population. We recently determined that beta cells were generated during development from precursors that expressed the homeodomain-containing transcription f...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.138.4.5049
更新日期:1997-04-01 00:00:00
abstract::The microenvironment of placental mesenchymal stem cells (PMSCs) is dynamic throughout gestation and determines changes in cell fate. In vivo, PMSCs initially develop in low-oxygen tension and low IGF-I concentrations, and both increase gradually with gestation. The impact of varying concentrations of IGF-I and changi...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1842
更新日期:2014-04-01 00:00:00
abstract::We investigated the effect of epidermal growth factor (EGF) on collagen and protein synthesis in clone MC3T30-E1, a cell line which retains osteoblast-like characteristics. EGF at concentrations of 2-50 ng/ml significantly the hydroxyproline content of the cell layer. These effects were completely abolished by the add...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-111-6-1810
更新日期:1982-12-01 00:00:00
abstract::Parathyroid hormone (PTH) secretion rate was measured in seven calves by using a technique which involved RIA of parathyroid venous blood collected during timed intervals and measured volumetrically. Infusion of solutions of NA2EDTA and MgCl2 into the jugular vein was used to alter plasma calcium and magnesium concent...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-102-6-1803
更新日期:1978-06-01 00:00:00
abstract::Previous studies from our laboratory demonstrated that daily afternoon melatonin injections from 20-40 days of age inhibited sexual development of young male rats, whereas in adult animals, similar injections had no effect. The present study was designed to determine more precisely the critical age period during which...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-115-6-2303
更新日期:1984-12-01 00:00:00
abstract::The heart has epicardial adipose tissue that produces adipokines and mesenchymal stem cells. Systemic adipose tissue is involved in the pathophysiology of obesity-related heart diseases. However, the method for analyzing the direct interaction between adipose tissue and cardiomyocytes has not been established. Here we...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2010-1106
更新日期:2011-04-01 00:00:00
abstract::Previous studies have shown that increased sodium chloride in drinking water failed to suppress serum renin activity (SRA) in the etheranesthetized rat. In the absence of anesthesia, sodium chloride decreased SRA by 76% and serum aldosterone by 72%. Deoxycorticosterone acetate, when given alone, produced similar resul...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-97-6-1394
更新日期:1975-12-01 00:00:00
abstract::In different types of mammalian cells, insulin has been shown to promote the release of an inositol phosphate glycan (InsP-glycan) through the hydrolysis of a glycosyl-phosphatidylinositol (glycosyl-PtdIns). This InsP-glycan, which has been demonstrated to be taken up by intact cells, may mediate some of the biologica...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.134.3.8119190
更新日期:1994-03-01 00:00:00
abstract::Estradiol imprinting plays an important role in the regulation of galanin (GAL) gene expression in the rat. In the anterior pituitary gland, GAL gene expression is greatly induced by estrogen. The relative involvement that the two estrogen receptor subtypes, alpha and beta, have in regulating this induction is not kno...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.140.6.6932
更新日期:1999-06-01 00:00:00
abstract::Sex differences in vocal communication are prevalent in both the animals and humans. The mechanism(s) mediating gender differences in human language are unknown, although, sex hormones, principally androgens, play a central role in the development of vocalizations in a wide variety of animal species. The discovery of ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2014-1486
更新日期:2014-12-01 00:00:00
abstract::Although the extent of proptosis in exophthalmic Graves' disease has been measured directly and shown to correlate with serum content of a bioassayable exophthalmus-producing factor (EPS;1), a comparable relationship in an experimental model has not been reported. Progressive exophthalmos, measured from photographs an...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-96-1-151
更新日期:1975-01-01 00:00:00
abstract::We have examined the expression, postnatal ontogeny, and localization of mouse GH (mGH) and its relative expression during pregnancy, lactation, and weaning in the mouse. mGH mRNA and protein was expressed predominantly in the epithelial component of the mammary gland, and maximal expression was observed during the pu...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2005-1082
更新日期:2006-04-01 00:00:00
abstract::Bisphenol A (BPA) is an endocrine-disrupting compound used to manufacture plastics; it is present in linings of food cans, bottles, thermal receipts, and many other everyday items and is detectable in human urine and blood. Exposure to BPA during development can disrupt sexual differentiation of some brain regions. Mo...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1188
更新日期:2017-01-01 00:00:00
abstract::Our previous studies implicated the involvement of protein kinase-A in the inhibitory effects of isoproterenol and relaxin on oxytocin-stimulated phosphoinositide turnover in rat myometrium. To understand the possible mechanisms involved, the properties and regulation of phospholipase-C (PLC) in purified myometrial pl...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.131.3.1324160
更新日期:1992-09-01 00:00:00
abstract::The glucocorticoid (GC) rhythm is entrained to light-dark (LD) cycles via a molecular clock in the suprachiasmatic nucleus (SCN) and is maintained by an adrenal clock synchronized by SCN-dependent signals. Targeted deletion of the core clock gene Bmal1 can disrupt adrenal clock function. The requirement of the adrenal...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2018-00769
更新日期:2018-12-01 00:00:00
abstract::Human decidual cells synthesize and release decidual PRL (dPRL) immunologically and biochemically identical to human pituitary PRL. However, stimulators and inhibitors of PRL secretion such as TRH, bromocriptine or dopamine have no effect on dPRL release. The evidence for the involvement of Ca2+ in dPRL release is bas...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.130.6.1597150
更新日期:1992-06-01 00:00:00
abstract::Extracts of rat pancreas contain significant amounts of an [3H]estradiol-binding protein. The amount of steroid-binding activity that could be measured varied considerably depending on the tonicity of the homogenizing medium. High speed supernatants of homogenates initially prepared in isotonic buffer contained about ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-116-6-2221
更新日期:1985-06-01 00:00:00
abstract::Disruption of the pituitary adenylate cyclase-activating polypeptide (PACAP) gene in mice has demonstrated a role for this highly conserved neuropeptide in the regulation of metabolism and temperature control. Localization of PACAP neurons within hypothalamic nuclei that regulate appetite suggest PACAP may affect feed...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2007-0515
更新日期:2008-04-01 00:00:00
abstract::In order to delineate the ages of onset and decline in sensitivity to growth hormone (GH) in rats, the ability of ovine GH in vitro to stimulate amino acid uptake and protein synthesis was studied in diaphragm muscle. GH (25 mug/ml) produced a significant, but small (12-17%), stimulation of alpha-aminoisobutyric acid ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-98-5-1273
更新日期:1976-05-01 00:00:00
abstract::Estrogens are crucial for growth and function of the female genital tract. Recently, we showed that induction of uterine epithelial proliferation by estradiol is a paracrine event requiring an estrogen receptor-positive stroma. Growth factors [such as EGF (epidermal growth factor) ligands] are likely paracrine mediato...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.139.3.5817
更新日期:1998-03-01 00:00:00
abstract::Prostaglandin (PG) E2 (PGE(2)) plays a central role in the regulation of smooth muscle contractions. Classically, PGE(2) stimulates contractions via EP1 and EP3 receptors, whereas EP2 and EP4 maintain quiescence. Labor involves a change from myometrial quiescence to contractions with a shift from anti- to proinflammat...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1761
更新日期:2014-02-01 00:00:00
abstract::Ovary-specific acidic protein (OSAP) is a novel molecule discovered from a genomic project designed to identify ovary-selective genes in mice. Whereas public databases suggest extraovarian expression of OSAP, its tissue distribution has not yet been well documented. Thus, the expression profile of mouse and human OSAP...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2008-1584
更新日期:2009-07-01 00:00:00
abstract::We previously described significant differences in maximal testosterone production by Leydig cells from the following strains of inbred mice: C57BL/10J, C57BL/6J, DBA/2J, and C3H/HeJ. To evaluate whether these differences in maximal testosterone production related to the activities of the steroidogenic enzymes of the ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-115-4-1500
更新日期:1984-10-01 00:00:00
abstract::We constructed seven chimeric molecules in which sequential segments in the cDNA for thyroid peroxidase (TPO) were replaced with the homologous regions of myeloperoxidase (MPO) cDNA. The sizes of the translated cDNA segments A through G ranged from 23-175 amino acid residues in length. The TPO-MPO cDNA chimeras, inser...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.133.6.8243270
更新日期:1993-12-01 00:00:00
abstract::Synthetic selective thyroid hormone (TH) receptor (TR) modulators (STRM) exhibit beneficial effects on dyslipidemias in animals and humans and reduce obesity, fatty liver, and insulin resistance in preclinical animal models. STRM differ from native TH in preferential binding to the TRβ subtype vs. TRα, increased uptak...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2011-1325
更新日期:2012-01-01 00:00:00