The Intermediate lactotroph: a morphologically distinct, ghrelin-responsive pituitary cell in the dwarf (dw/dw) rat.

abstract：:We tested the hypothesis that depressed duodenal calcium absorption in the streptozotocin diabetic rat is the consequence of diabetes rather than nephrotoxicity of the diabetogenic agent causing abnormal renal vitamin D metabolism. We treated streptozotocin diabetic rats with insulin and compared their duodenal calciu...

journal_title：Endocrinology

authors： Schneider LE,Nowosielski LM,Schedl HP

更新日期：1977-01-01 00:00:00

abstract：:We have recently disclosed sustained episodes of LH release (minisurges) during the afternoons of the juvenile-peripubertal transition period in the female rat. To determine if these LH minisurges are gonad independent, i.e. develop in the absence of the ovaries, animals were ovariectomized when neonates, and the mode...

journal_title：Endocrinology

authors： Urbanski HF,Ojeda SR

更新日期：1986-03-01 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I) is produced in multiple tissues and is believed to exert its action in a paracrine or autocrine fashion. We have investigated the GH dependency of tissue IGF-I gene expression in rats harboring implanted somatomammotropic tumors. Circulating GH and radioimmunoassayable IGF-I levels...

journal_title：Endocrinology

authors： Fagin JA,Brown A,Melmed S

更新日期：1988-05-01 00:00:00

abstract：:Homeostatic control of endocrine systems proceeds via feedforward (agonistic, stimulatory) and feedback (antagonistic, inhibitory) interactions mediated via implicit dose-response functions. However, neither the feedback/feedforward pathways nor the dose-response interfaces are directly observed in vivo. Thus, the goa...

journal_title：Endocrinology

authors： Keenan DM,Clarke IJ,Veldhuis JD

更新日期：2011-12-01 00:00:00

abstract：:The serum pharmacokinetics of recombinant human inhibin A (rh-inhibin A) and rh-activin A were examined in immature female Sprague Dawley-derived rats after iv and sc injection of the drugs. After iv administration of rh-inhibin A (120 micrograms/kg), the serum concentrations were described by a biexponential equation...

journal_title：Endocrinology

authors： Woodruff TK,Krummen LA,Chen S,DeGuzman G,Lyon R,Baly DL,Allison DE,Garg S,Wong WL,Hebert N

更新日期：1993-02-01 00:00:00

abstract：:Single-minded 1 (SIM1) mutations are associated with obesity in mice and humans. Haploinsufficiency of mouse Sim1 causes hyperphagic obesity with increased linear growth and enhanced sensitivity to a high-fat diet, a phenotype similar to that of agouti yellow and melanocortin 4 receptor knockout mice. To investigate t...

journal_title：Endocrinology

authors： Kublaoui BM,Holder JL Jr,Tolson KP,Gemelli T,Zinn AR

更新日期：2006-10-01 00:00:00

abstract：:Female Chinese hamsters (n = 10) were immunized with Chinese hamster ovary (CHO) cells that expressed the human TSH receptor (TSHR) to generate a model of Graves' disease. TSHR-autoantibodies (TSHR-Ab) were determined by CHO-TSHR. Two hamsters with stimulating TSHR-Ab showed thyrocyte hypertrophy associated with a foc...

journal_title：Endocrinology

authors： Ando T,Imaizumi M,Graves P,Unger P,Davies TF

更新日期：2003-02-01 00:00:00

abstract：:The importance of thyroid hormone (TH) in wound healing is not well understood. To gain insight, we evaluated the impact of TH deficiency on wound-healing genes in cultured keratinocytes. By RT-PCR, keratin 6a (K6a) and 16 (K16) gene expression in TH replete cells was 3.8- (P < 0.005) and 1.9-fold (P < 0.05) greater, ...

journal_title：Endocrinology

authors： Safer JD,Crawford TM,Holick MF

更新日期：2004-05-01 00:00:00

abstract：:Neuropeptide Y (NPY) readily stimulates the release of hypothalamic LHRH and pituitary LH release in intact and gonadal steroid-primed gonadectomized rats. We have now tested the hypothesis that the release and synthesis of hypothalamic NPY may be regulated by gonadal steroids. To measure the effects of gonadal hormon...

journal_title：Endocrinology

authors： Sahu A,Phelps CP,White JD,Crowley WR,Kalra SP,Kalra PS

更新日期：1992-06-01 00:00:00

abstract：:To investigate the possibility that a common phenomenon might exist by which glucocorticoids influence responses to thyroid hormones, the cytosol levels of four proteins were measured after 2 days of treatment with L-T3 (T3; 50 micrograms/100 g. day 2) and/or cortisone (2 mg/100 g./day) in adult male hypothyroid rats....

journal_title：Endocrinology

authors： Shapiro LE,Sachchidananda J

更新日期：1982-08-01 00:00:00

abstract：:We looked for the presence of vitamin D-dependent intestinal calcium binding protein (CaBP), relative molecular mass (mol wt) about 10,000, in kidneys of mammals, birds, and reptiles, and compared the localization of this 10,000 mol wt CaBP with the localization of the 28,000 mol wt vitamin D-dependent CaBP. Antiserum...

journal_title：Endocrinology

authors： Rhoten WB,Bruns ME,Christakos S

更新日期：1985-08-01 00:00:00

abstract：:We recently reported that bone morphogenetic proteins (BMPs) 2 and 4 can stimulate FSHbeta-subunit (Fshb) transcription alone and in synergy with activins. We further showed that BMP2 signals via the BMP type IA receptor (or activin receptor-like kinase 3) to mediate its effects. However, the intracellular mechanisms ...

journal_title：Endocrinology

authors： Ho CC,Bernard DJ

更新日期：2010-07-01 00:00:00

abstract：:PTH increased PG synthase-2 transcription in osteoblastic MC3T3-E1 cells at 30 min, as assessed by nuclear run-on assays. To determine the signaling pathways used by PTH, the activity of a construct containing the PG synthase-2 gene between nucleotides -963 and +70 linked to a luciferase reporter was analyzed in stabl...

journal_title：Endocrinology

authors： Tetradis S,Pilbeam CC,Liu Y,Herschman HR,Kream BE

更新日期：1997-09-01 00:00:00

abstract：:The assembly of the developmentally arrested primordial follicle and the subsequent transition of the primordial follicle to the primary follicle are critical processes in normal ovarian physiology that remain to be elucidated. Ovarian follicles do not proliferate and the primordial follicles present in the neonate re...

journal_title：Endocrinology

authors： Kezele P,Skinner MK

更新日期：2003-08-01 00:00:00

abstract：:Ghrelin stimulates and leptin inhibits appetite by modulating neuropeptide Y (NPY) signaling in the hypothalamus. Analysis of plasma ghrelin and leptin by sensitive radioimmunoassays showed that the two peripheral hormones are secreted in pulsatile fashion in rats consuming ad libitum rat chow. Fasting augmented all p...

journal_title：Endocrinology

authors： Bagnasco M,Kalra PS,Kalra SP

更新日期：2002-02-01 00:00:00

abstract：:Some 17 alpha-alkylated androgens used as anabolic agents, such as stanozolol (ST) and danazol (DA), have specific effects on the liver that are not exerted by testosterone. This gives rise to the possibility that a steroid-binding protein, other than the androgen receptor, could modulate the intracellular actions of ...

journal_title：Endocrinology

authors： Fernández L,Chirino R,Boada LD,Navarro D,Cabrera N,del Rio I,Díaz-Chico BN

更新日期：1994-03-01 00:00:00

abstract：:Aldosterone plays a major role in regulating sodium and potassium flux in epithelial tissues such as kidney and colon. Recent evidence suggests that serum- and glucocorticoid-regulated kinase (SGK) is induced by aldosterone and acts as a key mediator of aldosterone action in epithelial tissues. Induction of SGK messen...

journal_title：Endocrinology

authors： Bhargava A,Fullerton MJ,Myles K,Purdy TM,Funder JW,Pearce D,Cole TJ

更新日期：2001-04-01 00:00:00

abstract：:Local androgen synthesis in prostate cancer (PC) may contribute to the development of castration-resistant PC (CRPC), but pathways controlling intratumoral steroidogenic enzyme expression in PC are unknown. We investigated the effects of activin, a factor involved in the regulation of PC growth and steroidogenic enzym...

journal_title：Endocrinology

authors： Hofland J,van Weerden WM,Steenbergen J,Dits NF,Jenster G,de Jong FH

更新日期：2012-12-01 00:00:00

abstract：:The somatic Sertoli cells of the testis are major targets for FSH and are important for the regulation of spermatogenesis. The binding of FSH to Sertoli cells activates the cAMP-dependent protein kinase A signaling pathway, resulting in phosphorylation of the cAMP response element-binding protein (CREB), which is requ...

journal_title：Endocrinology

authors： Walker WH,Fucci L,Habener JF

更新日期：1995-08-01 00:00:00

abstract：:The effect of collagenase dissociation of virgin mouse mammary glands on the level of mammary epithelial cytosolic estrogen receptors (ER) and progesterone receptors (PR) was assessed. After cell dissociation, ER was present in mammary epithelial cells at concentrations similar to those found in the whole gland. Howev...

journal_title：Endocrinology

authors： Edery M,Imagawa W,Larson L,Nandi S

更新日期：1985-01-01 00:00:00

abstract：:The xenoestrogen bisphenol A (BPA) has been shown to mimic estrogen both in vivo and in vitro. BPA stimulates PRL secretion and the expression of a PRL regulating factor from the posterior pituitary in the estrogen-sensitive Fischer 344 rat (F344), but not in Sprague-Dawley (SD) rats. The goal of the present studies w...

journal_title：Endocrinology

authors： Steinmetz R,Mitchner NA,Grant A,Allen DL,Bigsby RM,Ben-Jonathan N

更新日期：1998-06-01 00:00:00

abstract：:Apolipoprotein A-IV (apo A-IV) is a satiety factor involved in the control of food intake and body weight. Our previous studies demonstrated that apo A-IV is present in areas of the hypothalamus where leptin acts to influence energy homeostasis. In the present studies, we found that leptin-deficient obese (ob/ob) mice...

journal_title：Endocrinology

authors： Shen L,Tso P,Woods SC,Sakai RR,Davidson WS,Liu M

更新日期：2007-06-01 00:00:00

abstract：:Under acute stress conditions in the rat, there is rapid and transient increase in circulating prolactin (PRL). This leads to an elevated expression of the long form of PRLR (PRLR-L) first in the hypothalamus and the choroid plexus. This increase in PRL is involved in the inhibition of stress-induced hypocalcemia and ...

journal_title：Endocrinology

authors： Fujikawa T,Tamura K,Kawase T,Mori Y,Sakai RR,Sakuma K,Yamaguch A,Ogata M,Soya H,Nakashima K

更新日期：2005-08-01 00:00:00

abstract：:Parathyroid hormone (PTH) secretion rate was measured in seven calves by using a technique which involved RIA of parathyroid venous blood collected during timed intervals and measured volumetrically. Infusion of solutions of NA2EDTA and MgCl2 into the jugular vein was used to alter plasma calcium and magnesium concent...

journal_title：Endocrinology

authors： Mayer GP,Hurst JG

更新日期：1978-06-01 00:00:00

abstract：:The effects of leptin on the levels of CRF messenger RNA (mRNA) in the paraventricular hypothalamic nucleus (PVN), on the activation of the PVN CRF cells, and on the plasma levels of corticosterone were investigated in lean (+/?) and obese (ob/ob) C57BL/6J male mice. Murine leptin was s.c. infused using osmotic minipu...

journal_title：Endocrinology

authors： Huang Q,Rivest R,Richard D

更新日期：1998-04-01 00:00:00

abstract：:Aldo-keto-reductase 1B7/mouse vas deferens protein (AKR1B7/MVDP) is expressed in rodent steroidogenic glands and in the mouse vas deferens. In steroidogenic organs, AKR1B7/MVDP scavenges isocaproaldehyde produced from the cholesterol side-chain cleavage reaction. Akr1b7/mvdp is responsive to ACTH in adrenals and to an...

journal_title：Endocrinology

authors： Martinez A,Val P,Sahut-Barnola I,Aigueperse C,Veyssière G,Lefrançois-Martinez AM

更新日期：2003-05-01 00:00:00

abstract：:Glucocorticoid feedback inhibition at the level of the brain is extremely complex, involving feedback at both hypothalamic and suprahypothalamic levels. The hippocampus has been implicated as a suprahypothalamic mediator of such feedback, based on numerous lesion, stimulation, and steroid implantation studies. These r...

journal_title：Endocrinology

authors： Sapolsky RM,Armanini MP,Sutton SW,Plotsky PM

更新日期：1989-12-01 00:00:00

abstract：:Purified rat Leydig cell cytosol was found to contain a protein kinase which was dependent on the presence of both calcium and phospholipids (phosphatidylserine and diolein), i.e. calcium/phospholipid-dependent protein kinase. The peak of Ca/phospholipid-dependent protein kinase was separated from type I and type II c...

journal_title：Endocrinology

authors： Lin T

更新日期：1985-07-01 00:00:00

abstract：:Removal of fetuses at day 14 of gestation (Ftx14) in the pregnant rat leads to a marked suppression of serum levels of rat placental lactogen (rPL-II). One might attribute this to compromised placental growth in the absence of a fetus. However, if ovariectomy and fetectomy (Ftx14 Ovx14) are carried out at the same tim...

journal_title：Endocrinology

authors： Robertson MC,Owens RE,McCoshen JA,Friesen HG

更新日期：1984-01-01 00:00:00

abstract：:The purpose of this experiment was to determine whether surgical stress on the morning of proestrus would elicit an early release of gonadotropin from the pituitary. Animals exhibiting 5-day estrous cycles underwent bilateral sham-ovariectomy under ether anesthesia at 0800 h of proestrus. These animals had high levels...

journal_title：Endocrinology

authors： Nequin LG,Alvarez JA,Campbell CS

更新日期：1975-09-01 00:00:00