Noninvasive analytical estimation of endogenous GnRH drive: analysis using graded competitive GnRH-receptor antagonism and a calibrating pulse of exogenous GnRH.

abstract：:A novel class of targeted chemotherapeutic agents based on cytotoxic compounds linked to LHRH analogs was tested in a long term superfusion system in order to determine their effects on different types of rat pituitary cells. The compounds investigated included two cytotoxic LHRH agonists, T-98 ([D-Lys6]LHRH coupled t...

journal_title：Endocrinology

authors： Rékási Z,Szöke B,Nagy A,Groot K,Rékási ES,Schally AV

更新日期：1993-05-01 00:00:00

abstract：:Bromocriptine, a dopamine agonist, inhibited secretion of PRL and did not affect GH release from rat anterior pituitary cells in culture. The reversal of this inhibition of PRL release by butaclamol, a dopamine antagonist, was stereospecific; 10 nM d-butaclamol completely reversed the inhibition caused by 10 nM bromoc...

journal_title：Endocrinology

authors： West B,Dannies PS

更新日期：1979-04-01 00:00:00

abstract：:Mechanisms underlying lymphocyte infiltration of the thyroid gland and orbit in Graves' disease (GD) are poorly understood. The IGF-I receptor (IGF-IR) is a newly recognized self-antigen that, when activated in GD fibroblasts by IGF-I or GD-IgGs, provokes the expression of IL-16 and RANTES (regulated upon activation, ...

journal_title：Endocrinology

authors： Gianoukakis AG,Douglas RS,King CS,Cruikshank WW,Smith TJ

更新日期：2006-04-01 00:00:00

abstract：:To determine whether glucagon plays a significant role in the restitution of blood volume after hemorrhage, pentobarbital-anesthetized dogs were treated with somatostatin (SRIF). The administration of SRIF (14 micrograms/kg.h) prevented the increase in osmolality and the complete restitution of plasma protein and bloo...

journal_title：Endocrinology

authors： Byrnes GJ,Engeland WC,Gann DS

更新日期：1982-06-01 00:00:00

abstract：:Kisspeptin regulates reproductive events, including puberty and ovulation, primarily via GnRH neurons. Prolonged treatment of prepubertal striped bass females with kisspeptin (Kiss) 1 or Kiss2 peptides failed to enhance puberty but suggested a gnrh-independent pituitary control pathway. Kiss2 inhibited, but Kiss1 stim...

journal_title：Endocrinology

authors： Zmora N,Stubblefield J,Golan M,Servili A,Levavi-Sivan B,Zohar Y

更新日期：2014-05-01 00:00:00

abstract：:Resorption of devitalized bone particles by monocytes grown in culture was stimulated by platelet-derived growth factor (PDGF) in a dose-dependent manner. Bone resorption in response to PDGF was time-dependent with a significant increase over control cultures evident by 72 hours. These data are the first to demonstrat...

journal_title：Endocrinology

authors： Key LL Jr,Carnes DL Jr,Weichselbaum R,Anast CS

更新日期：1983-02-01 00:00:00

abstract：:Morphine sulfate was found to have a direct inhibitory effect on both basal and GnRH-stimulated LH release by cultured rat pituitary cells. The inhibitory effect of morphine on LH release was prevented by the opiate antagonist naltrexone, and treatment of cells with naltrexone or beta-endorphin antiserum significantly...

journal_title：Endocrinology

authors： Blank MS,Fabbri A,Catt KJ,Dufau ML

更新日期：1986-05-01 00:00:00

abstract：:Pregnancy-associated plasma protein-A (PAPP-A) is the major IGF binding protein-4 (IGFBP-4) protease in follicular fluid, consistent with its proposed role in folliculogenesis. Despite growing interest, almost nothing is known about how PAPP-A expression is regulated in any tissue. Here we show that FSH and oocytes re...

journal_title：Endocrinology

authors： Matsui M,Sonntag B,Hwang SS,Byerly T,Hourvitz A,Adashi EY,Shimasaki S,Erickson GF

更新日期：2004-08-01 00:00:00

abstract：:Estrogens are essential hormones for the regulation of fertility. Cellular responses to estrogens are mediated by estrogen receptor α (ESR1) and estrogen receptor β (ESR2). In mouse and rat models, disruption of Esr1 causes infertility in both males and females. However, the role of ESR2 in reproductive function remai...

journal_title：Endocrinology

authors： Rumi MAK,Singh P,Roby KF,Zhao X,Iqbal K,Ratri A,Lei T,Cui W,Borosha S,Dhakal P,Kubota K,Chakraborty D,Vivian JL,Wolfe MW,Soares MJ

更新日期：2017-07-01 00:00:00

abstract：:The cytokine interleukin-1 (IL-1) has numerous actions in brain, including pronounced neuroendocrine effects. Recent radioligand binding studies have identified high-affinity binding sites for 125I-recombinant human IL-1 alpha in the hippocampus with characteristics similar to those of IL-1 receptors in immune cells. ...

journal_title：Endocrinology

authors： Cunningham ET Jr,Wada E,Carter DB,Tracey DE,Battey JF,De Souza EB

更新日期：1991-05-01 00:00:00

abstract：:The present experiments investigated the time course of maternal modulation of GH secretion and examined the possible role of milk in the regulation of GH secretion in neonatal rats. Serum GH concentrations in neonatal rats were high at birth and declined over time postpartum. Separation of rat pups from their mothers...

journal_title：Endocrinology

authors： Kacsoh B,Terry LC,Meyers JS,Crowley WR,Grosvenor CE

更新日期：1989-09-01 00:00:00

abstract：:Seven adult female rhesus monkeys were laparotomized at days 22, 42, and 157 of pregnancy and blood was collected from the uterine vein and peripheral circulation. Plasma samples were analyzed for monkey chorionic gonadotropin (mCG), monkey chorionic somatomammotropin (mCS), and prolactin by radioimmunoassay. Levels o...

journal_title：Endocrinology

authors： Walsh SW,Wolf RC,Meyer RK,Aubert ML,Friesen HG

更新日期：1977-03-01 00:00:00

abstract：:To determine the relative role of the androgenic and/or estrogenic components of the action of dehydroepiandrosterone (DHEA) on the histomorphology and structure of the rat mammary gland, ovariectomized (OVX) female animals received DHEA administered alone or in combination with the pure antiandrogen flutamide or the ...

journal_title：Endocrinology

authors： Sourla A,Martel C,Labrie C,Labrie F

更新日期：1998-02-01 00:00:00

abstract：:The biological activity of 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25(OH)2D3], 23(S)25(R)-1 alpha,25(OH)2D3-26,23-lactone, and three intermediate metabolites of the lactone in vivo and in vitro was comparatively examined. The three intermediate metabolites, 1 alpha,25(R)26(OH)3D3, 1 alpha,23(S)25(R)26(OH)4D3, and 23(S...

journal_title：Endocrinology

authors： Ishizuka S,Sumitani K,Hiura K,Kawata T,Okawa M,Hakeda Y,Kumegawa M

更新日期：1990-08-01 00:00:00

abstract：:UMR106-06 cells predominantly express the C1a isoform of the rat calcitonin (CT) receptor (CTR). We have compared the homologous regulation of the C1a CTR endogenously expressed in UMR106-06 cells with the cloned C1a CTR in transfected HEK 293 cells, in which expression is driven by a heterologous promoter. It was fou...

journal_title：Endocrinology

authors： Findlay DM,Houssami S,Christopoulos G,Sexton PM

更新日期：1996-11-01 00:00:00

abstract：:Pheochromocytomas (PCCs) are tumors arising from neural crest-derived chromaffin cells. There are currently few animal models of PCC that recapitulate the key features of human tumors. Because such models may be useful for investigations of molecular pathomechanisms and development of novel therapeutic interventions, ...

journal_title：Endocrinology

authors： Wiedemann T,Peitzsch M,Qin N,Neff F,Ehrhart-Bornstein M,Eisenhofer G,Pellegata NS

更新日期：2016-08-01 00:00:00

abstract：:The distribution and density of selectively labeled mu-, delta-, and kappa-opioid binding sites were examined by in vitro radioautography in the hypothalamus of normal, estradiol valerate (EV)-injected, and estradiol (E2)-implanted female rats. Hypothalamic beta-endorphin concentration was also examined by RIA in thes...

journal_title：Endocrinology

authors： Desjardins GC,Beaudet A,Brawer JR

更新日期：1990-12-01 00:00:00

abstract：:Our research programs required the preparation of hypophysectomized and orchidectomized rhesus monkeys. This afforded us the possibility to characterize and compare levels of the gonadotropin and inhibin subunit mRNAs in pituitaries from intact and castrate monkeys. Eighteen adult male monkeys, four of which had been ...

journal_title：Endocrinology

authors： Attardi B,Marshall GR,Zorub DS,Winters SJ,Miklos J,Plant TM

更新日期：1992-03-01 00:00:00

abstract：:The active form of vitamin D, 1,25-dihydroxyvitamin D3, [1,25(OH)2D3] has potent actions on innate and adaptive immunity. Although endocrine synthesis of 1,25(OH)2D3 takes place in the kidney, the enzyme that catalyzes this, 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27b1 in humans, Cyp27b1 in mice), is expressed at m...

journal_title：Endocrinology

authors： Liu N,Nguyen L,Chun RF,Lagishetty V,Ren S,Wu S,Hollis B,DeLuca HF,Adams JS,Hewison M

更新日期：2008-10-01 00:00:00

abstract：:Previous descriptions of pulsatile LH release in immature female rats have been mostly inaccurate because of infrequent blood sampling, discontinuous and unbalanced blood replacement procedures, and possibly because of the use of a heterologous RIA. The present study was undertaken to circumvent these problems and to ...

journal_title：Endocrinology

authors： Urbanski HF,Ojeda SR

更新日期：1985-08-01 00:00:00

abstract：:Traditionally, it has been thought that the bioavailable fraction of circulating serum hormones, i.e. that which is available for cellular uptake and is physiologically active, is limited to the free (nonprotein bound) hormone. However, recent evidence, based on acute organ uptake of labeled hormone, suggests that the...

journal_title：Endocrinology

authors： Glass AR,Vigersky RA,Rajatanavin R,Pardridge W,Smallridge RC,Wartofsky L,Burman KD

更新日期：1984-05-01 00:00:00

abstract：:Puberty in primates is timed by 2 hypothalamic events: during late infancy a decline in pulsatile GnRH release occurs, leading to a hypogonadotropic state that maintains quiescence of the prepubertal gonad; and in late juvenile development, pulsatile GnRH release is reactivated and puberty initiated, a phase of develo...

journal_title：Endocrinology

authors： Ramaswamy S,Dwarki K,Ali B,Gibbs RB,Plant TM

更新日期：2013-05-01 00:00:00

abstract：:Dopamine D2 receptor agonists are commonly used in the control of PRL-secreting adenomas, and the sensitivity of dopamine agonists during long term therapy is exquisite. However, the molecular mechanisms responsible for the maintenance of this cellular sensitivity to dopamine agonists remain poorly understood. In the ...

journal_title：Endocrinology

authors： Ng GY,Varghese G,Chung HT,Trogadis J,Seeman P,O'Dowd BF,George SR

更新日期：1997-10-01 00:00:00

abstract：:In rats, protein hydrolysates (peptones) stimulate cholecystokinin (CCK) release both in vivo and in a model of isolated vascularly perfused duodeno-jejunum. However, the mechanisms involved in peptone-induced stimulation of CCK cells are not well understood. In particular, the possibility that peptones may directly i...

journal_title：Endocrinology

authors： Cordier-Bussat M,Bernard C,Haouche S,Roche C,Abello J,Chayvialle JA,Cuber JC

更新日期：1997-03-01 00:00:00

abstract：:PTH is an important peptide hormone regulator of calcium homeostasis and osteoblast function. However, its mechanism of action in osteoblasts is poorly understood. Our previous study demonstrated that PTH activates mouse osteocalcin (Ocn) gene 2 promoter through the osteoblast-specific element 1 site, a recently ident...

journal_title：Endocrinology

authors： Yu S,Franceschi RT,Luo M,Zhang X,Jiang D,Lai Y,Jiang Y,Zhang J,Xiao G

更新日期：2008-04-01 00:00:00

abstract：:The preoptic area (POA) of the male dove is a known target area for separable behavioral actions of testosterone and 17 beta-estradiol (E2) and contains an active aromatase system. We have examined the regulatory influence of gonadal hormones on aromatase using an in vitro microassay that measures conversion of [1 alp...

journal_title：Endocrinology

authors： Hutchison JB,Steimer T

更新日期：1986-06-01 00:00:00

abstract：:The pregnancy hormone relaxin has recently been shown to be cardio-protective. Despite its well-established antifibrotic actions in the heart, the effects of relaxin on cardiomyocytes (CM) remain to be determined. We investigated effects of isoform 2 of the human relaxin (H2-relaxin) on CM hypertrophy and apoptosis. I...

journal_title：Endocrinology

authors： Moore XL,Tan SL,Lo CY,Fang L,Su YD,Gao XM,Woodcock EA,Summers RJ,Tregear GW,Bathgate RA,Du XJ

更新日期：2007-04-01 00:00:00

abstract：:To determine whether the insulinotropic effects of dopamine were mediated through the adrenergic system, dogs were infused with dopamine before or after various combinations of adrenergic and cholinergic blockade. Plasma glucose levels did not change significantly throughout the individual experiments, although cardio...

journal_title：Endocrinology

authors： Cyrus J,Stagner J,Samols E

更新日期：1982-07-01 00:00:00

abstract：:Down regulation of insulin receptor number by insulin at physiological concentrating (10(-9) M) has been demonstrated in primary cultures of adult rat liver parenchymal cells in monolayer. However, because insulin is rapidly degraded in this culture system, special efforts are necessary to maintain the concentration o...

journal_title：Endocrinology

authors： Blackard WG,Guzelian PS,Small ME

更新日期：1978-08-01 00:00:00

abstract：:An estrogen-binding protein (EBP) has been identified and characterized in the cytosol of the pathogenic yeast Candida albicans. Binding of [3H]estradiol was found to be optimal at pH 7.4 in the presence of 0.3 M KCl and was linearly related to protein concentration. Binding was very rapid, reaching maximal levels in ...

journal_title：Endocrinology

authors： Skowronski R,Feldman D

更新日期：1989-04-01 00:00:00