Antipsychotic drugs inhibit prolactin release from rat anterior pituitary cells in culture by a mechanism not involving the dopamine receptor.

abstract：:Mouse β-cell-specific reporter lines have played a key role in diabetes research. Although the rat provides several advantages, its use has lagged behind the mouse due to the relative paucity of genetic models. In this report we describe the generation and characterization of transgenic rats expressing a Renilla lucif...

journal_title：Endocrinology

authors： Ghislain J,Fontés G,Tremblay C,Kebede MA,Poitout V

更新日期：2016-03-01 00:00:00

abstract：:The preovulatory LH surge in the sheep is accompanied by a massive and sustained surge of GnRH. The objective of this study was to examine the duration of the endogenous GnRH signal required to induce and maintain a LH surge of full amplitude and duration. For this purpose, we assessed the effect of a competitive GnRH...

journal_title：Endocrinology

authors： Evans NP,Dahl GE,Caraty A,Padmanabhan V,Thrun LA,Karsch FJ

更新日期：1996-11-01 00:00:00

abstract：:The mineralocorticoid receptor (MR), a member of the nuclear receptor superfamily of transcription factors, is activated by aldosterone and mediates its natriferic action in tight epithelia. MR is also expressed in nonepithelial tissues. Importantly, it mediates the deleterious effects of inappropriately high aldoster...

journal_title：Endocrinology

authors： Aguilar-Sánchez C,Hernández-Díaz I,Lorenzo-Díaz F,Navarro JF,Hughes TE,Giraldez T,Alvarez de la Rosa D

更新日期：2012-07-01 00:00:00

abstract：:The present studies were designed to evaluate the binding characteristics of arginine vasopressin (AVP), using rat anterior pituitary dispersed cells, in correlation with the biological activity of the peptide. Synthetic AVP released ACTH from dispersed anterior pituitary cells in a concentration-dependent fashion, wi...

journal_title：Endocrinology

authors： Spinedi E,Negro-Vilar A

更新日期：1984-06-01 00:00:00

abstract：:We recently identified a novel hypothalamic neuropeptide stimulating GH release in bullfrogs and termed it frog GH-releasing peptide (fGRP). The fGRP precursor encodes fGRP and its related peptides (fGRP-RP-1, -RP-2, and -RP-3), and fGRP-RP-2 also stimulates GH and prolactin (PRL) release. Cell bodies and terminals co...

journal_title：Endocrinology

authors： Chowdhury VS,Yamamoto K,Saeki I,Hasunuma I,Shimura T,Tsutsui K

更新日期：2008-03-01 00:00:00

abstract：:Obesity and insulin resistance-related proteinuria is associated with oxidative stress and impaired tissue bioavailable nitric oxide. Recent data suggest that nicotinamide adenine dinucleotide phosphate oxidase-mediated oxidative injury to the proximal tubule, like that seen in the glomerulus, contributes to proteinur...

journal_title：Endocrinology

authors： Habibi J,Hayden MR,Sowers JR,Pulakat L,Tilmon RD,Manrique C,Lastra G,Demarco VG,Whaley-Connell A

更新日期：2011-02-01 00:00:00

abstract：:Sex difference in the number of neurons projecting axons from the lateral septum (LS) to the midbrain central gray (MCG) that are concerned with the lordosis-inhibiting system was investigated by injection of Fluoro-Gold (FG), a retrograde tracer, into the rostral MCG on the right side in male and female rats. Immunoh...

journal_title：Endocrinology

authors： Tsukahara S,Yamanouchi K

更新日期：2002-01-01 00:00:00

abstract：:Insulin-like growth factor (IGF)-1, IGF binding protein (IGFBP)-2, and IGFBP-3 are expressed in the rat brain in regions of neuronal loss by 3 days after hypoxic- ischemic (HI) brain injury and IGF-2 somewhat later. Central administration of rh-IGF-1 after HI injury reduces neuronal loss in vivo. To clarify the mode o...

journal_title：Endocrinology

authors： Guan J,Williams CE,Skinner SJ,Mallard EC,Gluckman PD

更新日期：1996-03-01 00:00:00

abstract：:The CRH-binding protein (CRH-BP) antagonizes the ACTH-releasing activity of the neuropeptide CRH in vitro. However, the function of CRH-BP in vivo and the molecular mechanisms that regulate CRH-BP expression are not well understood. In this study, the rat CRH-BP gene was characterized, and CRH-BP promoter sequences we...

journal_title：Endocrinology

authors： Cortright DN,Goosens KA,Lesh JS,Seasholtz AF

更新日期：1997-05-01 00:00:00

abstract：:5-Hydroxytryptamine (5-HT) is synthesized and secreted by thyroid parafollicular (PF) cells. As all PF granules contain 5-HT, it is released whenever PF cells secrete. Because 5-HT stimulates follicular (F) cells and can modulate their response to TSH, 5-HT has been proposed to be a paracrine PF to F cell transmitter....

journal_title：Endocrinology

authors： Tamir H,Hsiung SC,Liu KP,Blakely RD,Russo AF,Clark MS,Nunez EA,Gershon MD

更新日期：1996-10-01 00:00:00

abstract：:In the present study the effects of stimulus deprivation on vasoactive intestinal peptide (VIP)- and alpha 1-adrenergically mediated amplification of VIP-stimulated cAMP and cGMP accumulation were examined. Dispersed pinealocytes were prepared from either Sprague-Dawley rats maintained for 2 weeks in a normal lighting...

journal_title：Endocrinology

authors： Chik CL,Ho AK

更新日期：1991-02-01 00:00:00

abstract：:Mineralocorticoid receptor (MR), highly expressed in the hippocampus, binds corticosteroid hormones and coordinately participates, with the glucocorticoid receptor, to the control of stress responses, memorization, and behavior. To investigate the impact of MR in neuronal survival, we generated murine embryonic stem (...

journal_title：Endocrinology

authors： Munier M,Law F,Meduri G,Le Menuet D,Lombès M

更新日期：2012-03-01 00:00:00

abstract：:Polyadenylated RNA, extracted from rat hypothalami, cross-hybridized with a RNA probe complementary in sequence to rat PTH (rPTH) messenger RNA (mRNA). Amplification of complementary DNA (cDNA) by the polymerase chain reaction also demonstrated the presence of rPTH mRNA in the rat hypothalamus and parathyroid gland. r...

journal_title：Endocrinology

authors： Fraser RA,Kronenberg HM,Pang PK,Harvey S

更新日期：1990-11-01 00:00:00

abstract：:The adrenal cortex contains a kallikrein-like enzyme that may lead to bradykinin (BK) formation. This study was designed to determine whether BK acts on adrenocortical cells to stimulate steroid secretion. BK, Lys-BK, a specific BK 2 (B2) receptor agonist, and desArg9-BK, a specific BK 1 (B1) receptor agonist, all sti...

journal_title：Endocrinology

authors： Rosolowsky LJ,Campbell WB

更新日期：1992-04-01 00:00:00

abstract：:Repeated injections of recombinant human (rh) activin-A over a 2- to 3-day period are reportedly needed to stimulate the in vivo secretion of FSH. In this paper we present results showing that acute treatment with rh-activin-A caused marked and dose-dependent increases in plasma FSH, but not LH, levels in adult female...

journal_title：Endocrinology

authors： Rivier C,Vale W

更新日期：1991-11-01 00:00:00

abstract：:Progestins have been implicated in breast cancer development, yet a role for progesterone (Pg) in ductal morphogenesis (DM) has not been established. To determine whether Pg could cause DM, we compared relative effects of Pg, estradiol (E2) and IGF-I on anatomical and molecular biological parameters of IGF-I-related D...

journal_title：Endocrinology

authors： Ruan W,Monaco ME,Kleinberg DL

更新日期：2005-03-01 00:00:00

abstract：:Progesterone synthesis by the human placenta requires the conversion of mitochondrial cholesterol to pregnenolone by cytochrome P450scc. Most steroidogenic tissues use the steroidogenic acute regulatory protein (StAR) to deliver cholesterol to the inner mitochondrial membrane where P450scc is located, but StAR is not ...

journal_title：Endocrinology

authors： Tuckey RC,Bose HS,Czerwionka I,Miller WL

更新日期：2004-04-01 00:00:00

abstract：:In the present study, steroidogenesis in two different Leydig tumor cell lines was compared. One, the MA-10 mouse tumor cell line, produces steroids and the steroidogenic acute regulatory (StAR) protein only when stimulated by trophic hormones and cAMP analogs. The other, the R2C rat tumor cell line, produces steroids...

journal_title：Endocrinology

authors： Jo Y,Stocco DM

更新日期：2004-12-01 00:00:00

abstract：:Isoforms of the recently cloned vesicular glutamate transporters (VGLUT1-3) selectively accumulate glutamic acid into synaptic vesicles in excitatory axon terminals and are viewed as reliable markers for glutamatergic neurons. Our present studies provided dual-label in situ hybridization evidence that virtually all (9...

journal_title：Endocrinology

authors： Hrabovszky E,Turi GF,Kalló I,Liposits Z

更新日期：2004-09-01 00:00:00

abstract：:Specific polyclonal antisera to the rat estrogen receptor (rER) were developed using a synthetic peptide as the antigen. The peptide corresponds to amino acids 270-284 deduced from the cloned rER cDNA and has no homology to other steroid hormone receptors. Antipeptide antisera raised in rabbits specifically recognize ...

journal_title：Endocrinology

authors： Furlow JD,Ahrens H,Mueller GC,Gorski J

更新日期：1990-09-01 00:00:00

abstract：:The two peptides pancreastatin and diazepam binding inhibitor (DBI) were recently demonstrated in pancreatic islets and were shown to inhibit insulin secretion in short term experiments. In the present study we investigated long term effects of pancreastatin and DBI on the DNA synthesis, polyamine content, and insulin...

journal_title：Endocrinology

authors： Sjöholm A,Funakoshi A,Efendić S,Ostenson CG,Hellerström C

更新日期：1991-06-01 00:00:00

abstract：:A study of the synthesis and migration of thyroglobulin has been carried out by the incubation of calf thyroid slices in the presence of [14C]leucine followed by the separation of intracellular compartments from the colloid by differential and density gradient centrifugation. The effect of inhibitors on these processe...

journal_title：Endocrinology

authors： Spiro MJ,Gorski KM

更新日期：1986-09-01 00:00:00

abstract：:Fluorescence resonance energy transfer using genetically encoded biosensors has proven to be a powerful technique to monitor the spatiotemporal dynamics of cAMP signals stimulated by G(s)-coupled receptors in living cells. In contrast, real-time imaging of G(i)-mediated cAMP signals under native conditions remains cha...

journal_title：Endocrinology

authors： Jacobs S,Calebiro D,Nikolaev VO,Lohse MJ,Schulz S

更新日期：2010-09-01 00:00:00

abstract：:The effects of alloxan-induced diabetes on uterine decidualization and the associated changes in uterine blood flow (UBF) and corpus luteum activity were evaluated in rats between days 4-9 of pseudopregnancy (day 0 = ovulation). Rats were made diabetic (D) with a 40 mg/kg injection (iv) of alloxan on day 1 of pseudopr...

journal_title：Endocrinology

authors： Garris DR

更新日期：1988-02-01 00:00:00

abstract：:We describe a new animal model of obesity and GH deficiency and report the effects on body fat of administering (GH) and insulin-like growth factor (IGF-I) in the model. Female GH-deficient dwarf rats fed a high-fat diet became obese and insulin-resistant compared with chow-fed controls. They were treated with recombi...

journal_title：Endocrinology

authors： Clark RG,Mortensen DL,Carlsson LM,Carlsson B,Carmignac D,Robinson IC

更新日期：1996-05-01 00:00:00

abstract：:Analysis of GH gene structure in the mouse permits evolutionary comparisons with GH gene structure in the rat and provides information about the mechanism responsible for heritable deficiencies of anterior pituitary hormones. The little mutation in mice is analogous to autosomal recessive, isolated, partial deficiency...

journal_title：Endocrinology

authors： Parks JS,Herd JE,Wurzel JM,Martial JA

更新日期：1982-05-01 00:00:00

abstract：:p-Tyramine, an endogenous amine with sympathomimetic action, is found in the mammalian hypothalamus. When injected ip, p-tyramine reduced serum PRL without altering LH and TSH serum titers in adult orchidectomized rats and rats subjected to ether or immobilization stress. The hyperprolactinemia achieved by this last p...

journal_title：Endocrinology

authors： Becú-Villalobos D,Lacau de Mengido IM,Libertun C

更新日期：1985-05-01 00:00:00

abstract：:Immunosympathectomy produced by treatment of newborn rats with antibodies to nerve growth factor (NGF) delays ovarian development and disrupts estrous cyclicity. While these alterations have been ascribed to loss of sympathetic neurons innervating the ovary, the treatment also causes partial loss of ovarian sensory in...

journal_title：Endocrinology

authors： Lara HE,McDonald JK,Ahmed CE,Ojeda SR

更新日期：1990-11-01 00:00:00

abstract：:The increase in glucagon-like peptide-1 (GLP-1) activity has emerged as a useful therapeutic tool for the treatment of type 2 diabetes mellitus. The actions of GLP-1 on β-cells and the nervous and digestive systems are well known. The action of this peptide in adipose tissue (AT), however, is still poorly defined. Fur...

journal_title：Endocrinology

authors： Vendrell J,El Bekay R,Peral B,García-Fuentes E,Megia A,Macias-Gonzalez M,Fernández Real J,Jimenez-Gomez Y,Escoté X,Pachón G,Simó R,Selva DM,Malagón MM,Tinahones FJ

更新日期：2011-11-01 00:00:00

abstract：:IGF1-a small, single-chain, secreted peptide in mammals-is essential for normal somatic growth and is involved in a variety of other physiological and pathophysiological processes. IGF1 expression appears to be controlled by several different signaling mechanisms in mammals, with GH playing a key role by activating an...

journal_title：Endocrinology

authors： Rotwein P

更新日期：2018-06-01 00:00:00