Nebivolol attenuates redox-sensitive glomerular and tubular mediated proteinuria in obese rats.

abstract：:FSH has been shown to stimulate the uptake of calcium in cultured rat Sertoli cells, resulting in an increase in cytosolic calcium concentrations. One possibility which has been put forth is that the FSH receptor per se may act as a calcium channel. This is all the more tantalizing given the proposed structure of this...

journal_title：Endocrinology

authors： Shibata EF,Matsuda JJ,Volk KA,Collison KA,Segaloff DL

更新日期：1992-08-01 00:00:00

abstract：:The feedback sites of estrogen within the hypothalamus and lower brain stem involved in the suppression of pulsatile LH secretion during 48-h fasting were examined in ovariectomized rats with local estradiol (E2) implants. The animals were ovariectomized and immediately implanted stereotaxically with stainless steel c...

journal_title：Endocrinology

authors： Nagatani S,Tsukamura H,Maeda K

更新日期：1994-09-01 00:00:00

abstract：:Bisphenol A (BPA) is a ubiquitous endocrine-disrupting chemical. Developmental exposure produces changes in behavior and gene expression in the brain. Here, we examined social recognition behaviors in mice from the third familial generation (F3) after exposure to gestational BPA. Second-generation mice were bred in on...

journal_title：Endocrinology

authors： Wolstenholme JT,Drobná Z,Henriksen AD,Goldsby JA,Stevenson R,Irvin JW,Flaws JA,Rissman EF

更新日期：2019-08-01 00:00:00

abstract：:Using a 0-32% continuous metrizamide density gradient, interstitial cells could be separated into five distinct bands. Cells localized in bands 1 (B1), 2 (B2), and 3 (B3) were isolated and incubated for 1h with or without human chorionic gonadotropin (hCG). Both B2 and B3 cells responded to hCG with increased cyclic A...

journal_title：Endocrinology

authors： Lin T,Lincoln TM,Brown N,Murono EP,Osterman J,Nankin HR

更新日期：1982-10-01 00:00:00

abstract：:Ghrelin is an acylated peptide recently isolated from rat stomach that potently stimulates GH release in vitro and in vivo in rat and man. Ghrelin specifically activates the receptor for the growth hormone secretagogues (GHS-Rla), and it has been proposed as the endogenous ligand mimicked by these synthetic compounds....

journal_title：Endocrinology

authors： Torsello A,Ghe' C,Bresciani E,Catapano F,Ghigo E,Deghenghi R,Locatelli V,Muccioli G

更新日期：2002-05-01 00:00:00

abstract：:Mice bearing IL-1beta-secreting tumor were used to study the chronic effect of IL-1beta on glucose metabolism. Mice were injected with syngeneic tumor cells transduced with the human IL-1beta gene. Serum IL-1beta levels increased exponentially with time. Secretion of IL-1beta from the developed tumors was associated w...

journal_title：Endocrinology

authors： Metzger S,Nusair S,Planer D,Barash V,Pappo O,Shilyansky J,Chajek-Shaul T

更新日期：2004-11-01 00:00:00

abstract：:Proteolytic degradation of extracellular matrix components has been suggested to play an essential role in the occurrence of ovulation. Recent studies in our laboratory have indicated that the plasminogen activator and matrix metalloproteinase systems, which were previously believed to be crucial for ovulation, are no...

journal_title：Endocrinology

authors： Wahlberg P,Nylander A,Ahlskog N,Liu K,Ny T

更新日期：2008-10-01 00:00:00

abstract：:We examined the levels and stability of glucocorticoid receptor activity in cytosol preparations of rat lung and other tissues. [3H]Dexamethasome binding capacity at 2 C in lung cytosol decreases with a t1/2 of 40 min in the absence of steroid or a sulfhydryl compound. This rapid inactivation of unbound receptor is pr...

journal_title：Endocrinology

authors： Granberg JP,Ballard PL

更新日期：1977-04-01 00:00:00

abstract：:Although the effectiveness of nuclear hormone-receptor complexes is known to depend on coregulator partner proteins, relatively little is known about the roles of coregulators in uterine development and early stages of pregnancy and implantation. Because conventional genetic deletion of the coregulator, repressor of e...

journal_title：Endocrinology

authors： Park S,Yoon S,Zhao Y,Park SE,Liao L,Xu J,Lydon JP,DeMayo FJ,O'Malley BW,Bagchi MK,Katzenellenbogen BS

更新日期：2012-08-01 00:00:00

abstract：:Arginine vasopressin (AVP) stimulates the secretion of ACTH from pituitary corticotropes. We investigated the action of AVP in single corticotropes of male rats. Corticotropes were identified with the reverse hemolytic plaque assay using antibodies against ACTH. Using the whole-cell recording technique in conjunction ...

journal_title：Endocrinology

authors： Tse A,Lee AK

更新日期：1998-05-01 00:00:00

abstract：:Binding of lactogenic hormones to particulate and solubilized microsomal membranes isolated from mammary glands of lactating mice is inhibited by direct addition of 10(-10) M or greater concentrations of triphenylethylene antiestrogens [i.e. tamoxifen (TAM), 4-hydroxy-tamoxifen, and Nafoxidine] to the binding assays. ...

journal_title：Endocrinology

authors： Biswas R,Vonderhaar BK

更新日期：1991-01-01 00:00:00

abstract：:Hepatic stellate cells (HSC) play a pivotal role in hepatic tissue repair and fibrogenesis. IGF-I has been considered a mitogenic signal for activation and proliferation of HSC in vitro. In the present study IGF-I and IGF-binding protein (IGFBP) gene expression was studied in a model of acute liver injury induced by a...

journal_title：Endocrinology

authors： Scharf JG,Dombrowski F,Novosyadlyy R,Eisenbach C,Demori I,Kübler B,Braulke T

更新日期：2004-07-01 00:00:00

abstract：:Somatostatin has been demonstrated to negatively regulate pancreatic growth in vivo. In this study we used the AR4-2J rat pancreatic acinar tumor cell line to investigate the effect of a stable somatostatin analog, SMS 201-995 (SMS) on cell proliferation. SMS induced an antiproliferative effect on both serum or epider...

journal_title：Endocrinology

authors： Viguerie N,Tahiri-Jouti N,Ayral AM,Cambillau C,Scemama JL,Bastié MJ,Knuhtsen S,Estève JP,Pradayrol L,Susini C

更新日期：1989-02-01 00:00:00

abstract：:Hormone-dependent breast cancers respond to inhibitors of estrogen synthesis or action with tumor regression and with a reduction of new metastases. The mechanisms underlying the effects of estrogen on metastasis likely differ from those on tumor regression. Cell migration is a key first step in the metastatic process...

journal_title：Endocrinology

authors： Li Y,Wang JP,Santen RJ,Kim TH,Park H,Fan P,Yue W

更新日期：2010-11-01 00:00:00

abstract：:Earlier studies have shown that lactation-induced bone loss in the rat is both PTH- and vitamin D-independent and have suggested the involvement of another, as yet unidentified, factor(s) in the altered calcium metabolism which accompanies lactation. In the present study, we investigated the possibility that PTH-relat...

journal_title：Endocrinology

authors： Yamamoto M,Duong LT,Fisher JE,Thiede MA,Caulfield MP,Rosenblatt M

更新日期：1991-11-01 00:00:00

abstract：:Mature 31- and 34-kDa inhibin A and B negatively regulate the release of FSH from the anterior pituitary; however, a direct comparison of these hormones in vivo has not been undertaken. The bioactivities of highly purified preparations of recombinant human 31-kDa inhibin A and B were determined in rat pituitary cells ...

journal_title：Endocrinology

authors： Makanji Y,Temple-Smith PD,Walton KL,Harrison CA,Robertson DM

更新日期：2009-10-01 00:00:00

abstract：:Primary cultures of bovine calf anterior pituitary cells were observed to proliferate for at least eight doublings in a serum-free defined medium without the addition of mitogens or hormones. Insulin caused minor increments both in the rate of proliferation of cells from a doubling time of 31 h to 26 h and in the satu...

journal_title：Endocrinology

authors： Kudlow JE,Gerrie BM

更新日期：1983-07-01 00:00:00

abstract：:The purpose of this experiment was to determine whether surgical stress on the morning of proestrus would elicit an early release of gonadotropin from the pituitary. Animals exhibiting 5-day estrous cycles underwent bilateral sham-ovariectomy under ether anesthesia at 0800 h of proestrus. These animals had high levels...

journal_title：Endocrinology

authors： Nequin LG,Alvarez JA,Campbell CS

更新日期：1975-09-01 00:00:00

abstract：:Recent studies suggest that hyperinsulinemia and insulin resistance are linked to Alzheimer's disease (AD). In this study, we used Tg2576 transgenic (Tg) mice, a widely used transgenic mouse model for AD, to explore the relationship between increased amyloid beta-peptide (Abeta) and insulin resistance. When fed a high...

journal_title：Endocrinology

authors： Kohjima M,Sun Y,Chan L

更新日期：2010-04-01 00:00:00

abstract：:A binding protein for activin was purified from bovine pituitary by affinity chromatography on dextran sulfate-Sepharose CL-4B and activin-Affi-Gel 10. A 52,700-fold purification over the starting crude homogenate was achieved. The purified preparation showed two bands of 36 and 33 kilodalton in sodium dodecyl sulfate...

journal_title：Endocrinology

authors： Kogawa K,Nakamura T,Sugino K,Takio K,Titani K,Sugino H

更新日期：1991-03-01 00:00:00

abstract：:The regulation of TRH gene expression in the paraventricular nucleus of the hypothalamus (PVH) by leptin is critical for normal function of the thyroid axis in rodents and humans. The TRH neuron in the PVH expresses both leptin and melanocortin-4 receptors, suggesting that both signaling systems may regulate TRH gene ...

journal_title：Endocrinology

authors： Guo F,Bakal K,Minokoshi Y,Hollenberg AN

更新日期：2004-05-01 00:00:00

abstract：:Agouti-related protein (AGRP) is a homologue of the agouti gene product and, when overexpressed, promotes obesity. Like neuropeptide Y (NPY) messenger RNA (mRNA), AGRP mRNA is produced in the hypothalamic arcuate nucleus and is elevated in leptin-deficient ob/ob and leptin-resistant db/db mice. These data suggest that...

journal_title：Endocrinology

authors： Mizuno TM,Mobbs CV

更新日期：1999-02-01 00:00:00

abstract：:Orexins/hypocretins heavily innervate the posterior division of the paraventricular nucleus of the thalamus (pPVT), which expresses both orexin receptor types. The pPVT is important for adaptations to repeated stress, particularly the ability to facilitate to novel stress after repeated stress exposure. Here, we exami...

journal_title：Endocrinology

authors： Heydendael W,Sharma K,Iyer V,Luz S,Piel D,Beck S,Bhatnagar S

更新日期：2011-12-01 00:00:00

abstract：:This study determined whether a rise in tonic secretion of LH occurred before long day-induced precocious puberty of the female ferret. Twenty immature females were assigned to 1 of 2 photoperiods at 15 weeks of age. Ten ferrets were placed in a long day, stimulatory photoperiod (16 h of light, 8 h of darkness) to ind...

journal_title：Endocrinology

authors： Ryan KD,Robinson SL

更新日期：1985-05-01 00:00:00

abstract：:We previously demonstrated that the mitochondrial peripheral-type benzodiazepine receptor (PBR) is coupled to hormone-activated steroidogenesis by regulating the intramitochondrial cholesterol transport, the rate-determining step of steroid biosynthesis. In the present study we examined whether PBR is the site of horm...

journal_title：Endocrinology

authors： Boujrad N,Gaillard JL,Garnier M,Papadopoulos V

更新日期：1994-10-01 00:00:00

abstract：:The present study was undertaken to determine whether T3 could modify anterior pituitary Ca++ metabolism under basal conditions and in the presence of TRH. Paired hemipituitaries from hypothyroid rats were preincubated with T3 (10(-7) M) for 2 h, allowed to accumulate 45Ca++ for the third hour, and repeatedly washed i...

journal_title：Endocrinology

authors： Schrey MP,Larsen PR

更新日期：1981-05-01 00:00:00

abstract：:Glucocorticoids and their synthetic derivatives are known to alter cardiac function in vivo; however, the nature of these effects and whether glucocorticoids act directly on cardiomyocytes are poorly understood. To explore the role of glucocorticoid signaling in the heart, we used rat embryonic H9C2 cardiomyocytes and...

journal_title：Endocrinology

authors： Ren R,Oakley RH,Cruz-Topete D,Cidlowski JA

更新日期：2012-11-01 00:00:00

abstract：:Dexamethasone-induced changes in insulin and epidermal growth factor (EGF) receptor number, autophosphorylation, and kinase activity were studied in intact rat hepatocytes. Hepatocytes were freshly isolated from Sprague-Dawley rats treated with dexamethasone (1 mg/kg) for 4 days and from untreated littermates. Dexamet...

journal_title：Endocrinology

authors： Karasik A,Kahn CR

更新日期：1988-11-01 00:00:00

abstract：:A transient increase in serum progesterone concentrations (to 1 ng/ml for 1-2 days) is observed in the majority of ewes before the first estrous cycle of the breeding season. To determine whether such a brief antecedent rise in progesterone ensures initiation of a full-length cycle by the next LH surge, synthetic GnRH...

journal_title：Endocrinology

authors： Legan SJ,I'Anson H,Fitzgerald BP,Akaydin MS Jr

更新日期：1985-10-01 00:00:00

abstract：:Maternal and fetal metabolism of vitamin D was examined in term pregnant rabbits fed a normal diet and in those supplemented with a large amount of vitamin D3. Term pregnant rabbits (27--30 days of gestation) fed the normal diet showed lower levels of plasma calcium, 25-hydroxyvitamin D3 (250HD3), and 24,25-dihydroxyv...

journal_title：Endocrinology

authors： Kubota M,Ohno J,Shiina Y,Suda T

更新日期：1982-06-01 00:00:00