Estrogen feedback needed at the paraventricular nucleus or A2 to suppress pulsatile luteinizing hormone release in fasting female rats.

abstract：:In the ewe, photoperiod modulates LH and PRL secretion as well as median eminence (ME) dopaminergic activity. The studies reported here were designed to characterize the functional significance of this photoperiodic modulation of ME dopaminergic neuron activity in relation to the regulation of LH and PRL secretion. Th...

journal_title：Endocrinology

authors： Viguié C,Thibault J,Thiéry JC,Tillet Y,Malpaux B

更新日期：1997-01-01 00:00:00

abstract：:Pituitary growth hormone (GH) content and plasma GH response to pentobarbital (PB) of severely hypothyroid rats are markedly decreased compared with euthyroid rats. Both pituitary and plasma GH may be increased by single ip injections of physiologic doses of thyroxine (T4) (1.75 mug/100g BW) or triiodothyronine (T3) (...

journal_title：Endocrinology

authors： Hervás F,Morreale de Escobar G,Escobar del Rey F

更新日期：1976-01-01 00:00:00

abstract：:The effect of TSH stimulation on cellular (c)-myc mRNA content in cultured thyroid cells was examined by Northern blot analysis. Polyadenylated mRNA was prepared from quiescent FRTL-5 rat thyroid cells and from cells stimulated by TSH for 8 h. A major 2.1 kilobase (kb) transcript was enhanced 5.5-fold by TSH. (Bu)2cAM...

journal_title：Endocrinology

authors： Dere WH,Hirayu H,Rapoport B

更新日期：1985-11-01 00:00:00

abstract：:Although renal hypertrophy occurs rapidly after uninephrectomy, restoring the majority of renal excretory function, it remains unknown whether similar compensatory mechanisms maintain 1,25-dihydroxyvitamin D production (and calcium homeostasis). To address this issue we compared plasma calcitriol levels and renal 25-h...

journal_title：Endocrinology

authors： Almond JR,Bales CW,Lobaugh B,Klotman PE,Drezner MK

更新日期：1989-05-01 00:00:00

abstract：:The intermediate filament protein nestin was originally found to be expressed in neuronal progenitor cells, but recent studies have shown that other cell types, including endocrine and vascular endothelial cells, express nestin. In the present study, we examined the expression and localization of nestin in the ovaries...

journal_title：Endocrinology

authors： Takahashi N,Itoh MT,Ishizuka B

更新日期：2008-01-01 00:00:00

abstract：:The effects of dopamine (DA) on voltage-dependent Ca2+ currents were investigated in cultured rat lactotroph cells using the patch clamp recording technique. Each recorded cell was identified by the reverse hemolytic plaque assay. In the whole-cell configuration, two types of Ca2+ currents, L and T, were characterized...

journal_title：Endocrinology

authors： Lledo PM,Legendre P,Israel JM,Vincent JD

更新日期：1990-09-01 00:00:00

abstract：:In this study, we demonstrate that disruption of neuroendocrine signaling is a major factor driving disease progression in myelin oligodendrocyte glycoprotein-induced chronic relapsing experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. Although the initial episode of chronic relapsing ex...

journal_title：Endocrinology

authors： Stefferl A,Storch MK,Linington C,Stadelmann C,Lassmann H,Pohl T,Holsboer F,Tilders FJ,Reul JM

更新日期：2001-08-01 00:00:00

abstract：:Stearoyl-CoA desaturase-1 (SCD-1) plays a pivotal role in an increase of triglyceride by an excess of dietary carbohydrate intake. Dietary carbohydrates increase SCD-1 gene expression in liver by sterol response element binding protein (SREBP)-1c-dependent and SREBP-1c -independent pathways. Previous report demonstrat...

journal_title：Endocrinology

authors： Hashimoto K,Ishida E,Miura A,Ozawa A,Shibusawa N,Satoh T,Okada S,Yamada M,Mori M

更新日期：2013-01-01 00:00:00

abstract：:In male hamsters, light deprivation was reported to reduce both testis weight and prolactin (PRL) levels. Therefore, we decided to examine the effects of PRL on testicular function in hamsters exposed to short day-length. Adult hamsters were exposed to 5 h of light per day to induce gonadal atrophy, and, starting two ...

journal_title：Endocrinology

authors： Bartke A,Croft BT,Dalterio S

更新日期：1975-12-01 00:00:00

abstract：:This study was designed to test the hypothesis that systemic immune challenge with endotoxin inhibits the reproductive axis centrally by suppressing GnRH pulsatile release into hypophyseal portal blood. Using alert, normally behaving, ovariectomized ewes, we sampled hypophyseal portal blood at 10-min intervals beginni...

journal_title：Endocrinology

authors： Battaglia DF,Bowen JM,Krasa HB,Thrun LA,Viguié C,Karsch FJ

更新日期：1997-10-01 00:00:00

abstract：:Obesity induced by high-fat (HF) feeding is associated with low-grade inflammation in peripheral tissues that predisposes to insulin resistance. Recent evidence suggests the occurrence of a similar process in the hypothalamus, which favors weight gain through impairment of leptin and insulin signaling. In addition to ...

journal_title：Endocrinology

authors： Thaler JP,Schwartz MW

更新日期：2010-09-01 00:00:00

abstract：:Mature male rat liver cytosol contains a moderate affinity and capacity estrogen-binding protein in at least a 200-fold higher level than mature female or immature male rat liver cytosol. Binding of estradiol to this protein is very rapid, is stabilized by EDTA, and is inhibited by divalent cations. This is the major ...

journal_title：Endocrinology

authors： Dickson RB,Aten RF,Eisenfeld AJ

更新日期：1978-11-01 00:00:00

abstract：:Free radical production and lipid peroxidation are potentially important mediators in testicular physiology and toxicology. The cytochrome P450 enzymes of the steroidogenic pathway are known to produce free radicals. The present study was conducted to elucidate in vivo the gonadotropin regulation of free radical-media...

journal_title：Endocrinology

authors： Peltola V,Huhtaniemi I,Metsa-Ketela T,Ahotupa M

更新日期：1996-01-01 00:00:00

abstract：:Multiple interferon (IFN)-tau genes exist in cattle, but it has remained unclear how many are expressed, the extent of their variation, and whether different genes exhibit similar patterns of expression and code for proteins with similar biological activities. A total of 118 complementary DNA (cDNA) were bi-directiona...

journal_title：Endocrinology

authors： Ealy AD,Larson SF,Liu L,Alexenko AP,Winkelman GL,Kubisch HM,Bixby JA,Roberts RM

更新日期：2001-07-01 00:00:00

abstract：:Tumor progression largely depends on blood supply and neovessel formation, and angiogenesis is emerging as a promising target for cancer therapy. Vascular endothelial growth factor (VEGF), a major proangiogenic molecule, stimulates angiogenesis via promoting endothelial proliferation, survival and migration. VEGF has ...

journal_title：Endocrinology

authors： Ye C,Feng C,Wang S,Wang KZ,Huang N,Liu X,Lin Y,Li M

更新日期：2004-02-01 00:00:00

abstract：:The present study was undertaken to investigate the effect of the Hyp mutation and diet-induced hyperparathyroidism on renal responsiveness to PTH and forskolin and to determine whether the renal brush border membrane phosphate transport defect is expressed in the vitamin D- and calcium-deficient Hyp mouse. Our result...

journal_title：Endocrinology

authors： Tenenhouse HS,Veksler A

更新日期：1986-03-01 00:00:00

abstract：:Immunohistochemical localization of two estrogen receptor (ER) subtypes, ER beta and ER alpha, was performed in neonatal, early postnatal, immature, and adult rats to determine whether ER alpha and ER beta are differentially expressed in the ovary. ER beta and ER alpha were visualized using a polyclonal anti-ER beta a...

journal_title：Endocrinology

authors： Sar M,Welsch F

更新日期：1999-02-01 00:00:00

abstract：:The GnRH receptor (GnRH-R) belongs to the rhodopsin/beta-adrenergic family of G protein-coupled receptors. The intracellular domains of these receptors, particularly the regions closest to the plasma membrane in intracellular loops 2 (2i) and 3 (3i) as well as some regions located in the membrane-proximal end of the C...

journal_title：Endocrinology

authors： Ulloa-Aguirre A,Stanislaus D,Arora V,Väänänen J,Brothers S,Janovick JA,Conn PM

更新日期：1998-05-01 00:00:00

abstract：:In amphibians, the secretion of alpha-MSH by melanotrope cells is stimulated by TRH and inhibited by NPY. We have previously shown that NPY abrogates the stimulatory effect of TRH on alpha-MSH secretion. The aim of the present study was to characterize the receptor subtypes mediating the action of NPY and to investiga...

journal_title：Endocrinology

authors： Galas L,Tonon MC,Beaujean D,Fredriksson R,Larhammar D,Lihrmann I,Jegou S,Fournier A,Chartrel N,Vaudry H

更新日期：2002-05-01 00:00:00

abstract：:Atrial, brain-type, and C-type natriuretic peptides (ANP, BNP, and CNP) act via receptors with intrinsic guanylate cyclase activity. The A-type and B-type ANP receptors are selectively activated by ANP and CNP, respectively. The anterior pituitary is a site of ANP production and action, suggesting a local regulatory f...

journal_title：Endocrinology

authors： McArdle CA,Poch A,Käppler K

更新日期：1993-05-01 00:00:00

abstract：:The adipokine leptin regulates energy homeostasis through ubiquitously expressed leptin receptors. Leptin has a number of major signaling targets in the brain, including cells of the anterior pituitary (AP). We have previously reported that mice lacking leptin receptors in AP somatotropes display growth hormone (GH) d...

journal_title：Endocrinology

authors： Allensworth-James M,Banik J,Odle A,Hardy L,Lagasse A,Moreira ARS,Bird J,Thomas CL,Avaritt N,Kharas MG,Lengner CJ,Byrum SD,MacNicol MC,Childs GV,MacNicol AM

更新日期：2021-03-01 00:00:00

abstract：:2,5-Hexanedione (2,5-HD) exposure in the rat produces irreversible testicular atrophy, a model of human male infertility that can be used for mechanistic and therapeutic studies. Following testicular injury by 2,5-HD, stem cell factor (SCF), a Sertoli cell-derived growth factor that binds the c-kit receptor on spermat...

journal_title：Endocrinology

authors： Blanchard KT,Lee J,Boekelheide K

更新日期：1998-01-01 00:00:00

abstract：:Estrogen receptor alpha and beta proteins (ERalpha and ERbeta) at various stages of development of the rat mammary gland were quantified by Western blotting. ERalpha and ERbeta recombinant proteins were used as standards, and their molar concentrations were measured by ligand binding assays. In 3-week-old pregnant, la...

journal_title：Endocrinology

authors： Saji S,Sakaguchi H,Andersson S,Warner M,Gustafsson J

更新日期：2001-07-01 00:00:00

abstract：:We have recently reported that a subpopulation of galanin (GAL)-immunoreactive perikarya in the preoptic area near the organum vasculosum of the lamina terminalis (OVLT) has morphological characteristics similar to those of LHRH-containing neurons. In fact, both peptides are colocalized in those neurons in the male ra...

journal_title：Endocrinology

authors： Merchenthaler I,López FJ,Lennard DE,Negro-Vilar A

更新日期：1991-10-01 00:00:00

abstract：:In rat pancreatic islets, the effect of old age (24-month-old) on [125I]insulin binding, glucose-induced insulin release and inhibition of insulin secretion by exogenous insulin were studied. The results were compared with corresponding data obtained from young (3-month-old) rats. Specifically bound [125I]insulin in i...

journal_title：Endocrinology

authors： Verspohl EJ,Ammon HP

更新日期：1983-06-01 00:00:00

abstract：:IGF binding protein-3 (IGFBP-3), the most abundant circulating IGF binding protein, inhibits cell growth and induces apoptosis by both IGF-I-dependent and -independent pathways. The ability of IGFBP-3 to inhibit tumor growth has been demonstrated in many cancers including prostate cancer (PCa). High concentrations of ...

journal_title：Endocrinology

authors： Peng L,Malloy PJ,Wang J,Feldman D

更新日期：2006-10-01 00:00:00

abstract：:The dynamics of dopamine (DA) action on PRL release was studied in superfused rat anterior pituitary cell aggregates, cultured for for 5 days either in conventional or in serum-free defined medium. In aggregates cultured in conventional medium 0.1-1 nM DA applied for 20 min provoked a rapid and concentration-dependent...

journal_title：Endocrinology

authors： Denef C,Baes M,Schramme C

更新日期：1984-04-01 00:00:00

abstract：:Endocrine-disrupting chemicals (EDCs) that interfere with the steroid axis can affect amelogenesis, leading to enamel hypomineralization similar to that of molar incisor hypomineralization, a recently described enamel disease. We investigated the sex steroid receptors that may mediate the effects of EDCs during rat am...

journal_title：Endocrinology

authors： Jedeon K,Loiodice S,Salhi K,Le Normand M,Houari S,Chaloyard J,Berdal A,Babajko S

更新日期：2016-11-01 00:00:00

abstract：:Experiments were carried out to characterize the prolactin stimulation of labeled uridine uptake into mammary gland explants which were initially preincubated for 2 days in medium containing insulin plus hydrocortisone. Prolactin was found to enhance labeled uridine uptake after 4 h but not after 2 h when uridine conc...

journal_title：Endocrinology

authors： Rillema JA

更新日期：1975-05-01 00:00:00

abstract：:MRL-lpr/lpr mice manifest a systemic lupus-like autoimmune disease. As part of this syndrome, the mice spontaneously develop autoimmune thyroiditis, which is morphologically and biochemically similar to human autoimmune thyroiditis. In this study we investigated whether thyroid tissue obtained from sites of chronic in...

journal_title：Endocrinology

authors： Green LM,Lazarus JP,LaBue M,Shah MM

更新日期：1995-08-01 00:00:00