Production of growth factor activity by cultured bovine calf anterior pituitary cells.

abstract：:Estrogens play a central role in regulating female reproduction throughout the reproductive axis, and the pituitary is one of the major targets of estrogen action. We hypothesized that estrogen receptor alpha (ERalpha) mediates estrogen action in the pituitary gonadotroph. To test this hypothesis, we generated a mouse...

journal_title：Endocrinology

authors： Gieske MC,Kim HJ,Legan SJ,Koo Y,Krust A,Chambon P,Ko C

更新日期：2008-01-01 00:00:00

abstract：:Antiestrogens such as tamoxifen are the mainstay of treatment for estrogen receptor-positive breast cancer. However, their effectiveness is limited by the development of endocrine resistance, allowing tumor regrowth and progression. Importantly, in vitro MCF7 cell models of acquired tamoxifen resistance (TamR cells) d...

journal_title：Endocrinology

authors： Taylor KM,Vichova P,Jordan N,Hiscox S,Hendley R,Nicholson RI

更新日期：2008-10-01 00:00:00

abstract：:A continuous flow incubation (perifusion) system was used to examine the effect of testosterone (T) and three of its 5alpha-reduced metabolites, dihydrotestosterone (DHT), 5alpha-androstane-3alpha, 17beta-diol (3alpha-Adiol) and its 3beta-epimer (3beta-Adiol) on LH and FSH release, induced by hypothalamic extract (HE)...

journal_title：Endocrinology

authors： Kao LW,Weisz J

更新日期：1975-02-01 00:00:00

abstract：:The roles of alpha- and beta-subunits of human TSH (hTSH) were studied by investigating the inhibitory effects of monoclonal antibodies on the biological activity of hTSH. Four monoclonal antibodies directed toward different epitopes on the beta-subunit (hTSH beta) inhibited completely the receptor binding of hTSH to ...

journal_title：Endocrinology

authors： Endo Y,Tetsumoto T,Nagasaki H,Kashiwai T,Tamaki H,Amino N,Miyai K

更新日期：1990-07-01 00:00:00

abstract：:Hereditary vitamin D-resistant rickets (HVDRR) is an autosomal recessive disease caused by mutations in the vitamin D receptor (VDR). We studied a young Saudi Arabian girl who exhibited the typical clinical features of HVDRR, but without alopecia. Analysis of her VDR gene revealed a homozygous T to C mutation in exon ...

journal_title：Endocrinology

authors： Malloy PJ,Xu R,Peng L,Peleg S,Al-Ashwal A,Feldman D

更新日期：2004-11-01 00:00:00

abstract：:The serum pharmacokinetics of recombinant human inhibin A (rh-inhibin A) and rh-activin A were examined in immature female Sprague Dawley-derived rats after iv and sc injection of the drugs. After iv administration of rh-inhibin A (120 micrograms/kg), the serum concentrations were described by a biexponential equation...

journal_title：Endocrinology

authors： Woodruff TK,Krummen LA,Chen S,DeGuzman G,Lyon R,Baly DL,Allison DE,Garg S,Wong WL,Hebert N

更新日期：1993-02-01 00:00:00

abstract：:Targeted disruption [knockout (KO)] of the mouse prolactin (PRL) gene created an animal model of primary isolated PRL deficiency in which there is no detectable PRL bioactivity. Pituitary glands of young adult female PRLKO mice were hyperplastic, and many cells had expanded cytoplasms with granular accumulations of an...

journal_title：Endocrinology

authors： Cruz-Soto ME,Scheiber MD,Gregerson KA,Boivin GP,Horseman ND

更新日期：2002-11-01 00:00:00

abstract：:Although it is well known that chronic treatment with glucocorticoids inhibits somatic growth, the mechanism of action of this inhibitory effect is not completely understood. It is likely that glucocorticoids act at various levels, including pituitary, hypothalamus, and peripheral organs modulating GH synthesis, secre...

journal_title：Endocrinology

authors： Señarís RM,Lago F,Coya R,Pineda J,Diéguez C

更新日期：1996-12-01 00:00:00

abstract：:The steroid sex hormone progesterone (P) induces the expression of a variety of genes through a signal transduction pathway mediated by the P receptor, a DNA-binding regulator of transcription. To identify genes and gene networks that are P dependent in the rhesus endometrium, we used a powerful technique employing su...

journal_title：Endocrinology

authors： Ace CI,Balsamo M,Le LT,Okulicz WC

更新日期：1994-03-01 00:00:00

abstract：:Recent evidence indicates that catecholamines may directly alter anterior pituitary function. In the present study, an in vitro perifusion system was used to investigate whether catecholamines affect the gonadotrope. Pituitary tissue from castrated ram lambs was incubated in the presence of epinephrine (EPI), norepine...

journal_title：Endocrinology

authors： Swartz SR,Moberg GP

更新日期：1986-06-01 00:00:00

abstract：:We showed that insulin appears in the chick embryo before beta-cells are recognizable, as well as in the egg constituents even before fertilization. Acid-ethanol extracts of 2- to 8-day-old embryos were gel-filtered on Sephadex G-50. The peak of immunoreactive insulin chromatographed in a position corresponding to tha...

journal_title：Endocrinology

authors： De Pablo F,Roth J,Hernandez E,Pruss RM

更新日期：1982-12-01 00:00:00

abstract：:As a model of the changes in peripheral iodothyronine metabolism that occur during ontogeny, we have studied the metabolism of 125I-labeled T4 and several of its partially deiodinated derivatives by the liver of the chick embryo. Homogenates of livers obtained from chicks varying in embryonic age from 8 days to the ti...

journal_title：Endocrinology

authors： Borges M,LaBourene J,Ingbar SH

更新日期：1980-12-01 00:00:00

abstract：:In previous studies, we have shown that calcitonin gene-related peptide (CGRP) acutely inhibits 45Ca2+ uptake in osteoblastic UMR106 cells, and we have proposed that ATP-sensitive potassium (K(ATP)) channels are involved in mediating this action of CGRP. To directly test this proposed mechanism, we have now examined t...

journal_title：Endocrinology

authors： Kawase T,Burns DM

更新日期：1998-08-01 00:00:00

abstract：:Early postnatal exposures to sex steroids have been well recognized to modulate predisposition to diseases of adulthood. There is a complex interplay between timing, duration and dose of endocrine exposures through environmental or dietary sources that may alter the sensitivity of target tissues to the exogenous stimu...

journal_title：Endocrinology

authors： Jang H,Bhasin S,Guarneri T,Serra C,Schneider M,Lee MJ,Guo W,Fried SK,Pencina K,Jasuja R

更新日期：2015-10-01 00:00:00

abstract：:Fetal adrenal steroid hydroxylase activity and messenger RNA (mRNA) expression increases concurrent with the preterm rise in fetal plasma cortisol during late gestation in sheep. By placing bilateral lesions of the fetal paraventricular nuclei (PVN) we have previously demonstrated that the fetal PVN is necessary for t...

journal_title：Endocrinology

authors： Myers DA,McDonald TJ,Nathanielsz PW

更新日期：1992-07-01 00:00:00

abstract：:Studies were undertaken using the opiate receptor antagonist naloxone (NAL) to evaluate the relative influence of endogenous opioid peptides (EOP) on LH secretion in cycling and ovariectomized, steroid-treated adult rats. Intact animals received NAL (2 mg/kg, sc) or saline (control vehicle) at 0800 and 1400 h on estru...

journal_title：Endocrinology

authors： Gabriel SM,Simpkins JW,Kalra SP

更新日期：1983-11-01 00:00:00

abstract：:The expression of genes encoding key hepatic gluconeogenic enzymes, including phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase), is regulated at the transcriptional level by a network of transcription factors and cofactors, including cAMP response element-binding protein (CREB). It has been ...

journal_title：Endocrinology

authors： Seo HY,Kim MK,Min AK,Kim HS,Ryu SY,Kim NK,Lee KM,Kim HJ,Choi HS,Lee KU,Park KG,Lee IK

更新日期：2010-02-01 00:00:00

abstract：:Pulmonary alveolar type 2 cells act as a reservoir of stem cells which can be induced to proliferate during periods of lung growth and repair after lung injury. Despite the importance of this process, the mechanisms that regulate type 2 cell proliferation have not been well characterized. We show in this study that in...

journal_title：Endocrinology

authors： Mouhieddine OB,Cazals V,Maitre B,Le Bouc Y,Chadelat K,Clement A

更新日期：1994-07-01 00:00:00

abstract：:Endocrine regulation of uterine biology is critical for embryo receptivity and human reproduction. Uterine endometrium depends on extrinsic sex steroid input and hence likely has mechanisms that enable adaptation to hormonal variation. Emerging evidence suggests that sex steroid bioavailability in the endometrium is d...

journal_title：Endocrinology

authors： Zheng Y,Tabbaa ZM,Khan Z,Schoolmeester JK,El-Nashar S,Famuyide A,Keeney GL,Daftary GS

更新日期：2014-11-01 00:00:00

abstract：:The G protein α-subunit G(s)α mediates receptor-stimulated cAMP generation. Heterozygous inactivating G(s)α mutations on the maternal allele result in obesity primarily due to reduced energy expenditure in Albright hereditary osteodystrophy patients and in mice. We previously showed that mice with central nervous syst...

journal_title：Endocrinology

authors： Chen M,Berger A,Kablan A,Zhang J,Gavrilova O,Weinstein LS

更新日期：2012-09-01 00:00:00

abstract：:The mouse mammary gland and uterus expressed the gene for the secretory protein lactotransferrin under various physiological conditions. Lactotransferrin, however, was induced by estrogen in a time- and dose-dependent fashion in the uterus of the immature mouse, but was not affected by estrogen in the mammary gland. D...

journal_title：Endocrinology

authors： Teng CT,Pentecost BT,Chen YH,Newbold RR,Eddy EM,McLachlan JA

更新日期：1989-02-01 00:00:00

abstract：:We have examined the effects of a new synthetic inhibitor of mammalian tissue collagenase, CI-1 (N-[3-N-(benzyloxycarbonyl)amino-1-(R)carboxypropyl]L-leucyl-O-methyl-L- tyrosine N-methylamide; G. D. Searle SC 40827), and a general metalloproteinase inhibitor, 1,10-phenanthroline, on ovulation, as judged by the observa...

journal_title：Endocrinology

authors： Brännström M,Woessner JF Jr,Koos RD,Sear CH,LeMaire WJ

更新日期：1988-05-01 00:00:00

abstract：:Administration of ovine or rat PRL to animals, including man, has resulted in decreased urine volume and increased urine osmolality. Contamination of PRL preparations with vasopressin is the most likely explanation for the apparent antidiuretic effect. In this study, diabetes insipidus rats lacking vasopressin(homozyg...

journal_title：Endocrinology

authors： Adler RA,Dolphin S,Szefler M,Sokol HW

更新日期：1979-10-01 00:00:00

abstract：:In cultured rat pituitary cells, increases in the cytosolic calcium concentration ([Ca2+]i) and LH release are induced by activation of GnRH receptors as well as by nonreceptor-mediated stimuli. Treatment of pituitary cells with the myosin light chain kinase (MLCK) inhibitor, wortmannin, attenuated GnRH-induced LH rel...

journal_title：Endocrinology

authors： Rao K,Paik WY,Zheng L,Jobin RM,Tomić M,Jiang H,Nakanishi S,Stojilkovic SS

更新日期：1997-04-01 00:00:00

abstract：:Activin A is a dimeric protein hormone that regulates numerous cellular functions. A clear physiological role for this molecule in pregnancy is suggested by previous studies in the human, wherein activin A rises dramatically as women approach parturition. To determine whether the rodent is a suitable animal model for ...

journal_title：Endocrinology

authors： Draper LB,Chong H,Wang E,Woodruff TK

更新日期：1997-07-01 00:00:00

abstract：:Cyclic somatostatin strongly stimulated secretion of histamine from rat peritoneal mast cells. The energy, temperature and calcium dependence of this effect indicate that the action of somatostatin on the mast cells is similar to that of the classic mast cell secretagogue compound 48/80 and is to induce exocytosis. ...

journal_title：Endocrinology

authors： Theoharides TC,Douglas WW

更新日期：1978-05-01 00:00:00

abstract：:A subline of an x-ray-induced transplantable rat insulinoma has been studied in vivo and in vitro. Tumors grew rapidly after sc transplantation and were rich in insulin, but contained only small amounts of glucagon and somatostatin. Despite marked basal hyperinsulinemia, iv glucose administration caused a further incr...

journal_title：Endocrinology

authors： Masiello P,Wollheim CB,Janjic D,Gjinovci A,Blondel B,Praz GA,Renold AE

更新日期：1982-12-01 00:00:00

abstract：:Amplification of insulin secretion by cAMP is mediated by protein kinase A (PKA) and exchange protein directly activated by cAMP (Epac). Using selective activators, we determined how each effector influences the cytosolic free Ca(2+) concentration ([Ca(2+)]c) and insulin secretion in mouse islets. Alone PKA activator ...

journal_title：Endocrinology

authors： Henquin JC,Nenquin M

更新日期：2014-09-01 00:00:00

abstract：:During the purification of skeletal growth factor/insulin-like growth factor-II and transforming growth factor-beta (TGF beta) from EDTA extracts of bovine bone matrix significant mitogenic activity for cultured osteoblast (Ob)-like cells eluted in fractions that contained a nearly homogeneous peptide with a mol wt of...

journal_title：Endocrinology

authors： Jennings JC,Mohan S,Baylink DJ

更新日期：1989-07-01 00:00:00

abstract：:Endotoxin has been shown to stimulate GH secretion in human and sheep. However, changes in hypothalamic neurohormones involved in the GH regulation by endotoxin have never been studied in vivo. In sheep it is possible to collect hypophysial portal blood (HPB) and quantify GH-releasing hormone (GHRH) and somatostatin (...

journal_title：Endocrinology

authors： Briard N,Guillaume V,Frachebois C,Rico-Gomez M,Sauze N,Oliver C,Dutour A

更新日期：1998-06-01 00:00:00