Dual role for glucocorticoids in cardiomyocyte hypertrophy and apoptosis.

abstract：:Male Siberian hamsters undergo physiological weight change in changing photoperiod. Weight loss was induced by food restriction in long days to mimic short-day weight loss, or by food restriction superimposed on short-day weight loss, to test the hypothesis that the hypothalamus differentiates between weight change in...

journal_title：Endocrinology

authors： Mercer JG,Moar KM,Logie TJ,Findlay PA,Adam CL,Morgan PJ

更新日期：2001-10-01 00:00:00

abstract：:Leptin has been shown to activate multiple signaling molecules in cultured cells, including Janus kinase-2, STAT (signal transducer and activator of transcription) proteins, and mitogen-activated protein kinase, and to stimulate the DNA-binding activity of STAT3 in mouse hypothalamus. In this study, the activation of ...

journal_title：Endocrinology

authors： McCowen KC,Chow JC,Smith RJ

更新日期：1998-11-01 00:00:00

abstract：:Homeostatic control of endocrine systems proceeds via feedforward (agonistic, stimulatory) and feedback (antagonistic, inhibitory) interactions mediated via implicit dose-response functions. However, neither the feedback/feedforward pathways nor the dose-response interfaces are directly observed in vivo. Thus, the goa...

journal_title：Endocrinology

authors： Keenan DM,Clarke IJ,Veldhuis JD

更新日期：2011-12-01 00:00:00

abstract：:The role of GH during the ovine estrous cycle is unknown. In this study, pituitary GH mRNA and peripheral serum GH levels were measured in ewes representing the major phases of the estrous cycle. There was a significant rise (P less than 0.05) in both GH mRNA and serum GH concentrations during the follicular phase of ...

journal_title：Endocrinology

authors： Landefeld TD,Suttie JM

更新日期：1989-09-01 00:00:00

abstract：:Exposure of FRTL-5 thyroid cells to ATP (1 microM to 1 mM) resulted in the stimulation of I- efflux in association with the induction of inositol trisphosphate production and intracellular Ca2+ mobilization. Nonhydrolyzable ATP derivatives, ADP and GTP, were also as effective in magnitude as ATP, whereas neither AMP n...

journal_title：Endocrinology

authors： Okajima F,Sho K,Kondo Y

更新日期：1988-08-01 00:00:00

abstract：:Retinoic acid (RA) slows growth and induces differentiation of tumor cells through activation of RA receptors (RARs). However, melanoma cell lines display highly variable responsiveness to RA, which is a poorly understood phenomenon. By using Northern and Western blot analyses, we show that RA-resistant A375 and RA-re...

journal_title：Endocrinology

authors： Demary K,Wong L,Liou JS,Faller DV,Spanjaard RA

更新日期：2001-06-01 00:00:00

abstract：:In young adult female rats, the patterns of inhibin subunit mRNA expression during the estrous cycle are regulated by cyclic changes in gonadotropin secretion and follicular development. Since there are distinct alterations in profiles of both hormone secretion and folliculogenesis during the reproductive lifespan of ...

journal_title：Endocrinology

authors： Jih MH,Lu JK,Wan YJ,Wu TC

更新日期：1993-01-01 00:00:00

abstract：:Prostaglandin (PG) E2 (PGE(2)) plays a central role in the regulation of smooth muscle contractions. Classically, PGE(2) stimulates contractions via EP1 and EP3 receptors, whereas EP2 and EP4 maintain quiescence. Labor involves a change from myometrial quiescence to contractions with a shift from anti- to proinflammat...

journal_title：Endocrinology

authors： Kandola MK,Sykes L,Lee YS,Johnson MR,Hanyaloglu AC,Bennett PR

更新日期：2014-02-01 00:00:00

abstract：:Recently, we have reported that retinoic acid (RA), similarly to retinol acetate, is able to reinitiate spermatogenesis in vitamin A-deficient rats. Here, we investigated the expression of RA receptors RAR alpha, RAR beta, RAR gamma, and retinoid X receptor RXR alpha by Northern blot analysis of poly(A)+ RNA of testes...

journal_title：Endocrinology

authors： van Pelt AM,van den Brink CE,de Rooij DG,van der Saag PT

更新日期：1992-07-01 00:00:00

abstract：:To further characterize the effect of TSH administration on thyroid iodothyronine monodeiodinating activity, we have evaluated the in vitro conversion of T4 to T3 (outer ring deiodination) and T3 to 3,3'-diiodothyronine (T2; inner ring deiodination) by mouse thyroid, liver, and kidney homogenates, comparing tissues fr...

journal_title：Endocrinology

authors： Wu SY,Reggio R,Florsheim WH

更新日期：1985-03-01 00:00:00

abstract：:Activin A is a dimeric protein hormone that regulates numerous cellular functions. A clear physiological role for this molecule in pregnancy is suggested by previous studies in the human, wherein activin A rises dramatically as women approach parturition. To determine whether the rodent is a suitable animal model for ...

journal_title：Endocrinology

authors： Draper LB,Chong H,Wang E,Woodruff TK

更新日期：1997-07-01 00:00:00

abstract：:In the present report, the action of leukemia inhibitory factor (LIF) on testicular steroid hormone formation was studied. For this purpose, the direct effects of LIF were evaluated on basal and human (h)CG-stimulated testosterone synthesis by cultured, purified Leydig cells isolated from porcine testes. LIF reduced (...

journal_title：Endocrinology

authors： Mauduit C,Goddard I,Besset V,Tabone E,Rey C,Gasnier F,Dacheux F,Benahmed M

更新日期：2001-06-01 00:00:00

abstract：:Circulating levels of insulin-like growth factor-I (IGF-I) increase during puberty, concurrent with an increase in the levels of GH and the gonadal steroids. The relationship between the changes observed in IGF-I and testosterone (T) levels are not understood. This study was designed to determine whether T has a direc...

journal_title：Endocrinology

authors： Phillip M,Palese T,Hernandez ER,Roberts CT Jr,LeRoith D,Kowarski AA

更新日期：1992-05-01 00:00:00

abstract：:Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1-S phase of the cell cycle. Amplification or overexpression of cyclin D1 plays pivotal roles in the development of a subset of human cancers including parathyro...

journal_title：Endocrinology

authors： Fu M,Wang C,Li Z,Sakamaki T,Pestell RG

更新日期：2004-12-01 00:00:00

abstract：:The present studies investigated whether insulin inhibits the stimulatory effect of dexamethasone (DEX) on angiotensinogen (ANG) gene expression and induction of hypertrophy in rat immortalized renal proximal tubular cells (IRPTCs) in a high-glucose milieu. Rat IRPTCs were cultured in monolayer. ANG and ANG mRNA expre...

journal_title：Endocrinology

authors： Zhang SL,Chen X,Wei CC,Filep JG,Tang SS,Ingelfinger JR,Chan JS

更新日期：2002-12-01 00:00:00

abstract：:Although the interactions between sex steroids and GnRH have been extensively studied, little is known about the mechanism of estradiol (E2) effects on GnRH secretion. In the present study, we used retrochiasmatic hypothalamic explants of 50-d-old male rats, and we observed that E2 significantly increased the glutamat...

journal_title：Endocrinology

authors： Matagne V,Lebrethon MC,Gérard A,Bourguignon JP

更新日期：2005-05-01 00:00:00

abstract：:To further our understanding of the role of pituitary gonadotropin secretion in the control of corpus luteum function during the primate menstrual cycle, we have used an experimental model which enables us to directly control pituitary gonadotropin secretion throughout the luteal phase. Specifically, we have asked whe...

journal_title：Endocrinology

authors： Hutchison JS,Zeleznik AJ

更新日期：1985-09-01 00:00:00

abstract：:Addition of somatostatin-14 (SRIF) inhibits corticotropin releasing factor (CRF) and forskolin-stimulated cyclic AMP formation and ACTH release from tumor cells of the mouse anterior pituitary (AtT-20/D16-16). After long-term pretreatment of these cells with SRIF, the ability of SRIF to inhibit CRF and forskolin-stimu...

journal_title：Endocrinology

authors： Reisine T,Axelrod J

更新日期：1983-08-01 00:00:00

abstract：:The majority of ovarian follicles undergo atresia through a mechanism involving apoptotic cell death. Although GnRH and its agonists have been shown to suppress ovarian growth and differentiation in hypophysectomized rats, studies on the induction of follicle atresia by GnRH are contradictory. In the present study, th...

journal_title：Endocrinology

authors： Billig H,Furuta I,Hsueh AJ

更新日期：1994-01-01 00:00:00

abstract：:GnRH neurons are the central regulators of fertility, and their activity is modulated by steroid feedback. In women with hyperandrogenemic infertility and in animal models of these disorders, elevated androgen levels interfere with progesterone (P) negative feedback. Our previous work showed that steroids altered the ...

journal_title：Endocrinology

authors： Pielecka J,Quaynor SD,Moenter SM

更新日期：2006-03-01 00:00:00

abstract：:Mesenchymal stem cells can differentiate into mature chondrocytes, osteoblasts, and adipocytes. Excessive and dysfunctional visceral adipocytes increase upon menopause and importantly contribute to altered metabolism in postmenopausal women. We previously showed both plasma membrane and nuclear estrogen receptors alph...

journal_title：Endocrinology

authors： Ahluwalia A,Hoa N,Ge L,Blumberg B,Levin ER

更新日期：2020-11-01 00:00:00

abstract：:In this study, the potential interactions between dihydrotestosterone (DHT), a survival factor, and transforming growth factor-beta (TGF-beta), an apoptotic inducer, were examined in a derivative of the hormone-sensitive prostate cancer cell line LNCAP: The LNCaP TGF-beta receptor II cells, engineered to express TGF-b...

journal_title：Endocrinology

authors： Bruckheimer EM,Kyprianou N

更新日期：2001-06-01 00:00:00

abstract：:Osteoclast precursors reach sites of osteoclast formation and remodelling via the vasculature and are therefore destined to encounter endothelium before migrating to the bone surface. Here we investigated the hypothesis that endothelium may be involved in the regulation of osteoclast precursor recruitment to sites of ...

journal_title：Endocrinology

authors： McGowan NW,Walker EJ,Macpherson H,Ralston SH,Helfrich MH

更新日期：2001-04-01 00:00:00

abstract：:Diabetes is associated with increased generation of cytokines and tissue inflammation, but it is unclear how increased cytokine synthesis is causally related to the development of diabetic complications. Here, we report that exposure to high (25 mm) glucose, but not iso-osmotic concentrations of mannitol or 3-methyl g...

journal_title：Endocrinology

authors： Ramana KV,Tammali R,Reddy AB,Bhatnagar A,Srivastava SK

更新日期：2007-09-01 00:00:00

abstract：:We investigated the effects of intraventricular (ivt) injection of bombesin on the TRH-induced increase in temperature in the midbrain reticular formation (mrf) of the rat brain under pentobarbital anesthesia. Ivt injection of TRH in a dose of 3 nmol significantly antagonized the decrease in brain temperature induced ...

journal_title：Endocrinology

authors： Mori M,Yamaguchi M,Yamada M,Kobayashi I,Kobayashi S,Ishikawa K,Suzuki M

更新日期：1986-10-01 00:00:00

abstract：:Dispersed pancreatic islet cells were analyzed for their low forward angle light scatter using flow cytometry. The cells produced a distinct light scatter pattern which appeared to be a function of cell size and not cell granularity. RIA of hormone content of cells collected from different regions of the pattern revea...

journal_title：Endocrinology

authors： Fletcher DJ,Grogan WM,Barras E,Weir GC

更新日期：1983-11-01 00:00:00

abstract：:The actions of IGFs are regulated at various levels. One mechanism involves binding to IGF-binding protein-3 (IGFBP-3) for transport, thus governing bioavailability. IGFBP3 transcription is modulated by many hormones and agents that stimulate or inhibit growth. We have previously shown in pediatric and adult cohorts a...

journal_title：Endocrinology

authors： Paquette J,Bessette B,Ledru E,Deal C

更新日期：2007-12-01 00:00:00

abstract：:Reproductive function is dependent on the interaction between GnRH and its cognate receptor found on gonadotrope cells of the anterior pituitary gland. GnRH activation of the GnRH receptor (GnRHR) is a potent stimulus for increased expression of multiple genes including the gene encoding the GnRHR itself. Thus, homolo...

journal_title：Endocrinology

authors： Ellsworth BS,White BR,Burns AT,Cherrington BD,Otis AM,Clay CM

更新日期：2003-03-01 00:00:00

abstract：:Primary ovarian insufficiency (POI) resulting from ovarian autoimmunity is a poorly understood clinical condition lacking in effective treatments. Understanding the targets of the autoimmune response and induction of ovarian-specific tolerance would allow development of focused therapies to preserve fertility in an at...

journal_title：Endocrinology

authors： Otsuka N,Tong ZB,Vanevski K,Tu W,Cheng MH,Nelson LM

更新日期：2011-06-01 00:00:00

abstract：:Sex differences in vocal communication are prevalent in both the animals and humans. The mechanism(s) mediating gender differences in human language are unknown, although, sex hormones, principally androgens, play a central role in the development of vocalizations in a wide variety of animal species. The discovery of ...

journal_title：Endocrinology

authors： Bowers JM,Perez-Pouchoulen M,Roby CR,Ryan TE,McCarthy MM

更新日期：2014-12-01 00:00:00