Effect of testosterone on insulin-like growth factor-I (IGF-I) and IGF-I receptor gene expression in the hypophysectomized rat.

abstract：:FSH and IGF-I are both important determinants of testicular development and Sertoli cell function. The present studies were performed to determine the actions of FSH and IGF-I on PI3K/AKT protein kinase signaling in immature rat Sertoli cells. Primary cultures of rat Sertoli cells were prepared from 10-d-old rats. Aft...

journal_title：Endocrinology

authors： Khan SA,Ndjountche L,Pratchard L,Spicer LJ,Davis JS

更新日期：2002-06-01 00:00:00

abstract：:The Leydig cells of the testis are known to possess high affinity receptors for luteinizing hormone and human chorionic gonadotropin (hCG), but no information concerning the synthesis of these receptors is available yet. In order to investigate this question, we have purified crude rat interstitial cell preparations o...

journal_title：Endocrinology

authors： Aubry M,Collu R,Ducharme JR,Crine P

更新日期：1982-12-01 00:00:00

abstract：:Mammary gland explants from mature virgin mice, rats, and rabbits exhibit an increased rate of both DNA and casein syntheses when cultured in the presence of specific combinations of insulin, hydrocortisone, and PRL. If cytosine arabinoside, a potent inhibitor of DNA synthesis, is added to the culture medium, casein s...

journal_title：Endocrinology

authors： Nicholas KR,Bolander FF Jr,Sankaran L,Topper YJ

更新日期：1983-03-01 00:00:00

abstract：:Limited proteolysis in vivo of insulin-like growth factor-binding protein-3 (IGFBP-3) by as yet unidentified serine proteases plays a key role in controlling the bioavailability of IGFBP-3-associated insulin-like growth factors (IGFs). Both the IGF system and the system of plasminogen activators (PAs) and their inhibi...

journal_title：Endocrinology

authors： Lalou C,Silve C,Rosato R,Segovia B,Binoux M

更新日期：1994-12-01 00:00:00

abstract：:Decidual tissue of the rat produces a hormone with physiological and biochemical characteristics similar to those of PRL. Because PRL affects both follicular and luteal production of testosterone and estradiol, it was of interest to determine whether decidual luteotropin affects basal and/or LH-stimulated ovarian secr...

journal_title：Endocrinology

authors： Gibori G,Kalison B,Warshaw ML,Basuray R,Glaser LA

更新日期：1985-05-01 00:00:00

abstract：:We have characterized opioid binding sites in the Sertoli cells of adult and 18-day-old rat testes. Maximal specific etorphine binding was attained after 30 min at 4 C. The binding was reversible, with association and dissociation rate constants of 0.98 X 10(5) M-1 min-1 and 0.33 min-1, respectively. Scatchard analyse...

journal_title：Endocrinology

authors： Fabbri A,Tsai-Morris CH,Luna S,Fraioli F,Dufau ML

更新日期：1985-12-01 00:00:00

abstract：:ACTH and cAMP stimulate steroidogenesis and the mitochondrial electron transport system for steroid hydroxylation in cultured mouse adrenal cortex tumor cells. During this stimulation, the biosynthesis of adrenodoxin, a non-heme iron protein which is one of the electron transport enzymes, was examined. 14C-labeled adr...

journal_title：Endocrinology

authors： Asano K,Harding BW

更新日期：1976-10-01 00:00:00

abstract：:We investigated the effect of epidermal growth factor (EGF) on collagen and protein synthesis in clone MC3T30-E1, a cell line which retains osteoblast-like characteristics. EGF at concentrations of 2-50 ng/ml significantly the hydroxyproline content of the cell layer. These effects were completely abolished by the add...

journal_title：Endocrinology

authors： Hiramatsu M,Kumegawa M,Hatakeyama K,Yajima T,Minami N,Kodama H

更新日期：1982-12-01 00:00:00

abstract：:LH receptor (LHR) expression in the ovary is regulated by the RNA binding protein, (LHR mRNA binding protein [LRBP]), which has been identified as being mevalonate kinase. This study examined the role of microRNA miR-122 in LRBP-mediated LHR mRNA expression. Real-time PCR analysis of ovaries from pregnant mare serum g...

journal_title：Endocrinology

authors： Menon B,Sinden J,Franzo-Romain M,Botta RB,Menon KM

更新日期：2013-12-01 00:00:00

abstract：:The effect of synthetic atrial natriuretic factor (ANF) on adrenal steroidogenesis has been studied in primary culture of bovine adrenal cells. ANF-(8-33) produced a potent 40-70% inhibition of angiotensin II-, ACTH-, PGE1-, and forskolin-stimulated secretion of aldosterone production from zona glomerulosa cells with ...

journal_title：Endocrinology

authors： De Léan A,Racz K,Gutkowska J,Nguyen TT,Cantin M,Genest J

更新日期：1984-10-01 00:00:00

abstract：:The mouse mammary gland and uterus expressed the gene for the secretory protein lactotransferrin under various physiological conditions. Lactotransferrin, however, was induced by estrogen in a time- and dose-dependent fashion in the uterus of the immature mouse, but was not affected by estrogen in the mammary gland. D...

journal_title：Endocrinology

authors： Teng CT,Pentecost BT,Chen YH,Newbold RR,Eddy EM,McLachlan JA

更新日期：1989-02-01 00:00:00

abstract：:Bisphenol A (BPA) is an endocrine-disrupting compound used to manufacture plastics; it is present in linings of food cans, bottles, thermal receipts, and many other everyday items and is detectable in human urine and blood. Exposure to BPA during development can disrupt sexual differentiation of some brain regions. Mo...

journal_title：Endocrinology

authors： Goldsby JA,Wolstenholme JT,Rissman EF

更新日期：2017-01-01 00:00:00

abstract：:This study investigates the signaling pathways that lead to acute augmentation of secretagogue-induced LH secretion, the physiologically relevant manifestation of which is LHRH self-potentiation. The consequence of LHRH self-potentiation is an augmented LH secretory response to subsequent exposure to the peptide. Alth...

journal_title：Endocrinology

authors： Waring DW,Turgeon JL

更新日期：1992-06-01 00:00:00

abstract：:Stearoyl-CoA desaturase-1 (SCD-1) plays a pivotal role in an increase of triglyceride by an excess of dietary carbohydrate intake. Dietary carbohydrates increase SCD-1 gene expression in liver by sterol response element binding protein (SREBP)-1c-dependent and SREBP-1c -independent pathways. Previous report demonstrat...

journal_title：Endocrinology

authors： Hashimoto K,Ishida E,Miura A,Ozawa A,Shibusawa N,Satoh T,Okada S,Yamada M,Mori M

更新日期：2013-01-01 00:00:00

abstract：:Hormonal induction of steroidogenesis in the adrenal and gonads is dependent on the synthesis and function of the steroidogenic acute regulatory protein (StAR). As a first approach to investigate the role of translation in the control of StAR expression, we examined StAR protein synthesis and steroid production in MA-...

journal_title：Endocrinology

authors： Clark BJ,Combs R,Hales KH,Hales DB,Stocco DM

更新日期：1997-11-01 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that plays a pivotal role in several immunoinflammatory and autoimmune diseases. In this study we examined the role of MIF in the development of immunoinflammatory diabetes induced in susceptible strains of mice by multiple low doses of strepto...

journal_title：Endocrinology

authors： Cvetkovic I,Al-Abed Y,Miljkovic D,Maksimovic-Ivanic D,Roth J,Bacher M,Lan HY,Nicoletti F,Stosic-Grujicic S

更新日期：2005-07-01 00:00:00

abstract：:The response of fat tissue to GH or insulin-like growth factor I (IGF-I) differs between humans with hypopituitarism and those with exogenous obesity; the effects of combined GH and IGF-I administration have not been compared in these two situations. In GH-deficient dwarf rats (who have a primary GH deficiency), the e...

journal_title：Endocrinology

authors： Dubuis JM,Deal C,Tsagaroulis P,Clark RG,Van Vliet G

更新日期：1996-07-01 00:00:00

abstract：:Although atrial and brain natriuretic peptides are well known to be involved in the regulation of cardiovascular and endocrine functions as circulating hormones, the roles of the C-type natriuretic peptide (CNP) remain unknown. We examined the effects of CNP on the secretion of aldosterone and cyclic nucleotides from ...

journal_title：Endocrinology

authors： Kawai M,Naruse M,Yoshimoto T,Naruse K,Shionoya K,Tanaka M,Morishita Y,Matsuda Y,Demura R,Demura H

更新日期：1996-01-01 00:00:00

abstract：:Glucose release from the liver is mediated by hypothalamic norepinephrine (NE) neuronal activity, but glucose itself (or a metabolite of it) exerts negative feedback effects on central NE activity. The aim of the present study was to investigate a possible role for insulin in these central glucose homeostatic mechanis...

journal_title：Endocrinology

authors： Smythe GA,Bradshaw JE,Nicholson MV,Grunstein HS,Storlien LH

更新日期：1985-10-01 00:00:00

abstract：:The present study employed the dehydroepiandrosterone (DHA) loading test to determine if the placenta in baboons remains functional following fetectomy. A bolus iv injection of 100 mg DHA was given to 4 baboons prior to and at various intervals following fetectomy at midgestation. Blood samples were withdrawn over a 4...

journal_title：Endocrinology

authors： Albrecht ED,Pepe GJ

更新日期：1985-02-01 00:00:00

abstract：:The effects of insulin to stimulate metabolic and mitogenic responses were examined in Rat 1 fibroblast cells that overexpressed either normal (HIRc) or kinase-deficient human insulin receptors. When studied at the optimal growth stage for each cell line, insulin-stimulated responses measured in cells containing kinas...

journal_title：Endocrinology

authors： Wong EH,Tan CH,Khoo HE,Ng FH,Lim KL,Ciaraldi TP

更新日期：1995-04-01 00:00:00

abstract：:GH promotes not only longitudinal growth in children but is active throughout life in protein, fat, and carbohydrate metabolism. The multiple actions of GH start when GH binds to the cell surface-expressed GH receptor. Effectiveness of the hormone depends both on its presence in the circulation and the availability of...

journal_title：Endocrinology

authors： van Kerkhof P,Smeets M,Strous GJ

更新日期：2002-04-01 00:00:00

abstract：:Previous studies have shown that estradiol indirectly stimulated the proliferation of oviduct epithelial cells in the quail. The present study was undertaken to investigate the effects of estradiol and other steroid hormones on the cAMP concentration. The ability of forskolin, a specific activator of the catalytic sub...

journal_title：Endocrinology

authors： Laugier C,Courion C,Pageaux JF,Fanidi A,Dumas MY,Sandoz D,Nemoz G,Prigent AF,Pacheco H

更新日期：1988-01-01 00:00:00

abstract：:The primate brain was thought to contain only the GnRH known as mammalian GnRH (mGnRH). This study investigates whether a second form of GnRH exists within the primate brain. We found that brain extracts from adult stumptail and rhesus monkeys contained two forms of GnRH that were similar to mGnRH and chicken GnRH-II ...

journal_title：Endocrinology

authors： Lescheid DW,Terasawa E,Abler LA,Urbanski HF,Warby CM,Millar RP,Sherwood NM

更新日期：1997-12-01 00:00:00

abstract：:In animal models of inflammation, the pregnancy hormone relaxin was shown to reduce the recruitment of leukocytes, especially neutrophils, in inflamed tissues. The current study was designed to clarify whether relaxin could inhibit activation of isolated human neutrophils and, if so, whether the nitric oxide (NO) bios...

journal_title：Endocrinology

authors： Masini E,Nistri S,Vannacci A,Bani Sacchi T,Novelli A,Bani D

更新日期：2004-03-01 00:00:00

abstract：:The mechanism of mitogen-activated protein kinase (MAPK, ERK) stimulation by the GnRH analog [D-Trp6]GnRH (GnRH-a) was investigated in the gonadotroph-derived alphaT3-1 cell line. GnRH-a as well as the protein kinase C (PKC) activator 12-O-tetradecanoyl phorbol-13-acetate (TPA) stimulated a sustained response of MAPK ...

journal_title：Endocrinology

authors： Reiss N,Llevi LN,Shacham S,Harris D,Seger R,Naor Z

更新日期：1997-04-01 00:00:00

abstract：:We have confirmed the serum calcium-raising effect of adrenalectomy in young male rats 5-6 h after parathyroidectomy that was first observed by others many years ago. (The phenomenon has also been reported in cats, dogs, and mice.) In addition, we have shown that adrenalectomy raises the serum ionized calcium as well ...

journal_title：Endocrinology

authors： Nishino K,Hirsch PF,Mahgoub A,Munson PL

更新日期：1991-05-01 00:00:00

abstract：:In male hamsters, light deprivation was reported to reduce both testis weight and prolactin (PRL) levels. Therefore, we decided to examine the effects of PRL on testicular function in hamsters exposed to short day-length. Adult hamsters were exposed to 5 h of light per day to induce gonadal atrophy, and, starting two ...

journal_title：Endocrinology

authors： Bartke A,Croft BT,Dalterio S

更新日期：1975-12-01 00:00:00

abstract：:As we showed previously, the extracellular matrix (ECM) derived from rat bladder carcinoma cells (804G-ECM) has positive effects on rat primary beta-cell function and survival in vitro. The aim of this study was to define beta-cell genes induced by this ECM with a specific focus on cytokines. Analysis of differential ...

journal_title：Endocrinology

authors： Ribaux P,Ehses JA,Lin-Marq N,Carrozzino F,Böni-Schnetzler M,Hammar E,Irminger JC,Donath MY,Halban PA

更新日期：2007-11-01 00:00:00

abstract：:We tested the hypothesis that depressed duodenal calcium absorption in the streptozotocin diabetic rat is the consequence of diabetes rather than nephrotoxicity of the diabetogenic agent causing abnormal renal vitamin D metabolism. We treated streptozotocin diabetic rats with insulin and compared their duodenal calciu...

journal_title：Endocrinology

authors： Schneider LE,Nowosielski LM,Schedl HP

更新日期：1977-01-01 00:00:00