Mechanism of mitogen-activated protein kinase activation by gonadotropin-releasing hormone in the pituitary of alphaT3-1 cell line: differential roles of calcium and protein kinase C.

abstract：:Endocrine regulation of uterine biology is critical for embryo receptivity and human reproduction. Uterine endometrium depends on extrinsic sex steroid input and hence likely has mechanisms that enable adaptation to hormonal variation. Emerging evidence suggests that sex steroid bioavailability in the endometrium is d...

journal_title：Endocrinology

authors： Zheng Y,Tabbaa ZM,Khan Z,Schoolmeester JK,El-Nashar S,Famuyide A,Keeney GL,Daftary GS

更新日期：2014-11-01 00:00:00

abstract：:Recent in vitro and in vivo evidence shows that secretion of parathyroid hormone (PTH) and calcitonin (CT) is stimulated by beta-adrenergic agonists and inhibited by beta-adrenergic antagonists. To assess the possible roles of adrenal medullary or adrenergic nerve terminal catecholamines in calcium homeostasis, we hav...

journal_title：Endocrinology

authors： Heath H 3rd

更新日期：1980-10-01 00:00:00

abstract：:The p44/p42 MAPKs (ERK1/2) cascade regulates beta-cell nuclear events, which modulates cell differentiation and gene transcription, whereas its implication in processes occurring in the cytoplasm, such as activation of the exocytotic machinery, is still unclear. Using the MIN6 beta-cell line and isolated rat islets of...

journal_title：Endocrinology

authors： Longuet C,Broca C,Costes S,Hani EH,Bataille D,Dalle S

更新日期：2005-02-01 00:00:00

abstract：:We investigated the effect of TSH on calcium transport in mouse thyroid, as well as the influence of iodide thereupon. Thyroid lobes were incubated in Krebs-Ringer bicarbonate buffer containing [45Ca2+] and the time-dependent uptake of [45Ca2+] by the lobes was observed. In the presence of 0.5 mU/ml TSH, the uptake of...

journal_title：Endocrinology

authors： Hashizume K,Ichikawa K,Komiya I,Onaya T

更新日期：1984-05-01 00:00:00

abstract：:We have previously shown that dopamine-evoked inhibition of corticosteroid production from adrenocortical cells is mediated through a decrease in prostaglandin biosynthesis. Since the catecholamine did not alter the stimulatory effect of arachidonic acid, it was proposed that dopamine may inhibit the formation of arac...

journal_title：Endocrinology

authors： Morra M,Leboulenger F,Desrues L,Tonon MC,Vaudry H

更新日期：1991-05-01 00:00:00

abstract：:Recent studies have revealed that C-type natriuretic peptide (CNP) is a potent stimulator of endochondral bone growth. Nevertheless, the effect of CNP on bone turnover has not yet been well studied. To elucidate this issue, we investigated the bone phenotype of a mouse model with elevated plasma CNP concentrations (SA...

journal_title：Endocrinology

authors： Kondo E,Yasoda A,Fujii T,Nakao K,Yamashita Y,Ueda-Sakane Y,Kanamoto N,Miura M,Arai H,Mukoyama M,Inagaki N,Nakao K

更新日期：2015-07-01 00:00:00

abstract：:This study provides the first demonstration that human hepatocarcinoma-derived cell line HepG2 contains GnRH receptors and responds to various molecular forms of GnRH in terms of inhibition of proliferation in a time- and dose-related manner. In addition, GnRH peptides also significantly inhibited the uptake of [3H]th...

journal_title：Endocrinology

authors： Pati D,Habibi HR

更新日期：1995-01-01 00:00:00

abstract：:The role of GH during the ovine estrous cycle is unknown. In this study, pituitary GH mRNA and peripheral serum GH levels were measured in ewes representing the major phases of the estrous cycle. There was a significant rise (P less than 0.05) in both GH mRNA and serum GH concentrations during the follicular phase of ...

journal_title：Endocrinology

authors： Landefeld TD,Suttie JM

更新日期：1989-09-01 00:00:00

abstract：:Three members of the progestin and adipoQ receptor (PAQR) family, PAQR-7, PAQR-8, and PAQR-5 [membrane progesterone (P4) receptor (PR) (mPR)α, mPRβ, and mPRγ], function as plasma mPRs coupled to G proteins in mammalian cells, but the characteristics of two other members, PAQR6 and PAQR9 (mPRδ and mPRε), remain unclear...

journal_title：Endocrinology

authors： Pang Y,Dong J,Thomas P

更新日期：2013-01-01 00:00:00

abstract：:Cell proliferation, terminal differentiation, and angiogenesis occur during cycles of follicular and luteal development. In other paradigms, mac25, a potent tumor inhibitor is strongly induced in senescent epithelial cells, whereas CTGF stimulates angiogenesis and wound healing. Using in situ hybridization and immunoh...

journal_title：Endocrinology

authors： Wandji SA,Gadsby JE,Barber JA,Hammond JM

更新日期：2000-07-01 00:00:00

abstract：:The largest subtype of breast cancer is characterized by the expression and activity of the estrogen receptor alpha (ERalpha/ER). Although several effective therapies have significantly improved survival, the adaptability of cancer cells means that patients frequently stop responding or develop resistance to endocrine...

journal_title：Endocrinology

authors： Farcas AM,Nagarajan S,Cosulich S,Carroll JS

更新日期：2021-02-01 00:00:00

abstract：:The effects of diabetes on basal calcium metabolism and the response to endocrine stimulation were studied in hepatocytes from acute and long term diabetic rats. Hepatocyte calcium sequestration and turnover were increased in both acute and chronic diabetes. Cytosolic free calcium (Cai2+) was significantly increased i...

journal_title：Endocrinology

authors： Studer RK,Ganas L

更新日期：1989-11-01 00:00:00

abstract：:The influence of GH and several other pituitary hormones on the secretion and intracellular content of immunoreactive somatostatin (IRS) in cultured hypothalamic cells was examined. Hypothalamic cells prepared from 17-day-old rat embryos and maintained as reaggregate monolayers for 12 days in vitro were used. Short te...

journal_title：Endocrinology

authors： Robbins RJ,Leidy JW Jr,Landon RM

更新日期：1985-08-01 00:00:00

abstract：:We investigated, in five cell strains per experiment, whether several cytokines known or believed to have effects on bone resorption were produced by nearly homogeneous strains of cultured normal human osteoblast-like (hOB) cells that display virtually the complete phenotype of the mature osteoblast. In unstimulated h...

journal_title：Endocrinology

authors： Chaudhary LR,Spelsberg TC,Riggs BL

更新日期：1992-05-01 00:00:00

abstract：:Like insulin-like growth factor binding protein-3 (IGFBP-3), IGFBP-5 forms a ternary complex with insulin-like growth factor (IGF)-I or IGF-II, and the acid-labile subunit (ALS). The study of IGFBP-5/IGFBP-6 chimeric proteins with amino-terminal and middle domain swaps, has revealed the existence of a site in the midd...

journal_title：Endocrinology

authors： Twigg SM,Kiefer MC,Zapf J,Baxter RC

更新日期：2000-01-01 00:00:00

abstract：:Swine granulosa cells cultured under serum-free conditions in vitro exhibit significant responsivity to the stimulatory actions of estradiol (E2) and FSH or LH. Under these conditions, granulosa cells harvested from either immature or mature Graafian follicles synthesized significantly increased quantities of progeste...

journal_title：Endocrinology

authors： Veldhuis JD,Gwynne JT,Strauss JF 3rd,Demers LM

更新日期：1984-06-01 00:00:00

abstract：:The binding of oxytocin (OT) to receptors in rabbit amnion cells stimulates PGE2 release. We previously studied the binding characteristics, changes in receptor concentration during pregnancy, and agonist specificity of OT action on amnion cells. In this study the molecular size of OT receptors in rabbit amnion was es...

journal_title：Endocrinology

authors： Hinko A,Soloff MS,Potier M

更新日期：1992-06-01 00:00:00

abstract：:A cell-free system was used to characterize the binding reaction between the progesterone receptor and nuclear acceptor sites prepared from rat placenta. Two forms of receptor-acceptor complex were examined. One was extracted from nuclei by exposure to 0.6 M KCl; the other type was resistant to salt extraction. Kineti...

journal_title：Endocrinology

authors： Ogle TF

更新日期：1987-07-01 00:00:00

abstract：:Rats were made unilaterally cryptorchid by cutting the gubernaculum testis at birth. At 100 days age, the rats were injected with 600 IU/kg hCG. A biphasic testosterone response was seen in the scrotal (Scr) testis in response to hCG, with maxima at 1 h and 3 days after injection. The acute peak of testosterone was of...

journal_title：Endocrinology

authors： Huhtaniemi I,Bergh A,Nikula H,Damber JE

更新日期：1984-08-01 00:00:00

abstract：:Sertoli cells regulate differentiation and development of the testis and are essential for maintaining adult testis function. To model the effects of dysregulating Sertoli cell number during development or aging, we have used acute diphtheria toxin-mediated cell ablation to reduce Sertoli cell population size. Results...

journal_title：Endocrinology

authors： Rebourcet D,Darbey A,Monteiro A,Soffientini U,Tsai YT,Handel I,Pitetti JL,Nef S,Smith LB,O'Shaughnessy PJ

更新日期：2017-09-01 00:00:00

abstract：:The maternal plasma concentrations of GH and PRL increase dramatically upon the initiation of lactation in the rat. In light of the fact that these two hormones have evolved from one common precursor, we sought to determine if the neuroendocrine mechanisms regulating their concomitant increase during lactation are com...

journal_title：Endocrinology

authors： Wehrenberg WB,Gaillard RC

更新日期：1989-01-01 00:00:00

abstract：:Fetal pancreatic islets (21.5 days old) were cultured in RPMI 1640 containing either 2.8 or 11.1 mM glucose for 7 days. After the 7-day culture period, islets cultured in 2.8 mM glucose demonstrated a minimal first phase of insulin secretion in response to acute glucose stimulation, whereas islets cultured in 11.1 mM ...

journal_title：Endocrinology

authors： Dudek RW,Kawabe T,Brinn JE,O'Brien K,Poole MC,Morgan CR

更新日期：1984-02-01 00:00:00

abstract：:Thyroid cell growth and function are regulated by hormones and growth factors binding to cell surface receptors that are coupled via G proteins, Gs and Gq, to the adenylyl cyclase and phospholipase C signal transduction systems, respectively. Activating mutations of the TSH receptor and G alpha s have been documented ...

journal_title：Endocrinology

authors： Zeiger MA,Saji M,Gusev Y,Westra WH,Takiyama Y,Dooley WC,Kohn LD,Levine MA

更新日期：1997-08-01 00:00:00

abstract：:The mouse mammary gland and uterus expressed the gene for the secretory protein lactotransferrin under various physiological conditions. Lactotransferrin, however, was induced by estrogen in a time- and dose-dependent fashion in the uterus of the immature mouse, but was not affected by estrogen in the mammary gland. D...

journal_title：Endocrinology

authors： Teng CT,Pentecost BT,Chen YH,Newbold RR,Eddy EM,McLachlan JA

更新日期：1989-02-01 00:00:00

abstract：:The existence of a vasoactive molecule released in response to hCG is believed to be the main feature in the development of ovarian hyperstimulation syndrome (OHSS) in women, and vascular endothelial growth factor (VEGF) is the main candidate as the human chorionic gonadotropin (hCG) mediator. This study was conducted...

journal_title：Endocrinology

authors： Gómez R,Simón C,Remohí J,Pellicer A

更新日期：2002-11-01 00:00:00

abstract：:Exposure of FRTL-5 thyroid cells to ATP (1 microM to 1 mM) resulted in the stimulation of I- efflux in association with the induction of inositol trisphosphate production and intracellular Ca2+ mobilization. Nonhydrolyzable ATP derivatives, ADP and GTP, were also as effective in magnitude as ATP, whereas neither AMP n...

journal_title：Endocrinology

authors： Okajima F,Sho K,Kondo Y

更新日期：1988-08-01 00:00:00

abstract：:Although Na+/H+ exchange is important to maintenance of pH and volume and thus placental-fetal homeostasis, regulation of the Na+/H+ exchange system is incompletely understood. We previously showed that Na+/H+ exchanger (NHE)1 and -3 and their regulatory factors NHERF1 and -2 were expressed in human and nonhuman prima...

journal_title：Endocrinology

authors： Pepe GJ,Burch MG,Albrecht ED

更新日期：2006-06-01 00:00:00

abstract：:We previously described a novel alternatively spliced mRNA transcript of the betacellulin (BTC) gene. This splice isoform, termed BTC-delta4, lacks the C-loop of the epidermal growth factor motif and the transmembrane domain as a result of exon 4 'skipping'. In this study, we expressed BTC-delta4 recombinantly to expl...

journal_title：Endocrinology

authors： Ogata T,Dunbar AJ,Yamamoto Y,Tanaka Y,Seno M,Kojima I

更新日期：2005-11-01 00:00:00

abstract：:We have used immunohistochemistry to define the cellular distribution of GH receptors in the gastrointestinal tract (GIT) and its derivatives. Immunohistochemistry was performed in the adult rat GIT with a panel of characterized monoclonal antibodies to the GH receptor. The most intense and heterogeneous immunoreactiv...

journal_title：Endocrinology

authors： Lobie PE,Breipohl W,Waters MJ

更新日期：1990-01-01 00:00:00

abstract：:We studied the structural and functional characteristics of insulin receptors from rat brain and liver from late gestation through adulthood as well as from cultured neuronal and glial cells from neonatal rats. Specific insulin binding was present on membrane preparations from brain and liver at all stages of developm...

journal_title：Endocrinology

authors： Lowe WL Jr,Boyd FT,Clarke DW,Raizada MK,Hart C,LeRoith D

更新日期：1986-07-01 00:00:00