Increased Bone Turnover and Possible Accelerated Fracture Healing in a Murine Model With an Increased Circulating C-Type Natriuretic Peptide.

abstract：:Pancreastatin, a novel 49-amino acid peptide isolated from porcine pancreas, shows over 70% sequence homology to the central part of bovine and human chromogranin-A. Using an N-terminal and C-terminal synthetic peptide, we developed two sensitive and specific RIAs for the detection of pancreastatin-like immunoreactivi...

journal_title：Endocrinology

authors： Schmidt WE,Siegel EG,Lamberts R,Gallwitz B,Creutzfeldt W

更新日期：1988-09-01 00:00:00

abstract：:Neurotensin (NT) is a peptide expressed in the brain and in the gastrointestinal tract. Brain NT inhibits food intake, but the effects of peripheral NT are less investigated. In this study, peripheral NT decreased food intake in both mice and rats, which was abolished by a NT antagonist. Using c-Fos immunohistochemist...

journal_title：Endocrinology

authors： Ratner C,Skov LJ,Raida Z,Bächler T,Bellmann-Sickert K,Le Foll C,Sivertsen B,Dalbøge LS,Hartmann B,Beck-Sickinger AG,Madsen AN,Jelsing J,Holst JJ,Lutz TA,Andrews ZB,Holst B

更新日期：2016-09-01 00:00:00

abstract：:Estrogen increases the alpha 1-adrenergic contractile sensitivity of the rabbit uterus. Since estrogen treatment increases prostaglandin (PG) production by the perfused rabbit uterus, and PGs contribute to the alpha 1-adrenergic contractile response, we postulated that estrogen's effects on PG production or response m...

journal_title：Endocrinology

authors： Hurd WW,Riemer RK,Goldfien A,Roberts JM

更新日期：1991-09-01 00:00:00

abstract：:Previous studies have shown that the adenylyl cyclase of intact granulosa cells from immature porcine follicles has a uniquely prolonged responsiveness to FSH and an atypically poor responsiveness to cholera toxin relative to other cells. The present studies were designed to determine if these characteristics were due...

journal_title：Endocrinology

authors： Hunzicker-Dunn M,LaBarbera AR

更新日期：1986-01-01 00:00:00

abstract：:Administration of a single injection of estradiol (E2) causes a maximum increase in DNA synthesis in the uterine luminal epithelium approximately 24 h later. We previously reported that animals receiving a second injection of E2 15-18 h after the first show an apparent decrease in DNA synthesis measured in this cell t...

journal_title：Endocrinology

authors： Kirkland JL,Mukku VR,Hardy M,Stancel GM

更新日期：1984-03-01 00:00:00

abstract：:Low basal GH secretion and reduced GH responsiveness to different GH secretagogues, including GHRF, have been reported in aged animals and humans. Parallel to the in vivo findings, an impaired GH responsiveness to GHRF is evident in somatotropes from old rats of either sex. We report here that in anterior pituitaries ...

journal_title：Endocrinology

authors： Parenti M,Dall'ara A,Rusconi L,Cocchi D,Müller EE

更新日期：1987-11-01 00:00:00

abstract：:Hyperactivation of the GHRH receptor or downstream signaling components is associated with hyperplasia of the pituitary somatotrope population, in which adenomas form relatively late in life, with less than 100% penetrance. Hyperplastic and adenomatous pituitaries of metallothionein promoter-human GHRH transgenic (Tg)...

journal_title：Endocrinology

authors： Luque RM,Soares BS,Peng XD,Krishnan S,Cordoba-Chacon J,Frohman LA,Kineman RD

更新日期：2009-07-01 00:00:00

abstract：:Trans-10, cis-12 conjugated linoleic acid (10,12 CLA) is a dietary fatty acid that promotes weight loss and disproportionate fat loss. Obese mice fed a high-fat, high-sucrose (HFHS) diet containing 10,12 CLA are resistant to weight gain and contain markedly reduced subcutaneous fat and adiponectin, with a concurrent l...

journal_title：Endocrinology

authors： Wang S,Goodspeed L,Turk KE,Houston B,den Hartigh LJ

更新日期：2017-09-01 00:00:00

abstract：:The epidermis has a great potential as a bioreactor to produce proteins with systemic action. However, the consequences of ectopic epidermal protein overexpression need to be carefully addressed to avoid both local and systemic adverse effects. Thus, the long-term effects of leptin on skin physiology have not been stu...

journal_title：Endocrinology

authors： Rico L,Del Rio M,Bravo A,Ramirez A,Jorcano JL,Page MA,Larcher F

更新日期：2005-10-01 00:00:00

abstract：:We examined the levels and stability of glucocorticoid receptor activity in cytosol preparations of rat lung and other tissues. [3H]Dexamethasome binding capacity at 2 C in lung cytosol decreases with a t1/2 of 40 min in the absence of steroid or a sulfhydryl compound. This rapid inactivation of unbound receptor is pr...

journal_title：Endocrinology

authors： Granberg JP,Ballard PL

更新日期：1977-04-01 00:00:00

abstract：:Chemerin is an adipokine with important regulatory roles in adipogenesis. In humans, serum total chemerin (i.e. prochemerin plus chemerin) levels are positively associated with body mass index and metabolic syndrome. However, the mechanisms that increase serum chemerin concentration are unknown. We hypothesized that c...

journal_title：Endocrinology

authors： Parlee SD,Ernst MC,Muruganandan S,Sinal CJ,Goralski KB

更新日期：2010-06-01 00:00:00

abstract：:Studies were undertaken to investigate the effects of synthetic 1-24 adrenocorticotropin (ACTH), bovine alpha melanocyte-stimulating hormone (alpha-MSH), and ovine beta lipotropin (beta-LPH) on plasma calcium and phosphate in rabbits. Equimolar concentrations of these hormones were infused intravenously in intact and ...

journal_title：Endocrinology

authors： Gildersleeve DL,Pearson TA,Baghdiantz A,Foster GV

更新日期：1975-12-01 00:00:00

abstract：:The uptake of [125I]triiodothyroacetic acid ([125I]Triac) in anterior pituitary cells was investigated and compared with that of [125I]T3. Furthermore, the effects of Triac, T3, and T4 on TSH release were compared. Cells isolated from adult male Wistar rats were cultured for 3 days in medium with 10% fetal calf serum....

journal_title：Endocrinology

authors： Everts ME,Visser TJ,Moerings EP,Docter R,van Toor H,Tempelaars AM,de Jong M,Krenning EP,Hennemann G

更新日期：1994-12-01 00:00:00

abstract：:Adrenals express a high level of neutral cholesteryl ester hydrolase (CEH) activity, and male rats have greater activity than females; however, the identity of the enzyme(s) responsible for this activity and the basis for the sex differences are unknown. Using mice in which hormone-sensitive lipase (HSL) was inactivat...

journal_title：Endocrinology

authors： Kraemer FB,Shen WJ,Natu V,Patel S,Osuga J,Ishibashi S,Azhar S

更新日期：2002-03-01 00:00:00

abstract：:Early obesity and late onset of insulin resistance associated with hormonal imbalances occur in FSH receptor-deficient follitropin receptor knockout female mice. This study tests the hypothesis that chronic high-fat diet aggravates obesogenic changes in a depot-specific manner and explores some molecular links of horm...

journal_title：Endocrinology

authors： Zhang H,Chen X,Aravindakshan J,Sairam MR

更新日期：2007-12-01 00:00:00

abstract：:We previously described a novel alternatively spliced mRNA transcript of the betacellulin (BTC) gene. This splice isoform, termed BTC-delta4, lacks the C-loop of the epidermal growth factor motif and the transmembrane domain as a result of exon 4 'skipping'. In this study, we expressed BTC-delta4 recombinantly to expl...

journal_title：Endocrinology

authors： Ogata T,Dunbar AJ,Yamamoto Y,Tanaka Y,Seno M,Kojima I

更新日期：2005-11-01 00:00:00

abstract：:[14C]-3-O-Methyl-D-glucose transport in response to GH stimulation was measured in freshly prepared and cultured hepatocytes from hypophysectomized (hypox) adult female rats. Sugar transport in freshly isolated hepatocytes from hypox animals was stimulated by 10(-9) M human GH (hGH) and 10(-9) M rat GH (rGH) during 0-...

journal_title：Endocrinology

authors： Fix JA,Moore WV

更新日期：1981-01-01 00:00:00

abstract：:T(4) activation into T(3) is catalyzed by type 2 deiodinase (D2) in the brain. The rapid induction of D2 in astrocytes by transient brain ischemia has prompted us to explore the effects of hypoxia on D2 in cultures of astrocytes. Hypoxia (2.5% O(2)) of cultured astrocytes increased D2 activity, alone or in association...

journal_title：Endocrinology

authors： Lamirand A,Mercier G,Ramaugé M,Pierre M,Courtin F

更新日期：2007-10-01 00:00:00

abstract：:To examine the possibility that the prepubertal hiatus in gonadotropin secretion in primates is occasioned by an endogenous opioid peptide (EOP)-dependent suppression of pulsatile GnRH release, the ability of an EOP receptor antagonist, naloxone (NAL), to elicit GnRH release was examined indirectly in the rhesus monke...

journal_title：Endocrinology

authors： Medhamurthy R,Gay VL,Plant TM

更新日期：1990-02-01 00:00:00

abstract：:We have tested the hypothesis that basic fibroblast growth factor (bFGF) and transforming growth factor beta (TGF beta) regulate the proliferation of osteoblast-like cells. Cells which migrated from central bone explants of fetal calf calvaria expressed markers characteristic of the osteoblast phenotype, including ost...

journal_title：Endocrinology

authors： Globus RK,Patterson-Buckendahl P,Gospodarowicz D

更新日期：1988-07-01 00:00:00

abstract：:Oxytocin (OT) is a hypothalamic nonapeptide that is synthesized as part of a larger precursor protein that also contains an approximately 10-kDa protein called neurophysin at its C-terminus. This precursor protein is trafficked through the regulated secretory pathway into secretory granules and then axonally transport...

journal_title：Endocrinology

authors： Zhang BJ,Kusano K,Zerfas P,Iacangelo A,Young WS 3rd,Gainer H

更新日期：2002-03-01 00:00:00

abstract：:It has previously been reported that treatment of rat luteal cells and human granulosa luteal cells with hydrogen peroxide (H2O2) results in a significant inhibition of steroid production. The mechanism of inhibition in the former was found to be at the level of cholesterol transport into the mitochondria, whereas in ...

journal_title：Endocrinology

authors： Stocco DM,Wells J,Clark BJ

更新日期：1993-12-01 00:00:00

abstract：:Isolated bone cells are often described according to the presence of PTH- and calcitonin (CT)-sensitive adenylate cyclase activities. Osteoblasts are thought to be cells with PTH-sensitive adenylate cyclase but without CT response, and osteoclasts are thought to be CT-sensitive cells. We have studied the adenylate cyc...

journal_title：Endocrinology

authors： Gutierrez GE,Mundy GR,Katz MS

更新日期：1984-12-01 00:00:00

abstract：:During luteinization of bovine granulosa cells in vitro in the presence of insulin, or insulin plus forskolin, there is a massive upregulation not only of progesterone production, but also of the gene for the peptide hormone oxytocin, with secretion of the peptide into the medium. By using the progesterone receptor an...

journal_title：Endocrinology

authors： Lioutas C,Einspanier A,Kascheike B,Walther N,Ivell R

更新日期：1997-11-01 00:00:00

abstract：:Studies were carried out to determine the regional central nervous system and species specificity of the previously observed [125I]iodoavian pancreatic polypeptide ( [125I]iodo-APP) specific binding to chick brain membranes. The avian species examined were chicken, pigeon, duck, quail, chukar, and pheasant. In all spe...

journal_title：Endocrinology

authors： Adamo ML,Hazelwood RL

更新日期：1984-03-01 00:00:00

abstract：:Insulin secretion by beta-cells of pancreatic islets is regulated by various soluble factors including glucose and hormones. The importance of direct cell-cell communication among beta-cells or between beta-cells and other cell types for such regulation has remained unclear, however. Transmembrane proteins Src homolog...

journal_title：Endocrinology

authors： Kobayashi M,Ohnishi H,Okazawa H,Murata Y,Hayashi Y,Kobayashi H,Kitamura T,Matozaki T

更新日期：2008-11-01 00:00:00

abstract：:Pancreatic beta-cells and HIT-T15 cells exhibit oscillations of cytosolic calcium ([Ca2+]i) that are dependent on glucose metabolism and appear to trigger pulsatile insulin secretion. Significantly, differences in the pattern of this [Ca2+]i oscillatory activity may have important implications for our understanding of...

journal_title：Endocrinology

authors： Leech CA,Holz GG 4th,Habener JF

更新日期：1994-07-01 00:00:00

abstract：:Estrogen deficiency causes bone loss by increasing the number of bone-resorbing osteoclasts. Selective p38α MAPK inhibitors prevent bone-wasting effects of estrogen withdrawal but implicated mechanisms remain to be identified. Here, we show that inactivation of the p38α-encoding gene in osteoblast lineage cells with t...

journal_title：Endocrinology

authors： Thouverey C,Caverzasio J

更新日期：2015-12-01 00:00:00

abstract：:An isolated perfused rabbit ovary preparation was used to determine the effects of cyanoketone, a potent inhibitor of 3 beta-hydroxysteroid dehydrogenase, on ovulation, ovum maturation and fertilizability, and steroid production. In the first experiment, cyanoketone (10(-4) M) was added to the perfusate of one ovary. ...

journal_title：Endocrinology

authors： Yoshimura Y,Hosoi Y,Bongiovanni AM,Santulli R,Atlas SJ,Wallach EE

更新日期：1987-06-01 00:00:00

abstract：:Germ cells were isolated from 30-day-old rat testes and purified by a Percoll gradient. Germ cells were cultured for 24 h to eliminate contaminant cells by utilizing the property of many nongerm cells of attaching to plastic surfaces. Germ cells were subsequently seeded on top of 7-day-old Sertoli cell monolayers. RNA...

journal_title：Endocrinology

authors： Rivarola MA,Sanchez P,Saez JM

更新日期：1985-11-01 00:00:00