Serum chemerin levels vary with time of day and are modified by obesity and tumor necrosis factor-{alpha}.

abstract：:High fat feeding is associated with impaired insulin action, an obese body composition, and down-regulation of glucose transporter-4 (GLUT4) expression in adipocytes. We recently showed that overexpression of GLUT4 selectively in adipocytes of transgenic mice using the aP2 (fatty acid-binding protein) promoter/enhance...

journal_title：Endocrinology

authors： Gnudi L,Tozzo E,Shepherd PR,Bliss JL,Kahn BB

更新日期：1995-03-01 00:00:00

abstract：:Aminoglutethimide, an inhibitor of pregnenolone synthesis, was used to study the relationship between oxidative phosphorylation and steroidogenesis in ovarian mitochondria. In vitro addition of aminoglutethimide to mitochondria prepared from porcine corpora lutea resulted in a decrease in oxygen uptake and an increase...

journal_title：Endocrinology

authors： Dimino MJ,Chavis TR,Downing JR

更新日期：1980-05-01 00:00:00

abstract：:The ontogenic changes in the somatotroph's responsiveness to TRH were examined in enzymatically dissociated rat pituitary cells in primary monolayer culture. Exposure to TRH (10(-8) M) caused a significant increase in GH release in cultured pituitary cells from rats ranging in age from -1 day (20 days of gestational a...

journal_title：Endocrinology

authors： Welsh JB,Cuttler L,Szabo M

更新日期：1986-11-01 00:00:00

abstract：:Pancreatic membrane receptors for cholecystokinin (CCK) in obese and nonobese Zucker rats were compared with the use of a biologically active [125I]iodo-CCK-8 radioprobe. Membrane homogenates from obese rats bound half the amount of radioligand in 2 h as did membranes from lean rats (specifically bound, 7.0% vs. 14.0%...

journal_title：Endocrinology

authors： Praissman M,Izzo RS

更新日期：1986-08-01 00:00:00

abstract：:A major issue of in the treatment of diabetes is the risk of hypoglycemia. Hypoglycemia is detected both centrally and peripherally in the porto-hepatic area. The portal locus for hypoglycemic detection was originally described using the "local irrigation of the liver" approach in a canine model. Further work using po...

journal_title：Endocrinology

authors： Ionut V,Castro AV,Woolcott OO,Stefanovski D,Iyer MS,Broussard JL,Mkrtchyan H,Burch M,Elazary R,Kirkman E,Bergman RN

更新日期：2014-04-01 00:00:00

abstract：:Type 1 diabetes is caused by autoimmune destruction of β-cells. Although immunotherapy can restore self-tolerance thereby halting continued immune-mediated β-cell loss, residual β-cell mass and function is often insufficient for normoglycemia. Using a growth factor to boost β-cell mass can potentially overcome this ba...

journal_title：Endocrinology

authors： Hyslop CM,Tsai S,Shrivastava V,Santamaria P,Huang C

更新日期：2016-01-01 00:00:00

abstract：:Acylation-stimulating protein (ASP) is a potent lipogenic protein produced by adipocytes. In vitro studies have shown that ASP increases triglyceride synthesis and glucose transport in both murine and human adipocytes. Our initial study indicated that complement C3-deficient (-/-) mice (and, therefore, ASP deficient) ...

journal_title：Endocrinology

authors： Murray I,Havel PJ,Sniderman AD,Cianflone K

更新日期：2000-03-01 00:00:00

abstract：:Insulin-like growth factors (IGFs), when isolated from serum or tissue fluids, are usually found as part of a protein complex which also contains one of several IGF binding proteins (IGFBPs). Although some IGFBPs have been shown to alter interactions of IGFs with their receptors in vitro and can modify the responses o...

journal_title：Endocrinology

authors： Green BN,Jones SB,Streck RD,Wood TL,Rotwein P,Pintar JE

更新日期：1994-02-01 00:00:00

abstract：:Estrogens bind to two nuclear estrogen receptor (ER) subtypes, ERα and ERβ, which are expressed in differing amounts in various tissues. The endogenous estrogen, 17β-estradiol (E2), binds to both subtypes with nearly equal affinity and is the prototypical agonist. Selective estrogen receptor modulators (SERMs) may bin...

journal_title：Endocrinology

authors： Starkey NJE,Li Y,Drenkhahn-Weinaug SK,Liu J,Lubahn DB

更新日期：2018-05-01 00:00:00

abstract：:Aside from studies of a possible synergism between T3 and glucocorticoids in regulating GH mRNA, there have been few previous studies of the modulation by hormones and other factors of glucocorticoid hormone regulation of pituitary cell GH gene expression. We have employed a serum-free medium containing no exogenously...

journal_title：Endocrinology

authors： Gick GG,Bancroft C

更新日期：1987-05-01 00:00:00

abstract：:The prevailing view of sexual differentiation of mammalian brain is that androgen synthesized in the fetal and neonatal testis and aromatized centrally during a perinatal sensitive period is the sole source of brain estradiol and the primary determinant of sex differences. Subregions of the diencephalon are among the ...

journal_title：Endocrinology

authors： Konkle AT,McCarthy MM

更新日期：2011-01-01 00:00:00

abstract：:In this study, the potential interactions between dihydrotestosterone (DHT), a survival factor, and transforming growth factor-beta (TGF-beta), an apoptotic inducer, were examined in a derivative of the hormone-sensitive prostate cancer cell line LNCAP: The LNCaP TGF-beta receptor II cells, engineered to express TGF-b...

journal_title：Endocrinology

authors： Bruckheimer EM,Kyprianou N

更新日期：2001-06-01 00:00:00

abstract：:The direct effects of glucocorticoids on testicular LH receptor content and steroidogenesis were studied in vivo and in vitro. Immature hypophysectomized rats were treated with varying doses of dexamethasone, corticosterone, or a synthetic progestin, 17,21-dimethyl-19-nor-pregna-4,9-diene-3,20-dione (R5020). Some anim...

journal_title：Endocrinology

authors： Bambino TH,Hsueh AJ

更新日期：1981-06-01 00:00:00

abstract：:In the present studies we examined the regulation of insulin-like growth factor I (IGF-I) expression in porcine granulosa cells in vitro. Using Northern analysis and ribonuclease protection assays with exon-specific probes, we identified the IGF-I messenger RNA (mRNA) transcripts present in these cells under basal and...

journal_title：Endocrinology

authors： Samaras SE,Canning SF,Barber JA,Simmen FA,Hammond JM

更新日期：1996-11-01 00:00:00

abstract：:Administration of a single injection of estradiol (E2) causes a maximum increase in DNA synthesis in the uterine luminal epithelium approximately 24 h later. We previously reported that animals receiving a second injection of E2 15-18 h after the first show an apparent decrease in DNA synthesis measured in this cell t...

journal_title：Endocrinology

authors： Kirkland JL,Mukku VR,Hardy M,Stancel GM

更新日期：1984-03-01 00:00:00

abstract：:Equine CG (eCG) both radioiodinated and unlabeled, was injected iv into male rats, and the disappearance of the hormone from the circulation was studied. The uptake and inactivation of the hormone by various tissues was also examined. The disappearance curve of eCG consisted of two exponential components with apparent...

journal_title：Endocrinology

authors： Aggarwal BB,Papkoff H

更新日期：1981-10-01 00:00:00

abstract：:The inhibitory effect of stress on reproductive function is potentially mediated by high concentrations of circulating glucocorticoids (GCs) acting via the GC receptor (GR). Gonadotropin-inhibitory hormone (GnIH) is a hypothalamic neuropeptide that inhibits gonadotropin secretion. GnIH may mediate stress-induced repro...

journal_title：Endocrinology

authors： Son YL,Ubuka T,Narihiro M,Fukuda Y,Hasunuma I,Yamamoto K,Belsham DD,Tsutsui K

更新日期：2014-05-01 00:00:00

abstract：:Prolactin (Prl) secreting cells in a mixed pituitary cell culture form microscopically-identifiable plaques (zones of hemolysis around the lactotropes) when incubated in a monolayer with staphylococcal protein-A-coated ovine erythrocytes in the presence of Prl antiserum and complement. Plaques form first at 15-30 min ...

journal_title：Endocrinology

authors： Neill JD,Frawley LS

更新日期：1983-03-01 00:00:00

abstract：:Steady state levels of plasma membrane receptors (measured in radioligand assays) result from processes that contribute to the production of receptors (synthesis, recycling, and unmasking) as well as those that contribute to the loss of receptors (degradation, internalization, and inactivation). Accordingly, we have p...

journal_title：Endocrinology

authors： Braden TD,Conn PM

更新日期：1990-05-01 00:00:00

abstract：:Hypothalamic insulin signaling is essential to the maintenance of glucose and energy homeostasis. During pathological states, such as obesity and type 2 diabetes mellitus, insulin signaling is impaired. One key mechanism involved in the development of insulin resistance is lipotoxicity, through increased circulating s...

journal_title：Endocrinology

authors： Mayer CM,Belsham DD

更新日期：2010-02-01 00:00:00

abstract：:A protein [steroidogenesis-inducing protein (SIP)] has been isolated from human ovarian follicular fluid and shown previously to stimulate steroidogenesis in Leydig cells, adrenal cells, and early luteal cells. Since proteins and peptides known to regulate steroidogenesis, such as gonadotropins and growth factors, als...

journal_title：Endocrinology

authors： Khan SA,Teerds K,Dorrington J

更新日期：1992-02-01 00:00:00

abstract：:Adult Leydig cells are derived from proliferating stem/progenitor Leydig cells in the infant testis and subsequent differentiation to steroidogenic cells in adult mice. Leydig cell proliferation in the infant testis occurs primarily in response to increased levels of LH that induce Leydig cell expression of neuregulin...

journal_title：Endocrinology

authors： Umehara T,Kawashima I,Kawai T,Hoshino Y,Morohashi KI,Shima Y,Zeng W,Richards JS,Shimada M

更新日期：2016-12-01 00:00:00

abstract：:It was shown previously that epidermal growth factor (EGF) plays a role in the testosterone-dependent fetal Wolffian duct differentiation. In this communication, the role of EGF was further investigated by determining whether EGF receptor plays a role in mediating the effect of EGF during Wolffian duct (male duct) dif...

journal_title：Endocrinology

authors： Gupta C,Jaumotte J

更新日期：1993-10-01 00:00:00

abstract：:Treatment of 5-day cyclic rats with 10 or 100 microgram estradiol benzoate on the day of estrus induced a luteal phase in all animals studied. On the other hand, an injection with 1 microgram estradiol benzoate given on the same day failed to induce pseudopregnancy. When 10 mg progesterone were injected on the day of ...

journal_title：Endocrinology

authors： de Greef WJ,Zeilmaker GH

更新日期：1979-07-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1), a cold-induced protein expressed in brown adipose tissue (BAT), plays a role in adaptive thermogenesis by up-regulating uncoupling proteins (UCP). Here, we explore its relationship to the thermogenic actions of leptin, which also up-regulates UCPs...

journal_title：Endocrinology

authors： Kakuma T,Wang ZW,Pan W,Unger RH,Zhou YT

更新日期：2000-12-01 00:00:00

abstract：:A monoclonal antibody directed against bovine TSH was obtained by hybridoma technology. This antibody was specific for TSH and did not react with bovine LH and FSH. Affinity chromatography of crude TSH was performed on anti-TSH Sepharose. Bovine TSH was purified in a single step to near homogeneity by this technique, ...

journal_title：Endocrinology

authors： Lock AJ,van Denderen J,Aarden LA

更新日期：1988-01-01 00:00:00

abstract：:It is well established that LH has an obligatory role in the acute production of progesterone by the primate corpus luteum in vivo because interruption of LH support to the corpus luteum at any time during the luteal phase is accompanied by an immediate and sustained fall in serum progesterone concentrations. However,...

journal_title：Endocrinology

authors： Ravindranath N,Little-Ihrig L,Benyo DF,Zeleznik AJ

更新日期：1992-11-01 00:00:00

abstract：:Vasoactive intestinal polypeptide (VIP)ergic nerves innervate both the neurohypophysis and the hypothalamus. To test the hypothesis that VIP is a releasing factor for neurohypophyseal hormones, rats were given intracerebroventricular (icv) infusions of VIP in doses varying from 0.3 pmol/kg.min to 3 nmol/kg.min for 5 m...

journal_title：Endocrinology

authors： Bardrum B,Ottesen B,Fahrenkrug J,Fuchs AR

更新日期：1988-11-01 00:00:00

abstract：:The antiapoptotic molecule Fas-associated death domain-like IL-1beta-converting enzyme inhibitory protein (FLIP) inhibits Fas-mediated apoptosis by blocking activation of caspase-8. We previously showed that expression of transgenic FLIP on thyroid epithelial cells (TECs) of DBA/1 and CBA/J mice promoted earlier resol...

journal_title：Endocrinology

authors： Fang Y,Braley-Mullen H

更新日期：2008-07-01 00:00:00

abstract：:Although it is well known that chronic treatment with glucocorticoids inhibits somatic growth, the mechanism of action of this inhibitory effect is not completely understood. It is likely that glucocorticoids act at various levels, including pituitary, hypothalamus, and peripheral organs modulating GH synthesis, secre...

journal_title：Endocrinology

authors： Señarís RM,Lago F,Coya R,Pineda J,Diéguez C

更新日期：1996-12-01 00:00:00